| 1. |
- Blomqvist, Maria, et al.
(författare)
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Chlamydia psittaci in birds of prey, Sweden
- 2012
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Ingår i: Infection Ecology and Epidemiology. - 2000-8686. ; 2, s. 8435-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chlamydia psittaci is an intracellular bacterium primarily causing respiratory diseases in birds but may also be transmitted to other animals, including humans. The prevalence of the pathogen in wild birds in Sweden is largely unknown. Methods: DNA was extracted from cloacae swabs and screened for C. psittaci by using a 23S rRNA gene PCR assay. Partial 16S rRNA and ompA gene fragments were sequence determined and phylogenies were analysed by the neighbour-joining method. Results and conclusion: The C. psittaci prevalence was 1.3% in 319 Peregrine Falcons and White-tailed Sea Eagles, vulnerable top-predators in Sweden. 16S rRNA and ompA gene analysis showed that novel Chlamydia species, as well as novel C. psittaci strains, are to be found among wild birds.
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| 2. |
- Blomqvist, Maria, et al.
(författare)
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Chlamydophila psittaci in birds of prey, Sweden
- 2012
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Ingår i: Infection Ecology & Epidemiology. - : Informa UK Limited. - 2000-8686. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Background: Chlamydia psittaci is an intracellular bacterium primarily causing respiratory diseases in birds but may also be transmitted to other animals, including humans. The prevalence of the pathogen in wild birds in Sweden is largely unknown.Methods: DNA was extracted from cloacae swabs and screened for C. psittaci by using a 23S rRNA gene PCR assay. Partial 16S rRNA and ompA gene fragments were sequence determined and phylogenies were analysed by the neighbour-joining method.Results and conclusion: The C. psittaci prevalence was 1.3% in 319 Peregrine Falcons and White-tailed Sea Eagles, vulnerable top-predators in Sweden. 16S rRNA and ompA gene analysis showed that novel Chlamydia species, as well as novel C. psittaci strains, are to be found among wild birds.
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| 3. |
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| 4. |
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| 5. |
- Gunnarsson, Gunnar, et al.
(författare)
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Zero Prevalence of Influenza A Virus in Two Raptor Species by Standard Screening
- 2010
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Ingår i: Vector-borne and zoonotic diseases. - : Mary Ann Liebert Inc. - 1530-3667 .- 1557-7759. ; 10:4, s. 387-390
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Tidskriftsartikel (refereegranskat)abstract
- Disease can have sever impact on animal populations, especially in rare species. Baseline data for atypical host species are missing for a range of infectious diseases, although such hosts are potentially more affected than the normal vectors and reservoir species. If highly pathogenic avian influenza strikes rare birds of prey, this may have crucial impact on the predator species itself, but also on the food web in which it interacts. Here we present the first large-scale screening of raptors that regularly consume birds belonging to the natural reservoir of influenza A viruses. Influenza A virus prevalence was studied in two rare raptors, the white-tailed sea eagle (Haliaetus albicilla) and the peregrine falcon (Falco peregrinus). Nestlings were screened for active (181 white-tailed sea eagles and 168 peregrine falcons) and past (123 white-tailed sea eagles and 6 peregrine falcons) infection in 2006-2007, and an additional 20 succumbed adult white-tailed sea eagles were sampled in 2003-2006. Neither high- nor low-pathogenic influnza infections were found in our sample, but this does not rule out that the former may have major impact on rare raptors and their food webs.
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| 6. |
- Lindberg, Magnus, et al.
(författare)
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A behavioural nursing intervention for reduced fluid overload in haemodialysis patients : Initial results of acceptability, feasibility and efficacy
- 2011
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Ingår i: Journal of nursing and healthcare of chronic illness. - : Wiley-Blackwell. - 1752-9824 .- 1752-9816. ; 3:2, s. 87-98
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Describe and perform an initial test of a tailored treatment programme based on a behavioural medicine approach to enhance haemodialysis patients’ self-management of fluid restriction. Methods: Cognitive-behavioural techniques were used in four quasi-experimental case-studies. Central features in the programme were individual analysis of dietetic knowledge and fluid intake, setting goals, self-monitoring and prevention of relapse. Fluid overload was continuously assessed. Results: Acceptability and feasibility of the intervention were demonstrated. A clear reduction of fluid overload was shown. Some problems related to treatment fidelity were identified. Conclusion: The behavioural medicine approach resulted in reduction of fluid overload in each of the four cases included. Practice implications: This approach could be used as a method for tailoring interventions targeted to fluid intake behaviour in a heterogeneous group of HD patients with excessive fluid overload. Such treatment should take account of individual cognitive-behavioural patterns and include self-efficacy to low fluid intake. The efficacy of the tailored approach in regular practice has to be further tested in controlled trials.
