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Träfflista för sökning "WFRF:(Li Guang Yue) srt2:(2015-2019)"

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1.	Klionsky, Daniel J, et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 12:1, s. 1-222 Journal article (peer-reviewed)
2.	Wei, Jiang, et al. (author) 17β-estradiol regulates the expression of apolipoprotein M through estrogen receptor α-specific binding motif in its promoter 2017 In: Lipids in Health and Disease. - : Springer Science and Business Media LLC. - 1476-511X. ; 16:1, s. 1-8 Journal article (peer-reviewed)abstract Background: We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. To further investigate the mechanism behind the estrogen induced up-regulation of apoM expression. Results: Our results demonstrated either free 17β-estradiol (E2) or membrane-impermeable bovine serum albumin-conjugated E2 (E2-BSA) could modulate human apoM gene expression via the estrogen receptor alpha (ER-α) pathway in the HepG2 cells. Moreover, experiments with the luciferase activity analysis of truncated apoM promoters could demonstrate that a regulatory region (from-1580 to −1575 bp (−GGTCA-)) upstream of the transcriptional start site of apoM gene was essential for the basal transcriptional activity that regulated by the ER-α. With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. Conculsion: In summary, the present study indicates that 17β-estradiol induced up-regulation of apoM in HepG2 cells is through an ER-α-dependent pathway involving ER-α binding element in the promoter of the apoM gene.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Zhang, Yan (1); Yu, Yang (1); Korhonen, Laura (1); Lindholm, Dan (1); Vertessy, Beata G. (1); Wang, Mei (1); show more...; Wang, Xin (1); Liu, Yang (1); Kumar, Rakesh (1); Wang, Dong (1); Li, Ke (1); Liu, Ke (1); Zhang, Yang (1); Nàgy, Péter (1); Kominami, Eiki (1); van der Goot, F. Gis ... (1); Bonaldo, Paolo (1); Thum, Thomas (1); Adams, Christopher M (1); Minucci, Saverio (1); Vellenga, Edo (1); Swärd, Karl (1); Nilsson, Per (1); De Milito, Angelo (1); Nilsson-Ehle, Peter (1); Zhang, Jian (1); Shukla, Deepak (1); Kågedal, Katarina (1); Chen, Guoqiang (1); Liu, Wei (1); Cheetham, Michael E. (1); Sigurdson, Christina ... (1); Clarke, Robert (1); Zhang, Fan (1); Gonzalez-Alegre, Ped ... (1); Jin, Lei (1); Chen, Qi (1); Taylor, Mark J. (1); Romani, Luigina (1); Wang, Ying (1); Kumar, Ashok (1); Simons, Matias (1); Ishaq, Mohammad (1); Yang, Qian (1); Algül, Hana (1); Brest, Patrick (1); Simon, Hans-Uwe (1); Mograbi, Baharia (1); Florey, Oliver (1); Ström, Anna-Lena (1); show less...

University: Lund University (2); Umeå University (1); Stockholm University (1); Linköping University (1); Karolinska Institutet (1); Swedish University of Agricultural Sciences (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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