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- Nillsson Lill, S. O., et al.
(författare)
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Development of chiral catalysts for stereoselective synthesis by deprotonations - Experimentation in interplay with computational chemistry
- 2004
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Ingår i: Advances in Quantum Chemistry. - : Elsevier. ; 47, s. 1-22
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Results are presented advancing the application of quantum chemistry in the field of organic synthesis. Computational chemistry in interplay with experimental chemistry has been given a key role in the development of stereoselective synthesis. Novel molecular systems are being created for catalytic stereoselective deprotonations, a reaction type useful for synthesizing many new compounds, e.g., some having important biological activities. Problems met in this approach to design catalysts and their solutions are presented.
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- Sitnicka Quinn, Ewa, et al.
(författare)
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Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis.
- 2003
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 198:10, s. 1495-1506
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Tidskriftsartikel (refereegranskat)abstract
- Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7R{alpha}, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7R{alpha} and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7R{alpha}-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7R{alpha}-/- mice, FL-/- x IL-7R{alpha}-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7R{alpha} are indispensable for fetal and adult B cell development.
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