| 1. |
- Hou, Liping, et al.
(författare)
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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
- 2016
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Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:15, s. 3383-94
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Tidskriftsartikel (refereegranskat)abstract
- Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
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| 2. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 3. |
- Lawson, Harold, et al.
(författare)
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Provisioning of Deterministic and Non-Deterministic Services for Vehicles: The Rubus Approach
- 2016
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Ingår i: 4th International Workshop on Critical Automotive Applications: Robustness & Safety CARS-2016. - Göteborg, Sweden.
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Konferensbidrag (refereegranskat)abstract
- Providing computer-based services for vehicle functions has evolved to the point where a large majority of functions are realized by software. However, the need to provide safety and security in critical functions such as braking, steering, motor control, etc. requires an approach that can guarantee the continuous reliable operation of the functions. At the same time, there are a variety of functions that are less critical from the vehicle operation perspective that can be provided where safety and security are less critical. From a vehicle manufacturers point of view, providing both types of services in an economic and reliable manner is a real challenge. To meet this challenge, we consider the Rubus Tool Suit for the software development and a well-proven (in industrial use for over twenty years) and certified (according to ISO 26262) operating system Kernel for its execution. In addition, a user-friendly approach to model- and component-based development concept called the “software circuits” has provided an approach to meet the demands of both safety-critical deterministic and as well as non-safety critical non-deterministic services. In this paper, a brief history of the evolution of Rubus approach as well as an overview of the driving concepts used in providing the Rubus products are described.
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| 4. |
- Mubeen, Saad, et al.
(författare)
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Academic-industrial Collaboration in the Vehicle Software Domain: Experiences and End-user Perspective
- 2016
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Ingår i: 4th International Workshop on Critical Automotive Applications. - Göteborg, Sweden.
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a success story of academic-industrial collaboration in the vehicular domain. The collaboration has resulted in the development and evolution of a model- and component-based software development tool chain that is used to develop safety-critical, robust, and certified, control software for vehicles. The tool chain has been successfully used in the vehicle industry for about 20 years. The sustained development of the tool chain is based one a unique collaboration, described in this paper, where the collaborators form a clear value chain from academia, through tool-developer, to the end-users of the technology. We describe experiences of each collaborator with a focus on the end-user's perspective. Moreover, we highlight some ongoing and future works within this collaboration.
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