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- Xu, Bing, et al.
(författare)
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Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer
- 2008
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Ingår i: Oncology. - : S. Karger AG. - 0890-9091 .- 0030-2414 .- 1423-0232. ; 74:3-4, s. 229-236
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To investigate the expression of caspase-8 and -10 in rectal adenoma, adenocarcinoma and the corresponding normal mucosa tissue, and to clarify the relationship between their expression and clinicopathological parameters of rectal cancer. Methods: The expression of caspase-8 and -10 was determined by real-time RT-PCR and immunohistochemistry in 36 rectal adenomas, 93 rectal cancers and 93 corresponding normal rectal mucosa samples. Results: Compared with normal mucosa, the mRNA expression of caspase-8 was higher in adenomas (p = 0.003), while that of caspase-10 was lower in adenomas (p = 0.035) and cancers (p = 0.001). Immunohistochemical results showed caspase-8 up-regulation in adenomas (p = 0.014), and caspase-10 down-regulation in adenomas (p = 0.034) and cancers (p < 0.001) compared with normal mucosa samples. Cancers with poor differentiation had lower caspase-10 mRNA and protein levels than those with better differentiation (p = 0.041 and p = 0.046, respectively). The protein expression of caspase-8 and -10 was in accordance with the mRNA expression (p = 0.043 and p = 0.018, respectively). Conclusions: Caspase-8 expression was up-regulated in rectal adenomas. Caspase-10 expression was down-regulated in both rectal adenomas and cancers, and was further related to differentiation. Caspase-8 and -10 may be involved in the pathogenesis of rectal cancer. Copyright © 2008 S. Karger AG.
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| 2. |
- WANG, Hai-feng, et al.
(författare)
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Study on Oasis Distribution Patterns in Dry In-land River Basins
- 2005
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Ingår i: Journal of Hydraulic Engineering. - 1943-7900. ; 36:12, s. 1457-1463
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Tidskriftsartikel (refereegranskat)abstract
- Based on a comparative analysis approach of oasis distributed in arid area of Northwest China, this paper brings up and describes two kinds of oasis distribution pattern: mid-lower reach pattern and middle reach pattern. It is found that the water availability per capita of mid-lower reach pattern is higher than that of middle reach pattern, while the water resources exploitation percentage of mid-lower reach pattern is lower than that of middle reach pattern. The GDP per capita and the urbanization percentage of middle lower reach pattern is lower than those of middle reach pattern in general. The general output per unit water resources of mid-lower reach pattern is lower than that of middle reach pattern as a whole. Through comparing and studying the characteristics of the representative distribution pattern, it is pointed out that the key factor that leads to different oasis pattern is the differences of water resources and social economy development. Under the circumstance of population fast growing, water availability per capita will decrease accordingly. To maintain the oasis stability in line with economic development, improved production efficiency of water resources and balanced social-economic pattern are strongly required.
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