| 1. |
- Berglund, Staffan K., et al.
(författare)
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Marginally low birth weight increases the risk of underweight and short stature at three and a half years of age
- 2016
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Ingår i: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 105:6, s. 610-617
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Little is known about the long-term health of marginally low birth weight (LBW) children. This study characterised growth among infants weighing 2,000g-2,500g and explored the prevalence and predictors of sustained growth restriction.METHOD: This prospective observational trial followed the weight and height of 281 Swedish marginally LBW children from birth to 3.5 years of age. Children with a standard deviation score (SDS) for body mass index or height below -2 were considered underweight and short respectively.RESULTS: The mean SDS for weight and height showed a rapid increase before 12-19 weeks of age. The most rapid weight gain was in infants born small for gestational age. However, at 3.5 years of age, 9.5% of the children remained underweight and 6.5% had short stature. Regression models showed that slow weight gain before 19 weeks of age was the strongest predictor for lasting underweight, while slow height gain before 19 weeks of age and male sex were associated with short stature.CONCLUSION: Marginally LBW infants were more likely to be underweight and have a short stature at 3.5 years of age and the absence of catch-up growth during the first five months after birth identified those at highest risk.
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| 2. |
- Atar, L., et al.
(författare)
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Quasifree (p, 2p) Reactions on Oxygen Isotopes: Observation of Isospin Independence of the Reduced Single-Particle Strength
- 2018
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 120:5
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Tidskriftsartikel (refereegranskat)abstract
- Quasifree one-proton knockout reactions have been employed in inverse kinematics for a systematic study of the structure of stable and exotic oxygen isotopes at the R3B/LAND setup with incident beam energies in the range of 300-450 MeV/u. The oxygen isotopic chain offers a large variation of separation energies that allows for a quantitative understanding of single-particle strength with changing isospin asymmetry. Quasifree knockout reactions provide a complementary approach to intermediate-energy one-nucleon removal reactions. Inclusive cross sections for quasifree knockout reactions of the type OA(p,2p)NA-1 have been determined and compared to calculations based on the eikonal reaction theory. The reduction factors for the single-particle strength with respect to the independent-particle model were obtained and compared to state-of-the-art ab initio predictions. The results do not show any significant dependence on proton-neutron asymmetry.
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| 3. |
- Beijer, Kristina, et al.
(författare)
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Removal of pharmaceuticals and unspecified contaminants in sewage treatment effluents by activated carbon filtration and ozonation : Evaluation using biomarker responses and chemical analysis
- 2017
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Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 176, s. 342-351
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Tidskriftsartikel (refereegranskat)abstract
- Traces of active pharmaceutical ingredients (APIs) and other chemicals are demonstrated in effluents from sewage treatment plants (STPs) and they may affect quality of surface water and eventually drinking water. Treatment of effluents with granular activated carbon (GAC) or ozone to improve removal of APIs and other contaminants was evaluated at two Swedish STPs, Kappala and Uppsala (88 and 103 APIs analyzed). Biomarker responses in rainbow trout exposed to regular and additionally treated effluents were determined. GAC and ozone treatment removed 87-95% of the total concentrations of APIs detected. In Kappala, GAC removed 20 and ozonation (7 g O-3/m(3)) 21 of 24 APIs detected in regular effluent. In Uppsala, GAC removed 25 and ozonation (5.4 g O-3/m(3)) 15 of 25 APIs detected in effluent. GAC and ozonation also reduced biomarker responses caused by unidentified pollutants in STP effluent water. Elevated ethoxyresorufin-O-deethylase (EROD) activity in gills was observed in fish exposed to effluent in both STPs. Gene expression analysis carried out in Kappala showed increased concentrations of cytochrome P450 (CYP1A5 and CYP1C3) transcripts in gills and of CYP1As in liver of fish exposed to effluent. In fish exposed to GAC- or ozone-treated effluent water, gill EROD activity and expression of CYP1As and CYP1C3 in gills and liver were generally equal to or below levels in fish held in tap water. The joint application of chemical analysis and sensitive biomarkers proved useful for evaluating contaminant removal in STPs with new technologies.
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| 4. |
- Björn, Catrine, et al.
(författare)
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Significant factors for work attractiveness and how these differ from the current work situation among operating department nurses
- 2016
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 25:1-2, s. 109-116
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Tidskriftsartikel (refereegranskat)abstract
- AIMS AND OBJECTIVES: The aim was to examine significant factors for work attractiveness and how these differ from the current work situation among operating department nurses. A second objective was to examine the associations between age, gender, length of employment, work engagement, work ability, self-rated health indicators and attractiveness of the current work situation.BACKGROUND: The attractiveness of work is rarely taken into account in research on nurse retention. To expand this knowledge, it is relevant to examine factors that make work attractive and their associations with related concepts.DESIGN: Correlational, cross-sectional survey using a convenience sample.METHODS: Questionnaires were answered by 147 nurses in four operating departments in Sweden. Correlation and regression analyses were conducted.RESULTS: The nurses rated the significance of all factors of work attractiveness higher than they rated those factors in their current work situation; salary, organisation and physical work environment had the largest differences. The most significant attractive factors were relationships, leadership and status. A statistically significant positive correlation between work engagement and attractive work was found. In the multiple regression model, the independent variables work engagement and older age significantly predicted work attractiveness.CONCLUSIONS: Several factors should be considered in the effort to increase work attractiveness in operating departments and thereby to encourage nurse retention. Positive aspects of work seem to unite work engagement and attractive work, while work ability and self-rated health indicators are other important dimensions in nurse retention.RELEVANCE TO CLINICAL PRACTICE: The great discrepancies between the significance of attractive factors and the current work situation in salary, organisation and physical work environment suggest ways in which work attractiveness may be increased. To discover exactly what needs to be improved may require a deeper look into the construct of the examined factors.
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| 5. |
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| 6. |
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| 7. |
- Carlström, Eric, 1957, et al.
(författare)
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Medical Emergencies During a Half Marathon Race - The Influence of Weather
- 2019
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Ingår i: International Journal of Sports Medicine. - Stuttgart : Georg Thieme Verlag KG. - 0172-4622 .- 1439-3964. ; 40:5, s. 312-316
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to analyze the influence of weather conditions on medical emergencies in a half-marathon, specifically by evaluating its relation to the number of non-finishers, ambulance-required assistances, and collapses in need of ambulance as well as looking at the location of such emergencies on the race course. Seven years of data from the world's largest half marathon were used. Meteorological data were obtained from a nearby weather station, and the Physiological Equivalent Temperature (PET) index was used as a measure of general weather conditions. Of the 315,919 race starters, 104 runners out of the 140 ambulance-required assistances needed ambulance services due to collapses. Maximum air temperature and PET significantly co-variated with ambulance-required assistances, collapses, and non-finishers (R (2) =0.65-0.92; p=0.001-0.03). When air temperatures vary between 15-29 degrees C, an increase of 1 degrees C results in an increase of 2.5 (0.008/1000) ambulance-required assistances, 2.5 (0.008/1000) collapses (needing ambulance services), and 107 (0.34/1000) non-finishers. The results also indicate that when the daily maximum PET varies between 18-35 degrees C, an increase of 1 degrees C PET results in an increase of 1.8 collapses (0.006/1000) needing ambulance services and 66 non-finishers (0.21/1000).
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| 8. |
- Diaz Fernandez, Paloma, 1983, et al.
