SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Larsson Torbjörn) srt2:(2020-2024)"

Sökning: WFRF:(Larsson Torbjörn) > (2020-2024)

  • Resultat 1-50 av 57
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Larsson, Karin, et al. (författare)
  • Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia
  • 2021
  • Ingår i: Growth Factors. - : Informa UK Limited. - 0897-7194 .- 1029-2292. ; 38:3-4, s. 189-196
  • Tidskriftsartikel (refereegranskat)abstract
    • Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Blood plasma and serum from 139 CLL patients and 71 healthy age-matched controls were analyzed for 11 proposed CVD risk biomarkers. The CLL cohort displayed a more heterogeneous pattern of biomarker expression compared to controls. The majority, eight out of 11, analyzed CVD risk biomarkers differed significantly in concentrations between CLL patients and controls. Increased levels of the biomarkers GDF15 and myostatin have not previously been reported in CLL. Further prospective studies are warranted to investigate whether these biomarkers predict future cardiovascular events in patients with CLL.
  •  
2.
  • Amirpour, Sepideh, 1980, et al. (författare)
  • Highly thermal conductive graphene-based heatsink tailored for electric propulsion SiC-based inverter
  • 2024
  • Ingår i: Applied Thermal Engineering. - 1359-4311. ; 243
  • Tidskriftsartikel (refereegranskat)abstract
    • This study introduces an innovative multidisciplinary design approach for highly conductive and lightweight pin-fin-based heatsinks leveraging the advantages of graphene technology. The primary objective is to optimize the thermal management of silicon carbide (SiC) based inverters within electric vehicles (EVs). To closely emulate the real SiC power module, comprehensive analyses, including scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS), are performed on the module. A detailed fluid dynamics model utilizing a 3D-conjugate heat transfer (CHT) methodology is employed to evaluate the thermal behavior of SiC power switches in contact with the coolant. The multidisciplinary analysis is initially implemented on an aluminum-based heatsink, validated experimentally, and subsequently compared to graphene. The integration of graphene in the heatsink design demonstrates notable improvements, including a 24.4 % increase in the heat transfer coefficient (HTC) and a 19.6 % reduction in thermal resistance (sink to fluid) at a 6 l/min fluid flow rate compared to its aluminum counterpart. Consequently, the SiC chips within the graphene-based heatsink exhibit an 11.5 % lower temperature rise compared to the aluminum version. The improvements in the cooling solution for SiC inverters in EVs, achieved through the adoption of graphene instead of traditional metals, serve as a proof of concept. This signifies a step forward in prioritizing the crucial balance between performance and power density.
  •  
3.
  • Bacchetti, Tiziana, et al. (författare)
  • Effects of Seven Weeks of Combined Physical Training on High-Density Lipoprotein Functionality in Overweight/Obese Subjects
  • 2023
  • Ingår i: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 13:10, s. 1068-1068
  • Tidskriftsartikel (refereegranskat)abstract
    • Our study aimed to investigate the effects of exercise on HDL composition and functional properties in overweight/obese subjects. Eighteen overweight/obese subjects (nine F and nine M, BMI = 30.3 ± 3 kg/m2) attended supervised training for 7 weeks. The protocol included combined resistance and conditioning training four to five times each week. The activity of the antioxidant enzyme paraoxonase-1 (PON1) associated with HDL was evaluated in all subjects before and after the training intervention. Moreover, myeloperoxidase (MPO) levels and oxidative stress markers (ox-LDLs and total antioxidant capacity) were studied in the serums of the subjects. At the end of the intervention, the activity of PON1 was increased (p < 0.0001), and MPO levels and the MPO/PON1 ratio were decreased (p < 0.0001). In addition, a significant improvement in muscle strength and maximal oxygen uptake (VO2max) (p < 0.0001) and a significant reduction in total and visceral adipose tissue mass (p < 0.001) and waist circumference (p < 0.008), without any significant decrease in body weight, were observed. A significant correlation was established between serum MPO/PON ratios, HDL redox activity and ox-LDLs. In conclusion, our results demonstrate that exercise training, without modifications of dietary habits, improved HDL functionality in overweight/obese adults, without any significant reduction in BMI or modifications of glucose and lipid biochemical parameters.
  •  
4.
  • Bigdeli, Sedigheh, 1984, et al. (författare)
  • Strategies for High-Temperature Corrosion Simulations of Fe-Based Alloys Using the Calphad Approach : Part I
  • 2021
  • Ingår i: Journal of Phase Equilibria and Diffusion. - : Springer Nature. - 1547-7037 .- 1863-7345. ; 42:3, s. 403-418
  • Tidskriftsartikel (refereegranskat)abstract
    • The environmental degradation of materials at high temperatures limits the useful life of different industrial components and hinders the development of more economical and environmentally friendly processes for the energy production. Despite the importance of this phenomena, a model to predict lifetime of materials that degrade due to high-temperature corrosion has up till now been lacking due to limitations of the computational possibilities and the complex nature of oxidation. In the present work we develop some strategies to model high-temperature corrosion in Fe-based alloys using the Calphad (Calculation of Phase Diagrams) approach. It is proposed that kinetic-based simulations for oxidation of Al and Cr can accurately represent the lifetime of the protective layers in FeCrAl and FeCr alloys at different temperatures in air. The oxide systems are in addition investigated by equilibrium calculations. The corrosion mechanisms of FeCr and FeCrAl alloys are discussed based on theoretical and experimental knowledge.
  •  
5.
  • Boethius, Adam, et al. (författare)
  • Assessing laser ablation multi-collector inductively coupled plasma mass spectrometry as a tool to study archaeological and modern human mobility through strontium isotope analyses of tooth enamel
  • 2022
  • Ingår i: Archaeological and Anthropological Sciences. - : Springer Science and Business Media LLC. - 1866-9557 .- 1866-9565. ; 14:5
  • Tidskriftsartikel (refereegranskat)abstract
    • To evaluate the possibility of obtaining detailed individual mobility data from archaeological teeth, the strontium isotope ratios on 28 human teeth from three separate Early-Mid Holocene, Swedish, foraging contexts (Norje Sunnansund, Skateholm and Västerbjers) were analysed through laser ablation. The teeth/individuals have previously been analysed using traditional bulk sampled thermal ionisation mass spectrometry. To validate the conclusions regarding the archaeological teeth, a tooth from a modern man with a known background was also analysed. The result shows that all of the teeth display less than 0.4% discrepancy between the mean values of the laser ablation profiles and the previously published bulk data and 25 (89%) of the teeth display less than a 0.2% discrepancy. By calculating linear and polynomial trendlines for each ablated tooth, it was possible to illustrate a strong correlation for the transition pattern between the measurements when following a chronological sequence from the tip to the cervix. Such correlations were not reproduced when the data sequence was randomized. The analyses show that the chronologically sequenced ablation data fit with a transition between local bioavailable strontium regions, that the measurements do not fluctuate between extremes and that their values are not caused by end-member mixing. This indicates an increasing data resolution when reducing strontium isotope ratio averaging time by minimizing the sampling area. The results suggest strontium incorporation in human teeth can be measured on an ordinal scale, with a traceable chronological order to enamel mineralization when sampled from tip to cervix at an equal distance from the surface. Micro-sampling enamel is considered a valid method to assess prehistoric, but not modern, human mobility; laser ablation technology increases the amount of information obtained from a single tooth while rendering minimal damage to the studied specimen.
  •  
6.
  • Boethius, Adam, et al. (författare)
  • Diachronic forager mobility : untangling the Stone Age movement patterns at the sites Norje Sunnansund, Skateholm and Västerbjers through strontium isotope ratio analysis by laser ablation
  • 2022
  • Ingår i: Archaeological and Anthropological Sciences. - : Springer Science and Business Media LLC. - 1866-9557 .- 1866-9565. ; 14:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Strontium isotope ratios in human teeth from the three Swedish prehistoric Stone Age hunter-fisher-gathering societies Norje Sunnansund (Maglemose), Skateholm (Ertebølle) and Västerbjers (Pitted Ware Culture) were analysed with laser ablation to produce data on both individual movement patterns and societal mobility trends. The analyses of teeth from both Skateholm and Västerbjers displayed homogeneous ratios and corresponding mobility patterns, while the data from Norje Sunnansund showed larger variances with heterogenous strontium ratios and varied inter-individual mobility patterns. Correlation with the bioavailable baseline suggests that the size of the geographical areas, where human strontium ratios could have originated, was roughly comparable for all three sites. The teeth measurements were reflected within a 50-km radius of the surrounding landscape and the 25–75% data quartile matched with distances between 3 and 30 km from the sites, suggesting limited mobility ranges among aquatically dependent foragers from southernmost Sweden. By applying ethnographic analogies and site-specific contextual inferences, the results suggest that mobility ranges at Norje Sunnansund were likely not delimited by neighbouring group territories. This changed over time and an increasing territorialisation of the landscape may have influenced movement patterns and caused restrictions to the foraging activities at both Skateholm and Västerbjers.
  •  
7.
