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- Ekberg, Karin, et al.
(författare)
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C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
- 2007
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 30:1, s. 71-76
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE - C-peptide replacement in animals results in amelioration of diabetes-induced functional and structural abnormalities in peripheral nerves. The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function. RESEARCH DESIGN AND METHODS - This was an exploratory, double-blinded, randomized, and placebo-controlled study with three study groups that was carried out at five centers in Sweden. C-peptide was given as a replacement dose (1.5 mg/day, divided into four subcutaneous doses) or a dose three times higher (4.5 mg/day) during 6 months. Neurological examination and neurophysiological measurements were performed before and after 6 months of treatment with C-peptide or placebo. RESULTS - The age of the 139 patients who completed the protocol was 44.2 ± 0.6 (mean ± SE) years and their duration of diabetes was 30.6 ± 0.8 years. Clinical neurological impairment (NIA) (score >7 points) of the lower extremities was present in 86% of the patients at baseline. Sensory nerve conduction velocity (SCV) was 2.6 ± 0.08 SD below body height-corrected normal values at baseline and improved similarly within the two C-peptide groups (P < 0.007). The number of patients responding with a SCV peak potential improvement >1.0 m/s was greater in C-peptide-treated patients than in those receiving placebo (P < 0.03). In the least severely affected patients (SCV < 2.5 SD below normal at baseline, n = 70) SCV improved by 1.0 m/s (P < 0.014 vs. placebo). NIA score and vibration perception both improved within the C-peptide-treated groups (P < 0.011 and P < 0.002). A1C levels (7.6 ± 0.1% at baseline) decreased slightly but similarly in C-peptide- and placebo-treated patients during the study. CONCLUSIONS - C-peptide treatment for 6 months improves sensory nerve function in early-stage type 1 diabetic neuropathy.
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- Lindfors, Eva-Lisa, et al.
(författare)
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Polysaccharide degradation in waterlogged oak wood from the ancient warship Vasa
- 2008
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Ingår i: Holzforschung. - : Walter de Gruyter GmbH. - 0018-3830 .- 1437-434X. ; 62:1, s. 57-63
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Tidskriftsartikel (refereegranskat)abstract
- A rather extensive degradation of cellulose and hemicelluloses was found in waterlogged oak wood samples from the ancient warship Vasa by size exclusion chromatography with the solvent system lithium chloride/ N,N-dimethylacetamide (LiCl/DMAc). The degradation has mainly occurred after salvage of the wreck, probably as a consequence of keeping iron contaminated wood in contact with air. The most likely explanation is Fenton type of reactions degrading the wood polymers and oxidising reduced sulphur forms to sulphuric acid. An increased degradation rate of the Vasa wood can be anticipated in the future if the sulphuric acid cannot be neutralised and the oxidative reactions cannot be quenched.
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| 6. |
- Lindfors, Eva-Lisa, et al.
(författare)
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Polysaccharide degradation in waterlogged oak wood from the ancient warship Vasa
- 2008
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Ingår i: Holzforschung. - 0018-3830 .- 1437-434X. ; 62:1, s. 57-63
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Tidskriftsartikel (refereegranskat)abstract
- A rather extensive degradation of cellulose and hemicelluloses was found in waterlogged oak wood samples from the ancient warship Vasa by size exclusion chromatography with the solvent system lithium chloride/N,N-dimethylacetamide (LiCl/DMAc). The degradation has mainly occurred after salvage of the wreck, probably as a consequence of keeping iron contaminated wood in contact with air. The most likely explanation is Fenton type of reactions degrading the wood polymers and oxidising reduced sulphur forms to sulphuric acid. An increased degradation rate of the Vasa wood can be anticipated in the future if the sulphuric acid cannot be neutralised and the oxidative reactions cannot be quenched.
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| 7. |
- Wijk, Helle, 1958, et al.
(författare)
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Verksamhetsförlagd utbildning på avancerad nivå : ny utmaning för specialistutbildningar för sjuksköterskor
- 2009
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Ingår i: Vård i Norden. - København : Sjuksköterskornas samarbete i Norden. - 0107-4083 .- 1890-4238. ; 29:94, s. 41-43
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this article is to discuss challenges in the development of Specialist Nursing Educations as a result of the 2007 Swedish Higher EducationReform: the implementation of the so-called Bologna process. Certain challenges follow this reform, particularly since the specialist nursingprogrammes will be part of the second cycle of the higher education system, and it will be possible to combine the professional degree witha masters degree (one year). Possible strategies in four areas related to the Specialist Nursing Education are discussed: integration of researchbasedknowledge, experienced-based knowledge, improvement knowledge, and strategies for collaboration between university institutions andclinics. Specific didactical issues are raised.
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