(författare)
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Quasifree (p, pN) scattering of light neutron-rich nuclei near N=14
- 2018
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 97:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: For many years, quasifree scattering reactions in direct kinematics have been extensively used to study the structure of stable nuclei, demonstrating the potential of this approach. The (RB)-B-3 collaboration has performed a pilot experiment to study quasifree scattering reactions in inverse kinematics for a stable C-12 beam. The results from that experiment constitute the first quasifree scattering results in inverse and complete kinematics. This technique has lately been extended to exotic beams to investigate the evolution of shell structure, which has attracted much interest due to changes in shell structure if the number of protons or neutrons is varied. Purpose: In this work we investigate for the first time the quasifree scattering reactions (p, pn) and (p, 2p) simultaneously for the same projectile in inverse and complete kinematics for radioactive beams with the aim to study the evolution of single-particle properties from N = 14 to N = 15. Method: The structure of the projectiles O-23, O-22, and N-21 has been studied simultaneously via (p, pn) and (p, 2p) quasifree knockout reactions in complete inverse kinematics, allowing the investigation of proton and neutron structure at the same time. The experimental data were collected at the (RB)-B-3-LAND setup at GSI at beam energies of around 400 MeV/u. Two key observables have been studied to shed light on the structure of those nuclei: the inclusive cross sections and the corresponding momentum distributions. Conclusions: The knockout reactions (p, pn) and (p, 2p) with radioactive beams in inverse kinematics have provided important and complementary information for the study of shell evolution and structure. For the (p, pn) channels, indications of a change in the structure of these nuclei moving from N = 14 to N = 15 have been observed, i.e., from the 0d(5/2) shell to the 1s(1/2). This supports previous observations of a subshell closure at N = 14 for neutron-rich oxygen isotopes and its weakening for the nitrogen isotopes.
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| 9. |
- Dlugosz, Aldona, et al.
(författare)
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No difference in small bowel microbiota between patients with irritable bowel syndrome and healthy controls
- 2015
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have indicated that colonic microbiota may exhibit important differences between patients with irritable bowel syndrome (IBS) and healthy controls. Less is known about the microbiota of the small bowel. We used massive parallel sequencing to explore the composition of small bowel mucosa-associated microbiota in patients with IBS and healthy controls. We analysed capsule biopsies from the jejunum of 35 patients (26 females) with IBS aged 18-(36)-57 years and 16 healthy volunteers (11 females) aged 20-(32)-48 years. Sequences were analysed based on taxonomic classification. The phyla with the highest total abundance across all samples were: Firmicutes (43%), Proteobacteria (23%), Bacteroidetes (15%), Actinobacteria (9.3%) and Fusobacteria (7.0%). The most abundant genera were: Streptococcus (19%), Veillonella (13%), Prevotella (12%), Rothia (6.4%), Haemophilus (5.7%), Actinobacillus (5.5%), Escherichia (4.6%) and Fusobacterium (4.3%). We found no difference among major phyla or genera between patients with IBS and controls. We identified a cluster of samples in the small bowel microbiota dominated by Prevotella, which may represent a common enterotype of the upper small intestine. The remaining samples formed a gradient, dominated by Streptococcus at one end and Escherichia at the other.
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| 10. |
- Ehrenholm, Carina
(författare)
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Den fantastiska resan: Hörspel
- 2015
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Premiär: Den fantastiska resanDen engagerade men utbrända läraren Ulf kämpar för att få sina elever att växa och utvecklas, men blir ständigt begränsad av skolpolitikens fyrkantiga villkor. Plötsligt en dag blir han kontaktad av Motståndsrörelsen, och det blir starten på en helt fantastisk resa.
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| 11. |
- Ehrenholm, Carina
(författare)
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Tillbaka till Renacer: Hörspel
- 2017
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Försommaren 2015 står Carina Ehrenholm på sin mormors begravning och pratar med Jimmy Martinez, som var ett av barnen på barnhemmet Renacer i Honduras, där Carina arbetade som volontär tjugo år tidigare. De har inte setts sen dess. Nu har han flyttat till Sverige, gift sig, skaffat barn och bor i en villa i Småland. Barnhemmet var av olika anledningar bådas hem under en period och nu möts de plötsligt igen. Carinas moster var föreståndare för barnhemmet och det är därför Jimmy nu är på begravningen – Carinas mormor är i någon mening också Jimmys mormor (vilket innebär att Jimmy i någon mening är hennes kusin). Med föreställningen Tillbaka till Renancer undersöks ramarna för vad en familj är, vad de skulle kunna vara och vad avsaknaden av en familj betyder.
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| 12. |
- Ehrenholm, Carina
(författare)
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Träd + Radio: Hörspel
- 2016
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Träd+radio är ett hörspel om trädens underjordiska rotsystem, om att lyssna på radio, om den stränga filosofen Simone Weil, om att finna den största njutningen i smärtan, våldet och lydnaden, om att förvandlas till ett träd och om en dröm om undergången.
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| 13. |
- Ekström, Magnus, et al.
(författare)
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Absolute lung size and the sex difference in breathlessness in the general population
- 2018
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Ingår i: Plos One. - San Francisco, USA : Public Library of Science (PLoS). - 1932-6203. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes. Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women). Breathlessness was measured using the modified Medical Research Council (mMRC) scale and analyzed using ordinal logistic regression adjusting for age, pack-years of smoking, body mass index, chronic airway limitation, asthma, chronic bronchitis, depression and anxiety in all models. Breathlessness was twice as common in women as in men; adjusted odds ratio (OR) 2.20 (95% confidence interval, 1.32-3.66). Lower absolute lung volumes were associated with increased breathlessness prevalence in both men and women. The sex difference in breathlessness was unchanged when adjusting for lung function in %predicted, but disappeared when controlling for absolute values of total lung capacity (OR 1.12; 0.59-2.15), inspiratory capacity (OR 1.26; 0.68-2.35), forced vital capacity (OR 0.84; 0.42-1.66), forced expiratory volume in one second (OR 0.70; 0.36-1.35) or lung diffusing capacity (OR 1.07; 0.58-1.97). In the general population, the markedly higher prevalence of breathlessness in women is related to their smaller absolute lung volumes.
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| 14. |
- Englund, Elias, et al.
(författare)
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Metabolic Engineering of Synechocystis sp. PCC 6803 for Production of the Plant Diterpenoid Manoyl Oxide
- 2015
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Ingår i: ACS Synthetic Biology. - : American Chemical Society (ACS). - 2161-5063. ; 4:12, s. 1270-1278
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Tidskriftsartikel (refereegranskat)abstract
- Forskolin is a high value diterpenoid with a broad range of pharmaceutical applications, naturally found in root bark of the plant Coleus forskohlii. Because of its complex molecular structure, chemical synthesis of forskolin is not commercially attractive. Hence, the labor and resource intensive extraction and purification from C. forskohlii plants remains the current source of the compound. We have engineered the unicellular cyanobacterium Synechocystis sp. PCC 6803 to produce the forskolin precursor 13R-manoyl oxide (13R-MO), paving the way for light driven biotechnological production of this high value compound. In the course of this work, a new series of integrative vectors for use in Synechocystis was developed and used to create stable lines expressing chromosomally integrated CfTPS2 and CfTPS3, the enzymes responsible for the formation of 13R-MO in C. forskohlii. The engineered strains yielded production titers of up to 0.24 mg g(-1) DCW 13R-MO. To increase the yield, 13R-MO producing strains were further engineered by introduction of selected enzymes from C. forskohlii, improving the titer to 0.45 mg g(-1) DCW. This work forms a basis for further development of production of complex plant diterpenoids in cyanobacteria.
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| 15. |
- Eriksson, Kaja, et al.
(författare)
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Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis
- 2019
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:5
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.
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| 16. |
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| 17. |
- Heine, M., et al.