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| 7. |
- Lindberg, Magnus, 1973-
(författare)
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Excessive Fluid Overload Among Haemodialysis Patients : Prevalence, Individual Characteristics and Self-regulation of Fluid Intake
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is comprised of four studies and concerns haemodialysis patients’ confidence in being able to manage fluid intake between treatment sessions, and whether the fluid intake is influenced by certain modifiable characteristics of the persons in question. The overall aim was to study aspects of excessive fluid overload and haemodialysis patients’ self-regulation of fluid allotment from a bio-psychosocial and behavioural medicine perspective. The extent of non-adherence to fluid allotment was described in Study I. National registry data were used. Three out of ten Swedish haemodialysis patients had excessive fluid overload and one out of five was at risk for treatment related complications due to too rapid ultrafiltration rate. The objective in Study II was to develop and psychometrically evaluate a self-administered scale to measure situation-specific self-efficacy to low fluid intake. The measure (the Fluid Intake Appraisal Inventory) was found to be reliable and valid in haemodialysis settings. Subgroups based on individual profiles of self-efficacy, attentional style and depressive symptoms were explored in Study III using a cluster analytic approach. Three distinct subgroups were found and the subgroup structure was validated for clinical relevance. The individuals’ profile concerning self-efficacy, attentional style and depressive symptoms has to be taken into account in nursing interventions designed to reduce haemodialysis patients’ fluid intake. In Study IV, an intervention designed to reduce haemodialysis patients’ fluid intake was introduced and its acceptability, feasibility and efficacy were evaluated and discussed. Acceptability of such an intervention was confirmed. Addressing beliefs, behaviours, emotions and physical feelings is clinically feasible and may reduce haemodialysis patient’s excessive fluid overload. This thesis indicates that there is a potential for improvement in the fluid management care of haemodialysis patients. Behavioural nursing strategies that aim to assist patients to achieve fluid control should be applied more extensively. Cognitive profiles of the patients should be taken into account when targeted nursing intervention aiming to encourage and maintain the patient’s fluid control is introduced.
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| 8. |
- Lindberg, Magnus, et al.
(författare)
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Subgroups of haemodialysis patients in relation to fluid intake restrictions : a cluster analytical approach
- 2010
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 19:21-22, s. 2997-3005
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Tidskriftsartikel (refereegranskat)abstract
- Aims To determine whether definable subgroups exist in a sample of haemodialysis patients with regard to self-efficacy, attentional style and depressive symptomatology and to compare whether interdialytic weight gain vary between patients in groups with different cognitive profiles.Background Theory-based research suggests that cognitive factors (e.g. self-efficacy and attentional style) and depressive symptomatology undermine adherence to health protective regimens. Preventing negative outcomes of fluid overload is essential for haemodialysis patients but many patients cannot achieve fluid control and nursing interventions aimed to help the patients reduce fluid intake are ineffective. Understanding the interaction between cognitive factors and how this is related to adherence outcomes might therefore lead to the development of helpful nursing interventions.Design Explorative cross-sectional multi-centre surveyMethods The sample consisted of 133 haemodialysis patients. Data were collected using structured questionnaires. A brief self-report form and data on interdialytic weight gain was also used. Two-step cluster analysis was used to identify subgroups. One way analysis of variance (ANOVA) or Pearson’s chi-square test were used for comparing subgroups.Results Three distinct subgroups were found and subsequently labelled: 1) low self-efficacy, 2) distraction and depressive symptoms and 3) high self-efficacy. The subgroups differed in fluid intake, but not in age, dialysis vintage, gender, residual urine output, or in receiving any fluid intake advice.Conclusions Clinically relevant subgroups of haemodialysis patients could be defined by their profiles regarding self-efficacy, attentional style and depressive symptoms.Relevance to clinical practice Based on this study we would encourage clinical practitioners to take into account cognitive profiles while performing their work. This is especially important when a targeted nursing intervention, which aims to encourage and maintain the patient’s fluid control, is introduced.
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| 9. |
- Accinelli, Cesare, et al.
(författare)
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Dissipation and removal of oseltamivir (Tamiflu) in different aquatic environments
- 2010
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Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 79:8, s. 891-897
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Tidskriftsartikel (refereegranskat)abstract
- The antiviral drug oseltamivir (Tamiflu) has received recent attention due to the potential use as a first-line defense against H5N1 and H1N1 influenza viruses. Research has shown that oseltamivir is not removed during conventional wastewater treatments, thus having the potential to enter surface water bodies. A series of laboratory experiments investigated the fate and the removal of oseltamivir in two surface water ecosystems of Japan and in a municipal wastewater treatment plant located in Northern Italy. Persistence of oseltamivir in surface water ranged from non-detectable degradation to a half-life of 53 d. After 40 d, <3% of radiolabeled oseltamivir evolved as (CO2)-C-14. The presence of sediments (5%) led to a significant increase of oseltamivir degradation and mineralization rates. A more intense mineralization was observed in samples of the wastewater treatment plant when applying a long incubation period (40 d). More precisely, 76% and 37% of the initial radioactivity applied as C-14-oseltamivir was recovered as (CO2)-C-14 from samples of the biological tank and effluent water, respectively. Two bacterial strains growing on oseltamivir as sole carbon source were isolated and used for its removal from synthetic medium and environmental samples, including surface water and wastewater. Inoculation of water and wastewater samples with the two oseltamivir-degrading strains showed that mineralization of oseltamivir was significantly higher in both inoculated water and wastewater, than in uninoculated controls. Denaturing gradient gel electrophoresis and quantitative PCR analysis showed that Tamiflu would not affect the microbial population of surface water and wastewater.
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| 10. |
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| 11. |
- Berglund, Björn, et al.