  • Boethius, Adam, et al. (författare)
  • Early Holocene Scandinavian foragers on a journey to affluence: Mesolithic fish exploitation, seasonal abundance and storage investigated through strontium isotope ratios by laser ablation (LA‐MC-ICP‐MS)
  • 2021
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:1, s. e0245222-e0245222
  • Tidskriftsartikel (refereegranskat)abstract
    • At Norje Sunnansund, an Early Holocene settlement in southern Sweden, the world’s earliest evidence of fermentation has been interpreted as a method of managing long-term and large-scale food surplus. While an advanced fishery is suggested by the number of recovered fish bones, until now it has not been possible to identify the origin of the fish, or whether and how their seasonal migration was exploited. We analysed strontium isotope ratios (87Sr/86Sr) in 16 cyprinid and 8 pike teeth, which were recovered at the site, both from within the fermentation pit and from different areas outside of it, by using laser ablation multi-collector inductively coupled plasma mass spectrometry. Our investigation indicates three different regions of origin for the fish at the site. We find that the most commonly fermented fish, cyprinids (roach), were caught in the autumn during their seasonal migration from the Baltic Sea to the sheltered stream and lake next to the site. This is in contrast to the cyprinids from other areas of the site, which were caught when migrating from nearby estuaries and the Baltic Sea coast during late spring. The pikes from the fermentation pit were caught in the autumn as by-catch to the mainly targeted roach while moving from the nearby Baltic Sea coast. Lastly, the pikes from outside the fermentation pit were likely caught as they migrated from nearby waters in sedimentary bedrock areas to the south of the site, to spawn in early spring. Combined, these data suggest an advanced fishery with the ability to combine optimal use of seasonal fish abundance at different times of the year. Our results offer insights into the practice of delayed-return consumption patterns, provide a more complete view of the storage system used, and increase our understanding of Early Holocene sedentism among northern hunter-fisher-gatherers. By applying advanced strontium isotope analyses to archaeological material integrated into an ecological setting, we present a methodology that can be used elsewhere to enhance our understanding of the otherwise elusive indications of storage practices and fish exploitation patterns among ancient foraging societies.
  •  
8.
  • Dohlmar, Frida, et al. (författare)
  • An audit of high dose-rate prostate brachytherapy treatment planning at six Swedish clinics
  • 2021
  • Ingår i: Journal of Contemporary Brachytherapy. - : TERMEDIA PUBLISHING HOUSE LTD. - 1689-832X .- 2081-2841. ; 13:1, s. 59-71
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: High dose-rate prostate brachytherapy has been implemented in Sweden in the late 1980s and early 1990s in six clinics using the same schedule: 20 Gy in two fractions combined with 50 Gy in 25 fractions with external beam radiation therapy. Thirty years have passed and during these years, various aspects of the treatment process have developed, such as ultrasound-guided imaging and treatment planning system. An audit was conducted, including a questionnaire and treatment planning, which aimed to gather knowledge about treatment planning methods in Swedish clinics. Material and methods: A questionnaire and a treatment planning case (non-anatomical images) were sent to six Swedish clinics, in which high-dose-rate prostate brachytherapy is performed. Treatment plans were compared using dosimetric indices and equivalent 2 Gy doses (EQD(2)). Treatment planning system report was used to compare dwell positions and dwell times. Results: For all the clinics, the planning aim for the target was 10.0 Gy, but the volume to receive the dose differed from 95% to 100%. Dose constraints for organs at risk varied with up to 2 Gy. The dose to 90% of target volume ranged from 10.0 Gy to 11.1 Gy, equivalent to 26.0 Gy EQD(2) and 31.3 Gy EQD(2), respectively. Dose non-homogeneity ratio differed from 0.18 to 0.32 for clinical target volume (CTV) in treatment plans and conformity index ranged from 0.52 to 0.59 for CTV. Conclusions: Dose constraints for the organs at risk are showing a larger variation than that reflected in compared treatments plans. In all treatment plans in our audit, at least 10 Gy was administered giving a total treatment of 102 Gy EQD(2), which is in the upper part of the prescription doses published in the GEC/ESTRO recommendations.
  •  
9.
  • Dohlmar, Frida, et al. (författare)
  • Validation of automated post-adjustments of HDR prostate brachytherapy treatment plans by quantitative measures and oncologist observer study
  • 2023
  • Ingår i: Brachytherapy. - : Elsevier BV. - 1538-4721 .- 1873-1449. ; 22:3, s. 407-415
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The aim was to evaluate a postprocessing optimization algorithm's ability to improve the spatial properties of a clinical treatment plan while preserving the target coverage and the dose to the organs at risk. The goal was to obtain a more homogenous treatment plan, minimizing the need for manual adjustments after inverse treatment planning. MATERIALS AND METHODS: The study included 25 previously treated prostate cancer pa-tients. The treatment plans were evaluated on dose-volume histogram parameters established clin-ical and quantitative measures of the high dose volumes. The volumes of the four largest hot spots were compared and complemented with a human observer study with visual grading by eight oncologists. Statistical analysis was done using ordinal logistic regression. Weighted kappa and Fleiss' kappa were used to evaluate intra-and interobserver reliability. RESULTS: The quantitative analysis showed that there was no change in planning target volume (PTV) coverage and dose to the rectum. There were significant improvements for the adjusted treatment plan in: V150% and V200% for PTV, dose to urethra, conformal index, and dose nonhomogeneity ratio. The three largest hot spots for the adjusted treatment plan were significantly smaller compared to the clinical treatment plan. The observers preferred the adjusted treatment plan in 132 cases and the clinical in 83 cases. The observers preferred the adjusted treatment plan on homogeneity and organs at risk but preferred the clinical plan on PTV coverage. CONCLUSIONS: Quantitative analysis showed that the postadjustment optimization tool could improve the spatial properties of the treatment plans while maintaining the target coverage.
  •  
10.
  • Engelkes, Torbjörn, et al. (författare)
  • Loyal to the end : Examining the meaning of loyalty among high-ranking military officers
  • 2023
  • Ingår i: Res Militaris. - 2265-6294. ; 13:3, s. 936-953
  • Tidskriftsartikel (refereegranskat)abstract
    • Organizations need co-workers who are committed to common goals and that are loyal to the core values of the organization.[1] The conscious fostering of organizational core values is seen as an important tool in creating loyal co-workers and hence an effective organization.[2] Professions with a strong vocational calling such as medicine (Kallin, 2010), the police (Ewin, 1990 ; Foust, 2018) or the military[3] have particular demands on loyalty to certain core values, and individuals are expected to adopt these as their own. However, organizational core values can be contradictive (Billig, 1988) and sometimes in conflict with the individual´s own core values which – when incompatible – can in turn cause severe moral stress and mental illness.[4] This implies a need for clarification about what is expected from members of an organization concerning the objectives and manifestations of core values. In terms of loyalty, the military profession is possibly one of the most demanding, expecting individuals to risk their own lives and to kill other human beings for the benefit of the organizational goals. However, since misplaced loyalty can cause destructive,[5] and unethical behaviour[6] with enormous consequences – especially in the military (Winslow, 1998) – there is a need to be clear about what kind of loyalty behaviour is constructive and vice versa. Although loyalty is a concept that seems to be defined in many different ways, the number of studies of loyalty and its meaning are quite limited - especially in military research.[7] The overall purpose of this study is to broaden understanding of the meaning of loyalty within the military. Because important core values of an organization are set – or strongly influenced[8] – by its leaders,[9] the aim of this study was to explore how high-ranking officers in the Swedish Armed Forces (SAF) give meaning to their own personal experiences of loyalty and to describe possible common patterns within the participant group. [1] Wieseke, Alavi & Habel, 2014.[2] Berghaus & Cartagena, 2013.[3] Huntington, 1985 ; Moskos & Wood, 1988 ; Kirkhaug, 2009 ; Olsthoorn, 2011 ; Beard, 2014.[4] Molendijk, Kramer & Verweij, 2018.[5] Gabriel, 1982 ; Connor, 2010.)[6] Umphress & Bingham, 2011.[7] Olsthoorn, 2011 ; Connor, Andrews, Noack-Lundberg & Wadham, 2019.[8] Larsson, Haerem, Sjöberg, Alvinius & Bakken, 2007.[9] Fergusson & Milliman, 2008 ; Oh, Cho & Lim, 2018.
  •  
11.
  • Engelkes, Torbjörn, et al. (författare)
  • Loyal to the End (?) : Examining the Meaning of Loyalty among High-Ranking Military Officers
  • 2023
  • Ingår i: Res Militaris. - 2265-6294. ; 13:3, s. 936-953
  • Tidskriftsartikel (refereegranskat)abstract
    • Loyalty is a desirable but possibly destructive virtue which is seen as an important trait in many contexts. In strongly vocational professions, loyalty to certain core values seems especially important. As senior leadership within an organization set the expectations of organizational behaviour, it is important to explore their perception of loyalty. The overall purpose of this study is to broaden understanding of the meaning of loyalty within the military by exploring how high-ranking officers in the Swedish Armed Forces give meaning to their own personal experiences of loyalty. Data was collected through nine interviews with senior military generals and admirals and was analyzed using interpretative phenomenological analysis (IPA). The results describe a strong normative virtue, creating a strong professional identity which at the same time gives rise to dilemmas and ambiguous choices. The most dilemmatic experience raised was between the norms of, on the one hand, being compliant and adaptable, and on the other, of questioning irrational decisions or opinions. The results were discussed in terms of contradictions or dilemmas concerning the individual´s choice of loyalties. This study contributes to a greater understanding of personal experiences concerning loyalty within a profession characterized by strong professional norms.
