| 1. |
- Ahmad, Shafqat, et al.
(författare)
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Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome : A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
- 2022
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 71:2, s. 329-339
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate the association between adiposity with circulating metabolites and to address causality with Mendelian randomization (MR). Metabolomics data was generated by non-targeted ultra-performance liquid-chromatography coupled to time-of-flight mass-spectrometry in plasma and serum from three population-based Swedish cohorts: ULSAM (N=1,135), PIVUS (N=970), and TwinGene (N=2,059). We assessed associations between general adiposity measured as body mass index (BMI) and central body fat distribution measured as waist-to-hip ratio adjusted for BMI (WHRadjBMI) with 210 annotated metabolites. We employed MR analysis to assess causal effects. Lastly, we attempted to replicate the MR findings in the KORA and TwinsUK cohorts (N=7,373), the CHARGE consortium (N=8,631), the Framingham Heart Study (N=2,076) and the DIRECT consortium (N=3,029). BMI was associated with 77 metabolites, while WHRadjBMI was associated with 11 and 3 metabolites in women and men, respectively. The MR analyses in the Swedish cohorts suggested a causal association (p-value <0.05) of increased general adiposity and reduced levels of arachidonic acid, dodecanedioic acid and lysophosphatidylcholine (P-16:0) as well as with increased creatine levels. The replication effort provided support for a causal association of adiposity on reduced levels of arachidonic acid (p-value 0.03). Adiposity is associated with variation of large parts of the circulating metabolome, however causality needs further investigation in well-powered cohorts.
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| 2. |
- Bergsten, Eva L., 1969-, et al.
(författare)
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Effects of relocation to activity-based workplaces on perceived productivity : importance of change-oriented leadership
- 2021
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Ingår i: Applied Ergonomics. - : Elsevier. - 0003-6870 .- 1872-9126. ; 93, s. 10-16
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Tidskriftsartikel (refereegranskat)abstract
- Activity-based workplaces (ABWs) are becoming popular in Western countries and were implemented at four office sites of a large Swedish government agency. A fifth office was used as a control group. The study aim was to examine the effects of relocation to ABW on perceived productivity among employees and to determine if perceived change-oriented leadership behavior prior to relocation moderates potential effects. Data were collected three months prior to relocation, and three and 12 months after. 407 respondents were included in linear mixed regression models. Perceived productivity decreased significantly after relocation compared to the control group and these effects persisted 12 months after the relocation. However, the decrease in perceived productivity was significantly smaller among employees perceiving high change-oriented leadership before relocation. Our results point out the importance of a change-oriented leadership behavior during the implementation to avoid productivity loss among employees when implementing ABWs.
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| 3. |
- Bjärntoft, Sofie, et al.
(författare)
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Occupational and individual determinants of work-life balance among office workers with flexible work arrangements
- 2020
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:4
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Tidskriftsartikel (refereegranskat)abstract
- Flexible work arrangements permitting workers to work anytime and anywhere are increasingly common. This flexibility can introduce both challenges and opportunities for the organisation, as well as for worker work-life balance (WLB). This cross-sectional study aimed to examine the extent to which occupational factors (organizational, leadership and psychosocial) and individual work-related behaviours (over-commitment, overtime work and boundary management) are associated with WLB, and whether these associations are modified by the perceived level of flexibility at work (i.e., control over when, where, and how to do the work). In total, 2960 full-time office workers with flexible work arrangements at the Swedish Transport Administration participated. Associations were determined using linear regression analyses with adjustment for covariates. The strongest negative associations with WLB were found for over-commitment, quantitative job demands, expectations of availability, and overtime work. Strongest positive associations were found for boundary management, information about organizing work, social support, and relation-oriented leadership. Perceived flexibility was positively associated with WLB, and interacted with several of the examined factors, buffering their negative associations with WLB. Results suggest that WLB can be promoted by organizational initiatives focusing on minimizing excessive job demands, increasing psychosocial resources, supporting boundary management, and enhancing perceived flexibility.
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| 4. |
- Engström, Gunnar, et al.