(författare)
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Abundance and dynamics of antibiotic resistance genes and integrons in lake sediment microcosms
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:9
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Tidskriftsartikel (refereegranskat)abstract
- Antibiotic resistance in bacteria causing disease is an ever growing threat to the world. Recently, environmental bacteria have become established as important both as sources of antibiotic resistance genes and in disseminating resistance genes. Low levels of antibiotics and other pharmaceuticals are regularly released into water environments via wastewater, and the concern is that such environmental contamination may serve to create hotspots for antibiotic resistance gene selection and dissemination. In this study, microcosms were created from water and sediments gathered from a lake in Sweden only lightly affected by human activities. The microcosms were exposed to a mixture of antibiotics of varying environmentally relevant concentrations (i.e., concentrations commonly encountered in wastewaters) in order to investigate the effect of low levels of antibiotics on antibiotic resistance gene abundances and dynamics in a previously uncontaminated environment. Antibiotic concentrations were measured using liquid chromatography-tandem mass spectrometry. Abundances of seven antibiotic resistance genes and the class 1 integron integrase gene, intL1, were quantified using real-time PCR. Resistance genes sulI and ermB were quantified in the microcosm sediments with mean abundances 5 and 15 gene copies/10(6) 16S rRNA gene copies, respectively. Class 1 integrons were determined in the sediments with a mean concentration of 3.86x10(4) copies/10(6) 16S rRNA gene copies. The antibiotic treatment had no observable effect on antibiotic resistance gene or integron abundances.
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| 12. |
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| 13. |
- Björn Milrad, Marianne
(författare)
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Studenter med läs- och skrivsvårigheter som deltagare i högre utbildning
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The emphasis on higher education (HE) in today’s knowledge society has increasedthe amount of students enrolled in universities in Sweden. Two percentof these students are people with disabilities, of whom more than half are studentswith dyslexia. Dyslexia is a disability that involves difficulty with writtentext which is the essence of HE. The disability affects these students’ readingand my assumption was therefore that their possibility to complete their educationon an equal footing with their peers was limited.The overall aim of this thesis is to illuminate the prerequisites for participationfor Swedish students with dyslexia in higher education, and to analyse if support,and information about support, offered by higher-education institutionsare accessible to them. Due to lack of previous research, this is a descriptivestudy using the theoretical framework of cultural-historical activity theory(CHAT), a theory that can be summarized in five principles: an activity systemis the unit of analysis, it has historicity, multi-voicedness, it views contradictionsas sources of change, and it has the potential for expansive transformation.To orient myself within the large field of HE and dyslexia, the following questionshave guided my work: What HE measures are taken to ensure accessibilityand participation for Swedish students with dyslexia? What tensions, as definedwithin CHAT, may be found in the HE activities in relation to studentswith dyslexia? How do students with dyslexia regard the support offered? Inorder to answer these questions, I have listened to some of the voices withinHE, by collecting data through a questionnaire sent to all coordinators for studentswith disabilities; by having focus group interviews with university teachers,as well as having individual interviews with students with dyslexia. Thedata were collected and analysed within a CHAT activity system, which depictedHE activities by coordinators and teachers in relation to students withdyslexia. The graph was used in the final discussion to formulate some ideas forexpansive transformation.
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| 14. |
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| 15. |
- Caesar, C., et al.
(författare)
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Beyond the neutron drip line: The unbound oxygen isotopes O-25 and O-26
- 2013
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 88:3
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Tidskriftsartikel (refereegranskat)abstract
- The very neutron-rich oxygen isotopes O-25 and O-26 are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from F-26 and F-27 at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of the decay into O-24 plus one or two neutrons, the O-25 ground-state energy and width are determined, and upper limits for the O-26 ground-state energy and lifetime are extracted. In addition, the results provide indications for an excited state in O-26 at around 4 MeV. The experimental findings are compared to theoretical shell-model calculations based on chiral two- and three-nucleon (3N) forces, including for the first time residual 3N forces, which are shown to be amplified as valence neutrons are added.
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| 16. |
- Dahlquist, Erik, 1951-, et al.
(författare)
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Combined solar power and TPV
- 2011
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Ingår i: Conference proceedings WREC 2011 in Linköping, Sweden, May 8-11, 2011. - Linköping : Linköping University Press. - 9789173930703 ; , s. 1-4240
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Konferensbidrag (refereegranskat)abstract
- In this paper design for a combined TPV and solar power system for local heat and power production is discussed. PV cells are producing electricity when there is light, while TPV cells are used when it is dark. Biomass is combusted and the heat is generating photons for the TPV system. Higher combustion temperature will give higher electric output, but also stronger deterioration of the materials in the combustor. By combining PV-cells that will generate a lot of electric power summer time with TPV-cells that can generate electric power winter time, when we also normally have a higher heat demand, we can achieve a flexible local heat and power system all year round. As both systems generate DC-power, we also can see a potential to use DC components generally, e.g for charging batteries for electrical vehicles, DC-pumps, LED-lamps etc. Design criteria for the systems are discussed in this paper for a house that is principally self sufficient on energy. Both theoretical and practical obstacles are discussed, as there are a number of issues to solve before the technique can be used in ”real life”.
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| 17. |
- Fick, Jerker, et al.
(författare)
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Therapeutic levels of levonorgestrel detected in blood plasma of fish: results from screening rainbow trout exposed to treated sewage effluents.