(författare)
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Determination of the neutron-capture rate of C-17 for r-process nucleosynthesis
- 2017
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 95:1, s. Article no 014613 -
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Tidskriftsartikel (refereegranskat)abstract
- With the (RB)-B-3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C-18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C-17 into the ground state of C-18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C-18. This allowed to derive the astrophysical cross section sigma(n gamma)*. accounting for the thermal population of C-17 target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures T-9
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| 18. |
- Hellfeldt, Karin, 1985-
(författare)
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The Hurt Self : Bullied Children's Experiences of Social Support, Recognition and Trust at School
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this dissertation is to add to the development the knowledge base of bullying research with particular focus on processes of victimization within a Swedish context. The goal is to a contribute to understanding the consequences of being bullied by examining patterns of change in bullying victimization over time and how potential positive social interactions and relationships might promote the well-being of bullied children. A mix-methods research design was used, including quantitative data from a one-year longitudinal study, using individual data, from 3,347 pupils (grades 4 to 9, in 44 schools) and five in-depth qualitative interviews with former victims of bullying. From an overview of the research field it was concluded that there is a general shortage of theoretical perspectives within the field of bullying research. Correlation studies have linked negative health consequences with bullying. However, this kind of research design provides few insights into how and why bullied children experience the kinds of problems that they do. By adopting a theoretical understanding of how ‘self’ is realized through interactions with others, this dissertation moves beyond correlation- based explanations of the mechanisms behind the link between bullying and its consequences in order to be able to offer more targeted support for those schoolchildren who are, or have been subjected to bullying. An argument is made for the importance of understanding the social processes behind bullying It is argued that being subjected to bullying victimization is a transient life experience for about three quarters of the small cohort (about 7%) of Swedish schoolchildren who are victims of bullying at any one time. The trajectories of bullying experiences these children are unstable. However, the negative consequences are likely to remain even after the bullying has ceased. For others, the persistent victims (1.6%). the state of being bullied may become stable and continue over periods of years. Nevertheless, peers and teachers may serve as important resources in supporting transitory and continuing victims of bullying.
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| 19. |
- Holl, M., et al.
(författare)
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Quasi-free neutron and proton knockout reactions from light nuclei in a wide neutron-to-proton asymmetry range
- 2019
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 795, s. 682-688
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Tidskriftsartikel (refereegranskat)abstract
- The quasi-free scattering reactions 11C(p,2p) and 10,11,12C(p,pn) have been studied in inverse kinematics at beam energies of 300–400 MeV/u at the R3B-LAND setup. The outgoing proton-proton and proton-neutron pairs were detected in coincidence with the reaction fragments in kinematically complete measurements. The efficiency to detect these pairs has been obtained from GEANT4 simulations which were tested using the 12C(p,2p) and 12C(p,pn) reactions. Experimental cross sections and momentum distributions have been obtained and compared to DWIA calculations based on eikonal theory. The new results reported here are combined with previously published cross sections for quasi-free scattering from oxygen and nitrogen isotopes and together they enable a systematic study of the reduction of single-particle strength compared to predictions of the shell model over a wide neutron-to-proton asymmetry range. The combined reduction factors show a weak or no dependence on isospin asymmetry, in contrast to the strong dependency reported in nucleon-removal reactions induced by nuclear targets at lower energies. However, the reduction factors for (p,2p) are found to be 'significantly smaller than for (p,pn) reactions for all investigated nuclei.
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| 20. |
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| 21. |
- Holmer, Björn, 1943, et al.
(författare)
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How to transform the standing man from a box to a cylinder – a modified methodology to calculate mean radiant temperature in field studies and models
- 2015
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Ingår i: ICUC9 – 9 th International Conference on Urban Climate jointly with 12th Symposium on the Urban Environment. 20-24 July, Toulouse, France.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Mean radiant temperature (Tmrt) has shown to be an important meteorological variable in studies of human comfort and health. The Tmrt is calculated as the surface temperature of a standing man approximated as a cylinder emitting the same amount of longwave radiation as all short- and longwave radiation fluxes received from the surrounding four cardinal points and down- and upwards. The calculation was introduced by Höppe in 1992 and has then been used both in models (e.g. SOLWEIG) and field studies. However, the formula by Höppe describes in fact a man shaped like a box and not a cylinder, which has resulted in some peculiar features noticed in studies of Tmrt such as a secondary daytime minimum and an influence of the orientation of the field equipment. A methodology to change the box man to a cylindrical man is proposed. It will remove the peculiarities that have been observed in earlier studies. The methodology is based on the partition of the observed shortwave fluxes in direct and diffuse radiation. The minimum shortwave radiation of the four cardinal points is used as diffuse radiation since it is monitored by a sensor that is not sunlit. By subtraction of this quantity the horizontal direct fluxes are obtained. Calculation of the resultant flux of the sunlit sensors and adjustment for solar angle gives the direct shortwave radiation. The surface of the standing man (as a cylinder) perpendicular to the direct radiation must be determined and the direct shortwave radiation received by the standing man can be calculated. Then the sum of the shortwave fluxes can be calculated. The diffuse and longwave fluxes can be calculated according to the Höppe formula since they differ little with direction. In the SOLWEIG model the direct shortwave radiation is used as an input. Thus the calculation according to the new methodology is easy to apply, only the solar position needs to be added. The new methodology is tested by model calculations with SOLWEIG and field studies in both high-latitude Gothenburg, Sweden and low-latitude Ouagadougou, Burkina Faso. The secondary minimum disappears. In Gothenburg at a site with SVF=0.95 the noon depression of Tmrt by the Höppe formula was about 2 °C and there was an overestimation of 1.5-1.7 °C two-three hours before and after noon.differences in summer. In Ouagadougou data from an open site (SVF=0.83) in the dry season the differences were slightly smaller. Sites with lower SVF and much reflected direct shortwave radiation differed less from the Tmrt obtained with the Höppe formula.
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| 22. |
- Holmer, Björn, 1943, et al.
(författare)
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Urban climatic map studies in Sweden: Gothenburg
- 2015
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Ingår i: The Urban Climatic Map: A Methodology for Sustainable Urban Planning. - Milton Park : Taylor and Francis. ; , s. 324-342
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Bokkapitel (refereegranskat)
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| 23. |
- IDS Collaboration, HASH(0x3dac240), et al.
(författare)
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Beta-delayed proton emission from 20Mg
- 2016
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 52:10, s. 304-
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Tidskriftsartikel (refereegranskat)abstract
- Beta-delayed proton emission from 20 Mg has been measured at ISOLDE, CERN, with the ISOLDE Decay Station (IDS) setup including both charged-particle and gamma-ray detection capabilities. A total of 27 delayed proton branches were measured including seven so far unobserved. An updated decay scheme, including three new resonances above the proton separation energy in 20 Na and more precise resonance energies, is presented. Beta-decay feeding to two resonances above the Isobaric Analogue State (IAS) in 20 Na is observed. This may allow studies of the 4032.9(2.4)keV resonance in 19 Ne through the beta decay of 20 Mg, which is important for the astrophysically relevant reaction 15O(?,?)19Ne. Beta-delayed protons were used to obtain a more precise value for the half-life of 20 Mg, 91.4(1.0)ms.
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| 24. |
- Kalzén, Håkan, et al.
