| 1. |
- Arvidsson, Alf, et al.
(författare)
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För Sverige i tiden?
- 2009
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Ingår i: Kulturella perspektiv - Svensk etnologisk tidskrift. - Umeå. - 1102-7908. ; 18:2, s. 2-8
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Cabric, Sanja, et al.
(författare)
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Islet Surface Heparinization Prevents the Instant-Blood Mediated Inflammatory Reaction in Islet Transplantation
- 2007
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 56:8, s. 2008-2015
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE—In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently identified systemic inhibitors of the IBMIR are associated with a significantly increased risk of bleeding or other side effects. To avoid systemic treatment, the aim of the present study was to render the islet graft blood biocompatible by applying a continuous heparin coating to the islet surface.RESEARCH DESIGN AND METHODS—A biotin/avidin technique was used to conjugate preformed heparin complexes to the surface of pancreatic islets. This endothelial-like coating was achieved by conjugating barely 40 IU heparin per full-size clinical islet transplant.RESULTS—Both in an in vitro loop model and in an allogeneic porcine model of clinical islet transplantation, this heparin coating provided protection against the IBMIR. Culturing heparinized islets for 24 h did not affect insulin release after glucose challenge, and heparin-coated islets cured diabetic mice in a manner similar to untreated islets.CONCLUSIONS—This novel pretreatment procedure prevents intraportal thrombosis and efficiently inhibits the IBMIR without increasing the bleeding risk and, unlike other pretreatment procedures (e.g., gene therapy), without inducing acute or chronic toxicity in the islets.
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| 4. |
- Eich, Torsten, et al.
(författare)
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Positron emission tomography : A real-time tool to quantify early islet engraftment in a preclinical large animal model
- 2007
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Ingår i: Transplantation. - : Ovid Technologies (Wolters Kluwer Health). - 0041-1337 .- 1534-6080. ; 84:7, s. 893-898
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Tidskriftsartikel (refereegranskat)abstract
- Background. Clinical islet transplantation is currently being explored as a therapeutic option for persons with type I diabetes and hypoglycemic unawareness. Techniques to monitor graft survival are urgently needed to optimize the procedure. Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase.Methods. Isolated porcine islets were labeled in vitro with 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) and infused intraportally into anesthetized pigs (n=10). Dynamic examination was performed on a positron emission tomography/computed tomography hybrid system.Results. More than 95% of the radioactivity was confined to the islets at the time of transplantation. The peak percentage of infused radioactivity within the liver, quantified at the end of the islet infusion, was only 54±5.1%. The distribution of the radioactivity in the liver was found to be heterogeneous. A whole-body examination showed no accumulation in the lungs or brain; extrahepatic radioactivity was, except urinary excretion, evenly distributed in the pig body.Conclusions. Our results imply that almost 50% of the islets were damaged to the extent that the FDG contained was release within minutes after intraportal transplantation. The distribution of radioactivity without accumulation in the brain indicates that the activity is released from lysed islet cells in the form of [18F]FDG-6P rather than native [18F]FDG. The presented technique shows promise to become a powerful and quantitative tool, readily available in the clinic, to evaluate initial islet engraftment and survival.
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| 5. |
- Ericzon, Bo-Göran, et al.
(författare)
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Liver Transplantation for Transthyretin Amyloidosis
- 2009
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Ingår i: Recent Advances in Transthyretin Evolution, Structure and Biological Functions. - New York : Springer Berlin/Heidelberg. - 9783642006456 - 9783642006463 ; , s. 239-260
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Liver transplantation has until now proved to be the only treatment available that halts the progression of hereditary transthyretin (TTR) associated amyloidosis. The rationale behind the procedure is to replace the liver producing variant TTR with one that produces wild type TTR only, and thereby cease the production of amyloidogenic TTR (ATTR). Even though the transplantation does not improve the patient's symptoms, the progression of the disease comes to a halt for a majority of patients. However, unforeseen complications after the transplantation have emerged, in particular a continuous amyloid formation in the heart observed in non-ATTR Val30Met mutations. Thus, combined liver and heart transplantation has been performed in selected cases. Since the ATTR liver functions normally apart from a synthesis of the variant TTR, utilisation of ATTR-amyloid patients' livers for transplantation of liver disease patients has been performed. In a few patients, development of amyloid disease has been reported, but the procedure remains an important source of organs, especially for patients with hepatocellular cancer.
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| 6. |
- Eriksson, Olof, et al.
(författare)
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Positron emission tomography in clinical islet transplantation
- 2009
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 9:12, s. 2816-2824
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Tidskriftsartikel (refereegranskat)abstract
- The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed tomography (PET/CT) was performed for 60 min during islet transplantation in five patients receiving six transplants. A fraction of the islets (23%) were labeled with 18F-fluorodeoxyglucose ([(18)F]FDG) and carefully mixed with unlabeled islets just prior to intraportal transplantation. The peak radioactivity concentration in the liver was found at 19 min after start of islet infusion and corresponded to only 75% of what was expected, indicating that islets are lost during the transplantation procedure. No accumulation of radioactivity was found in the lungs. A nonphysiological peak of C-peptide was found in plasma during and immediately after transplantation in all subjects. Distribution in the liver was heterogeneous with wide variations in location and concentration. Islets found in areas with concentrations of >400 IEQ/cc liver tissue varied between 1% and 32% of the graft in different subjects. No side effects attributed to the PET/CT procedure were found. Clinical outcome in all patients was comparable to that previously observed indicating that the [(18)F]FDG labeling procedure did not harm the islets. The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation.
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| 7. |
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| 8. |
- Johansson, Helena, et al.
(författare)
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Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation
- 2005
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 54:6, s. 1755-62
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Tidskriftsartikel (refereegranskat)abstract
- There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present study, we show that islets intended for islet transplantation produce tissue factor in both the transmembrane and the alternatively spliced form and that the membrane-bound form is released as microparticles often associated with both insulin and glucagon granules. A low-molecular mass factor VIIa (FVIIa) inhibitor that indirectly blocks both forms of tissue factor was shown in vitro to be a promising drug to eliminate the IBMIR. Thrombin-antithrombin complex (TAT) and FVIIa-antithrombin complex (FVIIa-AT) were measured in nine patients who together received 20 infusions of isolated human islets. Both the TAT and FVIIa-AT complexes increased rapidly within 15-60 min after infusion. When the initial TAT and FVIIa-AT levels were plotted against the increase in C-peptide concentration after 7 days, patients with an initially strong IBMIR showed no significant increase in insulin synthesis after 7 days. In conclusion, tissue factor present in both the islets and the culture medium and elicits IBMIR, which affects the function of the transplanted islets.
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| 9. |
- Korsgren, Olle, et al.
(författare)
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Optimising islet engraftment is critical for successful clinical islet transplantation
- 2008
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:2, s. 227-32
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Tidskriftsartikel (refereegranskat)abstract
- Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.
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| 10. |
- Lannering, Birgitta, 1948, et al.
(författare)
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Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005.
- 2009
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253. ; 98:10, s. 1620-7
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Primary tumours in the central nervous system (CNS) are the second most common malignancy in childhood after leukaemia. Sweden has a high incidence and a high-survival rate in international comparative studies. This has raised the question about the type of tumours included in the Swedish Cancer registry. We therefore compared international data to the Swedish Childhood Cancer registry. METHODS: Central nervous system tumours registered in the Swedish Childhood Cancer Registry were reclassified according to ICCC-3. Incidence and survival analyses were performed in the study population. RESULTS: There were 1479 children (<15 years) in Sweden diagnosed with CNS tumours 1984-2005. The distribution of diagnoses was similar to that reported in other studies. The annual incidence was 4.2/100,000 children. The survival rates have not improved significantly between the two time periods before/after 1995 (70% vs. 74%; p = 0.10). CONCLUSIONS: The mean annual incidence of children with CNS tumours was 4.2/100,000 and has not increased during the study period. Survival rate for brain tumours at 10 years follow-up was 72%.
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| 11. |
- Lindberg, Anne, et al.
(författare)
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10-year cumulative incidence of COPD and risk factors for incident disease in a symptomatic cohort
- 2005
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Ingår i: Chest. - : Elsevier BV. - 0012-3692 .- 1931-3543. ; 127:5, s. 1544-1552
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Tidskriftsartikel (refereegranskat)abstract
- STUDY OBJECTIVES: To determine the 10-year cumulative incidence of COPD in a cohort of subjects with respiratory symptoms (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 0) using the British Thoracic Society (BTS) and GOLD spirometric criteria. Furthermore, we sought to evaluate risk and gender factors for incident COPD. DESIGN AND SETTING: A postal questionnaire was administered in 1986 to all 6,610 subjects in eight areas of northern Sweden who had been born in 1919 to 1920 (group 1), 1934 to 1935 (group 2), and 1949 to 1950 (group 3). The response rate was 86%. All of the subjects reporting respiratory symptoms were invited to participate in a structured interview and pulmonary function test (PFT), and 1,506 (91%) participated. In 1996, 90% could be traced for follow-up, of whom 1,165 (86%) of the invited subjects participated and 1,109 subjects (534 women) were able to perform technically adequate PFTs in both 1986 and 1996. RESULTS: The 10-year cumulative incidence of COPD was estimated at 8.2% (using BTS criteria) and 13.5% (using GOLD criteria). Significant risk factors for incident COPD (using BTS and GOLD criteria) in a multivariate analysis were higher age (group 1 odds ratio [OR]: BTS criteria, 3.49; GOLD criteria, 3.37; group 2 OR: BTS criteria, 4.50; GOLD criteria, 5.70) and smoking (OR: BTS criteria, 5.37; GOLD criteria, 4.56), but not gender or heredity. Respiratory symptoms were significantly associated with incident COPD when added to the same model. In analogous analyses that were conducted separately for men and women, smoking yielded an OR of 8.52 among women (95% confidence interval [CI], 3.43 to 21.2) compared with 3.14 among men (95% CI, 1.26 to 7.84). The symptoms cough, sputum production, and chronic productive cough reached statistical significance in women, while dyspnea and wheeze did so in men. CONCLUSION: In this cohort, the 10-year cumulative incidence of COPD was 8.2% (using BTS criteria) and 13.5% (using GOLD criteria). Increasing age, smoking, and bronchitic symptoms, but not gender, were risk factors for incident COPD. GOLD stage 0 therefore appears to identify subjects who are at risk of COPD, but men and women presented different risk profiles.
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| 12. |
- Lindberg, Anne, et al.
(författare)
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Prevalence of chronic obstructive pulmonary disease according to BTS, ERS, GOLD and ATS criteria in relation to doctor's diagnosis, symptoms, age, gender, and smoking habits.
- 2005
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Ingår i: Respiration. - : S. Karger AG. - 0025-7931 .- 1423-0356. ; 72:5, s. 471-9
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Tidskriftsartikel (refereegranskat)abstract
- <i>Background:</i> Guidelines and standards for diagnosis and management of chronic obstructive pulmonary disease (COPD) have been presented by different national and international societies, but the spirometric criteria for COPD differ between guidelines. <i>Objectives:</i> To estimate prevalence of COPD using the guidelines of the British Thoracic Society (BTS), the European Respiratory Society (ERS), the Global Initiative for Chronic Obstructive Lung Disease (GOLD), and the American Thoracic Society (ATS). Further, to evaluate reported airway symptoms, contacts with health care providers, and physician diagnosis of COPD in relation to the respective criteria, and gender differences. <i>Method:</i> In 1992 a postal questionnaire was sent to a random sample of adults aged 20–69 years, 4,851 (85%) out of 5,681 subjects responded. In 1994–1995 a random sample of the responders, 970 subjects, were invited to a structured interview and a lung function test; 666 (69%) participated. <i>Results:</i> The prevalence of COPD was 7.6, 14.0, 14.1, 12.2 and 34.1% according to BTS, ERS, GOLD, clinical ATS (with symptoms or physician diagnosis), and spirometric ATS criteria, respectively. Prevalent COPD was related to age, smoking habits and family history of obstructive airway disease but not to gender. Physician diagnosis of chronic bronchitis or emphysema was only reported by 16.3, 12.2, 11.0, 23.4 and 8.2% of subjects fulfilling the respective criteria, though a majority reported airway symptoms. <i>Conclusion:</i> The main determinants for prevalent COPD were age, smoking habits and spirometric criteria of COPD. Though a majority reported airway symptoms and contact with health care providers due to respiratory complaints, only a minority was diagnosed as having COPD, indicating a large underdiagnosis.
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| 13. |
- Lundgren, Anna Sofia, 1972-, et al.
(författare)
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Kulturanalytiska perspektiv
- 2009
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Ingår i: Att förhandla plats och tillhörighet<em> </em>. - Umeå : Institutionen för kultur- och medievetenskaper, Umeå universitet. - 9789163352805 ; , s. 5-9
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 14. |
- Lundgren, Caroline, et al.
(författare)
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2-DE protein expression in endometrial carcinoma
- 2006
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Ingår i: Acta Oncologica. - Oslo : Taylor & Francis. - 0284-186X .- 1651-226X. ; 45:6, s. 685-694
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to explore the protein expression pattern in normal endometrial mucosa (n = 5) and endometrial carcinoma ( n = 15) of low ( diploid) and high ( aneuploid) malignancy potential by two-dimensional gel electrophoresis (2-DE). The specimens were evaluated for histopathologic subtype, stage and grade in relation to DNA ploidy. A match-set consisting of five samples from normal endometrium, eight diploid and seven aneuploid tumours was created. All the diploid and three of the aneuploid tumours were of endometrioid subtype, while the remaining four were of uterine seropapillary type. There were 192 protein spots differentiating diploid tumours from normal endometrium and 238 protein spots were separating aneuploid tumours from normal endometrium (p < 0.01). A cluster analysis based on 52 significantly deviating protein spots within the groups showed clustering and separation of the normal endometrium, diploid and aneuploid tumours. In conclusion this study showed significant differences in protein expression between normal endometrium and endometrial carcinoma as well as between endometrial carcinoma of low and high malignancy potential. In future studies these results may provide useful in finding new sensitive prognostic markers for endometrial cancer.
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| 15. |
- Lundgren, Katja, et al.
(författare)
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Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
- 2008
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Ingår i: Breast cancer research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 10:5, s. R81-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, namely CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer patients. Over-expression of cyclin D-1 protein, however, confers tamoxifen resistance but not a tamoxifen-induced adverse effect. Potentially, co-amplification of an additional 11q13 gene, with a resulting protein over-expression, is required to cause an agonistic effect. Moreover, during 11q13 amplification a deletion of the distal 11q region has been described. In order to assess the potential impact of the deletion we examined a selected marker for this event. Method: Array comparative genomic hybridization analysis was employed to identify and confirm changes in the gene expression of a number of different genes mapping to the 11q chromosomal region, associated with CCND1 amplification. The subsequent protein expression of these candidate genes was then examined in a clinical material of 500 primary breast cancers from premenopausal patients who were randomly assigned to either tamoxifen or no adjuvant treatment. The protein expression was also compared with gene expression data in a subset of 56 breast cancer samples. Results: Cortactin and FADD (Fas-associated death domain) over-expression was linked to CCND1 amplification, determined by fluorescence in situ hybridization, but was not associated with a diminished effect of tamoxifen. However, deletion of distal chromosome 11q, defined as downregulation of the marker Chk1 (checkpoint kinase 1), was associated with an impaired tamoxifen response, and interestingly with low proliferative breast cancer of low grade. For Pak1 (p21-activated kinase 1) and cyclin D-1 the protein expression corresponded to the gene expression data. Conclusions: The results indicate that many 11q13 associated gene products are over-expressed in conjunction with cyclin D-1 but not linked to an agonistic effect of tamoxifen. Finally, the deletion of distal 11q, linked to 11q13 amplification, might be an important event affecting breast cancer outcome and tamoxifen response.
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| 16. |
- Lundgren, Katja, et al.
(författare)
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Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
- 2009
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Ingår i: BRITISH JOURNAL OF CANCER. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 101:10, s. 1769-1781
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Hypoxia is an element of the tumour microenvironment that impacts upon numerous cellular factors linked to clinical aggressiveness in cancer. One such factor, Snail, a master regulator of the epithelial-mesenchymal transition (EMT), has been implicated in key tumour biological processes such as invasion and metastasis. In this study we set out to investigate regulation of EMT in hypoxia, and the importance of Snail in cell migration and clinical outcome in breast cancer. METHODS: Four breast cancer cell lines were exposed to 0.1% oxygen and expression of EMT markers was monitored. The migratory ability was analysed following Snail overexpression and silencing. Snail expression was assessed in 500 tumour samples from premenopausal breast cancer patients, randomised to either 2 years of tamoxifen or no adjuvant treatment. RESULTS: Exposure to 0.1% oxygen resulted in elevated levels of Snail protein, along with changes in vimentin and E-cadherin expression, and in addition increased migration of MDA-MB-468 cells. Overexpression of Snail increased the motility of MCF-7, T-47D and MDA-MB-231 cells, whereas silencing of the protein resulted in decreased migratory propensity of MCF-7, MDA-MB-468 and MDA-MB-231 cells. Moreover, nuclear Snail expression was associated with tumours of higher grade and proliferation rate, but not with disease recurrence. Interestingly, Snail negativity was associated with impaired tamoxifen response (P = 0.048). CONCLUSIONS: Our results demonstrate that hypoxia induces Snail expression but generally not a migratory phenotype, suggesting that hypoxic cells are only partially pushed towards EMT. Furthermore, our study supports the link between Snail and clinically relevant features and treatment response.
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| 17. |
- Lundgren, Maria, et al.
(författare)
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Coke reactivity under blast furnace condition and in the CSR/CRI test
- 2008
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Ingår i: SCANMET III. - Luleå : MEFOS. - 9789163322709 ; , s. 125-134
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Konferensbidrag (refereegranskat)abstract
- The present work aims to study the high-temperature strength of coke. Mechanisms of disintegration were evaluated using basket samples charged into LKAB's experimental blast furnace prior to quenching and dissection. Coke charged into basket samples were analysed with CSR/CRI tests and compared with treated coke from the blast furnace. Results from tumbling tests, chemical analyses of coarse and fine material, as well as light optical microscopy studies of original and treated coke have been combined and evaluated.The results indicate a correlation between the ash composition and the CSR values. Differences in the texture of the coke were noted with light optical microscopy, and a significant change in the coke texture during the CSR/CRI test conditions was found. The results suggest that the main reaction between coke and CO2 took place in isotropic areas, which was especially pronounced in coke with a low CSR. Signs of degradation were apparent throughout the coke pieces that have undergone CSR/CRI testing, but were less observable in coke reacted in the blast furnace. The results indicate that reaction with CO2 is generally limited by the chemical reaction rate in the CSR/CRI test, while in the blast furnace the reaction is limited by the diffusion rate. Coke degradation is therefore mostly restricted to the coke surface in the blast furnace.
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| 18. |
- Lundgren, Maria, et al.
(författare)
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Coke reactivity under blast furnace conditions and in the CSR/CRI test
- 2009
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Ingår i: Steel Research International. - : Wiley. - 1611-3683 .- 1869-344X. ; 80:6, s. 396-401
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Tidskriftsartikel (refereegranskat)abstract
- The present work aims to study the high-temperature strength of coke. Mechanisms of disintegration were evaluated using basket samples charged into LKAB's experimental blast furnace prior to quenching and dissection. Coke charged into basket samples was analysed with CSR/CRI tests and compared with treated coke from the blast furnace. Results from tumbling tests, chemical analyses of coarse and fine material, as well as light optical microscopy studies of original and treated coke have been combined and evaluated. The results indicate a correlation between the ash composition and the CSR values. Differences in the texture of the coke were noted with light optical microscopy, and a significant change in the coke texture during the CSR/CRI test conditions was found. The results suggest that the main reaction between coke and CO2 took place in isotropic areas, which was especially pronounced in coke with a low CSR. Signs of degradation were apparent throughout the coke pieces that have undergone CSR/CRI testing, but were less observable in coke reacted in the blast furnace. The results indicate that reaction with CO2 is generally limited by the chemical reaction rate in the CSR/CRI test, while in the blast furnace the reaction is limited by the diffusion rate. Coke degradation is therefore mostly restricted to the coke surface in the blast furnace.
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| 19. |
- Masquelier, Michéle, et al.
(författare)
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Cytotoxic effect of a lipophilic alkylating agent after incorporation into low density lipoprotein or emulsions : Studies in human leukemic cells
- 2006
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Ingår i: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 30:2, s. 136-144
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Tidskriftsartikel (refereegranskat)abstract
- The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-valerate (AD32), a lipophilic derivative of daunorubicin (DNR), and WB4291, a lipophilic alkylating agent, into LDL or lipid microemulsions and evaluated their cytotoxic activities towards leukemic cell lines using as references DNR and melphalan. The incorporation of AD32 into LDL or emulsion resulted in complexes with poor cytotoxicity. WB4291-LDL and WB4291-emulsion exerted, on the other hand, promising cytotoxic effects towards parental and resistant K562 and HL60 cell lines. © 2005 Elsevier Ltd. All rights reserved.
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| 20. |
- Nguyen Thuy, Lan, 1975-, et al.
(författare)
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Influence of redox cycle on the mobilisation of Fe, Zn, Cu and Cd from contaminated sediments : a laboratory study
- 2007
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Ingår i: Water Rescources Managment. - Boston : WITPRESS. ; , s. 283-291
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- An international forum for original contributions and the exchange of knowledge and experience on the management of water resourcesPublishes contributions on water resources assessment, development, conservation and control, emphasizing policies and strategiesSupported scientifically by the European Water Resources AssociationWater Resources Management is an international, multidisciplinary forum for the publication of original contributions and the exchange of knowledge and experience on the management of water resources. In particular, the journal publishes contributions on water resources assessment, development, conservation and control, emphasizing policies and strategies. Contributions examine planning and design of water resource systems, and operation, maintenance and administration of water resource systems.Coverage extends to these closely related topics: water demand and consumption; applied surface and groundwater hydrology; water management techniques; simulation and modelling of water resource systems; forecasting and control of quantity and quality of water; economic and social aspects of water use; legislation and water resources protection. Water Resources Management is supported scientifically by the European Water Resources Association, a scientific and technical nonprofit-making European association
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| 21. |
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| 22. |
- Nguyen Thuy, Lan, et al.
(författare)
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Release of metals from contaminated sediments under simulated redox changes induced by hydropower operations
- 2007
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Ingår i: International Journal of Sustainable Development and Planning. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to examine the consequent release of the metals Fe, Zn, Cu and Cd from the sediments under simulated redox changes. Two contaminated sediments, ‘A’ representing the top layer and ‘B’ representing the deeper layers taken from Lake Håcklasjön downstream of a hydropower plant in southern Sweden, were incubated in the lake water in flow-cells under both anoxic and aerated conditions. Under anoxic conditions, Fe was rapidly released from both sediments (A and B) into the solution, which was likely a result of diffusion from porewater along with the reductive dissolution of hydroxides, whereas the concentrations of dissolved Zn, Cu and Cd remained low. The opposite results occurred for all the studied metals during aeration: i.e. precipitation of Fe and a progressive release of Zn, Cu and Cd. The oxidation of ferrous to ferric Fe was the most likely process responsible for the removal of Fe from the water column from both sediments. Meanwhile the release of the trace metals was probably a result of the oxidation of sulphides, degradation of particulate organic matter or diffusion/advection. The water flow applied during the aeration period likely induced resuspension, which would be a contributing factor to the metal release by enhancing both porewater diffusion/advection and interactions between the resuspended sediments and the overlying water. The decrease in pH in overlying water of sediment A could be the reason for the faster increase in trace metal concentrations compared to that of sediment B. Copper was probably not affected by pH change, as Cu was complexed with dissolved organic carbon and carbonates using the Visual MINTEQ model. The results from the experiment show that aeration of the sediment samples is an important factor for the release of Zn, Cu and Cd into the water column. The low flow of water applied in the experiment compared to that generated by operation periods of the hydropower plant suggests that probably more metals will be released under field conditions.