- 2010
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Ingår i: Environmental science & technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 44:7, s. 2661-2666
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Tidskriftsartikel (refereegranskat)abstract
- Pharmaceuticals are found in surface waters worldwide, raising concerns about effects on aquatic organisms. Analyses of pharmaceuticals in blood plasma of fish could provide means to assess risk for pharmacological effects, as these concentrations could be compared with available human therapeutic plasma levels. In this study we investigated if fish exposed to sewage effluents have plasma concentrations of pharmaceuticals that are approaching human therapeutic levels. We also evaluated how well the bioconcentration of pharmaceuticals into fish blood plasma can be predicted based on lipophilicity. Rainbow trout were exposed to undiluted, treated sewage effluents at three sites in Sweden for 14 days. Levels of 25 pharmaceuticals in blood plasma and effluents were analyzed with liquid chromatography-mass spectrometry/mass spectrometry and gas chromatography-high resolution mass spectrometry. The progestin pharmaceutical levonorgestrel was detected in fish blood plasma at concentrations (8.5-12 ng mL(-1)), exceeding the human therapeutic plasma level. In total 16 pharmaceuticals were detected in fish plasma at concentrations higher than 1/1000 of the human therapeutic plasma concentration. Twenty-one pharmaceuticals were detected in either plasma or effluent, and 14 were detected in both compartments, allowing plasma bioconcentration factors to be determined. For 11 of these, theoretically calculated and experimentally measured values were in reasonably good agreement. However a few drugs, including levonorgestrel, did not bioconcentrate according to the screening model used. This study shows that rainbow trout exposed to sewage effluents have blood plasma levels of pharmaceuticals similar to human therapeutic concentrations, suggesting a risk for pharmacological effects in the fish. There is a particular concern about effects of progestin pharmaceuticals. For levonorgestrel, the measured effluent level (1 ng/L) was higher than water levels shown to reduce the fertility of fish.
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| 18. |
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| 19. |
- Flygare, Erik, et al.
(författare)
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Utvärdering av metoder mot mobbning
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna utvärdering ger besked om insatser och arbetssätt som effektivt förebygger och åtgärdar mobbning. Utvärderingen är unik genom att den omfattar stora mängder data, både kvalitativa och kvantitativa från 39 skolor, att enskilda individers utsatthet följs upp vid tre tillfällen och att den omfattar flera program samtidigt.Resultaten visar bland annat att olika insatser har olika effekt för pojkar och flickor samt olika effekt beroende på om mobbningen är social eller fysisk. Den visar också att ingen enskild insats har dramatiskt positiva effekter. För att en skola ska lyckas förebygga och åtgärda mobbning krävs ett systematiskt arbete och en kombination av insatser. Åtta namngivna program som används mot mobbning har ingått i utvärderingen: Farstametoden, Friends, Lions Quest, Olweusprogrammet, SET - Social och emotionell träning, Skolkomet, Skolmedling samt Stegvis. I utvärderingens fristående metodfördjupning Utvärdering av metoder mot mobbning. Metodappendix och bilagor till rapport 353, (endast publicerad som pdf ) redovisar forskarna utförligt utvärderingens design och redogör för tillvägagångssättet vid datainsamling och analys.
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| 20. |
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| 21. |
- Gillman, Anna, et al.
(författare)
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Resistance Mutation R292K Is Induced in Influenza A(H6N2) Virus by Exposure of Infected Mallards to Low Levels of Oseltamivir
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Resistance to neuraminidase inhibitors (NAIs) is problematic as these drugs constitute the major treatment option for severe influenza. Extensive use of the NAI oseltamivir (Tamiflu(R)) results in up to 865 ng/L of its active metabolite oseltamivir carboxylate (OC) in river water. There one of the natural reservoirs of influenza A, dabbling ducks, can be exposed. We previously demonstrated that an influenza A(H1N1) virus in mallards (Anas platyrhynchos) exposed to 1 mu g/L of OC developed oseltamivir resistance through the mutation H274Y (N2-numbering). In this study, we assessed the resistance development in an A(H6N2) virus, which belongs to the phylogenetic N2 group of neuraminidases with distinct functional and resistance characteristics. Mallards were infected with A(H6N2) while exposed to 120 ng/L, 1.2 mu g/L or 12 mu g/L of OC in their sole water source. After 4 days with 12 mu g/L of OC exposure, the resistance mutation R292K emerged and then persisted. Drug sensitivity was decreased approximate to 13,000-fold for OC and approximate to 7.8-fold for zanamivir. Viral shedding was similar when comparing R292K and wild-type virus indicating sustained replication and transmission. Reduced neuraminidase activity and decrease in recovered virus after propagation in embryonated hen eggs was observed in R292K viruses. The initial, but not the later R292K isolates reverted to wild-type during egg-propagation, suggesting a stabilization of the mutation, possibly through additional mutations in the neuraminidase (D113N or D141N) or hemagglutinin (E216K). Our results indicate a risk for OC resistance development also in a N2 group influenza virus and that exposure to one NAI can result in a decreased sensitivity to other NAIs as well. If established in influenza viruses circulating among wild birds, the resistance could spread to humans via re-assortment or direct transmission. This could potentially cause an oseltamivir-resistant pandemic; a serious health concern as preparedness plans rely heavily on oseltamivir before vaccines can be mass-produced.
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| 22. |
- Hellfeldt, Karin, 1985-, et al.