  •  
12.
  • Engelkes, Torbjörn, 1971- (författare)
  • Loyal until death (?) : The nature, measurement and predictors of loyalty in a military context
  • 2024
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The overall aim of this thesis was to broaden the understanding of the concept of loyalty within a military context, by focusing on how the nature of loyalty is experienced, how it can be measured and how it can be predicted. To achieve this, the thesis was structured in three interrelated studies, which initially aimed to examine the content of loyalty within the Swedish Armed Forces (SAF), then to develop and validate a scale to measure loyalty, and finally to examine possible predictors of loyalty.The aim of Study I was to examine how loyalty is experienced within the SAF. To achieve this, Study I examined how high-ranking officers – presumed to have a large influence on professional ethics within the SAF – gave meaning to their experiences of loyalty. The results showed that although the nature of loyalty in the military organization is based on a strong identification with the profession, loyalty is a multifaceted phenomenon which requires the individual to manage competing and sometimes counteracting domains (objects) of loyalty.The aim of Study II was to develop a psychometric scale for measuring loyalty in a military context, based on the findings of Study I. Given the complex and varying nature of loyalty and dealing with different domains of loyalty in the military, the scale was developed to consider several domains for an individual’s loyalty (e.g., workgroup, mission, nation). Additionally, there was a focus on the overall nature of loyalty involving sacrifice and action to protect the domain of loyalty. To achieve this, three independent samples, consisting of military personnel (in training and on overseas mission), were invited to answer a questionnaire based on the results from Study I. Exploratory and confirmatory factor analyses resulted in a scale measuring loyalty, denoted the Swedish Military Loyalty Scale (SMiLS). The SMiLS was found to consist of a four-dimensional representation of the willingness to act loyally. The dimensions are sectioned in loyal sacrifice and loyal action, further divided into moderate and extreme loyal sacrifice and loyal action, respectively.The aim of Study III was to examine how individuals’ willingness to act loyally to certain domains (the closest workgroup, the unit, and the unit mission) can be predicted by social identity fusion and developmental leadership. To achieve this, a sample consisting of military personnel serving on an overseas mission in Mali, took part in a survey, using the SMiLS as the dependent variable. Demographic factors, such as rank and gender, were also examined, taking the outcome of loyalty into consideration. The results show that social identity mainly predicted the sacrificial dimensions of loyalty, while developmental leadership predicted all dimensions of loyalty for all domains.In conclusion, the present thesis broadens the understanding of loyalty within a military context. It also contributes with a scale for measuring loyalty and identifies two predictors for loyalty. Further research should focus on a deepened understanding of loyalty within the military and in the context of total defense organizations, further validation of the SMiLS and the examination of additional possible predictors for loyalty.
  •  
13.
  • Gard Timmerfors, Jessica, 1989-, et al. (författare)
  • The impact of using different wood qualities and wood species on chips produced using a novel type of pilot drum chipper
  • 2021
  • Ingår i: Nordic Pulp & Paper Research Journal. - : De Gruyter Open. - 0283-2631 .- 2000-0669. ; 36:2, s. 214-226
  • Tidskriftsartikel (refereegranskat)abstract
    • Resource-efficient wood chipping for forest-industrial processes demands large fractions of accept chips and small fractions of small-sized material, such as pin chips and fines. In Kraft pulping, a narrow distribution of wood chip thickness is important for even impregnation and for making high-quality pulp. Using newly developed forest-industrial drum-chipping technology, the investigation covered wood of varying moisture content, frozen versus unfrozen wood, and the use of different wood species. Using conventional techniques for analyzing wood chip dimensions, fast-grown spruce wood with high moisture content gave 4.2 % pin chips and fines, which was less than half of the fractions obtained with spruce wood with lower moisture content. A comparison between frozen and unfrozen pine resulted in slightly thinner and shorter chips for the frozen wood, but in both cases accept yields of up to ∼85 % were achieved. A comparison of different tree species (aspen, birch, pine, and spruce) resulted in larger accept fractions (∼90 %) for the hardwood species, even though the average length of these wood chips was as low as 17 mm. The results provide a first indication of how basic wood log properties affect the yields of accept chips and small-sized material when using modern industrial drum-chipping technology.
  •  
14.
  • Hidman, Josefin, et al. (författare)
  • Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
  • 2023
  • Ingår i: Upsala Journal of Medical Sciences. - : Upsala Medical Society. - 0300-9734 .- 2000-1967. ; 128
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Increased microvascular density correlates with more advanced disease and unfavorable overall survival in non-Hodgkin lymphoma (NHL), suggesting that angiogenesis is important for disease progression. However, studies of anti-angiogenic agents in NHL patients, have generally not shown favorable outcomes. The aim of this study was to investigate whether plasma levels of a subset of angiogenesis-associated proteins are increased in indolent B-cell derived NHL (B-NHL) and to investigate whether the levels differ between patients with asymptomatic versus symptomatic disease.METHODS: Plasma levels of growth differentiation factor 15 (GDF15), endostatin, matrix metalloproteinase 9 (MMP9), neutrophil gelatinase-associated lipocalin (NGAL), long pentraxin 3 (PTX3), and galectin 3 (GAL-3) were measured by ELISA in 35 patients with symptomatic indolent B-NHL, 41 patients with asymptomatic disease, and 62 healthy controls. Bootstrap t-tests were used to assess the relative differences in biomarker levels between groups. Group differences were visualized using a principal component plot.RESULTS: Mean plasma endostatin and GDF15 levels were significantly higher in symptomatic and asymptomatic lymphoma patients than in controls. Symptomatic patients had higher mean MMP9 and NGAL than controls.CONCLUSIONS: The finding of increased plasma endostatin and GDF15 in patients with asymptomatic indolent B-NHL suggests that increased angiogenic activity is an early event in indolent B-NHL disease progression.
  •  
15.
  • Hidman, Josefin, et al. (författare)
  • Increased Plasma GDF15 Is Associated with Altered Levels of Soluble VEGF Receptors 1 and 2 in Symptomatic Multiple Myeloma.
  • 2022
  • Ingår i: Acta Haematologica. - : S. Karger AG. - 0001-5792 .- 1421-9662. ; 145:3, s. 326-333
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: In multiple myeloma, there is an increase in bone marrow microvascular density and enhanced renal lymphangiogenesis. Increased levels of the proangiogenic protein growth differentiation factor-15 (GDF15) have previously been reported to be associated with poor prognosis in myeloma. A possible association between GDF15 and the soluble forms of vascular endothelial growth factor receptors (sVEGFR) 1 and 2 has not yet been investigated, and a role for these receptors in pathological angiogenesis in myeloma is still to be defined.METHODS: Plasma levels of GDF15 and sVEGFR1 and 2 were determined by ELISA in patients with smouldering multiple myeloma (sMM), patients with symptomatic multiple myeloma (abbreviated as MM), and healthy controls. The levels were compared between the three groups, and correlation coefficients were calculated, as were Kaplan-Meier curves for GDF15 and sVEGFR1 and sVEGFR2.RESULTS: Levels of GDF15 were significantly higher in MM than in both patients with sMM and controls. A gradual decrease in mean sVEGFR1 concentration was observed, with MM > sMM > controls. Mean sVEGFR2 was lower in patients with MM than in controls. There was a positive correlation between GDF15 and sVEGFR1, and GDF15 correlated negatively with sVEGFR2. High GDF15 (>3 ng/mL) was associated with poor prognosis.CONCLUSION: In multiple myeloma, increased expression of GDF15 correlates positively with sVEGFR1 and negatively with sVEGFR2. It is possible that the altered levels of sVEGFR1 and 2 contribute to the increased angio- and lymphangiogenesis observed in myeloma.
  •  
16.
  • Isomura, Kayoko, et al. (författare)
  • Insomnia in Tourette Syndrome and Chronic Tic Disorder
  • 2022
  • Ingår i: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257. ; 37:2, s. 392-400
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Insomnia is common in Tourette syndrome (TS) and chronic tic disorder (CTD), but precise prevalence estimates are lacking.OBJECTIVE: In this Swedish register-based cohort study, we estimated the prevalence of insomnia in TS/CTD and quantified the magnitude of this association, accounting for familial confounders and relevant somatic and psychiatric comorbidities.METHODS: Of 10,444,702 individuals living in Sweden during the period from 1997 to 2013, 5877 had a diagnosis of TS/CTD and were compared to unexposed individuals from the general population on the presence of insomnia using logistic regression models.RESULTS: Individuals with TS/CTD had a period prevalence of insomnia of 32.16%, compared to 13.70% of the unexposed population. This translated into a 6.7-fold increased likelihood of insomnia in TS/CTD (odds ratio adjusted [aOR] for sex, birth year, birth country, and somatic disorders = 6.74; 95% confidence interval [CI], 6.37-7.15). A full sibling comparison, designed to adjust for shared familial factors, attenuated the estimates (aOR = 5.41; 95% CI, 4.65-6.30). When individuals with attention-deficit/hyperactivity disorder (ADHD) and pervasive developmental disorders were excluded, the association was also attenuated, whereas exclusion of other psychiatric comorbidities had minimal impact. Having persistent TS/CTD, comorbid ADHD, and taking ADHD medication greatly increased the likelihood of insomnia.CONCLUSIONS: Insomnia is significantly associated with TS/CTD, independently from somatic disorders, familial factors or psychiatric comorbidities, although familial factors, neurodevelopmental comorbidities, and ADHD/ADHD medication may explain part of the association. Insomnia should be routinely assessed and managed in TS/CTD, particularly in chronic patients and in those with comorbid ADHD. Other sleep disorders require further study. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
  •  
17.
