| 1. |
- Barthelmie, Rebecca, et al.
(författare)
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ENDOW: Efficient Development of Offshore Windfarms
- 2003
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Ingår i: Proceedings from Offshore Wind Energy in Meditteranean and Other Seas OWEMES2003, Naples, Italy, 10-12 April 2003.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Broberg, Karin, et al.
(författare)
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Trisomy 7 accumulates with age in solid tumors and non-neoplastic synovia
- 2001
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Ingår i: Genes, Chromosomes and Cancer. - 1045-2257. ; 30:3, s. 310-315
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Tidskriftsartikel (refereegranskat)abstract
- Trisomy 7 is a common finding in benign and malignant solid tumors, in several non-neoplastic lesions (for example, osteoarthritis and rheumatoid arthritis), and in apparently normal tissues as well, suggesting that the occurrence of +7 might be associated with factors other than the disease process itself. To find out whether the frequency of +7 varies with a patient's age, we cytogenetically analyzed short-term-cultured synovial samples from elderly persons without signs of arthritis and from young patients affected by juvenile chronic arthritis (JCA). In normal synovia, gain of a chromosome 7 was present as a clonal change in five of 10 cases and in single cells in four of the five remaining cases. In synovia from patients with JCA, cells with +7 were detected in only one of nine cases, representing the oldest patient in the series. Furthermore, we reviewed the cytogenetic literature on tumors of the brain, breast, colon, kidney, lung, skin, thyroid, and upper aerodigestive tract. In the majority (six of eight) of these tumor types, the frequency of cases displaying a clone with +7 as the sole aberration increased with age. Taken together, the results presented here suggest that the acquisition of trisomy 7 in some neoplastic and non-neoplastic tissues might be associated with age rather than with disease. The finding of a completely different frequency distribution in two of the tumor types (tumors of the brain and the thyroid gland), however, emphasizes the heterogeneity of +7 and indicates that other, possibly tissue-specific, factors might influence the occurrence of this mutation.
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| 4. |
- Broberg Palmgren, Karin, et al.
(författare)
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The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia
- 2001
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Ingår i: Modern Pathology. - : Elsevier BV. - 1530-0285 .- 0893-3952. ; 14:4, s. 311-317
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Tidskriftsartikel (refereegranskat)abstract
- Chromosomal rearrangements involving chromosome bands 12q13-15 are very frequent findings in benign solid tumors, and recently, the primary molecular target for these aberrations was identified as the gene HMGIC. However, mutations in this gene have also been observed in nonneoplastic tissues. In a previous study, we reported breakpoints within HMGIC of synovia affected by osteoarthritis (OA) in two cases with 12q15 aberrations. To analyze further the role of HMGIC in this disease, we have performed cytogenetic, fluorescent in situ hybridization (FISH), RNA, and protein expression analyses on synovial samples from patients with OA and individuals without signs of the disorder. Cytogenetic analysis of short-term cultured cells revealed clonal 12q13-15 aberrations in 2/36 cases of OA synovia and no rearrangement in any of the five controls. With FISH analysis, it was shown that the chromosomal breakpoints in the two aberrant cases were located outside the HMGIC locus. In contrast, at RNA and protein expression analyses, OA-affected as well as normal synovia displayed transcription and translation of the gene. We also analyzed whether immunoreactivity for HMGIC was associated with the proliferation-specific antigen Ki-67, but no correlation between the staining patterns of these proteins was observed. From the results of the present study, it is evident that expression of HMGIC cannot simply be considered a sign of neoplasia or an effect of proliferation.
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| 5. |
- Catani, F, et al.