(författare)
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Mobbning och socialt stöd från lärare och klasskamrater : en longitudinell studie av barns erfarenheter av mobbning
- 2014
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Ingår i: Sosiologi i dag. - 0332-6330 .- 1893-4617. ; 44:4, s. 79-104
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Tidskriftsartikel (refereegranskat)abstract
- Syftet med studien är att undersöka elevers utvecklingsvägar när det gäller upplevd utsatthet för mobbning samt att undersöka hur dessa olika utvecklingsvägar är relaterade till elevers upplevda sociala stöd från lärare och klasskamrater. En longitudinell design tillämpades där 3349 svenska elever i årskursena fyra till nio, besvarade en enkät vid två olika tillfällen, separerat med ett år. Fyra olika grupper kunde identifieras inom datamaterialet (1) ej utsatta elever, elever som inte var utsatta för mobbning vid något av mättillfällena, (2) undkomna offer, elever vars situation förändrades till det bättre, (3) nya offer, elever vars situation försämrades samt (4) fortsatt utsatta elever, elever som var utsatta för mobbning under hela mätperioden. Barn som aldrig varit utsatta för mobbning rapporterade de högsta nivåerna av upplevt socialt stöd från lärare såväl som klasskamrater vid mätning två. Gällande socialt stöd från klasskamrater hade undkomna offer högre nivåer än såväl nya som fortsatt utsatta elever. De nådde dock inte upp till samma nivå som de elever som aldrig varit utsatta för mobbning under mätperioden. När det gäller lärarstöd fanns dock inga signifikanta skillnader mellan de elever som undkommit mobbning, nya offer eller fortsatt utsatta elever.
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| 23. |
- Hellfeldt, Karin, 1985-, et al.
(författare)
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Social support from teachers as a buffering factor for bullied victim’s well-being
- 2013
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Konferensbidrag (refereegranskat)abstract
- Background: A significant body of research indicates that being victim of bullying increases the risk for negative health consequences, short term as well as throughout the lifespan. Children involved in bullying either as victims or bully-victims have higher risk for psychosomatic problems than their uninvolved peers. This risk is evenly distributed among victims of all different age groups, for both genders and between countries world over. Depression, psychosomatic problems, low self esteem and even thoughts of suicide are common consequences of being the victim of bullying. It is therefore important to study factors that may improve or protect these victims well-being. Social support has proven to be an important factor for handling different kind of stressors as well as being positive correlated with academics achievements and health. However little research has studied how social support may influence bullied children’s well being, especially social support deriving from teachers. The aim of this study is to explore the effects that social support from teachers may have on bullied children’s health, in particular, to explore if there are differences between bullied children experiences high or low levels of social support from teachers in relation to their well-being.Method: Data were collected during the spring of 2013 by using an online web-based questionnaire containing a variety of questions. The sample included all children in elementary schools, grades 4 to 9 in a mid-size Swedish m. In total, 5078 pupils completed the survey which gives a response rate at 82,01 %.Result: The result will explore how social support from teacher may serve as a protective factor for bullied children in relation to their total well-being as well as show how bullied children experiences different levels of victimization benefits from teachers social support. We will also discuss which implications the results gives to the importance of taking teacher and pupils relation into consideration when formulation anti bullying prevention programs and policies.
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| 24. |
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| 25. |
- Johansson, Lars, 1972, et al.
(författare)
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Statistical modelling of pedestrian wind speed using high‐resolution digital surface models
- 2012
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Ingår i: The Eight International Conference on Urban Climates. ; :abstract 183
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Spatial variations of near ground wind speed (2magl) within urban areas are simulated by using a statistical model. The model is built upon the statistical relationship between derivatives extracted from digital surface models characterizing urban geometries (sky view factor, fetch, frontal area index) and wind speed, using statistical regression techniques. The geometric parameters are calculated for a number of urban settings in Gothenburg, Sweden. Wind speed patterns are derived using the three-dimensional microclimate model, ENVI-met. The model closely estimate the wind speed within-the major parts of the model domains such as in squares, and narrow streets as well as canyons perpendicular to the incoming wind direction. However, the output wind speed patterns are largely different from the wind speed simulated by ENVI-met in wide streets and around buildings where wind speed is high. Statistical models, as presented here, would be useful for not only climatologist/ meteorologist but also urban designers to consider wind modes depending on urban geometries and also to estimate thermal comfort influenced by wind.
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| 26. |
- Konarska, Janina, 1986, et al.
(författare)
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Transmissivity of solar radiation through crowns of single urban trees—application for outdoor thermal comfort modelling
- 2014
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Ingår i: Theoretical and Applied Climatology. - : Springer Science and Business Media LLC. - 0177-798X .- 1434-4483. ; 117:3-4, s. 363-376
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Tidskriftsartikel (refereegranskat)abstract
- Trees play an important role in mitigating heat stress on hot summer days, mainly due to their ability to provide shade. However, an important issue is also the reduction of solar radiation caused by trees in winter, in particular at high latitudes. In this study, we examine the transmissivity of total and direct solar radiation through crowns of single street trees in Göteborg, Sweden. One coniferous and four deciduous trees of species common in northern European cities were selected for case study. Radiation measurements were conducted on nine clear days in 2011–2012 in foliated and leafless tree conditions using two sunshine pyranometers— one located in shade of a tree and the other one on the roof of an adjacent building. The measurements showed a significant reduction of total and direct shortwave radiation in the shade of the studied trees, both foliated and leafless. Average transmissivity of direct solar radiation through the foliated and defoliated tree crowns ranged from 1.3 to 5.3 % and from 40.2 to 51.9 %, respectively. The results confirm the potential of a single urban tree to reduce heat stress in urban environment. However, the relatively low transmissivity through defoliated trees should be considered while planning street trees in high latitude cities, where the solar access in winter is limited. The results were used for parameterisation of SOLWEIG model for a better estimation of the mean radiant temperature (Tmrt). Measured values of transmissivity of solar radiation through both foliated and leafless trees were found to improve the model performance.
