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- Lin, ZX, et al.
(author)
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Predicting the mobility of Zn, Fe, Cu, Pb, Cd from roasted sulfide (pyrite) residues - A case study of wastes from the sulfuric acid industry in Sweden
- 1996
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In: WASTE MANAGEMENT. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0956-053X. ; 16:8, s. 671-681
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Journal article (peer-reviewed)abstract
- Leachates from roasted sulfide residues, which are the wastes from the production of sulfuric acid at Falun, Sweden, have low pH and high concentrations of Zn, Fe, and SO4. The minerals are mainly hematite and maghemite and, because the various sulfides i
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- Lin, ZX, et al.
(author)
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The source and fate of Pb in contaminated soils at the urban area of Falun in central Sweden
- 1998
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In: SCIENCE OF THE TOTAL ENVIRONMENT. - : ELSEVIER SCIENCE BV. - 0048-9697. ; 209:1, s. 47-58
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Journal article (peer-reviewed)abstract
- For centuries the city of Falun in central Sweden has been an important industrial region of copper mining, producing sulphuric acid and paint pigment. The mining and chemical industries have generated vast amounts of wastes which have been deposited arou
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- Lu, WS, et al.
(author)
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PDGFD switches on stem cell endothelial commitment
- 2022
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In: Angiogenesis. - : Springer Science and Business Media LLC. - 1573-7209 .- 0969-6970. ; 25:4, s. 517-533
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Journal article (peer-reviewed)abstract
- The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy.
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- Tan, BYQ, et al.
(author)
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Left ventricular systolic dysfunction is associated with poor functional outcomes after endovascular thrombectomy
- 2021
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In: Journal of neurointerventional surgery. - : BMJ. - 1759-8486 .- 1759-8478. ; 13:6, s. 515-
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Journal article (peer-reviewed)abstract
- Endovascular thrombectomy (ET) has transformed acute ischemic stroke (AIS) therapy in patients with large vessel occlusion (LVO). Left ventricular systolic dysfunction (LVSD) decreases global cerebral blood flow and predisposes to hypoperfusion. We evaluated the relationship between LVSD, as measured by LV ejection fraction (LVEF), and clinical outcomes in patients with anterior cerebral circulation LVO who underwent ET.MethodsThis multicenter retrospective cohort study examined anterior circulation LVO AIS patients from six international stroke centers. LVSD was measured by assessment of the echocardiographic LVEF using Simpson’s biplane method of discs according to international guidelines. LVSD was defined as LVEF <50%. The primary outcome was defined as a good functional outcome using a modified Rankin Scale (mRS) of 0–2 at 3 months.ResultsWe included 440 AIS patients with LVO who underwent ET. On multivariate analyses, pre-existing diabetes mellitus (OR 2.05, 95% CI 1.24 to 3.39;p=0.005), unsuccessful reperfusion (Treatment in Cerebral Infarction (TICI) grade 0-2a) status (OR 4.21, 95% CI 2.04 to 8.66; p<0.001) and LVSD (OR 2.08, 95% CI 1.18 to 3.68; p=0.011) were independent predictors of poor functional outcomes at 3 months. On ordinal (shift) analyses, LVSD was associated with an unfavorable shift in the mRS outcomes (OR 2.32, 95% CI 1.52 to 3.53; p<0.001) after adjusting for age and ischemic heart disease.ConclusionAnterior circulation LVO AIS patients with LVSD have poorer outcomes after ET, suggesting the need to consider cardiac factors for ET, the degree of monitoring and prognostication post-procedure.
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