| 1. |
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| 2. |
- Lunardi, S, et al.
(författare)
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Highly deformed band in Nd-138
- 2004
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 69:5
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Nd-138 have been investigated with the reaction Zr-94(Ca-48,4n), using the GASP array. A new rotational band has been identified, which has close similarities with the well known highly deformed bands of the lighter Nd isotopes, and is therefore interpreted as built on the second minimum of the nuclear potential energy surface. From comparison with calculations a configuration is suggested which involves two neutrons in the i(13/2) deformation driving orbital.
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| 3. |
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| 4. |
- Petrache, C. M., et al.
(författare)
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Stable triaxiality at the highest spins in 138Nd and 139Nd
- 2000
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Ingår i: Physical Review C - Nuclear Physics. - 0556-2813. ; 61:1, s. 113051-113055
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Tidskriftsartikel (refereegranskat)abstract
- The nuclei 138Nd and 139Nd have been studied at very high spins via the 48Ca+94Zr reaction. Several new rotational bands were observed, four in 138Nd and two in 139Nd. The J(2) moments of inertia calculated from the observed γ-ray energies are very small and almost constant, indicating that these bands are triaxial. Cranked Nilsson-Strutinsky calculations reproduce the general behavior of the bands, supporting this interpretation and suggesting an approximately constant γ value of ∼ + 35° over a large spin range up to the highest observed spins. These bands and a few similar bands in other nuclei of the N≈80 region are a unique example of almost undisturbed triaxial bands.
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| 5. |
- Scherer, SW, et al.
(författare)
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Human chromosome 7: DNA sequence and biology
- 2003
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 300:5620, s. 767-772
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Tidskriftsartikel (refereegranskat)abstract
- DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.
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| 7. |
- Thunes, KH, et al.
(författare)
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The arthropod community of Scots pine (Pinus sylvestris L.) canopies in Norway
- 2004
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Ingår i: Entomologica Fennica. - 0785-8760. ; 15:2, s. 65-90
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Forskningsöversikt (refereegranskat)abstract
- We summarise the findings of arthropods collected by fogging the canopy of 24 pine trees in two sites in Eastern and Western Norway. From the samples, taken in 1998 and in 1999, almost 30,000 specimens were determined to 512 species, with Diptera being most species rich (210 species), followed by Coleoptera (76 species) and Araneae (49 species). Of the 96 new species records, nine were new to science (5 Diptera and 4 Oribatida), two were new to the European, three to the Scandinavian and 82 to the Norwegian faunas. The paper demonstrates the need for detailed faunistical inventories of European forests.
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| 9. |
- Belting, Mattias, et al.
(författare)
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Tumor attenuation by combined heparan sulfate and polyamine depletion.
- 2002
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Ingår i: Proceedings of the National Academy of Sciences. - 1091-6490. ; 99:1, s. 371-376
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Tidskriftsartikel (refereegranskat)abstract
- Cells depend on polyamines for growth and their depletion represents a strategy for the treatment of cancer. Polyamines assemble de novo through a pathway sensitive to the inhibitor, alpha-difluoromethylornithine (DFMO). However, the presence of cell-surface heparan sulfate proteoglycans may provide a salvage pathway for uptake of circulating polyamines, thereby sparing cells from the cytostatic effect of DFMO. Here we show that genetic or pharmacologic manipulation of proteoglycan synthesis in the presence of DFMO inhibits cell proliferation in vitro and in vivo. In cell culture, mutant cells lacking heparan sulfate were more sensitive to the growth inhibitory effects of DFMO than wild-type cells or mutant cells transfected with the cDNA for the missing biosynthetic enzyme. Moreover, extracellular polyamines did not restore growth of mutant cells, but completely reversed the inhibitory effect of DFMO in wild-type cells. In a mouse model of experimental metastasis, DFMO provided in the water supply also dramatically diminished seeding and growth of tumor foci in the lungs by heparan sulfate-deficient mutant cells compared with the controls. Wild-type cells also formed tumors less efficiently in mice fed both DFMO and a xylose-based inhibitor of heparan sulfate proteoglycan assembly. The effect seemed to be specific for heparan sulfate, because a different xyloside known to affect only chondroitin sulfate did not inhibit tumor growth. Hence, combined inhibition of heparan sulfate assembly and polyamine synthesis may represent an additional strategy for cancer therapy.
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| 10. |
- Carpten, JD, et al.
(författare)
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HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome
- 2002
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 32:4, s. 676-680
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Tidskriftsartikel (refereegranskat)abstract
- We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT-JT. The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. HRPT2 is a ubiquitously expressed, evolutionarily conserved gene encoding a predicted protein of 531 amino acids, for which we propose the name parafibromin. Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors.