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| 27. |
- Lindberg, Fredrik, 1974, et al.
(författare)
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Characteristics of the mean radiant temperature in high latitude cities—implications for sensitive climate planning applications
- 2014
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Ingår i: International Journal Of Biometeorology. - : Springer Science and Business Media LLC. - 0020-7128 .- 1432-1254. ; 58:5, s. 613-627
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Tidskriftsartikel (refereegranskat)abstract
- Knowledge of how the mean radiant temperature (T mrt ) is affected by factors such as location, climate and urban setting contributes to the practice of climate sensitive planning. This paper examines how T mrt varies within an urban setting and how it is influenced by cloudiness. In addition, variations of T mrt in three high latitude cities are investigated in order to analyse the impact of geographical context and climate conditions. Results showed large spatial variations between sunlit and shaded areas during clear weather conditions, with the highest values of T mrt close to sunlit walls and the lowest values in the areas shaded by buildings and vegetation. As cloudiness increases, the spatial pattern is altered and the differences are reduced. The highest T mrt under cloudy conditions is instead found in open areas where the proportion of shortwave diffuse radiation from the sky vault is high. A regional comparison between three Swedish coastal cities showed that T mrt during summer is similar regardless of latitudinal location. On the other hand, large differences in T mrt during winter were found. Shadows, both from buildings and vegetation are the most effective measure to reduce extreme values of T mrt . However, extensive areas of shadow are usually not desired within outdoor urban environments at high latitude cities. One solution is to create diverse outdoor urban spaces in terms of shadow and also ventilation. This would provide individuals with access to a choice of thermal environments which they can use to assist their thermal regulation, based on personal needs and desires.
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| 28. |
- Lindberg, Odd, et al.
(författare)
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Forskningen om mobbning
- 2010
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Ingår i: Elevhälsa. - : Gothia Förlag AB. - 1102-3112. ; :1, s. 11-13
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 29. |
- Lindberg, Odd, et al.
(författare)
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Ritualer, skam och sociala band
- 2010
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Ingår i: Elevhälsa. - : Gothia Förlag AB. - 1102-3112. ; :1, s. 16-24
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 30. |
- Lysholm, Fredrik, et al.
(författare)
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Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing
- 2012
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:2
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Tidskriftsartikel (refereegranskat)abstract
- The human respiratory tract is heavily exposed to microorganisms. Viral respiratory tract pathogens, like RSV, influenza and rhinoviruses cause major morbidity and mortality from respiratory tract disease. Furthermore, as viruses have limited means of transmission, viruses that cause pathogenicity in other tissues may be transmitted through the respiratory tract. It is therefore important to chart the human virome in this compartment. We have studied nasopharyngeal aspirate samples submitted to the Karolinska University Laboratory, Stockholm, Sweden from March 2004 to May 2005 for diagnosis of respiratory tract infections. We have used a metagenomic sequencing strategy to characterize viruses, as this provides the most unbiased view of the samples. Virus enrichment followed by 454 sequencing resulted in totally 703,790 reads and 110,931 of these were found to be of viral origin by using an automated classification pipeline. The snapshot of the respiratory tract virome of these 210 patients revealed 39 species and many more strains of viruses. Most of the viral sequences were classified into one of three major families; Paramyxoviridae, Picornaviridae or Orthomyxoviridae. The study also identified one novel type of Rhinovirus C, and identified a number of previously undescribed viral genetic fragments of unknown origin.
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| 31. |
- Noris, F., et al.
(författare)
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Implications of weighting factors on technology preference in net zero energy buildings
- 2014
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Ingår i: Energy and Buildings. - : Elsevier BV. - 1872-6178 .- 0378-7788. ; 82, s. 250-262
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Tidskriftsartikel (refereegranskat)abstract
- With the current movement towards Net Zero Energy Buildings (Net ZEBs) decisions regarding energy carrier weighting factors will have implications on which technologies could be favoured or disfavoured, and therefore adopted or not adopted, in the building sector of the near future. These implications should be taken into consideration by policy makers when developing legislation and regulations addressing the building sector. A parametric analysis was conducted on six buildings in Europe of different typologies and climates in order to assess how different weighting factors would impact the choice of technical systems to be installed. For each combination the amount of PV capacity necessary to achieve a net zero balance has been calculated and used as the main indicator for comparison; where less PV area means more favourable condition. The effect of including a solar thermal system is also discussed. With the current European national weighting factors, biomass boiler is largely the preferred solution, frequently achieving the balance with PV installed on the roof, while gas boiler is the most penalized. The situation changes when strategic weighting factors are applied. Lower weighting factors for electricity and district heating, e.g. reflecting national targets of increased penetration of renewables in such grids, would promote the use of heat pump and district heating, respectively. Asymmetric factors aimed at rewarding electricity export to the grid would facilitate the achievement of the zero balance for all technologies, promoting cogeneration in some cases. On the contrary, low weighting factors for electricity, e.g. reflecting a scenario of high decarbonisation of the power system, prove quite demanding; only few technical solutions would be able to reach the balance within the available roof area for PV, because of the low value credited to exported electricity. In this situation, the preferred solution would be heat pumps combined with solar thermal. In addition, the choice of weighting factors and the resulting favoured technologies will determine the temporal matching of load and generation. While all-electric solutions tend to use the grid as seasonal storage, other solutions will have a yearly net export of electricity to the grid to compensate for the supply of other (thermal) energy carriers. Therefore, it is important to consider the implications for the electricity grid resulting from the choice of weighting factors. (C) 2014 Elsevier B.V. All rights reserved.
