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- Fung, P. P. L., et al.
(författare)
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Time to onset of bisphosphonate-related osteonecrosis of the jaws : a multicentre retrospective cohort study
- 2017
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Ingår i: Oral Diseases. - : WILEY. - 1354-523X .- 1601-0825. ; 23:4, s. 477-483
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients.Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012.Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n=88) and 2.2years in those treated with zoledronate (n=218). Multivariable Cox regression showed that dentoalveolar surgery was inversely associated, and the use of antiangiogenics directly associated, with the TTO in patients with cancer treated with zoledronate.Conclusions: The incidence of ONJ increases with the duration of BP therapy, with notable differences observed with respect to BP type and potency, route of administration and underlying disease. When data are stratified by BP type, a time of 6.0 and 2.2years of oral alendronate and intravenous zoledronate therapy, respectively, is required for 50% of patients to develop ONJ. After stratification by disease, a time of 5.3 and 2.2years of BP therapy is required for 50% of patients with osteoporosis and cancer, respectively, to develop ONJ. These findings have significant implications for the design of future clinical studies and the development of risk-reduction strategies aimed at either assessing or modulating the risk of ONJ associated with BP.
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- Rutkowski, Lucile, et al.
(författare)
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Detection of OH and H2O in an Atmospheric Flame by Near-Infrared Optical Frequency Comb Spectroscopy
- 2017
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Ingår i: 2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC). - : IEEE. - 9781509067367
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Konferensbidrag (refereegranskat)abstract
- Absorption spectroscopy is attractive for combustion diagnostics because it allows in-situ and calibration-free quantification of reactants/products and thermometry. However, spectra measured at atmospheric pressure in the near-infrared telecom range, where laser sources and optical components are readily available, suffer from strong water interference. Cavity-enhanced optical frequency comb spectroscopy (CE-OFCS) is well suited for detection of other species, as it provides broad bandwidth with high signal-to-noise ratio and resolution, and allows de-convolving the spectra hidden among water transitions. Here we report detection of OH in the presence of H2O in an atmospheric premixed methane/air flat flame by CE-OFCS at 1.57 μm. We demonstrate a new water line list that is more accurate than HITEMP [1] and we isolate the OH lines by dividing spectra taken at different heights above the burner (HABs) to retrieve OH concentration and flame temperature.
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- Rutkowski, Lucile, et al.
(författare)
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Measurement of H2O and OH in a Flame by Optical Frequency Comb Spectroscopy
- 2016
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Ingår i: Proceedings Conference on Lasers and Electro-Optics. - Washington, D.C. : IEEE. - 9781943580118
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Konferensbidrag (refereegranskat)abstract
- We measure broadband H2O and OH spectra in a flame using near-infrared cavity-enhanced Fourier transform optical frequency comb spectroscopy, we retrieve temperature and OH concentration, and compare water spectra to an improved line list.
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