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- Fascista, Alessio, et al.
(författare)
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Uplink Joint Positioning and Synchronization in Cell-Free Deployments with Radio Stripes
- 2023
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Ingår i: 2023 IEEE International Conference on Communications Workshops: Sustainable Communications for Renaissance, ICC Workshops 2023. ; , s. 1330-1336
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Konferensbidrag (refereegranskat)abstract
- Radio stripes (RSs) is an emerging technology in beyond 5G and 6G wireless networks to support the deployment of cell-free architectures. In this paper, we investigate the potential use of RSs to enable joint positioning and synchronization in the uplink channel at sub-6 GHz bands. The considered scenario consists of a single-antenna user equipment (UE) that communicates with a network of multiple-antenna RSs distributed over a wide area. The UE is assumed to be unsynchronized to the RSs network, while individual RSs are time- and phase-synchronized. We formulate the problem of joint estimation of position, clock offset and phase offset of the UE and derive the corresponding maximum-likelihood (ML) estimator, both with and without exploiting carrier phase information. To gain fundamental insights into the achievable performance, we also conduct a Fisher information analysis and inspect the theoretical lower bounds numerically. Simulation results demonstrate that promising positioning and synchronization performance can be obtained in cell-free architectures supported by RSs, revealing at the same time the benefits of carrier phase exploitation through phase-synchronized RSs.
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- Grubelnik, V, et al.
(författare)
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Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells
- 2020
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Ingår i: Royal Society open science. - : The Royal Society. - 2054-5703. ; 7:1, s. 191171-
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Tidskriftsartikel (refereegranskat)abstract
- Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have had limited success. The focus is therefore shifting towards α-cells, in particular to the dysregulated secretion of glucagon. Our qualitative electron-microscopy-based observations gave an indication that mitochondria in α-cells are altered in Western-diet-induced T2DM. In particular, α-cells extracted from mouse pancreatic tissue showed a lower density of mitochondria, a less expressed matrix and a lower number of cristae. These deformities in mitochondrial ultrastructure imply a decreased efficiency in mitochondrial ATP production, which prompted us to theoretically explore and clarify one of the most challenging problems associated with T2DM, namely the lack of glucagon secretion in hypoglycaemia and its oversecretion at high blood glucose concentrations. To this purpose, we constructed a novel computational model that links α-cell metabolism with their electrical activity and glucagon secretion. Our results show that defective mitochondrial metabolism in α-cells can account for dysregulated glucagon secretion in T2DM, thus improving our understanding of T2DM pathophysiology and indicating possibilities for new clinical treatments.
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