  • Karlsson, Pernilla Rose-Marie, et al. (författare)
  • Swelling of Cellulose-Based Fibrillar and Polymeric Networks Driven by Ion-Induced Osmotic Pressure
  • 2020
  • Ingår i: Langmuir. - : American Chemical Society. - 0743-7463 .- 1520-5827. ; 36:41, s. 12261-12271
  • Tidskriftsartikel (refereegranskat)abstract
    • Cellulose-based model materials in the form of fibrillar networks and macromolecular hydrogels were used to investigate the ion-induced swelling in relation to the elasticity and structure of the network. Both networks were charged by the introduction of carboxyl groups onto the cellulose surface, and the dimensions of the networks in aqueous solution were measured as a function of pH. The use of cellulose-model materials that contained either noncrystalline cellulose or cellulose I fibrils made it possible to model the effect of the ion-induced osmotic pressure of a delignified wood fiber wall. The noncrystalline hydrogels represented the noncrystalline domains of the fiber wall and the fibrillar network represented the supramolecular network of cellulose I fibrils of the fiber wall. The experimental results were compared to swelling potentials computed using the Donnan theory, and it was found that the ion-induced water uptake within the cellulose networks followed the theoretical predictions to a large extent. However, fibrillar networks were found to plastically deform upon swelling and deviated from the ideal Donnan theory for polyelectrolyte gel networks. Upon addition of salt to the aqueous phase surrounding the cellulose materials, both hydrogels and fibrillar networks deviated from the Donnan theory predictions, suggesting that structural differences between the networks impact their swelling. ©
  •  
18.
  • Larsson, Anders, et al. (författare)
  • Falsely elevated thyroid-stimulating hormone results dueto Interference by M-component of IgG-lambda type
  • 2020
  • Ingår i: Case Reports in Oncology. - : S. Karger. - 1662-6575. ; 13:2, s. 680-682
  • Tidskriftsartikel (refereegranskat)abstract
    • Heterophilic antibodies but also M-components can interfere with laboratory tests causing erroneous results. We report the case of a 75-year-old man with myeloma and a monoclonal immunoglobulin component (M-component) that caused elevated thyroid-stimulating hormone (TSH) results. The M-component was of the IgG-lambda type. Thyroid markers were analyzed repeatedly, and there was a clear association between IgG concentrations and TSH values (R 2 = 0.724). The highest TSH value was 75 mIU/L. Polyethylene glycol (PEG) precipitation of intact immunoglobulins was used to investigate if there was an antibody-related interference problem. The PEG treatment normalized the TSH value, showing that the cause of the elevated TSH result was due to interference caused by the M-component. In conclusion, it is important to remember that both heterophilic antibodies and M-components may cause erroneous results.
  •  
19.
  • Larsson, Diane, et al. (författare)
  • Intrathecal immunoglobulins and neurofilament light after autologous haematopoietic stem cell transplantation for multiple sclerosis
  • 2020
  • Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 26:11, s. 1351-1359
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Oligoclonal bands (OCB) are widely believed to be stable over time and rarely affected by disease-modifying treatment in MS. It is presently unknown how intrathecal immunoglobulin production and other cerebrospinal fluid (CSF) biomarkers are impacted by a highly efficacious procedure such as autologous haematopoietic stem cell transplantation (aHSCT).OBJECTIVE: To describe the evolution of intrathecal immunoglobulin and neurofilament light (NFL) over time in MS patients treated with aHSCT.METHODS: In this retrospective study, available data from previously made CSF investigations in 46 patients treated with aHSCT were analysed.RESULTS: After a median follow-up time of 745 days, immunoglobulin G (IgG) OCB remained detectable in 74% of patients, the proportion of patients with a pathological IgG index went down from 70% to 46%, and the proportion of patients with a pathological NFL went down from 72% to 24%. In patients with follow-up time >1500 days, IgG OCB were detectable in 50% of patients, 14% had a pathological IgG index and none a pathological NFL.CONCLUSIONS: Intrathecal immunoglobulin production and NFL were lower after treatment with aHSCT, decreased over time and were normalised in a significant portion of patients. This challenges the notion that OCB are unaffected by therapeutic intervention in MS.
  •  
20.
  • Larsson, Erik, 1983, et al. (författare)
  • The Influence of KCl and HCl on the High-Temperature Oxidation of a Fe-2.25Cr-1Mo Steel at 400 °C
  • 2020
  • Ingår i: Oxidation of Metals. - : Springer Science and Business Media LLC. - 1573-4889 .- 0030-770X. ; 93:1-2, s. 29-52
  • Tidskriftsartikel (refereegranskat)abstract
    • The influence of alkali- and chlorine-containing compounds on the corrosion of superheater alloys has been studied extensively. The current paper instead investigates the corrosive effects of KCl and HCl under conditions relevant to waterwall conditions. A low-alloy (Fe-2.25Cr-1Mo) steel was exposed to KCl(s), 500 vppm HCl(g) and (KCl + HCl) in the presence of 5%O2 and 20% H2O at 400 °C. The results indicate that alloy chlorination by KCl occurs by an electrochemical process, involving cathodic formation of chemisorbed KOH on the scale surface and anodic formation of solid FeCl2 at the bottom of the scale. The process is accompanied by extensive cracking and delamination of the iron oxide scale, resulting in a complex, convoluted scale morphology. Adding 500 vppm HCl to the experimental environment (KCl + HCl) initially greatly accelerated the formation of FeCl2 at the scale/alloy interface. The accelerated alloy chlorination is attributed to HCl reacting with KOH at the scale surface, causing the cathodic process to be depolarized. A rapid slowing down of the rate of chlorination and corrosion in KCl + HCl environment was observed which was attributed to the electronically insulating nature of the FeCl2 layer which forms at the bottom of the scale, disconnecting the anodic and cathodic regions.
  •  
21.
  • Larsson, J., et al. (författare)
  • A developmentally descriptive method for quantifying shape in gastropod shells
  • 2020
  • Ingår i: Journal of the Royal Society Interface. - : The Royal Society. - 1742-5689 .- 1742-5662. ; 17:163
  • Tidskriftsartikel (refereegranskat)abstract
    • The growth of snail shells can be described by simple mathematical rules. Variation in a few parameters can explain much of the diversity of shell shapes seen in nature. However, empirical studies of gastropod shell shape variation typically use geometric morphometric approaches, which do not capture this growth pattern. Wehave developedaway toinfera setofdevelop-mentally descriptive shape parameters based on three-dimensional logarithmic helicospiral growth and using landmarks from two-dimensional shell images as input. We demonstrate the utility of this approach, and compare it to the geometric morphometric approach, using a large set of Littorina saxatilis shells in which locally adapted populations differ in shape. Our method can be modified easily to make it applicable to a wide range of shell forms, which would allow for investigations of the similarities and differences between and within many different species of gastropods. © 2020 The Authors.
  •  
22.
  • Larsson, Torbjörn, et al. (författare)
  • A Lagrangian bounding and heuristic principle for bi-objective discrete optimization
  • 2024
  • Ingår i: Operational Research. - : SPRINGER HEIDELBERG. - 1109-2858 .- 1866-1505. ; 24:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Lagrangian relaxation is a common and often successful way to approach computationally challenging single-objective discrete optimization problems with complicating side constraints. Its aim is often twofold; first, it provides bounds for the optimal value, and, second, it can be used to heuristically find near-optimal feasible solutions, the quality of which can be assessed by the bounds. We consider bi-objective discrete optimization problems with complicating side constraints and extend this Lagrangian bounding and heuristic principle to such problems. The Lagrangian heuristic here produces non-dominated candidates for points on the Pareto frontier, while the bounding forms a polyhedral outer approximation of the Pareto frontier, which can be used to assess the quality of the candidate points. As an illustration example we consider a facility location problem in which both CO2 emission and cost should be minimized. The computational results are very encouraging, both with respect to bounding and the heuristically found non-dominated solutions. In particular, the Lagrangian bounding is much stronger than the outer approximation given by the Pareto frontier of the problem's linear programming relaxation.
  •  
23.