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| 11. |
- Christenson, Andreas, et al.
(författare)
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Direct electron transfer between ligninolytic redox enzymes and electrodes
- 2004
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Ingår i: Electroanalysis. - : Wiley. - 1040-0397 .- 1521-4109. ; 16:13-14, s. 1074-1092
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Forskningsöversikt (refereegranskat)abstract
- The electrochemistry of the ligninolytic redox enzymes, which include lignin peroxidase, manganese peroxidase and laccase and possibly also cellobiose dehydrogenase, is reviewed and discussed in conjunction with their basic biochemical characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established and their ability to degrade lignin through a direct electron transfer mechanism is discussed.
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| 12. |
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| 13. |
- Fazekas, F, et al.
(författare)
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CT and MRI rating of white matter lesions
- 2002
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Ingår i: Cerebrovascular diseases (Basel, Switzerland). - : S. Karger AG. - 1015-9770 .- 1421-9786. ; 1313 Suppl 2, s. 31-36
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Tidskriftsartikel (refereegranskat)abstract
- Rating scales play an important role in the evaluation of computed tomography (CT) or magnetic resonance-detected white matter lesions (WML). Unfortunately, this type of visual semiquantitative assessment is not yet an optimal tool because commonly agreed concepts regarding its use are lacking. To generate a discussion platform for further improvement of CT and MRI rating, we will provide some basic definitions, summarize the advantages and disadvantages of scoring schemes and review current efforts towards the improvement of this tool. Future research will have to concentrate on deepening our understanding of the histopathologic substrates of WML and on strategies to document their progression.
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| 14. |
- Garjonyte, R, et al.
(författare)
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Investigation of electrochemical properties of FMN and FAD adsorbed on titanium electrode
- 2003
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Ingår i: Bioelectrochemistry. - 1878-562X. ; 61:1-2, s. 39-49
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Tidskriftsartikel (refereegranskat)abstract
- The electrochemical properties (such as the values of the formal potentials, the dependence of the formal potentials on solution pH, the reversibility of the electrochemical process) of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) adsorbed on a titanium electrode were dependent on the electrolyte. The formal potentials of adsorbed FMN and FAD in phosphate, HEPES and PIPES buffers at pH 7 were similar to those for dissolved flavins (−460 to −480 mV vs. SCE) and changed linearly with a slope of about 52 mV per pH unit in the pH region 3 to 8. In TRIS buffer, the formal potentials of adsorbed FMN and FAD were also pH-dependent, however, with invariance in the pH range 4.5 to 5.5. In non-buffered solutions (KCl, LiCl, NaCl, CsCl, CaCl2, Na2SO4 at different concentrations), the electrochemical behavior of adsorbed FMN and FAD differed from that of dissolved flavins and was dependent on the electrolyte (especially at pH 4.5 and pH 5). Under certain conditions (electrolyte, concentration, pH), a two-step oxidation of FMN could be observed
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| 24. |
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| 25. |
- Schonwasser, G, et al.
(författare)
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Coexisting normal and triaxial superdeformed structures in Lu-165
- 2004
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 735:3-4, s. 393-424
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Lu-165 were populated in the La-139(Si-30, 4n) reaction at a beam energy of 152 MeV and gamma-ray coincidences were measured with the EUROBALL spectrometer array. Nine new rotational bands were discovered, known band structures were considerably extended and many inter-band transitions were found. Structures with normal deformation coexist with bands associated with the strongly deformed triaxial energy minima found in calculations. Three of these triaxial bands form a family of wobbling excitations with phonon quanta n(w) = 0, 1 and 2. The wobbling mode is a unique signature of nuclear triaxiality. Configuration assignments are discussed for the observed band structures. An exchange of configuration between two of the new bands due to mixing is observed, resulting in different signature partnerships at low and high spins.
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| 26. |
- Schonwasser, G, et al.
(författare)
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One- and two-phonon wobbling excitations in triaxial Lu-165
- 2003
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 552:1-2, s. 9-16
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Lu-165 have been investigated by in-beam gamma-ray coincidence spectroscopy using the EUROBALL spectrometer array. Two new excited rotational bands have been discovered with features similar to a previously known triaxial superdeformed band in that nucleus. Comparison of the decay pattern of these bands, in particular the unusually large E2 transition strength from the first excited to the yrast superdeformed band, to theoretical calculations shows that they belong to a family of wobbling excitations with phonon numbers n(w) = 0, 1 and 2. These results, together with evidence for nuclear wobbling in the neighbouring isotopes Lu-163 and Lu-167, firmly establish this mode of excitation in the A = 165 mass region. The observation of wobbling is a unique signature of stable nuclear triaxiality. (C) 2002 Elsevier Science B.V. All rights reserved.
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