(författare)
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Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications
- 2024
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Ingår i: European Journal of Epidemiology. - : Springer Nature. - 0393-2990 .- 1573-7284. ; 39:1, s. 35-49
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Tidskriftsartikel (refereegranskat)abstract
- Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
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| 5. |
- Larsson, Johan, 1979-, et al.
(författare)
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Integration, Application and Importance of Collaboration in Sustainable Project Management
- 2020
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- The need to consider sustainability has substantially increased the complexity of implementing construction and infrastructure projects and new management practices have emerged during the past decade to tackle the global sustainability challenges, where the engagement and coordination of broader competences from stakeholders throughout the supply chain is required. This new project management paradigm has been accompanied by greater attention to the concept of collaborative business arrangements, often called partnering, that has emerged in construction and infrastructure projects to improve project deliveries. However, there are uncertainties about the optimal strategy to foster, integrate and maintain the required collaboration, particularly in sustainable management practices in infrastructure maintenance projects. This paper addresses these uncertainties, based on a single case study of an infrastructure maintenance contract involving an extensive collaborative business arrangement. The findings reveal that different collaborative practices affect diverse aspects of sustainable project management. Further, the extensive collaborative business arrangement has promoted sustainable deliveries based upon organizational learning and continuous improvements. Thus, this study offers an encouraging example of how extensive collaboration can be fostered and play a key role in sustainable project management practices.
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| 6. |
- Sayols-Baixeras, Sergi, et al.
(författare)
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Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
- 2023
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Ingår i: Circulation. - : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 148:6, s. 459-472
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Tidskriftsartikel (refereegranskat)abstract
- Background: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.Methods: We conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of stool, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.Results: The mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1×10-5). Associations were largely similar across coronary computed tomography angiography-based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malmö Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, and amino acid degradation were associated with coronary artery calcium score.Conclusions: This study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.
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| 7. |
- Ahmadi, Elena, 1978-, et al.
(författare)
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Managers’ work and behaviour patterns in profitable growth SMEs
- 2021
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Ingår i: Small Business Economics. - : Springer. - 0921-898X .- 1573-0913. ; 57, s. 849-863
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Tidskriftsartikel (refereegranskat)abstract
- We investigated managers’ work and behaviour patterns in profitable growth small- and medium-sized Swedish companies, and considered how these patterns might be associated with good health outcomes. Specifically, we looked at hours worked by managers, proportion of time spent on working activities, and leadership behaviour orientation. We used a quantitative cross-sectional design and collected data via a standardized questionnaire that was answered by 133 top managers. The data were analyzed with descriptive statistics, linear regression, and compositional data analysis. Our results indicate that the managers worked long hours, which is a health risk both for them as individuals and for their organizations, but also that they engaged in work practices and leadership behaviours that were favourable for organizational health and for their employees. The managers spent a high proportion of their time in touring, which could be beneficial to organizational health, and exercised active leadership through behaviours that contribute to both employee health and company effectiveness. Comparing our results to other studies, we can observe that patterns of managers’ time use differ between small and large companies, confirming that the size of the firm is an important determinant of managerial work.
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| 8. |
- Bjärntoft, Sofie, et al.
(författare)
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A participatory approach to identify key areas for sustainable work environment and health in employees with flexible work arrangements
- 2021
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 13:24
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Tidskriftsartikel (refereegranskat)abstract
- Flexible work arrangements are common worldwide, but knowledge on how to achieve a sustainable work environment is sparse. The aim of this study was to use a participatory approach to identify concrete suggestions and key areas for improvement that were considered relevant, effective, and feasible for promoting good work environment and health at organizational, work group and individual level (O-G-I), among office employees with flexible work arrangements. Eight focus group interviews (including 45 employees) were conducted in a large Swedish government agency in 2017. By using a Tree diagram approach, employees made a total of 279 suggestions for improvements, which were sorted into O-G-I levels and mapped into 18 key areas. We found that 13 key areas addressed organizational level (e.g., improving leadership, policy, job demands, and work efficiency), two key areas addressed group level (create common rules of availability and activity-based working), and three key areas addressed individual level (e.g., individuals’ responsibility to clearly communicate their availability). The participatory process was effective in obtaining concrete suggestions and key areas in need of improvement, which may provide an action plan that can guide organizations in developing interventions to promote good work environment and health in flexible work.