(författare)
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Survival after PICU admission : The impact of multiple admissions and complex chronic conditions
- 2018
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- Objective Factors predicting survival over time after pediatric intensive care unit (PICU) admissions are not fully understood. The primary aim of the current study was to investigate whether multiple admissions (MADM) compared to single PICU admissions (SADM) were associated with poor survival over time after being admitted to PICU facilities. Our secondary aim was to investigate if the presence of a complex chronic condition (CCC) would further impair prognosis. Design A closed cohort of all children up to 16 years of age admitted to the three PICUs in Sweden between 2008 and 2010 was prospectively collected and followed until 2012, providing survival data for at least one but up to four years of follow-up. Setting Three Swedish tertiary referral centers for pediatric intensive care and extracorporeal membrane oxygenation (ECMO) care were used. Patients In total, 3, 688 Swedish children with 5, 019 PICU admissions were included. Interventions No interventions were conducted. Measurements An extensive data set was recorded, including up to four-year survival information following first PICU admission. The patients were assigned to seven admission diagnostic groups, which were then divided into SADM or MADM groups. The difference in survival over time and mortality rates (MR) and mortality rate ratios (MRR) were calculated. SADM and MADM groups with and without an existing CCC were formed. The difference in survival over time between groups was calculated. Main results A highly significant difference in survival over time was noted between SADM and MADM patients (p<0.0001), which was intensified by the presence of a CCC. MADM patients with a CCC had the worst outcome, while SADM patients without a CCC had the best outcome. MADM patients with no CCC demonstrated decreased survival over time compared to SADM patients with a CCC. Survival over time was statistically worsened for patients with MADM compared to SADM for the following admission diagnostic groups: Cardiovascular, Gastrointestinal/Renal, Respiratory, Neurological, and Miscellaneous. The mortality rate (deaths/patient year of follow-up) during the time of follow-up was 0.023 for SADM and 0.062 for MADM patients. The mortality rate ratio (MRR) between these groups was 2.69. Conclusion Compared to single admissions, multiple admissions to PICU were associated with a significant decrease in survival over time in some but not all diagnostic groups. Regarding our secondary aim, we found that when the presence of a CCC is factored into the survival analysis, survival over time is further impaired.
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| 25. |
- Konarska, Janina, 1986, et al.
(författare)
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Influence of vegetation and building geometry on the spatial variations of air temperature and cooling rates in a high latitude city
- 2016
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Ingår i: International Journal of Climatology. - : Wiley. - 0899-8418 .- 1097-0088. ; 36:5, s. 2379-2395
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to provide a better understanding of how vegetation and building geometry influence the spatial distribution of air temperature and nocturnal cooling rates (CR) in a high-latitude city. Intra-urban thermal variations were analysed in two seasons (May–September and November–March) and in different weather conditions (clear, calm and cloudy, windy) in Gothenburg, Sweden. Simultaneous air temperature measurements were conducted for 2years (2012–2013) at ten fixed park and street sites characterized by varying type and amount of vegetation, building geometry, openness and surface cover. Several spatial characteristics, including sky view factor (SVF) as well as the cover and volume of buildings and trees, were calculated within circular areas of radii ranging from 10 to 150m. Spatial characteristics were found to explain air temperature distribution in the studied area to a large extent throughout the day and year, in both clear, calm as well as cloudy, windy conditions. The highest correlations were found for weighted calculation areas accounting for the influence of both nearest (10m) and wider (25–150m) surroundings. Park sites remained cooler than built-up areas, with the most pronounced cooling effect (0.8°C) on clear, calm days of the warm season. The most important factor governing CR around sunset was SVF. However, on clear, calm nights of the warm season, they were also enhanced by vegetation, indicating the influence of evapotranspiration. Minimum night-time air temperature was governed mostly by the presence of buildings. Within the street canyon, a daytime cooling and night-time warming effect of a street tree was observed, particularly in the warm season. The study shows the importance of various spatial characteristics describing openness, amount of vegetation and building geometry in analysing intra-urban variations in daytime and night-time air temperature.
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| 26. |
- Konarska, Janina, 1986, et al.
(författare)
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Transpiration of urban trees and its cooling effect in a high latitude city
- 2016
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Ingår i: International journal of biometeorology. - : Springer Science and Business Media LLC. - 0020-7128 .- 1432-1254. ; 60:1, s. 159-172
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Tidskriftsartikel (refereegranskat)abstract
- An important ecosystem service provided by urban trees is the cooling effect caused by their transpiration. The aim of this study was to quantify the magnitude of daytime and night-time transpiration of common urban tree species in a high latitude city (Gothenburg, Sweden), to analyse the influence of weather conditions and surface permeability on the tree transpiration, and to find out whether tree transpiration contributed to daytime or nocturnal cooling. Stomatal conductance and leaf transpiration at day and night were measured on mature street and park trees of seven common tree species in Gothenburg: Tilia europaea, Quercus robur, Betula pendula, Acer platanoides, Aesculus hippocastanum, Fagus sylvatica and Prunus serrulata. Transpiration increased with vapour pressure deficit and photosynthetically active radiation. Midday rates of sunlit leaves ranged from less than 1 mmol m−2 s−1 (B. pendula) to over 3 mmol m−2 s−1 (Q. robur). Daytime stomatal conductance was positively related to the fraction of permeable surfaces within the vertically projected crown area. A simple estimate of available rainwater, comprising of precipitation sum and fractional surface permeability within the crown area, was found to explain 68 % of variation in midday stomatal conductance. Night-time transpiration was observed in all studied species and amounted to 7 and 20 % of midday transpiration of sunlit and shaded leaves, respectively. With an estimated night-time latent heat flux of 24 W m−2, tree transpiration significantly increased the cooling rate around and shortly after sunset, but not later in the night. Despite a strong midday latent heat flux of 206 W m−2, a cooling effect of tree transpiration was not observed during the day.
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| 27. |
- Konarska, Janina, 1986, et al.
(författare)
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Transpiration of urban trees and its impact on nocturnal cooling in Gothenburg, Sweden
- 2015
-
Ingår i: ICUC9 – 9 th International Conference on Urban Climate jointly with 12th Symposium on the Urban Environment. 20-24 July 2015, Toulouse, France.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- One of the ecosystem services provided by urban trees is the cooling effect caused by their transpiration. However, while the transpiration of forest trees has been widely studied, little research has been conducted on the daytime and night-time transpirational cooling effect of mature urban trees. Knowledge about the transpiration of street and park trees and its response to different environmental factors can prove useful in estimating the thermal influence of urban greenery as well as in urban planning and management. The aim of this study is to i) quantify the magnitude and diurnal variation of transpiration of common urban tree species in a high latitude city (Gothenburg, Sweden), ii) analyse the influence of weather conditions and fraction of permeable surfaces within the vertically projected crown area on tree transpiration, and iii) find out whether transpiration of urban trees remains active during the night and therefore contributes to nocturnal cooling. Measurements were conducted on mature street and park trees of seven tree species common in Gothenburg: Tilia europaea (Common lime), Quercus robur (English oak), Betula pendula (Silver birch), Acer platanoides (Norway maple), Aesculus hippocastanum (Horse chestnut), Fagus sylvatica (European beech) and Prunus serrulata (Japanese cherry). Stomatal conductance and leaf transpiration were measured using a LI-6400XT Portable Photosynthesis System (LI-COR Biosciences) at daytime and night-time on warm summer days of 2012-2013 in Gothenburg. Leaf area index (LAI) of the studied trees was measured with a LAI-2200 Plant Canopy Analyser (LI-COR Biosciences) in order to estimate the latent heat flux due to tree transpiration. Leaf transpiration was found to increase with vapour pressure deficit and photosynthetically active radiation, with on average 22% of the midday incoming solar radiation being converted into latent heat flux. Midday rates of sunlit leaves varied between species, ranging from less than 1 mmol m-2 s-1 (B. pendula) to over 3 mmol m-2 s-1 (Q. robur). Daytime stomatal conductance was positively related to the fraction of permeable surfaces within the vertically projected tree crown area. A simple estimate of available rainwater, comprising of precipitation sum and a fractional surface permeability within the tree crown area, was found to explain 68% of variation in midday stomatal conductance. The results indicate that a high fractional surface permeability can minimize the frequency of water stress experienced by urban trees and enhance their transpirational cooling. Night-time transpiration was observed in all studied species and was positively related to daytime tree water use. Nocturnal transpiration amounted to 7% and 20% of midday transpiration of sunlit and shaded leaves, respectively. With an estimated latent heat flux of 27 W m-2, evening tree transpiration enhanced the cooling rates around and 1-2 hours after sunset, but not later in the night. The results of transpiration measurements will be combined with vegetation data derived from LIDAR and LAI measurements to estimate neighbourhood- to city-scale cooling effect provided by urban trees.