  • Larsson, Torbjörn, et al. (författare)
  • A theoretical justification of the set covering greedy heuristic of Caprara et al
  • 2022
  • Ingår i: Discrete Optimization. - : Elsevier. - 1572-5286 .- 1873-636X. ; 45
  • Tidskriftsartikel (refereegranskat)abstract
    • Large scale set covering problems have often been approached by constructive greedy heuristics, and much research has been devoted to the design and evaluation of various greedy criteria for such heuristics. A criterion proposed by Caprara et al. (1999) is based on reduced costs with respect to the yet unfulfilled constraints, and the resulting greedy heuristic is reported to be superior to those based on original costs or ordinary reduced costs. We give a theoretical justification of the greedy criterion proposed by Caprara et al. by deriving it from a global optimality condition for general nonconvex optimisation problems. It is shown that this criterion is in fact greedy with respect to incremental contributions to a quantity which at termination coincides with the deviation between a Lagrangian dual bound and the objective value of the feasible solution found.
  •  
24.
  • Larsson, Torbjörn, et al. (författare)
  • Column generation extensions of set covering greedy heuristics
  • 2022
  • Ingår i: Operations Research Letters. - : Elsevier. - 0167-6377 .- 1872-7468. ; 50:6, s. 738-744
  • Tidskriftsartikel (refereegranskat)abstract
    • Large-scale set covering problems are often approached by constructive greedy heuristics, and many selection criteria for such heuristics have been considered. These criteria are typically based on measures of the cost of setting an additional variable to one in relation to the number of yet unfulfilled constraints that it will satisfy. We show how such greedy selections can be performed on column-oriented set covering models, by using a fractional optimization formulation and solving sequences of ordinary column generation problems for the application at hand.
  •  
25.
  • Larsson, Torbjörn, et al. (författare)
  • One-parametric analysis of column-oriented linear programs
  • 2023
  • Ingår i: Oncoscience. - : ELSEVIER. - 0255-0156 .- 2214-7160. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • A linear optimization problem which is amenable to column generation and contains a single parameter in the objective function is considered. We extend and adapt the standard linear programming column generation scheme to effectively and efficiently solve this problem for all values of the parameter. As a potential application we consider bi-objective discrete optimization and describe how the one-parametric column generation scheme can be used to form an outer approximation of the Pareto frontier for such a problem.
  •  
26.
  • Larsson, Torbjörn, et al. (författare)
  • Politikerna : konflikt eller samarbete?
  • 2021
  • Ingår i: Megaprojektet Nya Karolinska Solna. - Göteborg : Makadam Förlag. - 9789170613494 ; , s. 172-189
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
27.
  • Malmgren, Linnea, et al. (författare)
  • The complexity of kidney disease and diagnosing it - Cystatin C, selective glomerular hypofiltration syndromes and proteome regulation.
  • 2023
  • Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 293:3, s. 293-308
  • Tidskriftsartikel (refereegranskat)abstract
    • Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous GFR-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterised by a selective reduction in the glomerular filtration of 5-30 kDa molecules, such as cystatin C, compared to the filtration of small molecules < 1kDa dominating the glomerular filtrate e.g., water, urea, creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine-based GFR-estimates. The syndromes are characterised by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor-blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C-based GFR-estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
  •  
28.
  •  
29.
  • Morén, Björn, 1987-, et al. (författare)
  • Dosimetric impact of a robust optimization approach to mitigate effects from rotational uncertainty in prostate intensity‐modulated brachytherapy
  • 2023
  • Ingår i: Medical physics (Lancaster). - : WILEY. - 0094-2405 .- 2473-4209. ; 50:2, s. 1029-1043
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundIntensity-modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide an additional degree of freedom, but also introduce an additional, directional, type of uncertainty, compared to conventional high-dose-rate brachytherapy (HDR BT). PurposeWe propose and evaluate a robust optimization approach to mitigate the effects of rotational uncertainty in the shields with respect to planning criteria. MethodsA previously suggested prototype for platinum-shielded prostate Yb-169-based dynamic IMBT is considered. We study a retrospective patient data set (anatomical contours and catheter placement) from two clinics, consisting of six patients that had previously undergone conventional Ir-192 HDR BT treatment. The Monte Carlo-based treatment planning software RapidBrachyMCTPS is used for dose calculations. In our computational experiments, we investigate systematic rotational shield errors of +/- 10 degrees and +/- 20 degrees, and the same systematic error is applied to all dwell positions in each scenario. This gives us three scenarios, one nominal and two with errors. The robust optimization approach finds a compromise between the average and worst-case scenario outcomes. ResultsWe compare dose plans obtained from standard models and their robust counterparts. With dwell times obtained from a linear penalty model (LPM), for 10 degrees errors, the dose to urethra (D0.1cc) and rectum (D0.1cc and D1cc) increase with up to 5% and 7%, respectively, in the worst-case scenario, while with the robust counterpart, the corresponding increases were 3% and 3%. For all patients and all evaluated criteria, the worst-case scenario outcome with the robust approach had lower deviation compared to the standard model, without compromising target coverage. We also evaluated shield errors up to 20 degrees and while the deviations increased to a large extent with the standard models, the robust models were capable of handling even such large errors. ConclusionsWe conclude that robust optimization can be used to mitigate the effects from rotational uncertainty and to ensure the treatment plan quality of IMBT.
  •  
30.
  • Morén, Björn, 1987-, et al. (författare)
  • Optimization in treatment planning of high dose‐rate brachytherapy : Review and analysis of mathematical models
  • 2021
  • Ingår i: Medical Physics. - : Wiley-Blackwell Publishing Inc.. - 2473-4209 .- 0094-2405. ; 48:5, s. 2057-2082
  • Forskningsöversikt (refereegranskat)abstract
    • Treatment planning in high dose‐rate brachytherapy has traditionally been conducted with manual forward planning, but inverse planning is today increasingly used in clinical practice. There is a large variety of proposed optimization models and algorithms to model and solve the treatment planning problem. Two major parts of inverse treatment planning for which mathematical optimization can be used are the decisions about catheter placement and dwell time distributions. Both these problems as well as integrated approaches are included in this review. The proposed models include linear penalty models, dose–volume models, mean‐tail dose models, quadratic penalty models, radiobiological models, and multiobjective models. The aim of this survey is twofold: (i) to give a broad overview over mathematical optimization models used for treatment planning of brachytherapy and (ii) to provide mathematical analyses and comparisons between models. New technologies for brachytherapy treatments and methods for treatment planning are also discussed. Of particular interest for future research is a thorough comparison between optimization models and algorithms on the same dataset, and clinical validation of proposed optimization approaches with respect to patient outcome.
  •  
31.
  • Morén, Björn, 1987-, et al. (författare)
  • Technical note: evaluation of a spatial optimization model for prostate high dose‐rate brachytherapy in a clinical treatment planning system
  • 2023
  • Ingår i: Medical physics (Lancaster). - : WILEY. - 0094-2405 .- 2473-4209. ; 50:2, s. 688-693
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundSpatial properties of a dose distribution, such as volumes of contiguous hot spots, are of clinical importance in treatment planning for high dose-rate brachytherapy (HDR BT). We have in an earlier study developed an optimization model that reduces the prevalence of contiguous hot spots by modifying a tentative treatment plan. PurposeThe aim of this study is to incorporate the correction of hot spots in a standard inverse planning workflow and to validate the integrated model in a clinical treatment planning system. The spatial function is included in the objective function for the inverse planning, as opposed to in the previous study where it was applied as a separate post-processing step. Our aim is to demonstrate that fine-adjustments of dose distributions, which are often performed manually in todays clinical practice, can be automated. MethodsA spatial optimization function was introduced in the treatment planning system RayStation (RaySearch Laboratories AB, Stockholm, Sweden) via a research interface. A series of 10 consecutive prostate patients treated with HDR BT was retrospectively replanned with and without the spatial function. ResultsOptimization with the spatial function decreased the volume of the largest contiguous hot spot by on average 31%, compared to if the function was not included. The volume receiving at least 200% of the prescription dose decreased by on average 11%. Target coverage, measured as the fractions of the clinical target volume (CTV) and the planning target volume (PTV) receiving at least the prescription dose, was virtually unchanged (less than a percent change for both metrics). Organs-at-risk received comparable or slightly decreased doses if the spatial function was included in the optimization model. ConclusionsOptimization of spatial properties such as the volume of contiguous hot spots can be integrated in a standard inverse planning workflow for brachytherapy, and need not be conducted as a separate post-processing step.
  •  
32.