(författare)
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The stability of the cemented tibial component of total knee arthroplasty
- 2004
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Ingår i: Journal of Arthroplasty. - : Elsevier BV. - 0883-5403. ; 19:6, s. 775-782
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Tidskriftsartikel (refereegranskat)abstract
- Micromotion of the tibial component in 40 knee arthroplasties for gonarthrosis was studied rising Roentgen stereophotogrammetric analysis. The stability of this component was assessed for 2 years' postoperatively. in all arthroplasties, an attempt was made to reconstruct the preoperative posterior slope. Posterior cruciate-retaining (CR) and posterior-stabilized (PS) components showed at 2 years a maximum total point motion of 0.6 +/- 0.4 mm and 0.7 +/- 0.5 mm, respectively. Whereas 92.5% of the implants were determined to be stable, 1 of the CR group and 2 of the PS group displayed migration between the first and the second year of at least 0.2 mm. A negative correlation between subsidence of the tibial component at 2 years of follow-up and the difference between preoperative and postoperative tibial slope was found. Consequently, we suggest that restoring the original posterior slope of the tibial plateau must be a goal of tibial component implantation.
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| 6. |
- Hansson, Ulrik, et al.
(författare)
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A randomised RSA study of Peri-apatite((TM)) HA coating of a knee prosthesis
- 2004
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Ingår i: Key Engineering Materials. - 1013-9826. ; 254-2, s. 623-625
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Tidskriftsartikel (refereegranskat)abstract
- Fifty knees scheduled for a total knee prosthesis were randomized in two groups. Both groups had a noncemented fixation of the porous-coated implants but one group received a prosthesis with ceramic coating on the porous surface of the implant. The knees were evaluated with RSA technique regarding micromotion the first two years. There were less micromotion in the coated group. The results indicate that the technique for ceramic coating here studied provides a safe and stable fixation of the implants.
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| 7. |
- Johansson, Cecilia, 1974-
(författare)
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Influence of External Factors on the Turbulence Structure in the Atmospheric Boundary Layer
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The theory used in today’s weather- and climate models to describe processes near the earth’s surface, i.e. transport of heat, moisture and momentum between the ground and the atmosphere, is based on the idea that only local factors are important, such as temperature and wind speed near the ground. However, from measurements made at two sites, one agricultural and one marine, it has been found that large eddies, which are related to the convective boundary layer height, influence the turbulence structure near the ground during unstable conditions more than previously realized. Especially the momentum transport is affected. The large eddies have similar size over land and over the sea, typically 1000 m. The important difference being that over land diurnal variation plays a fundamental role; over the sea such variations are typically absent. From the marine site it has also been found that the turbulence structure of the temperature field over the Baltic Sea is very different from over land. Instead of having a height dependence as expected from theory, the temperature structure seems to be constant with height within the surface layer. Typically, the heat flux over the sea is smaller than over land during convective conditions. This gives rise to a turbulence transport regime which is fundamentally different from that observed during daytime convective conditions over land.
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| 8. |
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| 9. |
- Lindstrand, Anders, et al.
(författare)
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The patella in total knee arthroplasty: resurfacing or nonresurfacing of patella
- 2001
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Ingår i: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer Science and Business Media LLC. - 1433-7347 .- 0942-2056. ; 9:Suppl 1, s. 21-23
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Tidskriftsartikel (refereegranskat)abstract
- Data from the Swedish Knee Arthroplasty Registry were analyzed to compare bi- and tricompartmental knee arthroplasties carried out in patients operated on for arthrosis in 1990-1996. Of the 16,607 primary arthroplasties that were carried out there were 5,139 with patellar replacement in the primary procedure and 10,928 without. By April 1998, 280 revisions were performed, 250 of these cases were analyzed in this study. Patella-related complications were commonly the reason for early revision: in 99 of the 168 knees with a primary bicompartmental procedure and in 36 of the 82 knees with a primary tricompartmental procedure. This presentation merely analyzes the extent of patellar problems in knee arthroplasty, as a detailed analysis of the causes of this common problem is not possible using data from a national multicenter study.
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| 10. |
- Roos, Ewa, et al.
(författare)
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Knee injury and Osteoarthritis Outcome Score (KOOS) - validation and comparison to the WOMAC in total knee replacement.