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| 28. |
- Langley, Ann, et al.
(författare)
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Boundary work among groups, occupations, and organizations: From cartography to process
- 2019
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Ingår i: Academy of Management Annals. - : Academy of Management. - 1941-6520 .- 1941-6067. ; 13:2, s. 704-736
-
Tidskriftsartikel (refereegranskat)abstract
- © Academy of Management Annals. This article reviews scholarship dealing with the notion of “boundary work,” defined as purposeful individual and collective effort to influence the social, symbolic, material, or temporal boundaries, demarcations; and distinctions affecting groups, occupations, and organizations. We identify and explore the implications of three conceptually distinct but interrelated forms of boundary work emerging from the literature. Competitive boundary work involves mobilizing boundaries to establish some kind of advantage over others. In contrast, collaborative boundary work is concerned with aligning boundaries to enable collaboration. Finally, configurational boundary work involves manipulating patterns of differentiation and integration among groups to ensure that certain activities are brought together, whereas others are kept apart, orienting the domains of competition and collaboration. We argue that the notion of boundary work can contribute to the development of a uniquely processual view of organizational design as open-ended, and continually becoming, an orientation with significant future potential for understanding novel forms of organizing, and for integrating agency, power dynamics, materiality, and temporality into the study of organizing.
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| 29. |
- Lau, Kevin Ka-Lun, 1983, et al.
(författare)
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Street geometry design and its effect on mean radiant temperature: A parametric study based on numerical modelling
- 2015
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Ingår i: ICUC9 – 9 th International Conference on Urban Climate jointly with 12th Symposium on the Urban Environment. 20-24 July 2015, Toulouse, France.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The spatial variation of hotspots, in terms of their locations and magnitude, is examined in the present study, using the Solar and LongWave Environmental Irradiance Geometry (SOLWEIG) model. The effect of street geometry design parameters such as H/W ratios and street orientations on the radiant heat load are analyzed for three European cities with different regional climatic conditions. Various physical configurations of street trees are examined for their corresponding potential in mitigating the radiant heat load within urban structures. Findings suggest that a dense urban structure (H/W ratio ≥ 2) is capable of reducing radiant heat load at street level. High H/W ratios do not only reduce the magnitude of hotspots, but also changes their spatial distribution. The N-S canyons are found to be more favourable than the E-W canyons since they limit sun exposure to several hours at noon, despite of the diminishing difference between two orientations when H/W ratio increases. Diagonal streets reduce the magnitude of hotspots but increase the areas affected by moderately high mean radiant temperature (Tmrt). NE-SW orientated streets exhibits higher average hourly Tmrt during daytime since they are largely sun-exposed at the hottest time of the day. The highest mitigating effect of street trees is found when they are located in the sunlit areas. The reduction in average Tmrt decreases with increasing H/W ratios but considerable mitigating effect is still observed in the NE-SW orientations. It is also observed that larger tree crowns, even with higher spacing between individual trees, provide better shading than closely placed trees with smaller tree crowns. The present study provides information about the locations and magnitude of hotspots in different urban settings as well as the design of street trees as a mitigation measure to radiant heat load. It helps urban planners and designers to better design neighbourhoods in order to improve pedestrian thermal comfort within urban areas.
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| 30. |
- Laursen, Tomas, et al.
(författare)
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Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
- 2016
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 354:6314, s. 890-893
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Tidskriftsartikel (refereegranskat)abstract
- Metabolic highways may be orchestrated by the assembly of sequential enzymes into protein complexes, or metabolons, to facilitate efficient channeling of intermediates and to prevent undesired metabolic cross-talk while maintaining metabolic flexibility. Here we report the isolation of the dynamic metabolon that catalyzes the formation of the cyanogenic glucoside dhurrin, a defense compound produced in sorghum plants. The metabolon was reconstituted in liposomes, which demonstrated the importance of membrane surface charge and the presence of the glucosyltransferase for metabolic channeling. We used in planta fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy to study functional and structural characteristics of the metabolon. Understanding the regulation of biosynthetic metabolons offers opportunities to optimize synthetic biology approaches for efficient production of high-value products in heterologous hosts.
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| 31. |
- Lindberg, Josefine, et al.
(författare)
-
Lower systolic blood pressure at age 7 y in low-birth-weight children who received iron supplements in infancy : results from a randomized controlled trial
- 2017
-
Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 106:2, s. 475-480
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Low birth weight (LBW) (≤2500 g) is associated with iron deficiency in infancy and high blood pressure (BP) later in life.Objective: We investigated the effect of iron supplementation that was given to LBW infants on midchildhood BP.Design: The study was a randomized, double-blind, controlled trial that included 285 marginally LBW (2000–2500-g) infants at 2 Swedish centers between May 2004 and November 2007. The infants were randomly assigned to receive a placebo or 1 or 2 mg Fe · kg−1 · d−1 from 6 wk to 6 mo of age. In secondary analyses at the age of 7 y, systolic blood pressure (SBP), diastolic blood pressure (DBP), and the prevalence of children with BP within the hypertensive range (>90th percentile) were compared between the groups.Results: BP was analyzed via intention to treat in 189 children (66%). The mean ± SD SBP was 103 ± 8.1, 101 ± 7.5, and 101 ± 7.8 mm Hg in children who had received the placebo (n = 70), 1 mg Fe · kg−1 · d−1 (n = 54), or 2 mg Fe · kg−1 · d−1 (n= 65), respectively. When the iron-supplemented groups were combined in covariate-adjusted analyses, the mean SBP in LBW children who had received iron supplementation in infancy was 2.2 mm Hg (95% CI: 0.3, 4.2 mm Hg) lower than in those who were unsupplemented (P = 0.026). Multivariate logistic regression showed that iron supplementation in infancy reduced the odds of having an SBP within the hypertensive range at 7 y of age (OR: 0.32; 95% CI: 0.11, 0.96). For DBP, there were no significant differences between the intervention groups.Conclusions: LBW children who receive iron supplementation (1 or 2 mg Fe · kg−1 · d−1) in infancy have lower SBP at 7 y. This (to our knowledge) novel observation suggests that the increased risk of hypertension that is observed in children and adults who are born small might be reduced with early micronutrient interventions.
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| 32. |
- Lindberg, Josefine, et al.
(författare)
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Overweight, obesity, and body composition in 3.5-and 7-year-old Swedish children born with marginally low birth weight
- 2015
-
Ingår i: The Journal of Pediatrics. - : Elsevier. - 0022-3476 .- 1097-6833. ; 167:6, s. 1246-1252.e3
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To assess the prevalence of overweight/obese children and to explore body composition in a Swedish cohort of preschool children born with marginally low birth weight (MLBW, ie, 2000-2500 g).Study design: We included 285 Swedish children with MLBW (44% small for gestational age), and 95 control children with normal birth weights. At 3.5 years and 7 years of age, we assessed anthropometrics, including the prevalence of overweight/obese children. At 7 years, dual-energy X-ray was used for body composition.Results: There were no significant differences between groups in the prevalence of overweight/obesity or in skinfold thickness; however, at 3.5 years, mean height, weight, and BMI in children with MLBW were 2.1 cm (95% CI 1.2-3.1), 1.2 kg (95% CI 0.7-1.6), and 0.47 kg/m(2) (95% CI 0.17-0.76) lower compared with controls. The corresponding mean differences also were lower in children with MLBW compared with control children at 7 years; 2.5 cm (95% CI 0.9-4.1), 1.6 kg (95% CI 0.6-2.8), and 0.48 kg/m(2) (95% CI 0.01-0.94). The differences were greater in those born small for gestational age. Dual-energy X-ray analyses showed lower fat-free mass index in MLBW infants and a similar trend in fat mass index. Within children with MLBW, BMI at 7 years correlated positively to growth velocity in infancy.Conclusion: Children with MLBW had lower BMI and did not show increased risk of overweight or obesity up to 7 years. Nevertheless, the BMI in MLBW children was positively correlated to growth-velocity in infancy.