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| 9. |
- Dahlkvist, Eva, et al.
(författare)
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First-Line Managers’ Leadership Behavior Profiles and Use of Gardens in Residential Care Facilities: An Interview Study
- 2023
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Ingår i: Journal of Aging and Environment. - : Taylor & Francis. - 2689-2618 .- 2689-2626. ; 37:1, s. 65-84
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Tidskriftsartikel (refereegranskat)abstract
- This study explored first-line managers’ leadership behavior profiles regarding their goals for utilizing the garden at residential care facilities for older people. Semi-structured interviews were conducted with a convenience sample of first-line managers (n = 12) in Sweden. Data were analyzed using deductive content analysis theoretically guided by the Three-dimensional Leadership Model. The results showed that the main leadership behavior profiles were related to the dimensions structure, relation and change. The managers emphasized workplace regulations and goals. They allowed staff to make decisions and encouraged them to see problems and opportunities.
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| 10. |
- Eriksson, Per-Erik, et al.
(författare)
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Governing technical and organizational complexity through supply chain integration: A dyadic perspective on performance in infrastructure projects
- 2023
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Ingår i: International Journal of Project Management. - : Elsevier Ltd. - 0263-7863 .- 1873-4634. ; 41:4
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Tidskriftsartikel (refereegranskat)abstract
- Despite its declared importance for governing complexity in projects, few empirical studies have studied how different types of supply chain integration (SCI) activities (e.g., coordinative and collaborative integration) interplay and affect performance. To address this gap, the purpose of this paper is to study how complexity can be governed through coordinative and collaborative SCI, and how their interplay affects performance in project-based buyer-supplier relationships. We apply structural equation modeling, using dyadic empirical data from 102 infrastructure projects. The overall results verify our developed model and illuminate how the interplay between contractual and relational governance, in terms of coordinative and collaborative SCI, mediates the effect of technical and organizational complexity on project performance. This study contributes to theory and practice by distinguishing between contractual governance based on formal coordinative SCI and relational governance based on emerged collaborative SCI, as well as showing how their interplay affects performance in project-based supply chains.
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| 11. |
- Gholiha, Alex R., et al.
(författare)
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Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
- 2022
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- In classical Hodgkin Lymphoma (cHL), immunoediting via protein signaling is key to evading tumor surveillance. We aimed to identify immune-related proteins that distinguish diagnostic cHL tissues (=diagnostic tumor lysates, n = 27) from control tissues (reactive lymph node lysates, n = 30). Further, we correlated our findings with the proteome plasma profile between cHL patients (n = 26) and healthy controls (n = 27). We used the proximity extension assay (PEA) with the OlinkTM multiplex Immuno-Oncology panel, consisting of 92 proteins. Univariate, multivariate-adjusted analysis and Benjamini–Hochberg’s false discovery testing (=Padj) were performed to detect significant discrepancies. Proteins distinguishing cHL cases from controls were more numerous in plasma (30 proteins) than tissue (17 proteins), all Padj < 0.05. Eight of the identified proteins in cHL tissue (PD-L1, IL-6, CCL17, CCL3, IL-13, MMP12, TNFRS4, and LAG3) were elevated in both cHL tissues and cHL plasma compared with control samples. Six proteins distinguishing cHL tissues from controls tissues were significantly correlated to PD-L1 expression in cHL tissue (IL-6, MCP-2, CCL3, CCL4, GZMB, and IFN-gamma, all p ≤0.05). In conclusion, this study introduces a distinguishing proteomic profile in cHL tissue and potential immune-related markers of pathophysiological relevance
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| 12. |
- Järvenpää, Anna-Therése, et al.
