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Sökning: WFRF:(Linn SC) > (2022)

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1.
  • Schmutzler, RK, et al. (författare)
  • Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors
  • 2022
  • Ingår i: Breast care (Basel, Switzerland). - : S. Karger AG. - 1661-3791 .- 1661-3805. ; 17:2, s. 208-223
  • Tidskriftsartikel (refereegranskat)abstract
    • <b><i>Background:</i></b> Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. <b><i>Summary:</i></b> Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept.
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2.
  • Tarroc Gil, Sergi, et al. (författare)
  • Zonal Model Based Aircraft Passenger Thermal Comfort Comparative Study
  • 2022
  • Ingår i: 33th Congress of the International Council of the Aeronautical SciencesStockholm, Sweden. - : International Council of the Aeronautical Sciences (ICAS). - 9781713871163 ; , s. 312-322
  • Konferensbidrag (refereegranskat)abstract
    • Computational simulations have become during the last decades an essential tool to be used every day sooner in the design chain within the aerospace industry, leading to better decision making and more efficient concepts. However, in the aircraft design field, the thermal comfort of the passengers is not assessed until late design stages due to the complexity and high computational cost of simulating the flow inside it. The present work has the aim to show the Zonal Model approach as a solid early design simulation alternative to conventional CFD. A complete Fractional Step based Zonal Model solver is proposed, able to provide first estimations to the two-dimensional fluid solution, for a given cabin concept, with a low computational cost associated. This solver has also integrated its own automatized mesh generation algorithm along with a Radial Basis Functionsmorphing tool. With this method, a set of comparative studies have been performed for comparing several cabin design parameters attending to the thermal comfort of passengers and crew, giving a demonstration of the capabilities that this Zonal Model approach has for early aircraft design optimization and decision making.
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