  • Morén, Björn, 1987- (författare)
  • Treatment Planning of High Dose-Rate Brachytherapy - Mathematical Modelling and Optimization
  • 2021
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Cancer is a widespread class of diseases that each year affects millions of people. It is mostly treated with chemotherapy, surgery, radiation therapy, or combinations thereof. High doserate (HDR) brachytherapy (BT) is one modality of radiation therapy, which is used to treat for example prostate cancer and gynecologic cancer. In BT, catheters (i.e., hollow needles) or applicators are used to place a single, small, but highly radioactive source of ionizing radiation close to or within a tumour, at dwell positions. An emerging technique for HDR BT treatment is intensity modulated brachytherapy (IMBT), in which static or dynamic shields are used to further shape the dose distribution, by hindering the radiation in certain directions. The topic of this thesis is the application of mathematical optimization to model and solve the treatment planning problem. The treatment planning includes decisions on catheter placement, that is, how many catheters to use and where to place them, as well as decisions for dwell times. Our focus is on the latter decisions. The primary treatment goals are to give the tumour a sufficiently high radiation dose while limiting the dose to the surrounding healthy organs, to avoid severe side effects. Because these aims are typically in conflict, optimization models of the treatment planning problem are inherently multiobjective. Compared to manual treatment planning, there are several advantages of using mathematical optimization for treatment planning. First, the optimization of treatment plans requires less time, compared to the time-consuming manual planning. Secondly, treatment plan quality can be improved by using optimization models and algorithms. Finally, with the use of sophisticated optimization models and algorithms the requirements of experience and skill level for the planners are lower. The use of optimization for treatment planning of IMBT is especially important because the degrees of freedom are too many for manual planning. The contributions of this thesis include the study of properties of treatment planning models, suggestions for extensions and improvements of proposed models, and the development of new optimization models that take clinically relevant, but uncustomary aspects, into account in the treatment planning. A common theme is the modelling of constraints on dosimetric indices, each of which is a restriction on the portion of a volume that receives at least a specified dose, or on the lowest dose that is received by a portion of a volume. Modelling dosimetric indices explicitly yields mixed-integer programs which are computationally demanding to solve. We have therefore investigated approximations of dosimetric indices, for example using smooth non-linear functions or convex functions. Contributions of this thesis are also a literature review of proposed treatment planning models for HDR BT, including mathematical analyses and comparisons of models, and a study of treatment planning for IMBT, which shows how robust optimization can be used to mitigate the risks from rotational errors in the shield placement. 
  •  
33.
  • Mukalazi, Herbert, et al. (författare)
  • Asset liability management for the Bank of Uganda defined benefits scheme by stochastic programming
  • 2022
  • Ingår i: Operations Research and Decisions. - : WROCLAW UNIV SCIENCE & TECHNOLOGY, FAC COMPUTER SCIENCE MANAGEMENT. - 2081-8858 .- 2391-6060. ; 32:2, s. 105-124
  • Tidskriftsartikel (refereegranskat)abstract
    • We develop a model for asset liability management of pension funds, which is solved by stochastic programming techniques. Using data provided by the Bank of Uganda Defined Benefits Scheme, which is closed to new members, we obtain the optimal investment policies. Randomly sampled scenario trees using the mean and covariance structure of the return distribution are used for generating the coefficients of the stochastic program. Liabilities are modelled by remaining years of life expectancy and guaranteed period for monthly pension. We obtain the funding situation of the scheme at each stage, and the terminal cash injection by the sponsor required to meet all future benefit payments, in absence of contributing members.
  •  
34.
  • Mukalazi, Herbert, et al. (författare)
  • Long term projection of the demographic and financial evolution of the parliamentary pension scheme of Uganda
  • 2022
  • Ingår i: Operations Research and Decisions. - : Politechnika Wroclawska Oficyna Wydawnicza,Wroclaw University of Technology. - 2081-8858 .- 2391-6060. ; 32:3, s. 92-123
  • Tidskriftsartikel (refereegranskat)abstract
    • We study the Parliamentary Pension Scheme of Uganda, a hybrid cash balance scheme which is contributory. It has two categories of members, the staff of the Parliamentary Commission and the Members of Parliament. A long term projection of the schemes demographic and financial evolution is done to asses its sustainability and fairness with respect to the two categories of members. The projection of the schemes future members is done using non-linear regression. The distribution of future members by age states is done by Markov model using frequencies of state transition of the scheme members. We project the future contributions, accumulated funds, benefits, asset and liability values together with associated funding ratios. The results show that the fund is neither sustainable nor fair with respect to the two categories of members.
  •  
35.
  • Mystek, Katarzyna, et al. (författare)
  • Wet-expandable capsules made from partially modified cellulose
  • 2020
  • Ingår i: Green Chemistry. - : ROYAL SOC CHEMISTRY. - 1463-9262 .- 1463-9270. ; 22:14, s. 4581-4592
  • Tidskriftsartikel (refereegranskat)abstract
    • Preparation of lightweight and biocompatible hollow capsules holds great promise for various advanced engineering applications. Here, we use a heterogeneously modified structure of cellulose, which on the molecular level increases the flexibility of the capsule shell, to form hollow capsules. These capsules expand in the wet state when they are exposed to an external stimulus, in the present case a decreased external pressure. The capsules were prepared by a dropwise precipitation of a propane-saturated solution of cellulose partially modified to dialcohol cellulose, dissolved in a mixture ofN,N-dimethylacetamide and lithium chloride, into a non-solvent. The mechanical properties of the capsules were determined by measuring the expansion of the capsules upon a controlled decrease in external pressure. In addition, indentation measurements using atomic force microscopy were used to independently quantify the moduli of the capsule walls. The results show that the wet, modified cellulose capsules are much softer and, upon the same pressure change, expand significantly more than those made from unmodified cellulose. The greatest expansion observed for the modified capsules was 1.9 times the original volume, which corresponds to a final density of the expanded capsules of about 14 kg m(-3). These capsules therefore hold great potential to form green and lightweight foam-like materials.
  •  
36.
  • Ngulo, Uledi, 1983-, et al. (författare)
  • A Dissection of the Duality Gap of Set Covering Problems
  • 2020
  • Ingår i: Operations Research Proceedings 2019. - Cham : Springer International Publishing. - 9783030484385 ; , s. 175-181
  • Konferensbidrag (refereegranskat)abstract
    • Set covering problems are well-studied and have many applications. Sometimes the duality gap is significant and the problem is computationally challenging. We dissect the duality gap with the purpose of better understanding its relationship to problem characteristics, such as problem shape and density. The means for doing this is a set of global optimality conditions for discrete optimization problems. These decompose the duality gap into two terms: near-optimality in a Lagrangian relaxation and near-complementarity in the relaxed constraints. We analyse these terms for numerous instances of large size, including some real-life instances. We conclude that when the duality gap is large, typically the near-complementarity term is large and the near-optimality term is small. The large violation of complementarity is due to extensive over-coverage. Our observations should have implications for the design of solution methods, and especially for the design of core problems.
  •  
37.
  • Ngulo, Uledi, 1983- (författare)
  • Decomposition Methods for Combinatorial Optimization
  • 2021
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis aims at research in the field of combinatorial optimization. Problems within this field often posses special structures allowing them to be decomposed into more easily solved subproblems, which can be exploited in solution methods. These structures appear frequently in applications. We contribute with both re-search on the development of decomposition principles and on applications. The thesis consists of an introduction and three papers. In Paper I, we develop a Lagrangian meta-heuristic principle, which is founded on a primal-dual global optimality condition for discrete and non-convex optimization problems. This condition characterizes (near-)optimal solutions in terms of near-optimality and near-complementarity measures for Lagrangian relaxed solutions. The meta-heuristic principle amounts to constructing a weighted combination of these measures, thus creating a parametric auxiliary objective function (which is a close relative to a Lagrangian function), and embedding a Lagrangian heuristic in a search procedure in the space of the weight parameters. We illustrate and assess the Lagrangian meta-heuristic principle by applying it to the generalized assignment problem and to the set covering problem. Our computational experience shows that the meta-heuristic extension of a standard Lagrangian heuristic principle can significantly improve upon the solution quality. In Paper II, we study the duality gap for set covering problems. Such problems sometimes have large duality gaps, which make them computationally challenging. The duality gap is dissected with the purpose of understanding its relationship to problem characteristics, such as problem shape and density. The means for doing this is the above-mentioned optimality condition, which is used to decompose the duality gap into terms describing near-optimality in a Lagrangian relaxation and near-complementarity in the relaxed constraints. We analyse these terms for numerous problem instances, including some large real-life instances, and conclude that when the duality gap is large, the near-complementarity term is typically large and the near-optimality term small. The large violation of complementarity is due to extensive over-coverage. Our observations have implications for the design of solution methods, especially for the design of core problems. In Paper III, we study a bi-objective covering problem stemming from a real-world application concerning the design of camera surveillance systems for large-scale outdoor areas. It is prohibitively costly to surveil the entire area, and therefore relevant to be able to present a decision-maker with trade-offs between total cost and the portion of the area that is surveilled. The problem is stated as a set covering problem with two objectives, describing cost and portion of covering constraints that are fulfilled, respectively. Finding the Pareto frontier for these objectives is very computationally demanding and we therefore develop a method for finding a good approximate frontier in a reasonable computing time. The method is based on the ε−constraint reformulation, an established heuristic for set covering problems, and subgradient optimization. 
  •  
38.
  • Olsson, Jonas, et al. (författare)
  • Automating the planning of container loading for Atlas Copco: Coping with real-life stacking and stability constraints
  • 2020
  • Ingår i: European Journal of Operational Research. - : ELSEVIER. - 0377-2217 .- 1872-6860. ; 280:3, s. 1018-1034
  • Tidskriftsartikel (refereegranskat)abstract
    • The Atlas Copco* distribution center in Allen, TX, supplies spare parts and consumables to mining and construction companies across the world. For some customers, packages are shipped in sea containers. Planning how to load the containers is difficult due to several factors: heterogeneity of the packages with respect to size, weight, stackability, positioning and orientation; the set of packages differs vastly between shipments; it is crucial to avoid cargo damage. Load plan quality is ultimately judged by shipping operators. This container loading problem is thus rich with respect to practical considerations. These are posed by the operators and include cargo and container stability as well as stacking and positioning constraints. To avoid cargo damage, the stacking restrictions are modeled in detail. For solving the problem, we developed a two-level metaheuristic approach and implemented it in a decision support system. The upper level is a genetic algorithm which tunes the objective function for a lower level greedy-type constructive placement heuristic, to optimize the quality of the load plan obtained. The decision support system shows load plans on the forklift laptops and has been used for over two years. Management has recognized benefits including reduction of labour usage, lead time, and cargo damage risk. (C) 2019 Elsevier B.V. All rights reserved.