(författare)
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Exploring a public client’s control systems in infrastructure projects from a relationship history perspective
- 2022
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Ingår i: Construction Management and Economics. - : Taylor & Francis. - 0144-6193 .- 1466-433X. ; 40:1, s. 56-71
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Tidskriftsartikel (refereegranskat)abstract
- Using a proper control system is vital to ensure that project delivery is satisfactory for the client. Prior research has identified relationship history as a potentially vital contingency factor in organizational control, but there is a lack of research on how relationship history affects how different control systems function in project-based contexts. In the Swedish infrastructure market, increased demand has resulted in a need for increased supply capacity. This has spurred new entrants that have no relationship history with the major client, the Swedish Transport Administration. The purpose is therefore to compare how the client’s control systems function in construction projects with familiar (known to the client) and unfamiliar (new to the client) contractors. The case study involves 32 interviews conducted in six infrastructure projects, three with unfamiliar contractors. Findings show that relationship history heavily influences how the control systems function, especially bureaucratic and clan control. The new contractors are unaccustomed with the client’s extensive use of bureaucratic control and perceive it as less suitable in design-build contracts. Furthermore, the lack of relationship history reduces the opportunity to use clan control from the beginning of a project, due to unfamiliarity with both the client and the control system.
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| 13. |
- Järvenpää, Anna-Therése, et al.
(författare)
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How public client’s control systems affect contractors’ innovation possibilities
- 2024
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Ingår i: Construction Innovation. - : Emerald Group Publishing Limited. - 1471-4175 .- 1477-0857.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - This paper aims to identify how a public client’s use of control systems (process, output and social control) affect innovation possibilities in construction projects.Design/methodology/approach - Semi-structured interviews about six infrastructure projects were conducted to identify respondents’ views on innovation possibilities. These possibilities were then analyzed from an organizational control perspective within principal–agent relationships between the Swedish Transport Administration (STA) and their contractors.Findings - How the client uses control systems affects innovation possibilities. Relying on process control could negatively affect innovation opportunities, whereas output control could have a positive influence. In addition, social control seems to have a weak effect, as the STA appears not to use social control to facilitate joint innovation. Public clients must comply with the Public Procurement Act and, therefore, retain the requirements specified in the tendering documents. Much of the steering of the execution is connected to the ex ante phase (before signing the contract), which affects innovation possibilities in the design and execution phases for the contractor.Research limitations/implicationsThis study was conducted with only one client, thus limiting its generalizability. However, the findings provide an important stepping stone to further investigation into balancing control systems and creating innovation possibilities in a principal–agent relationship.Originality/value - Although public procurement has increasingly been emphasized as a major potential source of innovation, studying how a public client’s use of organizational control systems affects innovation possibilities in the construction sector has received scant attention.
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| 14. |
- Järvenpää, Anna-Therése
(författare)
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How to promote innovation from an organizational control perspective : A case study of a public infrastructure client
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Within the infrastructure sector, a public client can have various roles and responsibilities that extend beyond its own organization, such as stimulating and supporting innovation. As an infrastructure project is seldom standardized, the client needs to procure each contract based on the relevant uncertainties and complexities for that specific context. To encourage a contractor’s compliance with the client’so bjectives, the client employs some degree of organizational control. When a public client procures all its infrastructure from contractors, it also needs to find ways of eliciting innovative solutions from the suppliers. Therefore, a public client needs strategies to both promote innovation by the contractors and direct and oversee the contractors’ work to ensure the deliverables meet the project’s objectives. The demands for increased innovation in the construction sector in general needs to be handled concomitant with the client’s need to check that the contractor delivers accordingly to the client’s objectives and demands. The overall purpose of this thesis is to explore the relationship between organizational control and promoting innovation by a public infrastructure client. More specifically, it explores how a public client can promote innovation by its contractors from an organizational control perspective. The theoretical background is provided by an organizational control framework (Ouchi, 1979; Aulakh et al., 1996), i.e. a client can manage and steer an agent via three different control systems: process, output, and social. The empirical data is derived from 47 semi-structured interviews, complemented by observations, from10 different infrastructure projects. The client (The Swedish Transport Administration; STA) is the same for each project, but the contractors differ. Two types of contractor are represented: contractors that have not worked with the STA before (“unfamiliar contractors”), and contractors that have worked with the STA before (“familiar contractors”). A majority of the contract type is design-build. Four appended papers, each presenting a public client perspective, provide the basis of the