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- Tanskanen, T., et al.
(författare)
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Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci
- 2018
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Ingår i: International Journal of Cancer. - Stockholm : Wiley. - 0020-7136 .- 1097-0215. ; 142:3, s. 540-546
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p=2.08 x 10(-4); OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p=1.50 x 10(-9); OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate<0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.
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| 4. |
- Iwaya, Leonardo H., et al.
(författare)
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Firewall Usability and Visualization : A Systematic Literature Review
- 2016
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Rapport (refereegranskat)abstract
- Firewalls are network security components that allow administrators to handle incoming and outgoing traffic based on a set of rules. Such security appliances are typically the first line of defense, creating a barrier between organization’s internal network and the outside network (e.g., Internet). The process of correctly configuring a firewall is complex and error prone, and it only gets worse as the complexity of the network grows. A vulnerable firewall configuration will very likely result in major threats to the organization’s security. In this report we aim to investigate how to make administrator task of planning and implementing firewall solutions easier, from the stand points of usability and visualization. Our scientific investigation starts with the understanding of the state-of-the-art on this specific field. To do so, we conducted a Systematic Literature Review (SLR), a strict methodology to plan a literature review, to gather relevant information, to synthesize and compare approaches, and to report findings. During the initial search process thousands of papers were screened, leading us to 125 papers carefully selected for further readings. In the secondary study, ten relevant works were identified and assessed, in which authors tackled the issues of usability and visualization for Firewalls and Personal Firewalls. Among the main findings, we perceive that there is a lack (or even absence) of user studies to validate the proposed models. This leads us to a series of unwarranted solutions, that need to be prototyped and tested with real users. We also see an huge opportunity for integrative approaches, that could combine firewall research areas, such as automatic anomaly detection, advisory systems, and varying visualization schemes.
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| 5. |
- Jounger, SL, et al.
(författare)
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Repeated buffered acidic saline infusion in the human masseter muscle as a putative experimental pain model
- 2019
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 15474-
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated if repeated buffered acidic saline infusions into the masseter muscles induced muscle pain and mechanical sensitization. Fourteen healthy men participated in this double-blind, randomized, and placebo-controlled study. Two repeated infusions (day 1 and 3) were given in the masseter muscles with either a buffered acidic saline solution (pH 5.2) or an isotonic saline solution (pH 6) as control. After 10 days of wash-out, the experiment was repeated with the other substance. Pressure pain thresholds (PPT), pain intensity, maximum unassisted mouth opening (MUO), and pain drawings were assessed before, directly following, and after each infusion at 5, 15, and 30 min and on day 4 and 7. Fatigue and pain intensity were assessed after a one-minute chewing test 30 min after infusions and day 4 and 7. Acidic saline induced higher pain intensity than control day 3 up to 5 min after infusions, but did not affect PPT. The chewing test did not evoke higher fatigue during chewing or MUO or after acidic saline infusion compared to control. Repeated acidic saline infusions in the masseter muscles induced a short-lasting muscle pain without mechanical hyperalgesia or functional pain. Hence, this model might not be superior to already existing experimental muscle pain models.
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| 8. |
- Staf, H., et al.
(författare)
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Numerical implementation of an advanced powder-die frictional model
- 2019
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Ingår i: Euro PM 2019 Congress and Exhibition. - : European Powder Metallurgy Association (EPMA).
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Konferensbidrag (refereegranskat)abstract
- It is known that the shape of a cutting insert blank, after pressing and sintering, can be predicted with FE-simulations. It is also known that such simulations have the potential to save costs and time when used for press tool compensation. In such simulations, the frictional behaviour has a great impact. Here, two frictional models are discussed and implemented into FEM. The results from the different frictional descriptions, when for instance analysing density after compaction, shows a clear difference. It can be concluded that friction also at low forces must be modelled in detail.
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| 9. |
- Voronkov, Artem, 1990-, et al.
(författare)
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Systematic Literature Review on Usability of Firewall Configuration
- 2018
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Ingår i: ACM Computing Surveys. - New York, NY, USA : Association for Computing Machinery (ACM). - 0360-0300 .- 1557-7341. ; 50:6
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Tidskriftsartikel (refereegranskat)abstract
- Firewalls are network security components that handle incoming and outgoing network traffic based on a set of rules. The process of correctly configuring a firewall is complicated and prone to error, and it worsens as the network complexity grows. A poorly configured firewall may result in major security threats; in the case of a network firewall, an organization’s security could be endangered, and in the case of a personal firewall, an individual computer’s security is threatened. A major reason for poorly configured firewalls, as pointed out in the literature, is usability issues. Our aim is to identify existing solutions that help professional and non-professional users to create and manage firewall configuration files, and to analyze the proposals in respect of usability. A systematic literature review with a focus on the usability of firewall configuration is presented in the article. Its main goal is to explore what has already been done in this field. In the primary selection procedure, 1,202 articles were retrieved and then screened. The secondary selection led us to 35 articles carefully chosen for further investigation, of which 14 articles were selected and summarized. As main contributions, we propose a taxonomy of existing solutions as well as a synthesis and in-depth discussion about the state of the art in firewall usability. Among the main findings, we perceived that there is a lack (or even an absence) of usability evaluation or user studies to validate the proposed models. Although all articles are related to the topic of usability, none of them clearly defines it, and only a few actually employ usability design principles and/or guidelines.
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