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| 32. |
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| 33. |
- Ohlsson, Monica, et al.
(författare)
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Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin
- 2012
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Ingår i: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 135:6, s. 1682-1694
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary myopathy with early respiratory failure and extensive myofibrillar lesions has been described in sporadic and familial cases and linked to various chromosomal regions. The mutated gene is unknown in most cases. We studied eight individuals, from three apparently unrelated families, with clinical and pathological features of hereditary myopathy with early respiratory failure. The investigations included clinical examination, muscle histopathology and genetic analysis by whole exome sequencing and single nucleotide polymorphism arrays. All patients had adult onset muscle weakness in the pelvic girdle, neck flexors, respiratory and trunk muscles, and the majority had prominent calf hypertrophy. Examination of pulmonary function showed decreased vital capacity. No signs of cardiac muscle involvement were found. Muscle histopathological features included marked muscle fibre size variation, fibre splitting, numerous internal nuclei and fatty infiltration. Frequent groups of fibres showed eosinophilic inclusions and deposits. At the ultrastructural level, there were extensive myofibrillar lesions with marked Z-disc alterations. Whole exome sequencing in four individuals from one family revealed a missense mutation, g.274375T > C; p.Cys30071Arg, in the titin gene (TTN). The mutation, which changes a highly conserved residue in the myosin binding A-band titin, was demonstrated to segregate with the disease in all three families. High density single nucleotide polymorphism arrays covering the entire genome demonstrated sharing of a 6.99 Mb haplotype, located in chromosome region 2q31 including TTN, indicating common ancestry. Our results demonstrate a novel and the first disease-causing mutation in A-band titin associated with hereditary myopathy with early respiratory failure. The typical histopathological features with prominent myofibrillar lesions and inclusions in muscle and respiratory failure early in the clinical course should be incentives for analysis of TTN mutations.
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| 34. |
- Singer, Andrew C., et al.
(författare)
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Compliance to Oseltamivir among Two Populations in Oxfordshire, United Kingdom Affected by Influenza A(H1N1)pdm09, November 2009 : A Waste Water Epidemiology Study
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Antiviral provision remains the focus of many pandemic preparedness plans, however, there is considerable uncertainty regarding antiviral compliance rates. Here we employ a waste water epidemiology approach to estimate oseltamivir (Tamiflu (R)) compliance. Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two waste water treatment plant (WWTP) catchments within the United Kingdom at the peak of the autumnal wave of the 2009 Influenza A (H1N1)pdm09 pandemic. Predictions of oseltamivir consumption from detected levels were compared with two sources of national government statistics to derive compliance rates. Scenario and sensitivity analysis indicated between 3-4 and 120-154 people were using oseltamivir during the study period in the two WWTP catchments and a compliance rate between 45-60%. With approximately half the collected antivirals going unused, there is a clear need to alter public health messages to improve compliance. We argue that a near real-time understanding of drug compliance at the scale of the waste water treatment plant (hundreds to millions of people) can potentially help public health messages become more timely, targeted, and demographically sensitive, while potentially leading to less mis- and un-used antiviral, less wastage and ultimately a more robust and efficacious pandemic preparedness plan.
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| 35. |
- Singer, Andrew C., et al.
(författare)
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Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers
- 2014
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Ingår i: PLOS ONE. - : Public library of science. - 1932-6203. ; 9:9
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Tidskriftsartikel (refereegranskat)abstract
- The concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, oseltamivir carboxylate (OC), were measured weekly at 21 locations within the River Thames catchment in England during the month of November 2009, the autumnal peak of the influenza A[H1N1]pdm09 pandemic. The aim was to quantify the pharmaceutical response to the pandemic and compare this to drug use during the late pandemic (March 2010) and the inter-pandemic periods (May 2011). A large and small wastewater treatment plant (WWTP) were sampled in November 2009 to understand the differential fate of the analytes in the two WWTPs prior to their entry in the receiving river and to estimate drug users using a wastewater epidemiology approach. Mean hourly OC concentrations in the small and large WWTP's influent were 208 and 350 ng/L (max, 2070 and 550 ng/L, respectively). Erythromycin was the most concentrated antibiotic measured in Benson and Oxford WWTPs influent (max = 6,870 and 2,930 ng/L, respectively). Napthazoline and oxymetazoline were the most frequently detected and concentrated decongestant in the Benson WWTP influent (1650 and 67 ng/L) and effluent (696 and 307 ng/L), respectively, but were below detection in the Oxford WWTP. OC was found in 73% of November 2009's weekly river samples (max = 193 ng/L), but only in 5% and 0% of the late-and inter-pandemic river samples, respectively. The mean river concentration of each antibiotic during the pandemic largely fell between 17-74 ng/L, with clarithromycin (max = 292 ng/L) and erythromycin (max = 448 ng/L) yielding the highest single measure. In general, the concentration and frequency of detecting antibiotics in the river increased during the pandemic. OC was uniquely well-suited for the wastewater epidemiology approach owing to its nature as a prodrug, recalcitrance and temporally-and spatially-resolved prescription statistics.