thesis. Previous findings that the client’s role is important for promoting innovation is explored further in this thesis from an organizational control perspective, emphasizing the role of the public client. It is important that during the procurement phase the client tries to find the right balance between achieving the intended objectives and creating space for innovation. Ex-ante planning is important, because how the client writes the control mechanisms into the procurement documents, and later the contract, has a direct effect on the opportunities for innovation by the contractors.In addition, the client has to manage the project in a way that does not cause irritation of frustration for the contractor, or hinder their work, thus supporting the view that organizational control should be enabling instead of coercive, so that the client’s input encourages innovation rather than creating obstacles. In addition, when adding a relationship history perspective on organizational control, an unfamiliar contractor (i.e. a contractor that has not worked with the client before) can find process control unsuitable and social control confusing, which means output control is probably the most appropriate approach to take when working with unfamiliar contractors. However, just relying on procurement strategies such as a design-build (DB)contract in combination with strict functional demands is not enough to promote innovation. Furthermore, a collaborative setting only seems to lead to innovative solutions if the client regards innovation as a mutual task and utilizes the collaborative setting for innovative co-creation. From the client’s perspective, the practical and managerial implication of this thesisis the importance of finding a balance between giving the contractor space to be innovative in the execution of the contract, and at the same time making sure that the requisite end product is delivered. The results of this thesis suggest that the client does not hand over the “how” to the contractor when it comes to executing the project, as would be expected in a DB contract. From the contractor’s perspective, the responsibility for innovation within a DB contract can be confounded by the client’s use of social control, by which the client may encourage discussions and collaboration regarding innovative solutions but blur the line over responsibilities. This could explain why social control often fails to have a positive impact on innovative output.
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| 15. |
- Larsson, Johan, 1979-, et al.
(författare)
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Innovation outcomes and processes in infrastructure projects–a co mparative study of Design-Build and Design-Build-Maintenance contracts
- 2022
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Ingår i: Construction Management and Economics. - : Informa UK Limited. - 0144-6193 .- 1466-433X. ; 40:2, s. 142-156
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Tidskriftsartikel (refereegranskat)abstract
- Innovation is often seen as essential for long-term development in the construction industry, but its actual outcomes and processes in construction projects require more attention. Many studies on procurement strategies and delivery systems have focussed on the public transport infrastructure sector, whereas most construction innovation scholars have addressed the innovation phenomenon in construction generally. Thus, the purpose of this study is to compare how two delivery systems, design-build (DB) and design-build-maintenance (DBM), influence project-level innovation. Findings are based on empirical data from a multiple case study of six infrastructure projects, three with DB contracts and three with DBM contracts, in which 12 innovations are identified, described, and compared. The findings show that various kinds of innovations in terms of outcomes and processes are implemented in infrastructure projects, and that the delivery system do effect both dimensions. Long maintenance responsibilities tend to spur contractors to engage in early exploration of sustainable solutions that could be of long-term benefit. The research contributes to procurement literature by exemplifying how delivery systems influence both the outcomes and processes of project-level innovations. It also increases our knowledge about construction innovation as a multi-dimensional phenomenon.
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| 16. |
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| 17. |
- Lööw, Joel, et al.
(författare)
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A CHANGING WORK ENVIRONMENT IN THE WAKE OF THE COVID-19 PANDEMIC? – OBSERVATIONS FROM MANAGERS IN A SWEDISH MINING COMPANY
- 2023
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Ingår i: Occupational Safety and Hygiene – SHO2023 Proceedings Book. - : Portuguese Society of Occupational Safety and Hygiene (SPOSHO). - 9789895486342 ; , s. 376-389, s. 376-389
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Konferensbidrag (refereegranskat)abstract
- Background: The Covid-19 pandemic has changed work life in many ways for many people; however, it is still an open question as to what changes will become permanent and what aspects of work life will return to that which was considered “normal” before the pandemic.Objective: In this study, the authors describe and analyse the effects of Covid-19 on managers in a large Swedish mining company.Method: This study is based on both quantitative and qualitative methods. Empirical material is used to explore the effects of the pandemic on the work environments of managers. Results are based on interviews in combination with a self-assessment process regarding how the managers allocated their work time during a work week.Results: The results describe the work activities of the studied managers supported with quotes from interview studies to illustrate to most central observations of how work has changed due to the Covid-19 pandemic.Conclusion: The results are summarized into six hypotheses: 1) the workday was densified due to remote meetings; 2) "double work" during meetings was the rule, rather than the exception; 3) meetings became more focused; 4) meetings became more accessible; 5) the manager became less operational; and 6) a new work culture was created.Application: This is an exploratory study of consequences and effects of Covid-19 pandemic summarized in six hypotheses that can befruitful for further and future studies.