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| 33. |
- Lindberg, Jonas, et al.
(författare)
-
The effect of O2 concentration on the reaction mechanism in Li-O2 batteries
- 2017
-
Ingår i: Journal of Electroanalytical Chemistry. - : Elsevier BV. - 1572-6657 .- 0022-0728 .- 1873-2569. ; 797, s. 1-7
-
Tidskriftsartikel (refereegranskat)abstract
- The promising lithium-oxygen battery chemistry presents a set of challenges that need to be solved if commercialization is ever to be realized. This study focuses on how the O2 reaction path is effected by the O2 concentration in the electrolyte. An electrochemical quartz crystal microbalance system was used to measure current, potential, and change in electrode mass simultaneously. It is concluded that the mass reversibility is O2 concentration dependent while the coulombic efficiency is not. The mass reversibility is higher at low O2 concentration meaning that more of the deposited Li2O2 is removed during oxidation in relation to the amount deposited during reduction. The first step of the reduction is the formation of soluble LiO2, which is then either reacting further at the electrode or being transported away from the electrode resulting in low current efficiency and low deposited mass per electrons transferred. During the oxidation, the first step involves de-lithiation of Li2O2 at low potential followed by bulk oxidation. The oxidation behavior is O2 concentration dependent, and this dependence is likely indirect as the O2 concentration effects the amount of discharge product formed during the reduction. The O2 concentration at different saturation pressures was determined using a mass spectrometer. It was found that the electrolyte follows Henry's law at the pressures used in the study. In conclusion, this study provides insight to the O2 concentration dependence and the preferred path of the O2 electrochemical reactions in lithium-oxygen batteries.
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| 34. |
- Lundmark, Anna, et al.
(författare)
-
Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis
- 2017
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Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 44:3, s. 247-254
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: Periodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth-supporting tissue including alveolar bone. We recently reported mucin 4 ( MUC4) and matrix metalloproteinase 7 (MMP7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of patients with periodontitis. Materials and Methods: Saliva and GCF samples were collected from periodontitis patients and healthy controls. The levels of MUC4, MMP7, and total protein concentrations were analysed using ELISA or Bradford assay. Results: MUC4 levels were significantly lower in saliva and GCF from periodontitis patients relative to healthy controls. MMP7 levels were significantly higher in saliva and GCF from periodontitis patients. Multivariate analysis revealed that MUC4 was significantly associated with periodontitis after adjusting for age and smoking habits and, moreover, that the combination of MUC4 and MMP7 accurately discriminated periodontitis from healthy controls. Conclusions: MUC4 and MMP7 may be utilized as possible novel biomarkers for periodontitis.
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| 35. |
- Luo, Dan, et al.
(författare)
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Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.
- 2016
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:34, s. E5082-E5089
-
Tidskriftsartikel (refereegranskat)abstract
- The seed oil of Euphorbia lathyris L. contains a series of macrocyclic diterpenoids known as Euphorbia factors. They are the current industrial source of ingenol mebutate, which is approved for the treatment of actinic keratosis, a precancerous skin condition. Here, we report an alcohol dehydrogenase-mediated cyclization step in the biosynthetic pathway of Euphorbia factors, illustrating the origin of the intramolecular carbon-carbon bonds present in lathyrane and ingenane diterpenoids. This unconventional cyclization describes the ring closure of the macrocyclic diterpene casbene. Through transcriptomic analysis of E. lathyris L. mature seeds and in planta functional characterization, we identified three enzymes involved in the cyclization route from casbene to jolkinol C, a lathyrane diterpene. These enzymes include two cytochromes P450 from the CYP71 clan and an alcohol dehydrogenase (ADH). CYP71D445 and CYP726A27 catalyze regio-specific 9-oxidation and 5-oxidation of casbene, respectively. When coupled with these P450-catalyzed monooxygenations, E. lathyris ADH1 catalyzes dehydrogenation of the hydroxyl groups, leading to the subsequent rearrangement and cyclization. The discovery of this nonconventional cyclization may provide the key link to complete elucidation of the biosynthetic pathways of ingenol mebutate and other bioactive macrocyclic diterpenoids.
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| 36. |
- Mattsson, Niklas, et al.
(författare)
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Effects of APOE ε4 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease
- 2018
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 71, s. 81-90
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Tidskriftsartikel (refereegranskat)abstract
- Apolipoprotein (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), but its importance for the clinical and biological heterogeneity in AD is unclear, particularly at the prodromal stage. We analyzed 151 prodromal AD patients (44 APOE ε4-negative and 107 APOE ε4-positive) from the BioFINDER study. We tested cognition, 18F-flutemetamol β-amyloid (Aβ) positron emission tomography, cerebrospinal fluid biomarkers of Aβ tau and neurodegeneration, and magnetic resonance imaging of white matter pathology and brain structure. Despite having similar cortical Aβ-load and baseline global cognition (mini mental state examination), APOE ε4-negative prodromal AD had more nonamnestic cognitive impairment, higher cerebrospinal fluid levels of Aβ-peptides and neuronal injury biomarkers, more white matter pathology, more cortical atrophy, and faster decline of mini mental state examination, compared to APOE ε4-positive prodromal AD. The absence of APOE ε4 is associated with an atypical phenotype of prodromal AD. This suggests that APOE ε4 may impact both the diagnostics of AD in early stages and potentially also effects of disease-modifying treatments.
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| 37. |
- Onomura, Shiho, 1985, et al.
(författare)
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An intra-urban nocturnal cooling rate model
- 2015
-
Ingår i: ICUC9 – 9 th International Conference on Urban Climate jointly with 12th Symposium on the Urban Environment. 20-24 July 2015, Toulouse, France.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Nocturnal urban heat island (UHI) and intra-urban heat island (IUHI) mainly develop through differences in cooling rates. The cooling process consists of two distinctive phases. In the first phase, around sunset, dense urban areas cool more slowly than more open sites, creating large intra-urban temperature differences that are preserved during the whole night. The intensity of this differential cooling is mainly determined by surface characteristics (geometry and material), prevailing weather conditions and season. On the other hand, the cooling during the rest of night, in the second phase, is independent of the surface characteristics. In this study, we investigated how intra-urban cooling rates in the two phases are statistically related to prevailing weather conditions, season, and sky view factor using observation data from Gothenburg, Sweden. Based on the results, a simple statistical intra-urban nocturnal cooling rate model was developed. The model requires only commonly-used meteorological variables and sky view factor. It was shown that the most intensive cooling rate at an open site, in the first phase, was chiefly dominated by the clearness of the sky and wind speed, i.e. the weather conditions. The cooling rate also had a linear relationship with maximum daily air temperature, which can be treated as the seasonal effect. Under clear sky condition, the magnitude of the cooling rate significantly decreased with lower sky view factor, but, under cloudy conditions, the cooling rate varied less or little. In the second phase, cooling rate seemed to linearly decrease as the night progressed and the slope of the decrease was determined by the clearness of the sky. The model was evaluated using three additional datasets, one from Gothenburg, one from London, UK and one from Ouagadougou, Burkina Faso. Gothenburg and London are classified to have a marine temperate climate (Cfb) and Ouagadougou has a tropical steppe climate (BSh) according to Köppen climate classification. The model simulated cooling rates along a smooth profile statistically determined, while observed cooling rates often fluctuated through night. Nevertheless, the model estimated well the total amount of cooling during the whole night. This resulted in the well-simulated nocturnal air temperature. Modeled cooling rates were deviated from the observation at the sites where the large effects of anthropogenic heat and evapotranspiration were present. The effects were not included in this model yet but were found to be significant. This model can be used for multiple applications such as nocturnal human thermal comfort estimation and climate-sensitive urban planning and design.