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| 36. |
- Sundh, Josefin, 1972-
(författare)
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Quality of life, mortality and exacerbations in COPD
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Risk factors for poor health related quality of life (HRQL), mortality and exacerbations in Chronic Obstructive Pulmonary Disease (COPD) need to be explored.Objectives: To examine associations of comorbidity and Body Mass Index (BMI) with HRQL using the Clinical COPD Questionnaire (CCQ); to examine the prognostic qualities of the multidimensional instrument DOSE index; to examine the association of health status estimated by the CCQ with mortality; and to examine management of exacerbations and subsequent exacerbation risk.Material: Randomly selected patients from primary and secondary care, usingthe COPD cohort of the PRAXIS study. Information was collected using apatient questionnaire, record review and a clinical questionnaire. Mortalitydata wereobtained from the National Board of Health and Welfare.Methods: Multiple linear regression analysis, survival analysis and standardisedmortality ratios.Results: Heart disease, depression and underweight were associated withhigher CCQ. A higher DOSE index was associated with higher mortality. Ahigher CCQ was associated with higher mortality risk and mortality risk wasraised compared with the general population. Exacerbation management inprimary care was not optimal. An extra scheduled visit to an asthma/COPDnurse was associated with a reduced risk of subsequent exacerbations.Conclusions: The influence of comorbidity on HRQL in COPD patients is important. The DOSE index is useful as it combines important issues in COPD management with prognostic qualities. Health status estimated by CCQ is predictive of mortality. Exacerbation management in primary care COPD patients needs to be optimised, and nurse led asthma/COPD clinics may be a way to optimise resources with possible beneficial effects on exacerbation risk. These results could be used to improve COPD care and to facilitate focusing resources for those at greatest risk.
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| 37. |
- Thorsson, Sofia, 1972, et al.
(författare)
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Mean radiant temperature - A predictor of heat related mortality
- 2014
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Ingår i: Urban Climate. - Amsterdam : Elsevier BV. - 2212-0955. ; 10:Part 2, s. 332-345
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Tidskriftsartikel (refereegranskat)abstract
- Health studies have repeatedly used air temperature (Ta ), sometimes adjusted for humidity, when analyzing the impact of weather on mortality. The aim of this study is to highlight the importance of mean radiant temperature (Tmrt ) and its impact on heat related mortality. Tmrt is an essential meteorological parameter that influences the thermal comfort (heat load) of humans. It is useful when assessing the impact of weather, especially heat, on people's health. Tmrt is directly influenced by urban geometry and surface material, which also makes it a good measure to identify urban hot spots. The performance of models using Ta and Tmrt for daily mortality is compared for Stockholm County, Sweden. It is demonstrated that Tmrt models fit heat related mortality better than Ta models, which implies that health studies should consider using Tmrt rather than Ta . The use of Tmrt models allows us to determine more accurate thresholds for increased risks of heat related mortality, and thus to better identify adverse weather conditions and heat prone urban geometries. Such information is needed to implement heat-warning systems and mitigate harmful effects of heat stress. © 2014 Elsevier Ltd. All rights reserved.
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| 38. |
- Thorsson, Sofia, 1972, et al.
(författare)
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Potential changes in outdoor thermal comfort conditions in Gothenburg, Sweden due to climate change: the influence of urban geometry
- 2011
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Ingår i: International Journal of Climatology. - : Wiley. - 1097-0088 .- 0899-8418. ; 31:2, s. 324-335
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Tidskriftsartikel (refereegranskat)abstract
- Quantitative information about outdoor thermal comfort, on various temporal and spatial scales, is required to design better cities and mitigate heat problems not only in warm but also in temperate climates. The overall objective of this study is to explore the augmentation of global/regional climate changes by urban features such as geometry in a compact mid-rise high-latitude city (Gothenburg). The magnitude of spatial and temporal variations of intra-urban mean radiant temperatures (Tmrt) is quantified using the SOLWEIG (SOlar and LongWave Environmental Irradiance Geometry) model. Hourly time resolution, statistically downscaled meteorological data, based on the ECHAM5-GCM under the A1B emission scenario is used to simulate changes in Tmrt and physiologically equivalent temperature (PET) at the 2080–2099 time horizon. Results show that urban geometry causes large intra-urban differences in Tmrt, on hourly, daytime and yearly time scales. In general, open areas are warmer than adjacent narrow street canyons in summer, but cooler in winter. According to the ECHAM5-based scenario, the daytime Tmrt will increase by 3.2 °C by the end of this century. This is 0.4° more than simulated increase in air temperature (2.8 °C) and is mainly a result of decreases in summer cloudiness. Occasions of strong/extreme heat stress are expected to triple. This equates to 20–100 h a year, depending on geometry. Conversely, the number of hours with strong/extreme cold stress decreases by 400–450 h. Furthermore, the number of hours with no thermal stress increases by 40–200 h a year. The study confirms the potential for using geometry to mitigate daytime thermal stress. A densely built structure mitigates extreme swings in Tmrt and PET, improving outdoor comfort conditions both in summer and in winter. Furthermore, it highlights the importance of including information on either Tmrt or thermal comfort in climate scenarios to describe the combined effects of changes in multiple climate variables and to more realistically measure the impact on humans.
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