  •  
39.
  • Orbay, Raik, et al. (författare)
  • Sustainable Design and LCA of non-RE PMSynRM with Bioplastic Rotor Shroud
  • 2022
  • Ingår i: Proceedings of 2022 12th International Conference on Power, Energy and Electrical Engineering, CPEEE 2022. ; , s. 34-40
  • Konferensbidrag (refereegranskat)abstract
    • The electric vehicle components should be audited from manufacturing to disposal to be aligned with the United Nations sustainable development goals. The electrical machines without rare-earth (RE) magnets will assure a much lower environmental impact. Non-RE designs will also reduce the cost and weight of the motor with a penalty on the performance. One of the most prominent non-RE magnet motor designs is the Synchronous Reluctance Motor (SynRM), where the rotor anisotropy is assured via flux barriers in the rotor quadrature direction. Held in place via iron bridges (aka. ribs), flux barriers will, in turn, impact the rotor saliency. As a remedy, the paper will report on a novel ribless rotor design accommodating bioplastic for the rotor structure design. The bioplastic rotor ribless machine will be compared to various state-of-The-Art electrical machine concept designs on their merit on sustainability, performance, structural integrity, and the active parts packaging volume. The electrical machine designs are also presented with ferrite magnets to enhance the specific torque. Finally, rib less ferrite assisted SynRM rotor will be further optimized in material choice to arrive at a design solution with minimized environmental impact. As a guideline, the total CO2 impact of this paper is also quantified in a separate section.
  •  
40.
  • Persdotter, Amanda, 1987, et al. (författare)
  • Oxidation of Fe-2.25Cr-1Mo in presence of KCl(s) at 400 °C – Crack formation and its influence on oxidation kinetics
  • 2020
  • Ingår i: Corrosion Science. - : Elsevier BV. - 0010-938X. ; 163
  • Tidskriftsartikel (refereegranskat)abstract
    • Accelerated corrosion of boiler equipment remains a challenge for efficiently utilising biomass- and waste for power production. To overcome this challenge a better understanding of the influence of corrosive species present is required. This study focuses on the influence of KCl(s) on corrosion of Fe-2.25Cr-1Mo at 400 °C. This is done by well-controlled laboratory exposures and detailed microstructural investigation with ion and electron microscopy (TEM, FIB, SEM, EDX, XRD, TKD). The scale microstructures are linked to oxidation kinetics. The results indicate that KCl(s) increases the ionic diffusion through the oxide scale as well as introduces cracks and delamination resulting in a rapid periodic growth process.
  •  
41.
  • Pettersson-Pablo, Paul, 1986- (författare)
  • Biomarkers of vascular function and structure in young healthy adults
  • 2021
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Atherosclerosis is a disease affecting the blood vessels in the body. Its pathophysiologic mechanisms involve infiltration of the vessel walls by fatty matter and immune cells. This process is slow, starting in childhood but typically not manifesting as symptomatic disease until late adulthood (after 60 years of age). The identification of younger individuals with a high risk for early intervention has a higher potential of preventing morbidity and mortality.In this thesis, part of the Lifestyle, Biomarkers and Atherosclerosis study (LBA), the earliest stages of vascular dysfunction have been examined in a population of young, healthy, non-smoking subjects. Vascularfunction and structure measurements predict a future risk of cardiovascular disease (CVD). The measurements were analyzed in relation to clinical chemistry analyses of various biomarkers in serum and plasma that have been associated with inflammation or cardiovascular risk. A secondary aim was to examine estrogen containing contraceptive use and its relation to the CVD biomarkers.In Paper I and Paper II of the thesis, the association between inflammatory biomarkers, body fat percentage and vascular function and structure measurements was examined in multivariable linear regression models. A higher body fat percentage predicted an increased serum concentration of C-reactive protein (CRP) and orosomucoid. In Paper II, a higher body fat percentage and a higher CRP were associated with a more unfavorable vascular function and structure.In Paper III and Paper IV, we employed two multiplex proteomics panels to analyze inflammatory proteins and proteins previously implicated in CVD. In multivariable linear regression models, proteins implicated in hemostasis, inflammatory signaling and chemoattraction correlated with different vascular function and structure measurements. InPaper IV, insulin-like growth factor-binding protein 1 (IGFBP1) and IGFBP2 were independently predictive of an increased vascular stiffness.In conclusion, even in young, healthy individuals, altered concentrations of serum biomarkers can be detected in subjects with increased body fat and unfavorable vascular function and structure.
  •  
42.
  • Quttineh, Nils-Hassan, et al. (författare)
  • An optimization approach to the design of outdoor thermal fire detection systems
  • 2022
  • Ingår i: Fire safety journal. - : Elsevier Science Ltd. - 0379-7112 .- 1873-7226. ; 129
  • Tidskriftsartikel (refereegranskat)abstract
    • With the recent growing usage of bio-fuels the need for fire detection in outdoor bio-fuel depots has increased, and several fire detection technologies for this purpose have been proposed. We consider the use of thermal cameras and present the problem of designing the placement of such cameras. Bio-fuel depots are often large and it might be prohibitively expensive to surveil the complete areas of interest, and it is therefore required to generate compromise solutions between area coverage and cost, to be presented to a customer. We give a bi-objective mathematical optimization formulation of the problem and fast heuristics that find compromise solutions, and present results from calculating camera placements for several real-world bio-fuel depots. Our approach has been implemented in a decision support software, which is currently in use.
  •  
43.
  • Quttineh, Nils-Hassan, 1979-, et al. (författare)
  • Approximating the Pareto frontier for a challenging real-world bi-objective covering problem
  • 2022
  • Ingår i: INFOR. Information systems and operational research. - : Taylor & Francis Inc. - 0315-5986 .- 1916-0615. ; 60:3, s. 342-358
  • Tidskriftsartikel (refereegranskat)abstract
    • We study a bi-objective covering problem stemming from a real-world application concerning the design of camera surveillance systems for large-scale outdoor areas. It is in this application prohibitively costly to surveil the entire area, and therefore necessary to be able to present a decision-maker with trade-offs between total cost and the portion of the area that is surveilled. The problem can be stated as a set covering problem with two objectives, describing cost and portion of covering constraints that are fulfilled. Finding the Pareto frontier for these objectives is very computationally demanding and we therefore derive a method for finding a good approximate frontier in a practically feasible computing time. The method is based on the epsilon-constraint reformulation, an established heuristic for set covering problems, and subgradient optimization.
  •  
44.
  • Quttineh, Nils-Hassan, 1979-, et al. (författare)
  • Dissecting the duality gap : the supporting hyperplane interpretation revisited
  • 2022
  • Ingår i: Optimization Letters. - : Springer Nature. - 1862-4472 .- 1862-4480. ; 16, s. 1093-1102
  • Tidskriftsartikel (refereegranskat)abstract
    • We revisit the classic supporting hyperplane illustration of the duality gap for non-convex optimization problems. It is refined by dissecting the duality gap into two terms: the first measures the degree of near-optimality in a Lagrangian relaxation, while the second measures the degree of near-complementarity in the Lagrangian relaxed constraints. We also give an example of how this dissection may be exploited in the design of a solution approach within discrete optimization.
  •  
45.
  • Rudolfsson, Magnus, et al. (författare)
  • Energy savings through late-steam injection - A new technique for improving wood pellet production
  • 2020
  • Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 254
  • Tidskriftsartikel (refereegranskat)abstract
    • Wood pellet production has developed into an important global industry. Improving pre-processing operations is vital in keeping the industry competitive as energy and material inputs are reflected in the cost and sustainability of wood pellets as a product. In this study, a new method of steam conditioning in pelleting was evaluated based on semi-industrial experiments and thermodynamics principles. Late-steam injection was compared to conventional steam conditioning in an industrial production scenario of 100,000 tonnes per year using a rotating ring-die pellet mill, the most common mill type used in the industry. The differences in energy use and production cost were determined and the environmental footprint of produced pellets was assessed using the renewable energy directive (RED) framework for biofuels. The results showed that late-steam injection dramatically reduced steam consumption and feedstock drying needs in pelleting and, to a lesser extent, the mill-specific energy use. The economic benefit, based on the industrial production scenario, equated to an annual operational savings of 0.25 MV (3.9 %) which, over a ten-year plant lifetime, had a present value of 1.3 MV. The CO2-equivalent emissions of produced pellets, for co-firing applications, was significantly improved. These findings were specific to rotating ring-die pellet mills so that the potential for retrofitting late-steam injection solutions in existing industrial sites is large. The technology is seen as a means of increasing the competitiveness of global wood pellet production. (C) 2020 Elsevier Ltd. All rights reserved.