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| 38. |
- Onomura, Shiho, 1985, et al.
(författare)
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Intra-urban nocturnal cooling rates: development and evaluation of the NOCRA model
- 2016
-
Ingår i: Meteorological Applications. - : Wiley. - 1469-8080 .- 1350-4827. ; 23:3, s. 339-352
-
Tidskriftsartikel (refereegranskat)abstract
- A nocturnal cooling rate model (NOCRAM) to simulate nocturnal air temperature at urban sites is presented. The model is designed for urban planners, practitioners and researchers who demand meteorological information for urban planning and research applications. The model is based on the concept of nocturnal cooling, progressing in two distinct phases, i.e. site-dependent cooling around sunset and site-independent cooling from about 1 or 2 h after sunset until sunrise. Cooling rates are usually determined predominantly by prevailing weather conditions (i.e. clearness of the sky and wind speed), followed by maximum daily air temperature and by sky view factors. Second phase cooling is chiefly determined by sky clearness and wind speed. The findings and statistical results from the analysis of observational data during warm months (May–September) from Gothenburg, Sweden, as well as from past studies, were used. The model requires standard meteorological variables (i.e. wind speed, incoming short-wave radiation, air temperature, relative air humidity, air pressure) at a reference station as well as geometrical information (i.e. the sky view factor of the site and the geographical co-ordinates of the reference meteorological station). The model simulates the characteristic development of cooling rates in the two phases at open sites and built-up sites with different sky view factors under a wide range of weather conditions in warm months. Using the modelled cooling rates, nocturnal air temperature is estimated easily with the accuracy of root mean square error (RMSE) ≤1.54°C and R2 ≥0.78.
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| 39. |
- Onomura, Shiho, 1985, et al.
(författare)
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Meteorological forcing data for urban outdoor thermal comfort models from a coupled convective boundary layer and surface energy balance scheme
- 2015
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Ingår i: Urban Climate. - : Elsevier BV. - 2212-0955. ; 11, s. 1-23
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Tidskriftsartikel (refereegranskat)abstract
- Site-specific meteorological forcing appropriate for applications such as urban outdoor thermal comfort simulations can be obtained using a newly coupled scheme that combines a simple slab convective boundary layer (CBL) model and urban land surface model (ULSM) (here two ULSMs are considered). The former simulates daytime CBL height, air temperature and humidity, and the latter estimates urban surface energy and water balance fluxes accounting for changes in land surface cover. The coupled models are tested at a suburban site and two rural sites, one irrigated and one unirrigated grass, in Sacramento, U.S.A. All the variables modelled compare well to measurements (e.g. coefficient of determination = 0.97 and root mean square error = 1.5 °C for air temperature). The current version is applicable to daytime conditions and needs initial state conditions for the CBL model in the appropriate range to obtain the required performance. The coupled model allows routine observations from distant sites (e.g. rural, airport) to be used to predict air temperature and relative humidity in an urban area of interest. This simple model, which can be rapidly applied, could provide urban data for applications such as air quality forecasting and building energy modelling, in addition to outdoor thermal comfort.
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| 40. |
- Pateraki, Irini, et al.
(författare)
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Total biosynthesis of the cyclic AMP booster for skolin from Coleus forskohlii
- 2017
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Ingår i: eLIFE. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii, in which forskolin accumulates in the root cork. Here, we report the discovery of five cytochrome P450s and two acetyltransferases which catalyze a cascade of reactions converting the forskolin precursor 13R-manoyl oxide into forskolin and a diverse array of additional labdane-type diterpenoids. A minimal set of three P450s in combination with a single acetyl transferase was identified that catalyzes the conversion of 13R-manoyl oxide into forskolin as demonstrated by transient expression in Nicotiana benthamiana. The entire pathway for forskolin production from glucose encompassing expression of nine genes was stably integrated into Saccharomyces cerevisiae and afforded forskolin titers of 40 mg/L.
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| 41. |
- Persson, Nils-Krister, et al.
(författare)
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Re: en ny samhällssektor spirar
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Resurser och hållbarhet är nära förknippade. Hållbarhet innebär att hushålla med resurser - materiella, miljömässiga och mänskliga. Och hushållning är per definition kärnan i ekonomi. Man börjar alltmer se framväxten av en hel arsenal av verktyg och förhållnings- och angreppssätt för att bygga hållbarhet. Detta förenas av ett synsätt att det som hitintills setts om avfall och värdelöst, och rent utav besvärligt att ta hand om, nu blir en värdefull resurs. Det glömda och gömda kommer åter. Faktum är att många ord och begrepp kring detta börjar på just åter- eller re- . Internationellt talar man om Redesign, Recycling, Remake, Recycle, Recraft, Reuse, Recreate, Reclaim, Reduce, Repair, Refashion.Vad är då allt detta? Ja, vill man dra det långt, är det inte mindre än framväxten av ett nyvunnet sätt att tänka, ja av en ny samhällssektor, en bransch och en industri, sammanbundet av filosofin att återanvändningen, spillminskningen, vidarebruket, efterlivet anses som viktiga faktorer för ett miljömedvetet samhälle. Re: blir paraplytermen för detta. I denna antologi av forskare från skilda discipliner vid Högskolan i Borås lyfts ett antal av dessa begrepp inom Re: fram.
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| 42. |
- Rayner, D.P. 1973, et al.
(författare)
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A statistical downscaling algorithm for thermal comfort applications
- 2015
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Ingår i: Journal of Theoretical and Applied Climatology. - : Springer Science and Business Media LLC. - 0177-798X .- 1434-4483. ; 122:3-4, s. 729-742
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Tidskriftsartikel (refereegranskat)abstract
- We describe a new two-step modeling framework for investigating the impact of climate change on human comfort in outdoor urban environments. In the first step, climate change scenarios for air temperature and solar radiation (global, diffuse, direct components) are created using a change-factor algorithm. The change factors are calculated by comparing ranked daily regional climate model outputs for a future-period and a present-day period, and then changes consistent with these daily change factors are applied to historical hourly climate observations. In the second step, the mean-radiant-temperature (Tmrt) is calculated using the SOLWEIG (SOlar and LongWave Environmental Irradiance Geometry) model. Tmrt, which describes the radiant heat exchange between a person and their surroundings, is one of the most important meteorologically derived parameters governing human energy balance and outdoor thermal comfort, especially during warm and sunny days.We demonstrate that change factors can be applied independently to maximum air temperature and daily global solar radiation, and show that the outputs from the algorithm, when aggregated to daily values, are consistent with the driving regional climate model. Finally, we demonstrate how to obtain quantitative information from the scenarios regarding the potential impact of climate change on outdoor thermal comfort, by calculating changes in the distribution of hourly summer day-time Tmrt and changes in the number of hours with Tmrt >55 °C.
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| 43. |
- Revel, A., et al.
(författare)
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Strong Neutron Pairing in core+4n Nuclei
- 2018
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 120:15
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Tidskriftsartikel (refereegranskat)abstract
- The emission of neutron pairs from the neutron-rich N=12 isotones C18 and O20 has been studied by high-energy nucleon knockout from N19 and O21 secondary beams, populating unbound states of the two isotones up to 15 MeV above their two-neutron emission thresholds. The analysis of triple fragment-n-n correlations shows that the decay N19(-1p)C18∗→C16+n+n is clearly dominated by direct pair emission. The two-neutron correlation strength, the largest ever observed, suggests the predominance of a C14 core surrounded by four valence neutrons arranged in strongly correlated pairs. On the other hand, a significant competition of a sequential branch is found in the decay O21(-1n)O20∗→O18+n+n, attributed to its formation through the knockout of a deeply bound neutron that breaks the O16 core and reduces the number of pairs.
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| 44. |
- Ribeiro, G., et al.