- 2003
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Ingår i: Health and Quality of Life Outcomes. - : Springer Science and Business Media LLC. - 1477-7525. ; 1:1, s. 17-17
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Knee injury and Osteoarthritis Outcome Score (KOOS) is an extension of the Western Ontario and McMaster Universities Osteoarthrtis Index (WOMAC), the most commonly used outcome instrument for assessment of patient-relevant treatment effects in osteoarthritis. KOOS was developed for younger and/or more active patients with knee injury and knee osteoarthritis and has in previous studies on these groups been the more responsive instrument compared to the WOMAC. Some patients eligible for total knee replacement have expectations of more demanding physical functions than required for daily living. This encouraged us to study the use of the Knee injury and Osteoarthritis Outcome Score (KOOS) to assess the outcome of total knee replacement. METHODS: We studied the test-retest reliability, validity and responsiveness of the Swedish version LK 1.0 of the KOOS when used to prospectively evaluate the outcome of 105 patients (mean age 71.3, 66 women) after total knee replacement. The follow-up rates at 6 and 12 months were 92% and 86%, respectively. RESULTS: The intraclass correlation coefficients were over 0.75 for all subscales indicating sufficient test-retest reliability. Bland-Altman plots confirmed this finding. Over 90% of the patients regarded improvement in the subscales Pain, Symptoms, Activities of Daily Living, and knee-related Quality of Life to be extremely or very important when deciding to have their knee operated on indicating good content validity. The correlations found in comparison to the SF-36 indicated the KOOS measured expected constructs. The most responsive subscale was knee-related Quality of Life. The effect sizes of the five KOOS subscales at 12 months ranged from 1.08 to 3.54 and for the WOMAC from 1.65 to 2.56. CONCLUSION: The Knee injury and Osteoarthritis Outcome Score (KOOS) is a valid, reliable, and responsive outcome measure in total joint replacement. In comparison to the WOMAC, the KOOS improved validity and may be at least as responsive as the WOMAC.
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| 11. |
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| 12. |
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| 13. |
- W-Dahl, Annette, et al.
(författare)
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Cigarette smoking delays bone healing: A prospective study of 200 patients operated on by the hemicallotasis technique
- 2004
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 75:3, s. 51-347
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in UndeterminedBackground Cigarette smoking is known to impede bone healing. The hemicallotasis technique is based on an external fixation and delayed healing prolongs treatment and increases the risk of further complications. Patients and methods 200 patients, 34 smokers and 166 nonsmokers, operated on by the hemicallotasis technique in the proximal tibia for deformities of the knee (knee arthrosis in 186 patients) were consecutively studied. We recorded their preoperative smoking habits, postoperative complications and the duration of treatment with external fixation. Results Half of the smokers and one fifth of the nonsmokers developed complications. Their mean time in external fixation was 96 (SD 20) days. Smokers required an average of 16 days more in external fixation. Delayed healing and pseudoarthrosis were commoner in smokers than nonsmokers. The risk ratio for smokers to develop complications was 2.5, as compared to nonsmokers.
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| 14. |
- W-Dahl, Annette, et al.
(författare)
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No difference between daily and weekly pin site care: a randomized study of 50 patients with external fixation.
- 2003
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Ingår i: Acta Orthopaedica Scandinavica. - : Medical Journals Sweden AB. - 0001-6470. ; 74:6, s. 704-708
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: We investigated whether there were any differences in the frequency and severity of pin site infections by performing pin site care daily or once a week. We studied patients operated on for gonarthrosis by the hemicallotasis technique, using hydroxyapatite-coated pins in the metaphyseal bone and standard pins in the diaphyseal bone. Patients and methods: 50 patients were prospectively randomized to daily (nÊ= 27) or weekly (nÊ= 23) pin site care. We evaluated pin sites, the occurrence of pain (VAS), the use of antibiotics and analgesics and complications every week. Bacterial cultures were taken from each pin site at 1, 6 and 10 weeks and from the pins on removal. Results: We found no differences between daily or weekly pin site care as regards the frequency and severity of pin site infections, pain, or the use of antibiotics and analgesics. Grade I infections (Checketts-Otterburns classification) occurred around 11% of the pins and grade II infections around 4%. 70% of the bacterial cultures were negative. The most frequent bacteria were coagulase negative staphylococcus and corynebacterium. Antibiotics were given an average of 47 days. More problems occurred around the proximal pins. 5/200 (all proximal) pins were clinically loose on removal. Interpretation: Pin site care once a week seems appropriate.
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| 15. |
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