  •  
46.
  • Salmasi, Armin, et al. (författare)
  • Liquid phase migration in cemented carbides – Experiments and modelling
  • 2023
  • Ingår i: International Journal of Refractory Metals and Hard Materials. - : Elsevier BV. - 0263-4368 .- 2213-3917. ; 112
  • Tidskriftsartikel (refereegranskat)abstract
    • Liquid phase migration (LPM) and its potential impact on the phenomenon known as cobalt capping in cemented carbides have been investigated through experiments on fully densified, pre-sintered samples and simulations. A model for LPM was developed based on interface energies, grain size, and contiguity, and was implemented and integrated with Thermo-Calc software to make predictions about the final microstructure. The model's predictions, when applied to cases with gradients in grain size and volume fraction of the binder phase, were found to somewhat match experimental observations. Additionally, it was obsereved that LPM can cause a phenomenon resembling cobalt capping due to gradients in carbon activity.
  •  
47.
  • Sevilla-Cermeño, Laura, et al. (författare)
  • Insomnia in obsessive-compulsive disorder : A Swedish population-based cohort study
  • 2020
  • Ingår i: Journal of Affective Disorders. - : Elsevier. - 0165-0327 .- 1573-2517. ; 266, s. 413-416
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The association between specific psychiatric disorders and insomnia is well established, but the prevalence of insomnia in obsessive-compulsive disorder (OCD) is unknown. This population-based study examined the prevalence of insomnia in patients with OCD compared to unaffected individuals from the general population and to their unaffected full siblings, and evaluated the contribution of psychiatric comorbidities to this association.METHODS: Individuals diagnosed with OCD (31,856) were identified from a cohort of 13,017,902 individuals living in Sweden anytime during 1973 and 2013. Logistic regression analyses were used to investigate the odds of insomnia in individuals with OCD, compared to the general population and their unaffected full siblings. Sensitivity analyses were performed in subgroups from which all individuals with comorbid psychiatric conditions were excluded, one at a time.RESULTS: Individuals with OCD had almost 7-fold increased odds of receiving an insomnia diagnosis or being dispensed a drug with specific indication for insomnia, compared to unaffected individuals from the general population (42.2% vs. 11.0%, respectively; OR=6.92 [95% CI, 6.76-7.08]). Familiar factors shared with siblings and comorbid conditions did not fully explain this association, but when individuals with comorbid depression and anxiety disorders were excluded, the odds of insomnia were significantly reduced (OR=4.97 [95% CI, 4.81-5.14] and OR=4.51 [95% CI, 4.33-4.69], respectively).LIMITATIONS: Due to the intrinsic coverage issues of the registers, results may not be generalizable to milder forms of the disorder and to individuals who do not seek help.CONCLUSIONS: Insomnia should be systematically evaluated and managed in individuals with OCD, particularly in those with comorbid anxiety and depression.
  •  
48.
  • Song, William Y., et al. (författare)
  • Emerging technologies in brachytherapy
  • 2021
  • Ingår i: Physics in Medicine and Biology. - : IOP Publishing Ltd. - 0031-9155 .- 1361-6560. ; 66:23
  • Forskningsöversikt (refereegranskat)abstract
    • Brachytherapy is a mature treatment modality. The literature is abundant in terms of review articles and comprehensive books on the latest established as well as evolving clinical practices. The intent of this article is to part ways and look beyond the current state-of-the-art and review emerging technologies that are noteworthy and perhaps may drive the future innovations in the field. There are plenty of candidate topics that deserve a deeper look, of course, but with practical limits in this communicative platform, we explore four topics that perhaps is worthwhile to review in detail at this time. First, intensity modulated brachytherapy (IMBT) is reviewed. The IMBT takes advantage of anisotropic radiation profile generated through intelligent high-density shielding designs incorporated onto sources and applicators such to achieve high quality plans. Second, emerging applications of 3D printing (i.e. additive manufacturing) in brachytherapy are reviewed. With the advent of 3D printing, interest in this technology in brachytherapy has been immense and translation swift due to their potential to tailor applicators and treatments customizable to each individual patient. This is followed by, in third, innovations in treatment planning concerning catheter placement and dwell times where new modelling approaches, solution algorithms, and technological advances are reviewed. And, fourth and lastly, applications of a new machine learning technique, called deep learning, which has the potential to improve and automate all aspects of brachytherapy workflow, are reviewed. We do not expect that all ideas and innovations reviewed in this article will ultimately reach clinic but, nonetheless, this review provides a decent glimpse of what is to come. It would be exciting to monitor as IMBT, 3D printing, novel optimization algorithms, and deep learning technologies evolve over time and translate into pilot testing and sensibly phased clinical trials, and ultimately make a difference for cancer patients. Todays fancy is tomorrows reality. The future is bright for brachytherapy.
  •  
49.
  • Strömberg, Ann-Brith, 1961, et al. (författare)
  • Mixed-Integer Linear Optimization: Primal–Dual Relations and Dual Subgradient and Cutting-Plane Methods
  • 2020
  • Ingår i: Numerical Nonsmooth Optimization: State of the Art Algorithms. - Cham : Springer International Publishing. ; , s. 499-547, s. 499-547
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • This chapter presents several solution methodologies for mixed-integer linear optimization, stated as mixed-binary optimization problems, by means of Lagrangian duals, subgradient optimization, cutting-planes, and recovery of primal solutions. It covers Lagrangian duality theory for mixed-binary linear optimization, a problem framework for which ultimate success—in most cases—is hard to accomplish, since strong duality cannot be inferred. First, a simple conditional subgradient optimization method for solving the dual problem is presented. Then, we show how ergodic sequences of Lagrangian subproblem solutions can be computed and used to recover mixed-binary primal solutions. We establish that the ergodic sequences accumulate at solutions to a convexified version of the original mixed-binary optimization problem. We also present a cutting-plane approach to the Lagrangian dual, which amounts to solving the convexified problem by Dantzig–Wolfe decomposition, as well as a two-phase method that benefits from the advantages of both subgradient optimization and Dantzig–Wolfe decomposition. Finally, we describe how the Lagrangian dual approach can be used to find near optimal solutions to mixed-binary optimization problems by utilizing the ergodic sequences in a Lagrangian heuristic, to construct a core problem, as well as to guide the branching in a branch-and-bound method. The chapter is concluded with a section comprising notes, references, historical downturns, and reading tips.
  •  
50.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-50 av 57
Typ av publikation
tidskriftsartikel (42)
konferensbidrag (4)
doktorsavhandling (4)
forskningsöversikt (2)
bokkapitel (2)
rapport (1)
visa fler...
annan publikation (1)
licentiatavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (46)
övrigt vetenskapligt/konstnärligt (10)
populärvet., debatt m.m. (1)
Författare/redaktör
Larsson, Anders (7)
Larsson, Lars (3)
Åkerfeldt, Torbjörn (3)
Pettersson, Torbjörn (2)
Thiringer, Torbjörn, ... (2)
Kielman-Schmitt, Mel ... (2)
visa fler...
Larsson, Gerry (1)
Mccormick, Kes (1)
Andersson, Magnus (1)
Johansson, Erik (1)
Löndahl, Jakob (1)
Hansson, Magnus (1)
Sernhed, Kerstin (1)
Lundberg, Anna (1)
Montesino, Norma (1)
Corvellec, Hervé (1)
Sandström, Ida (1)
Ståhl, Lars-Henrik (1)
Ärnlöv, Johan, 1970- (1)
Andersson, A (1)
Gren, Nina (1)
Eklundh, Lars (1)
Harrie, Lars (1)
Jeppsson, Bengt (1)
Höglund, Martin (1)
Larsson, H (1)
Mattisson, Kristoffe ... (1)
Malmqvist, Ebba (1)
Isaxon, Christina (1)
Friberg, Johan (1)
Sjöström, Cheryl (1)
Flanagan, Erin (1)
Magnusson, Martin (1)
Larsson, Per Tomas (1)
Abrahamson, Magnus (1)
Grubb, Anders (1)
Olafsson, Isleifur (1)
Larsson, J. (1)
Hassel, Henrik (1)
Becker, Per (1)
Filipsson, Helena L. (1)
Lindroth, Anders (1)
Cardeña, Etzel (1)
Carlson, Stefan (1)
Ahrné, Siv (1)
Carlson, Kristina (1)
Khan, Jamil (1)
Alcer, David (1)
Stalfors, Joacim (1)
Akselsson, Roland (1)
visa färre...
Lärosäte
Linköpings universitet (21)
Chalmers tekniska högskola (9)
Karolinska Institutet (9)
Uppsala universitet (8)
Kungliga Tekniska Högskolan (5)
Stockholms universitet (5)
visa fler...
Lunds universitet (5)
Örebro universitet (4)
Umeå universitet (3)
Naturhistoriska riksmuseet (3)
Göteborgs universitet (2)
Sveriges Lantbruksuniversitet (2)
RISE (1)
Försvarshögskolan (1)
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (53)
Svenska (4)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (22)
Medicin och hälsovetenskap (19)
Teknik (12)
Samhällsvetenskap (9)
Humaniora (3)
Lantbruksvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy