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Tumour gene express...
Tumour gene expression signature in primary melanoma predicts long-term outcomes
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- Garg, Manik (author)
- European Bioinformatics Institute
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- Couturier, Dominique Laurent (author)
- University of Cambridge
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- Nsengimana, Jérémie (author)
- University of Leeds,University of Newcastle upon Tyne
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- Fonseca, Nuno A. (author)
- University of Porto
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- Wongchenko, Matthew (author)
- Genentech, Inc
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- Yan, Yibing (author)
- Genentech, Inc
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- Lauss, Martin (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Jönsson, Göran B. (author)
- Lund University,Lunds universitet,Melanoma Genomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Newton-Bishop, Julia (author)
- University of Leeds
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- Parkinson, Christine (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Middleton, Mark R. (author)
- University of Oxford
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- Bishop, D. Timothy (author)
- University of Leeds
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- McDonald, Sarah (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Stefanos, Nikki (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Tadross, John (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Vergara, Ismael A. (author)
- University of Sydney
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- Lo, Serigne (author)
- University of Sydney,Imam Abdulrahman Bin Faisal University
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- Newell, Felicity (author)
- QIMR Berghofer Medical Research Institute
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- Wilmott, James S. (author)
- University of Sydney
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- Thompson, John F. (author)
- University of Sydney
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- Long, Georgina V. (author)
- Royal North Shore Hospital,University of Sydney
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- Scolyer, Richard A. (author)
- University of Sydney,Royal Prince Alfred Hospital
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- Corrie, Pippa (author)
- Cambridge University Hospitals NHS Foundation Trust
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- Adams, David J. (author)
- Wellcome Trust Sanger Institute
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- Brazma, Alvis (author)
- European Bioinformatics Institute
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- Rabbie, Roy (author)
- Wellcome Trust Sanger Institute,Cambridge University Hospitals NHS Foundation Trust
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(creator_code:org_t)
- 2021-02-18
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
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- Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated with progression-free (HR = 1.63, p = 5.24 × 10−5) and overall survival (HR = 1.61, p = 1.67 × 10−4), was validated in 175 regional lymph nodes metastasis as well as two externally ascertained datasets. The machine learning classification models trained using the signature genes performed significantly better in predicting metastases than models trained with clinical covariates (pAUROC = 7.03 × 10−4), or published prognostic signatures (pAUROC < 0.05). The signature score negatively correlated with measures of immune cell infiltration (ρ = −0.75, p < 2.2 × 10−16), with a higher score representing reduced lymphocyte infiltration and a higher 5-year risk of death in stage II melanoma. Our expression signature identifies melanoma patients at higher risk of metastases and warrants further evaluation in adjuvant clinical trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Garg, Manik
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Couturier, Domin ...
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Nsengimana, Jéré ...
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Fonseca, Nuno A.
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Wongchenko, Matt ...
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Yan, Yibing
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show more...
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Lauss, Martin
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Jönsson, Göran B ...
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Newton-Bishop, J ...
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Parkinson, Chris ...
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Middleton, Mark ...
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Bishop, D. Timot ...
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McDonald, Sarah
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Stefanos, Nikki
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Tadross, John
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Vergara, Ismael ...
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Lo, Serigne
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Newell, Felicity
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Wilmott, James S ...
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Thompson, John F ...
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Long, Georgina V ...
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Scolyer, Richard ...
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Corrie, Pippa
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Adams, David J.
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Brazma, Alvis
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Rabbie, Roy
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Nature Communica ...
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Lund University