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- Weber, G, et al.
(författare)
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The phospholipase C b 3 gene located in the MEN 1 region shows loss of expression in endocrine tumors
- 1994
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 3:10, s. 1775-1781
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Tidskriftsartikel (refereegranskat)abstract
- Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus, suggesting inactivation of a tumour suppressor gene in this region. Identification of meiotic cross-overs in MEN1 families has placed the MEN1 locus centromeric of D11S807. An extended deletion mapping was performed in 27 primary parathyroid tumours, and identified D11S427 as the closest centromeric flanking marker. Through physical mapping using newly isolated cDNA clones, we estimated the distance between the flanking markers D11S807 and D11S427 to be less than 900 kb. One of these cDNA clones showed expression of a 4.4 kb message in multiple tissues, including those affected in MEN1, while in five endocrine tumours no transcript was detected. Sequence characterization showed that this gene encodes for the phospholipase C beta 3, a key enzyme in signal transduction.
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- Eberhardt, Kerstin, et al.
(författare)
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Early rheumatoid arthritis--some social, economical, and psychological aspects
- 1993
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 22:3, s. 119-123
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Tidskriftsartikel (refereegranskat)abstract
- Physical, psychological, and social features were assessed with standardized methods in 84 early RA patients followed prospectively for 2 years. During this time disease activity decreased, and disability evaluated by HAQ remained small. Psychological distress measured by SCL-90 (Symptom Check List) was in general not very pronounced and fairly stable over time. A high pain level at baseline provided a 4 times higher risk for a high level of psychological distress after 2 years. The prevalence of early retirement was 37% at the end of the study. Physical demanding work and a high initial HAQ score were the best predictors of work disability, increasing the risk of not working 10.7 and 5.5 times, respectively. At least 28% of patients had lower annual income compared to the year before disease onset. The ability to do shopping, home work, leisure time activities and social activities were negatively influenced by the disease in more than half of the patients. The social and economical consequences were thus considerable in the early stages of RA.
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- Frasinski, L. J, et al.
(författare)
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Multielectron Dissociative Ionization of Co2 In Intense Laser Fields
- 1994
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Ingår i: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 27:6, s. 97-109
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Tidskriftsartikel (refereegranskat)abstract
- The multiphoton ionization of CO2 has been studied using a laser of 794 nm WaVelength and focused intensities in the region of 10(16) W cm-2. The kinetic energy distributions and ion yields obtained using time-of-flight spectroscopy coupled with covariance mapping can be interpreted most simply in terms of charge-symmetric fragmentation, the strongest channel being O2+ + C2+ + O2+. These results are compared with two recent experiments on CO2, one using an intense laser at 248 nm, the other using Si8+ ion projectiles of 3 MeV u-1 energy.
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- Svanberg, Sune, et al.
(författare)
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Applications of terawatt lasers
- 1994
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Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
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Konferensbidrag (refereegranskat)
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