(författare)
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Structure of Be-13 studied in proton knockout from B-14
- 2018
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Ingår i: Physical Review C. - 2469-9985 .- 2469-9993. ; 98:2
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Tidskriftsartikel (refereegranskat)abstract
- The neutron-unbound isotope Be-13 has been studied in several experiments using different reactions, different projectile energies, and different experimental setups. There is, however, no real consensus in the interpretation of the data, in particular concerning the structure of the low-lying excited states. Gathering new experimental information, which may reveal the Be-13 structure, is a challenge, particularly in light of its bridging role between Be-12, where the N = 8 neutron shell breaks down, and the Borromean halo nucleus Be-14. The purpose of the present study is to investigate the role of bound excited states in the reaction product Be-12 after proton knockout from B-14, by measuring coincidences between Be-12, neutrons, and gamma rays originating from de-excitation of states fed by neutron decay of Be-13. The Be-13 isotopes were produced in proton knockout from a 400 MeV/nucleon B-14 beam impinging on a CH2 target. The Be-12-n relative-energy spectrum d sigma/dE(fn) was obtained from coincidences between Be-12(g.s.) and a neutron, and also as threefold coincidences by adding gamma rays, from the de-excitation of excited states in Be-12. Neutron decay from the first 5/2(+) state in Be-13 to the 2(+) state in Be-12 at 2.11 MeV is confirmed. An energy independence of the proton-knockout mechanism is found from a comparison with data taken with a 35 MeV/nucleon B-14 beam. A low-lying p-wave resonance in Be-13(1/2(-)) is confirmed by comparing proton- and neutron-knockout data from B-14 and Be-14.
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| 45. |
- Röder, M., et al.
(författare)
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Coulomb dissociation of 20,21 N
- 2016
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 93:6
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Tidskriftsartikel (refereegranskat)abstract
- Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 excitation functions and thermonuclear reaction rates have been determined. The N19(n,γ)N20 rate is up to a factor of 5 higher at T
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| 46. |
- Singer, Andrew C., et al.
(författare)
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Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers
- 2015. - 1
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Ingår i: Water treatment in developed and developing nations. - Oakville, ON : Apple Academic Press. - 9781771882453 - 9781771882415 - 9780429154713 ; , s. 155-186
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Bokkapitel (refereegranskat)abstract
- Pandemics are unique public health emergencies that can result in a large sudden increase in the use of a restricted set of pharmaceuticals within a short time period. In the case of an influenza pandemic, antiviral use will greatly exceed inter-pandemic use in most countries by several orders of magnitude, as few countries maintain significant inter-pandemic usage-Japan being a notable exception [1]. Depending on the severity of the pandemic, antibiotics have the potential to significantly exceed inter-pandemic usage for the treatment of secondary bacterial respiratory infections [2]. Decongestant usage is also predicted to increase with an increase in upper-and lower-respiratory tract infections [3].
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| 47. |
- Surova, Yulia, et al.
(författare)
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Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy.
- 2015
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Ingår i: Neuroradiology. - : Springer Science and Business Media LLC. - 1432-1920 .- 0028-3940. ; 57:11, s. 1079-1091
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to identify disease-specific changes of the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), and multiple system atrophy with predominant parkinsonism (MSA-P) using diffusion tensor imaging and volumetric analysis.
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| 48. |
- Sävneby, Anna, 1985-
(författare)
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Reverse genetic studies of Enterovirus replication
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Enteroviruses belong to the Picornaviridae family and are small icosahedral viruses with RNA genomes of positive polarity, containing a single open reading frame. They mostly cause mild or asymptomatic infections, but also a wide array of diseases including: poliomyelitis, encephalitis, gastroenteritis, aseptic meningitis, myocarditis, hand-foot-and-mouth disease, hepatitis and respiratory diseases, ranging from severe infections to the common cold. The projects described in this thesis have been carried out through reverse genetic studies of Enterovirus B and Rhinovirus C. In Papers I and II, a cassette vector was used to study recombination and translation of the RNA genome. It was found that the non-structural coding region could replicate when combined with the structural protein-coding region of other viruses of the same species. Furthermore, the genome could be translated and replicated without the presence of the structural protein-coding region. Moreover, it was found that when two additional nucleotides were introduced, shifting the reading frame, the virus could revert to the original reading frame, restoring efficient replication. In Paper III, a vector containing the genome of echovirus 5 was altered to produce an authentic 5’end of the in vitro transcribed RNA, which increased efficiency of replication initiation 20 times. This result is important, as it may lead to more efficient oncolytic virotherapy. An authentic 5’end was further used in Paper IV, where replication of Rhinovirus C in cell lines was attempted. Although passaging of the virus was unsuccessful, the genome was replicated and cytopathic effect induced after transfection. The restriction of efficient replication was therefore hypothesized to lie in the attachment and entry stages of the replication cycle. In Paper V, a cytolytic virus was found to have almost 10 times larger impact on gene expression of the host cell than a non-cytolytic variant. Furthermore, the lytic virus was found to build up inside the host cell, while the non-cytolytic virus was efficiently released. As a whole, this thesis has contributed to a deeper understanding of replication of enteroviruses, which may prove important in development of novel vaccines, antiviral agents and oncolytic virotherapies.
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| 49. |
- Sävneby, Anna, et al.
(författare)
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The Transcriptome of Rhabdomyosarcoma Cells Infected with Cytolytic and Non-Cytolytic Variants of Coxsackievirus B2 Ohio-1
- 2016
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:10
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Tidskriftsartikel (refereegranskat)abstract
- The transcriptomes of cells infected with lytic and non-lytic variants of coxsackievirus B2 Ohio-1 (CVB2O) were analyzed using next generation sequencing. This approach was selected with the purpose of elucidating the effects of lytic and non-lytic viruses on host cell transcription. Total RNA was extracted from infected cells and sequenced. The resulting reads were subsequently mapped against the human and CVB2O genomes. The amount of intracellular RNA was measured, indicating lower proportions of human RNA in the cells infected with the lytic virus compared to the non-lytic virus after 48 hours. This may be explained by reduced activity of the cellular transcription/translation machinery in lytic enteroviral replication due to activities of the enteroviral proteases 2A and/or 3C. Furthermore, differential expression in the cells infected with the two virus variants was identified and a number of transcripts were singled out as possible answers to the question of how the viruses interact with the host cells, resulting in lytic or non-lytic infections.
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| 50. |
- Thies, Ronja, 1987, et al.
(författare)
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Systematic investigation of projectile fragmentation using beams of unstable B and C isotopes
- 2016
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Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993 .- 0556-2813. ; 93:5
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Tidskriftsartikel (refereegranskat)abstract
- Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neutron-rich nuclei, creating a need for models to describe also these reactions. Purpose: We want to extend the presently available data on fragmentation reactions towards the light exotic region on the nuclear chart. Furthermore, we want to improve the understanding of projectile fragmentation especially for unstable isotopes. Method: We have measured projectile fragments from C10,12-18 and B10-15 isotopes colliding with a carbon target. These measurements were all performed within one experiment, which gives rise to a very consistent data set. We compare our data to model calculations. Results: One-proton removal cross sections with different final neutron numbers (1pxn) for relativistic C10,12-18 and B10-15 isotopes impinging on a carbon target. Comparing model calculations to the data, we find that the epax code is not able to describe the data satisfactorily. Using abrabla07 on the other hand, we find that the average excitation energy per abraded nucleon needs to be decreased from 27 MeV to 8.1 MeV. With that decrease abrabla07 describes the data surprisingly well. Conclusions: Extending the available data towards light unstable nuclei with a consistent set of new data has allowed a systematic investigation of the role of the excitation energy induced in projectile fragmentation. Most striking is the apparent mass dependence of the average excitation energy per abraded nucleon. Nevertheless, this parameter, which has been related to final-state interactions, requires further study.
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