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| 23. |
- Rafael, Ehab, et al.
(författare)
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Intramuscular autotransplantation of pancreatic islets in a 7-year-old child : a 2-year follow-up
- 2008
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 8:2, s. 458-62
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Tidskriftsartikel (refereegranskat)abstract
- A 7-year-old girl with severe hereditary pancreatitis underwent total pancreatectomy. A total of 160,000 islet equivalents (6400 islet/kg) were transplanted to the brachioradialis muscle of the right forearm. Her plasma C-peptide level was undetectable after pancreatectomy but increased to 1.37 ng/mL after 17 days; at this time point, her insulin requirement was 0.75 units of insulin/kg/day. At 5- and 27-months, her hemoglobin A1c (HbA1c) and insulin requirements were 4.5 and 5.3% and 0.3 and 0.18 units/kg/day, respectively. Basal and stimulated C-peptide levels were 0.67 +/- 0.07 and 3.36 +/- 1.37 ng/mL, respectively. Stimulated insulin levels were 30% higher in the islet-bearing arm compared to the contralateral arm after glucagon stimulation. After surgery and islet transplantation, the quality of life improved dramatically and she gained 8 kg of weight. In summary, a normal HbA1c, a low insulin requirement and the absence of recurrent hypoglycemia and the gradient of insulin between the arms indicate that the intramuscularly transplanted islets contribute to a long-term clinically significant metabolic control.
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| 24. |
- Schmidt, Peter, et al.
(författare)
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Low molecular weight dextran sulfate is well tolerated in humans and increases endogenous expression of islet protective hepatocyte growth factor
- 2008
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Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 86:11, s. 1523-1530
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Low molecular weight dextran sulfate (LMW-DS) is a strong candidate to prevent early islet graft destruction caused by the instant blood-mediated inflammatory reaction. Pharmacokinetics, safety, tolerability, and the effect on endogenous release of various growth factors were studied in humans. MATERIALS AND METHODS: Thirty healthy volunteers were given LMW-DS as a combined bolus and 20 min intravenous infusion followed by a continuous intravenous infusion for 5 hr to reach different predetermined target-activated partial thromboplastin times (APTT) in five study groups. Monitoring of APTT was used to estimate and control the plasma concentration. Safety, including hemostasis parameters, was evaluated before proceeding to a higher target APTT-level. Plasma was collected continuously during the infusion and was analyzed for additional safety markers and the presence of six different growth factors. RESULTS: Predetermined target APTT levels were reached and kept for 5 hr without extensive dose corrections. After the 5 hr 20 min of LMW-DS infusion, the subjects in the highest dose group (target APTT=150 s) were back at APTT-levels below 75 s within 60 min. Plasma levels of hepatocyte growth factor were increased 100-fold within 20 min of infusion start and persisted more than 8 hr in the two highest dose groups. CONCLUSION: At doses that maintain APTT at up to 150 s for 5 hrs 20 min, LMW-DS could be safely infused without affecting the platelet count or revealing other signs of increased bleeding risk. The observed endogenous release of islet protective hepatocyte growth factor could be an additional beneficial effect of LMW-DS during the first critical hours after transplantation.
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