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| 18. |
- Mezheyeuski, Artur, et al.
(författare)
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
- 2023
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 88
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression.Methods: Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data sets were used for functional analysis and validation of prognostic and predictive associations.Findings: By combining the prognostic information of anti-tumoural CD8+ lymphocytes and tumour supportive CD68+CD163+ macrophages in colorectal cancer we generated a signature of immune activation (SIA). The prognostic impact of SIA was independent of conventional parameters and comparable with the state-of-art immune score. The SIA was also associated with patient survival in oesophageal adenocarcinoma, bladder cancer, lung adenocarcinoma and melanoma, but not in endometrial, ovarian and squamous cell lung carcinoma. We identified CD68+CD163+ macrophages as the major producers of complement C1q, which could serve as a surrogate marker of this macrophage subset. Consequently, the RNA-based version of SIA (ratio of CD8A to C1QA) was predictive for survival in independent RNAseq data sets from these six cancer types. Finally, the CD8A/C1QA mRNA ratio was also predictive for the response to checkpoint inhibitor therapy.Interpretation: Our findings extend current concepts to procure prognostic information from the tumour immune microenvironment and provide an immune activation signature with high clinical potential in common human cancer types.
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| 19. |
- Molnar, Malin, 1977-, et al.
(författare)
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Facilitating and straining factors affecting the health and sustainability of young managers in a modern mining industry : Self-fulfilment and development - a buffer for young managers?
- 2023
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Ingår i: Arbetsliv i omvandling. - Lund : Lunds universitet. - 1404-8426. ; :2, s. 3-53
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Tidskriftsartikel (refereegranskat)abstract
- To be able to attract, retain and develop talented individuals to managerial positions is important for organizations. Recently, however, there are indications that young professionals are reluctant to accept a leadership role. There is a lack of research exploring the reasons for this reluctance and investigating the working conditions and health of young managers; especially within heavy industries such as mining. The aim of the study is to gain a deeper understanding of the factors affecting the health and sustainability of young managers in the mining industry. A qualitative case study is conducted based on in-depth interviews with 10 managers aged 35 years or younger at a large international mining company in Northern Europe. A content analysis indicated several straining and facilitating aspects of the work situation in terms of maintaining sustainability and good health. The resulting themes are analyzed and discussed through the lens of the Job-demand-control-support (JDCS) model. Perceived stimulation, growth, and development seems to have a facilitating role in promoting sustainability and health, and is one theme that stood out from complete adaptation to the model. The study contributes with insights into how this model can be applied to a specific professional group (young managers) and in a certain context (mining and similar heavy industry). The findings have practical implications for organizations regarding the ability to ensure good, healthy, attractive, and sustainable working conditions for young managers.
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| 20. |
- Morfeldt, Johannes, 1983, et al.
(författare)
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Emission pathways and mitigation options for achieving consumption-based climate targets in Sweden
- 2023
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Ingår i: Communications Earth & Environment. - Göteborg : IVL Svenska Miljöinstitutet AB. - 2662-4435. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- National emission reduction targets under the Paris Agreement have a territorial focus, incentivizing mitigation actions domestically. Here we examine the theoretical basis for adopting complementary consumption-based net-zero emission targets and assess the consequences of adopting such proposed targets for Sweden. We apply scenario analyses based on a prospective lifecycle assessment framework. The framework is a hybrid of bottom-up simulations for passenger travel, construction and housing, and food, and top-down analyses for remaining consumption. In this work, we show how consumption-based climate targets may accentuate the need for new demand-side climate policies that contribute to reducing emissions along supply chains of products and services.Our scenario analysis suggests that combining advanced mitigation technologies with behavioral changes could reduce emissions from 9.8 tons of carbon dioxide equivalents per capita in 2019 to between 2.7 and 4.8 tons by 2045 for Swedish residents, depending on global decarbonization pathways. Combining advanced mitigation technologies with behavioural changes could achieve the lowest carbon emissions per capita in Sweden, suggest scenario analyses combining bottom-up simulations for passenger travel, construction and housing, and food, and top-down analyses for remaining consumption.
