| 1. |
- Li, Cong, et al.
(författare)
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Targeted therapy with anlotinib for a leptomeningeal spread recurrent glioblastoma patient
- 2021
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Ingår i: NANOMEDICINE AND NEUROPROTECTION IN BRAIN DISEASES. - : ELSEVIER ACADEMIC PRESS INC. - 9780323901628 ; , s. 407-414
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Bokkapitel (refereegranskat)abstract
- Glioblastoma (GBM) is the most common and the most aggressive primary malignant brain tumor in adults. Although tumor recurrence is inevitable, leptomeningeal spread is relatively rare. We describe a case of leptomeningeal spread recurrent GBM treated with anlotinib in this report. When the recurrent GBM patient had leptomeningeal spread was administered anlotinib 10mg p.o. once every day and added oral temozolomide chemotherapy 100mg/m(2) (days 1-7, days 15-21, 28-day cycle) after 3 months. The patient's overall survival time was more than 5 months and developed oral ulcer and acute cerebral infarction during his oral administration of anlotinib. This patient showed a favorable clinic outcome for treatment of leptomeningeal spread recurrent GBM with anlotinib and didn't show serious side effects.
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| 2. |
- Arif, Muhammad, et al.
(författare)
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INetModels 2.0: An interactive visualization and database of multi-omics data
- 2021
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 49:W1, s. W271-W276
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Tidskriftsartikel (refereegranskat)abstract
- It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wellness and disease. To date, very few studies have focused on collecting and exhibiting multi-omics associations in a single database. Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs). This platform describes the associations between the clinical chemistry, anthropometric parameters, plasma proteomics, plasma metabolomics, as well as metagenomics for oral and gut microbiome obtained from the same individuals. Moreover, iNetModels includes tissue- and cancer-specific Gene Co-expression Networks (GCNs) for exploring the connections between the specific genes. This platform allows the user to interactively explore a single feature's association with other omics data and customize its particular context (e.g. male/female specific). The users can also register their data for sharing and visualization of the MOBNs and GCNs. Moreover, iNetModels allows users who do not have a bioinformatics background to facilitate human wellness and disease research. iNetModels can be accessed freely at https://inetmodels.com without any limitation.
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| 3. |
- Maslyk, Marcel, et al.
(författare)
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Understanding the Stability and Recrystallization Behavior of Amorphous Zinc Phosphate
- 2021
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Ingår i: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 125:4, s. 2636-2647
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Tidskriftsartikel (refereegranskat)abstract
- Zinc phosphate, an important pigment in phosphate conversion coatings, forms protective films on rubbing surfaces. We have simulated the underlying reactions under shear by ball-milling zinc phosphate and monitored the reaction of hopeite (Zn3(PO4)2·4H2O) and the retarded recrystallization of the amorphous reaction product by powder X-ray diffraction (PXRD) and quantitative infrared (IR) spectroscopy. Abrasion of stainless steel was simulated by addition of pure 57Fe. The results provide insight into the chemistry of phosphate conversion coatings or during battery cycling of metal phosphates and give theoretical guidance for the preparation of amorphous phosphates. Thermal analysis revealed that the release of structural water is a key step during the reaction of hopeite under shear to ball-milled amorphous zinc phosphate. The back-reaction and associated recrystallization kinetics of amorphous zinc phosphate show a classical Langmuir behavior. Fe impurities inhibit the recrystallization of ball-milled amorphous zinc phosphate strongly. 57Fe Mössbauer spectroscopy and PXRD revealed that Fe is oxidized to Fe2+ and Fe3+ during ball-milling and incorporated locally at the tetrahedral and octahedral sites of the structure. Ball-milled amorphous zinc phosphate is metastable as γ-Zn3–xFex(PO4)2. EPR studies showed the incorporation of Fe3+ to be coupled with the formation of Zn2+ vacancies. The Fe3+ defect sites bind water because of their higher Pearson hardness (compared to Fe2+ and Zn2+), thereby reducing water mobility and inhibiting further reactions like the recrystallization to hopeite. Our findings reveal the amorphization mechanism of Zn3(PO4)2·4H2O in stainless steel ball mills at the atomic scale and highlight how the reactivity of amorphous products is affected by impurities associated with the processing method.
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