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1.	Editor's Choice - Management of Descending Thoracic Aorta Diseases : Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). 2017 In: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 53:1, s. 4-52 Journal article (peer-reviewed)
2.	Sun, J., et al. (author) Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation 2009 In: Circulation. - 0009-7322 .- 1524-4539. ; 120:11, s. 973-982 Journal article (peer-reviewed)abstract Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown. METHODS AND RESULTS: Human AAA lesions had high numbers of chymase-immunoreactive mast cells. Serum chymase level correlated with AAA growth rate (P=0.009) in a prospective clinical study. In experimental AAA produced by aortic elastase perfusion in wild-type (WT) mice or those deficient in the chymase ortholog mouse mast cell protease-4 (mMCP-4) or deficient in mMCP-5 (Mcpt4(-/-), Mcpt5(-/-)), Mcpt4(-/-) but not Mcpt5(-/-) had reduced AAA formation 14 days after elastase perfusion. Even 8 weeks after perfusion, aortic expansion in Mcpt4(-/-) mice fell by 50% compared with that of the WT mice (P=0.0003). AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice. Although Kit(W-sh/W-sh) mice had protection from AAA formation, reconstitution with mast cells from WT mice, but not those from Mcpt4(-/-) mice, partially restored the AAA phenotype. Mechanistic studies suggested that mMCP-4 regulates expression and activation of cysteine protease cathepsins, elastin degradation, angiogenesis, and vascular cell apoptosis. CONCLUSIONS: High chymase-positive mast cell content in human AAA lesions, greatly reduced AAA formation in Mcpt4(-/-) mice, and significant correlation of serum chymase levels with human AAA expansion rate suggests participation of mast cell chymase in the progression of human and mouse AAA.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Lindholt, J S (2); Zhang, J. (1); Liu, J. (1); Evangelista, A. (1); Björck, Martin (1); Sun, J. (1); show more...; Czerny, M (1); Thompson, M (1); Pejler, Gunnar (1); He, A (1); Libby, P (1); Chiesa, R (1); Stevens, R.L (1); Verhoeven, E. L. (1); Milner, R (1); Taylor, P R (1); Ricco, J. -B. (1); Setacci, C. (1); Cao, P. (1); Schmidli, J. (1); Dick, F. (1); Debus, E. S. (1); Kakkos, S. (1); Vermassen, F. (1); Hinchliffe, R J (1); Brunkwall, J (1); Kolh, P (1); Trimarchi, S. (1); Busund, R (1); Moll, F. L. (1); de Borst, G. J. (1); Riambau, V. (1); Böckler, D (1); Coppi, G (1); Fraedrich, G (1); Haulon, S (1); Jacobs, M J (1); Lachat, M L (1); Verhagen, H J (1); Chakfé, N (1); Koncar, I (1); Vega de Ceniga, M (1); Verzini, F (1); Black, J H (1); Dake, M (1); Eggebrecht, H (1); Grabenwöger, M (1); Naylor, A R (1); Rousseau, H (1); Sukhova, G.K. (1); show less...

University: Uppsala University (2); Swedish University of Agricultural Sciences (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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