| 1. |
- Akner, Gunnar, 1953-, et al.
(författare)
-
Adrenocorticotropin and cortisol response to lysine vasopressin in relation to the outcome of the dexamethasone suppression test in major depressive disorder
- 1988
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 77:4, s. 404-410
-
Tidskriftsartikel (refereegranskat)abstract
- The pathophysiology behind the abnormalities of the hypothalamic pituitary adrenal cortex axis found in patients with major depressive disorder was studied by the use of the vasopressin test. The response of plasma adrenocorticotropin (ACTH) and cortisol to the injection of 10 IU lysine-vasopressin (LVP) was investigated in 18 patients meeting the DSM-III criteria for major depressive episode. The response was correlated to the outcome of the dexamethasone suppression test (DST) with the use of two different cut-off points, 139 nmol/l and 200 nmol/l respectively. The results show that no significant difference was found in ACTH or cortisol response between patients having a normal or abnormal DST. The results do not seem to support the hypothesis that the abnormalities of the hypothalamic pituitary adrenal cortex axis involve a hypersecretion of corticotropin-releasing factor (CRF) and a subsequent desensitization of the corticotrophs to CRF-stimulated ACTH release.
|
|
| 2. |
- Ljunggren, Christer, et al.
(författare)
-
Rock stress measurements by means of hydraulic tests on pre-existing fractures at Gidea test site, Sweden
- 1987
-
Ingår i: International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts. - : Elsevier BV. - 0148-9062 .- 1879-2073. ; 24:6, s. 339-345
-
Tidskriftsartikel (refereegranskat)abstract
- In situ rock stress measurements were performed by means of hydraulic tests on pre-existing fractures (HTPF) at Gidea in northern Sweden. The paper presents a summary of the theory, technique and the results from these measurements. Hydraulic tests on pre-existing fractures were conducted in a vertical borehole, in which hydraulic fracturing rock stress measurements had been conducted earlier, and the state of stress was determined at depths from 90 to 270 m. Two- and three-dimensional solutions of stress vs depth are presented, giving similar results, both in the magnitude and orientation of stresses. At depths between 100 and 150 m, the stress state is almost isotropic in a plane perpendicular to the borehole axis. A rotation of the maximum horizontal stress with depth was found. A comparison has been made between HTPF results and those obtained by conventional hydraulic fracturing
|
|
| 3. |
- Zygmunt, S C, et al.
(författare)
-
Realignment and surgical fixation of atlanto-axial and subaxial dislocations in rheumatoid arthritis (RA) patients
- 1988
-
Ingår i: Acta Neurochirurgica. Supplementum. - 0065-1419. ; 43, s. 79-84
-
Tidskriftsartikel (refereegranskat)abstract
- One hundred consecutive patients with atlanto-axial dislocation(s) were subjected to posterior occipito-cervical fusion and followed up to 16 1/2 years postoperatively (mean: 4 1/2 years). The mean age at surgery was 60.3 years. At the time of follow-up, 45 patients had died, mostly due to cardiopulmonary disease. Out of the 100 patients, 67% showed a major improvement and in an additional 14% there was a slight or moderate improvement. Some patients with a stable fusion later developed subaxial dislocation(s) necessitating an anterior fusion which in patients with RA is difficult due to poor bone quality. MRI revealed pannus formation around the odontoid peg in many patients, in several to such a degree that cord compression was evident. Following the posterior fixation, the pannus disappeared or was reduced which may at least partly explain the generally favourable operative outcome following the fixation procedure. Early occipito-cervical fusion appears to prevent further vertical dislocation or upwards migration of the odontoid which is a more severe condition, and does not appear to result in increased incidence of subsequent subaxial dislocation(s). Such luxation(s) pose a technically difficult problem since the quality of the patients' own bone usually does not permit a common anterior fusion procedure with autologous graft. In such cases with cord compression, acrylic cement may be used to obtain a normalized realignment.
|
|
