| 1. |
- Björklund, Johanna, 1961-, et al.
(författare)
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Ecosystem-based agriculture combining production and conservation : a viable way to feed the world in the long term?
- 2012
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Ingår i: Journal of Sustainable Agriculture. - : Taylor & Francis. - 1044-0046 .- 1540-7578. ; 36:7, s. 824-855
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Tidskriftsartikel (refereegranskat)abstract
- This study analyzed examples of sustainable ecosystem-based agriculture where management methods supported livelihoods of smallholders while at the same time local ecosystem services were enhanced in Ethiopia, Brazil, and the Philippines. Participation by farmers and collective actions were found to be a crucial driving force, as local specific knowledge and “learning by doing” were main components of the development. Social cohesion, particularly through associations and cooperatives, and improved marketing opportunities were also important drivers. Furthermore, recognition by authorities at all levels was perceived as crucial. Effects of climate change, insecure property rights, and political instability were potential threats. The possibilities of such systems to be scaled up beyond self-sufficiency raised further questions.
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| 2. |
- Brokken, Leon, et al.
(författare)
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Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer.
- 2013
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 4:Feb.,14
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Tidskriftsartikel (refereegranskat)abstract
- In the Western world, testicular germ cell cancer (TGCC) is the most common malignancy of young men. The malignant transformation of germ cells is thought to be caused by developmental and hormonal disturbances, probably related to environmental and lifestyle factors because of rapidly increasing incidence of TGCC in some countries. Additionally, there is a strong genetic component that affects susceptibility. However, genetic polymorphisms that have been identified so far only partially explain the risk of TGCC. Many of the persistent environmental pollutants act through the aryl hydrocarbon receptor (AHR). AHR signaling pathway is known to interfere with reproductive hormone signaling, which is supposed to play a role in the pathogenesis and invasive progression of TGCC. The aim of the present study was to identify whether AHR-related polymorphisms were associated with risk as well as histological and clinical features of TGCC in 367 patients and 537 controls. Haplotype-tagging single-nucleotide polymorphisms (SNPs) were genotyped in genes encoding AHR and AHR repressor (AHRR). Binary logistic regression was used to calculate the risk of TGCC, non-seminoma versus seminoma, and metastasis versus localized disease. Four SNPs in AHRR demonstrated a significant allele association with risk to develop metastases (rs2466287: OR = 0.43, 95% CI 0.21-0.90; rs2672725: OR = 0.49, 95% CI: 0.25-0.94; rs6879758: OR = 0.27, 95% CI: 0.08-0.92; rs6896163: OR = 0.34, 95% CI: 0.12-0.98). This finding supports the hypothesis that compounds acting through AHR may play a role in the invasive progression of TGCC, either directly or through modification of reproductive hormone action.
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| 3. |
- Börjesson, Karl, 1982, et al.
(författare)
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Soft-Surface DNA Nanotechnology: DNA Constructs Anchored and Aligned to Lipid Membrane
- 2011
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 50:36, s. 8312-8315
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Tidskriftsartikel (refereegranskat)abstract
- No strings attached: At least three attachment points are needed to align a two-dimensional DNA nanoconstruct to a soft lipid membrane surface with a porphyrin nucleoside as membrane anchor (see picture). The resulting freely diffusing DNA constructs can be reversibly assembled on the surface thus enabling the possibility of a self-repairing system. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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| 4. |
- Dengjel, Joern, et al.
(författare)
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Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens
- 2012
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Autophagy is one of the major intracellular catabolic pathways, but little is known about the composition of autophagosomes. To study the associated proteins, we isolated autophagosomes from human breast cancer cells using two different biochemical methods and three stimulus types: amino acid deprivation or rapamycin or concanamycin A treatment. The autophagosome- associated proteins were dependent on stimulus, but a core set of proteins was stimulus- independent. Remarkably, proteasomal proteins were abundant among the stimulus- independent common autophagosome- associated proteins, and the activation of autophagy significantly decreased the cellular proteasome level and activity supporting interplay between the two degradation pathways. A screen of yeast strains defective in the orthologs of the human genes encoding for a common set of autophagosome- associated proteins revealed several regulators of autophagy, including subunits of the retromer complex. The combined spatiotemporal proteomic and genetic data sets presented here provide a basis for further characterization of autophagosome biogenesis and cargo selection.
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| 5. |
- Muftee, Mehek
(författare)
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“That will be your home” : Resettlement preparations for children and youth from the Horn of Africa
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyzes how children and youth being resettled from Kenya and Sudan were prepared for their upcoming resettlement to Sweden, through cultural orientation programs (COPs). COPs are held for refugees who have been granted permanent Swedish residence and are undergoing resettlement to Sweden. The Swedish Migration Board, in charge of resettlement, carries out COPs as a means to inform and prepare refugees for the move to Sweden. This thesis is based on ethnographic work carried out during COPs held in Kenya and Sudan in 2011. Through video-based observation of the meetings between the Swedish delegations and children and youth, current thesis examines what notions of resettlement and refugeeness inform the delegations work, and how does the children’s agency come about during these meetings? The thesis includes three articles. Article 1 examines how the delegations make use of images in order to establish certain ideas of Sweden and the ideal citizen specifically tailored for the group being resettled. Article 2 explores children’s agency within the COPs, focusing on how the children and youth manage the meetings and sometimes resisting being positioned in certain ways by the delegations. Article 3 analyzes how notions of gender equality are drawn upon by the delegations during their work, a topic frequently highlighted by the delegations in various implicit and dilemmatic ways. The thesis shows how the delegations’ work is carried out in paradoxical ways. Their quest to bring forth the ideal future as a means to instill hope among the children simultaneously ends up categorizing them as different and as others. The representatives draw n ideas that the children need to be socialized in order to be incorporated into another “us”.
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| 6. |
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| 7. |
- Västermark, Åke, et al.
(författare)
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Polymorphic variation in the androgen receptor gene : association with risk of testicular germ cell cancer and metastatic disease
- 2011
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 47:3, s. 413-419
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Tidskriftsartikel (refereegranskat)abstract
- Increasing incidence of testicular germ cell cancer (TGCC) is most probably related to environment and lifestyle. However, an underlying genetic predisposition may play a role and since sex steroids are assumed to be important for the rise and progression of TGCC, a study of androgen receptor (AR) gene polymorphisms in relation to the risk, histological type and progression of TGCC was undertaken. In 367 TGCC cases and 214 controls, AR CAG and GGN repeat lengths were determined and 11 haplotype-tagging single nucleotide polymorphisms (SNPs) were genotyped. By binary logistic regression, odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the risk of TGCC, non-seminoma versus seminoma and metastatic versus localised (stage I) disease. For the non-coding SNP, rs12014709, the minor genotype (G) was found in 10% of the cases and in 5.1% of the controls, conferring an OR of 2.07 (95% CI: 1.03-4.15) for having TGCC. Furthermore, short GGN (<23) was associated with an increased risk of metastatic disease (OR: 2.15; 95% CI: 1.04-4.45). The AR polymorphisms found by us might be involved in gene-environment interaction by increasing the susceptibility to the effect of endocrine disruptors. From a biological point of view, our findings strengthen the hypothesis of the importance of androgen action in the aetiology and pathogenesis of testicular malignancy. Future studies should focus on the impact of sex hormones on foetal germ cell development and the interaction between environmental factors and androgen receptor variants in relation to the risk of testicular malignancy.
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