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| 21. |
- Nilsson Vestola, Emilia, 1992-, et al.
(författare)
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Temporary and permanent aspects of project organizing – operation and maintenance of road infrastructure
- 2021
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Ingår i: International Journal of Managing Projects in Business. - : Emerald Group Publishing Limited. - 1753-8378 .- 1753-8386. ; 14:7, s. 1444-1462
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – To explore the interdependencies between temporary and permanent aspects of project organizing and how they affect the management of public infrastructure operation and maintenance (O&M) activities.Design/methodology/approach – The paper applies a case study approach and uses Lundin and Söderholm’s (1995) framework of the temporary organization (with the themes of time, task, team, and transition) to distinguish between temporary and permanent aspects of organizing two infrastructure O&M projects.Findings – This paper adds to the literature on temporary organizations by recognizing a mixture of temporary and permanent aspects of project organizing in an empirical project-level example. In line with previous research, the themes of time, task, team, and transition were shown to be interdependent. Furthermore, the paper broadens the theory of temporary organizations by presenting a project organization with significant permanent aspects.Practical implications – Project managers of public sector projects need to be aware of the possible mixture of temporary and permanent aspects of project organizing. Management of projects that are found to have a mixture of temporary and permanent aspects should combine the perspectives and management practices of both temporary and permanent organizing. Not acknowledging permanent aspects could lead to management that is not adapted to the prerequisites of project organizing in this context.Originality/value – The findings further develop the literature on temporary organizations by recognizing that there is not only a mixture of temporary and permanent aspects between the temporary organization and its permanent environment, but there is also a mixture of temporary and permanent aspects of organizing within project organizations.
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| 22. |
- Stenberg, Simon, et al.
(författare)
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Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation.
- 2022
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Ingår i: eLife. - 2050-084X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Deletion of mitochondrial DNA in eukaryotes is currently attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that this process critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication through Rtg2 and Rtg3. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. This shows that oxidative stress-induced mitochondrial impairment may be under strict regulatory control. If the results extend to human cells, the results may prove to be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.
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| 23. |
- Vinberg, Stig, 1954-, et al.
(författare)
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Do leadership behaviours, work environments and the health of managers in Sweden and outside Sweden differ?—a study of a large international mining company
- 2023
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Ingår i: Mineral Economics. - : Springer Nature. - 2191-2203 .- 2191-2211. ; 36:4, s. 655-666
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Tidskriftsartikel (refereegranskat)abstract
- The mining industry faces specific challenges related to the working conditions and safety of employees. Studies indicate that the leadership behaviours, working conditions and health of managers are of importance for the working conditions and health of subordinates. Therefore, the aim here is to study these factors in a large international mining company with its head office in Sweden. The specific focus is on identifying similarities and differences that may exist between managers in Sweden and managers outside Sweden. An online survey with validated questions has been distributed to all managers in the company. The main findings are that both managers in and outside of Sweden report relatively high values regarding relation-, structure- and change-oriented leadership behaviours. In addition, managers also rated HEL (healthy and effective leadership) behaviours with relatively high values. The managers in Sweden rate relation orientation with the highest value and the managers outside Sweden rate structure orientation with the highest value. These differences have been confirmed by a regression analysis that identified significant associations between the group of managers based outside Sweden and higher structure orientated leadership behaviours. Both manager groups rate relatively high values regarding job satisfaction and self-rated health. However, they rate relatively high work demand values. The main conclusions are that there are different patterns in leadership behaviours between these two manager groups that can be related to cross-culture factors. Further investigation of the reasons for these differences is important in this industrial sector.
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