| 1. |
- Borgmästars, Emmy, et al.
(författare)
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Metabolomics for early pancreatic cancer detection in plasma samples from a Swedish prospective population-based biobank
- 2024
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Ingår i: Journal of Gastrointestinal Oncology. - : AME Publishing Company. - 2078-6891 .- 2219-679X. ; 15:2, s. 755-767
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Tidskriftsartikel (refereegranskat)abstract
- Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival. To improve survival, more patients need to be diagnosed early when curative surgery is feasible. We aimed to identify circulating metabolites that could be used as early pancreatic cancer biomarkers.Methods: We performed metabolomics by liquid and gas chromatography-mass spectrometry in plasma samples from 82 future pancreatic cancer patients and 82 matched healthy controls within the Northern Sweden Health and Disease Study (NSHDS). Logistic regression was used to assess univariate associations between metabolites and pancreatic cancer risk. Least absolute shrinkage and selection operator (LASSO) logistic regression was used to design a metabolite-based risk score. We used receiver operating characteristic (ROC) analyses to assess the discriminative performance of the metabolite-based risk score.Results: Among twelve risk-associated metabolites with a nominal P value <0.05, we defined a risk score of three metabolites [indoleacetate, 3-hydroxydecanoate (10:0-OH), and retention index (RI): 2,745.4] using LASSO. A logistic regression model containing these three metabolites, age, sex, body mass index (BMI), smoking status, sample date, fasting status, and carbohydrate antigen 19-9 (CA 19-9) yielded an internal area under curve (AUC) of 0.784 [95% confidence interval (CI): 0.714–0.854] compared to 0.681 (95% CI: 0.597–0.764) for a model without these metabolites (P value =0.007). Seventeen metabolites were significantly associated with pancreatic cancer survival [false discovery rate (FDR) <0.1].Conclusions: Indoleacetate, 3-hydroxydecanoate (10:0-OH), and RI: 2,745.4 were identified as the top candidate biomarkers for early detection. However, continued efforts are warranted to determine the usefulness of these metabolites as early pancreatic cancer biomarkers.
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| 2. |
- Borgmästars, Emmy, et al.
(författare)
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Multi-omics profiling to identify early plasma biomarkers in pre-diagnostic pancreatic ductal adenocarcinoma : a nested case-control study
- 2024
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Ingår i: Translational Oncology. - : Elsevier. - 1944-7124 .- 1936-5233. ; 48
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor survival. Novel biomarkers are urgently needed to improve the outcome through early detection. Here, we aimed to discover novel biomarkers for early PDAC detection using multi-omics profiling in pre-diagnostic plasma samples biobanked after routine health examinations.A nested case-control study within the Northern Sweden Health and Disease Study was designed. Pre-diagnostic plasma samples from 37 future PDAC patients collected within 2.3 years before diagnosis and 37 matched healthy controls were included. We analyzed metabolites using liquid chromatography mass spectrometry and gas chromatography mass spectrometry, microRNAs by HTG edgeseq, proteins by multiplex proximity extension assays, as well as three clinical biomarkers using milliplex technology. Supervised and unsupervised multi-omics integration were performed as well as univariate analyses for the different omics types and clinical biomarkers. Multiple hypothesis testing was corrected using Benjamini-Hochberg's method and a false discovery rate (FDR) below 0.1 was considered statistically significant.Carbohydrate antigen (CA) 19-9 was associated with PDAC risk (OR [95 % CI] = 3.09 [1.31–7.29], FDR = 0.03) and increased closer to PDAC diagnosis. Supervised multi-omics models resulted in poor discrimination between future PDAC cases and healthy controls with obtained accuracies between 0.429–0.500. No single metabolite, microRNA, or protein was differentially altered (FDR < 0.1) between future PDAC cases and healthy controls.CA 19-9 levels increase up to two years prior to PDAC diagnosis but extensive multi-omics analysis including metabolomics, microRNAomics and proteomics in this cohort did not identify novel early biomarkers for PDAC.
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| 3. |
- Eek-Karlsson, Liselotte, 1955-, et al.
(författare)
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Likabehandlingsarbete — en reproduktion av rådande maktordning?
- 2020
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Ingår i: Educare. - Malmö : Malmö universitet. - 1653-1868 .- 2004-5190. ; :2, s. 49-73
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Tidskriftsartikel (refereegranskat)abstract
- This project sets out to examine how schools identify their assignment to make school to a place of equality. The research questions address how efforts to counteract discrimination regarding sexual orientation, gender and ethnicity are expressed as well as what power structures that can be identified in this respect. In total, 134 documents from compulsory school in municipalities in southern, mid and northern Sweden are collected. The documents are analyzed using Kumashiro´s (2002) four perspectives to conceptualize and work against oppression. The analysis shows different ways that schools address this assignment. Differences regarding what is identified as problems seems to build different approaches in how the work against oppression becomes visible. Double strategies are described in order to both strengthen and challenge the power structure that is prevalent between the norm carrying group and the group the schools identify as marginalized.
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| 4. |
- Lundin, Mattias, Docent, 1970-
(författare)
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Heteronormativity in Swedish schools : making a difference as an LGBT teacher
- 2024
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Ingår i: Teachers and Teaching. - : Taylor & Francis Group. - 1354-0602 .- 1470-1278.
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Tidskriftsartikel (refereegranskat)abstract
- In various respects, policy has been enhanced to support lesbian, gay, bisexual, and transgender (LGBT) individuals in Sweden, with improvements extending to the school environment and the circumstances faced by LGBT teachers. Nonetheless, research emphasises that legislative measures and policy documents serve as an initial step, necessitating supplementary comprehensive efforts to address negative attitudes and implement proactive measures within educational institutions. Research suggests that intensified initiatives focusing on norms and anti-oppressive education could improve the situation of LGBT teachers. This article delves into the educational endeavour to promote diversity by analysing written narratives provided by LGBT educators. The aim is to elucidate their contributions, using a second order perspective, to challenge heteronormativity and advancing educational objectives across three distinct functions of education. The LGBT teachers’ contributions move education forward by facilitating their colleagues’ learning about LGBT identities and thereby enhancing their colleagues’ acquisition of knowledge. Moreover, these educators pointed to facilitating students’ autonomy regarding LGBT identity by demonstrating the possibility for students to define independently and be acknowledged accordingly. To conclude, by analysing the LGBT teachers’ accounts of the heterosexual norm in the educational setting, it has been possible to discern empowering dynamics in otherwise overlooked situations.
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| 5. |
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| 6. |
- Lundin, Mattias, Docent, 1970-
(författare)
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Queering the school – a story of pride and given support : Tentative analysis of belonging and inclusion for a teacher with identity as trans
- 2024
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Ingår i: Presented at The European Conference on Educational Research (ECER) 2024, Nicosia, Cyprus, August 26-27, 2024.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In many ways, Sweden can be considered as an open community with respect to LGBT people. This notion includes the school setting and LGBT teachers’ situation, although research points out that their everyday situations yet not seem to fully reflect legislation and policy documents. However, the knowledge on trans people’s situation is limited in comparison to what we know about homo- and bisexual teachers’ situation. This text focuses on a narrative from a transgender, non-binary teacher named Kim. The research explores how heteronormative elements in the educational environment impact LGBT teachers and their professional interactions. Utilizing Yuval-Davis' framework on belonging, the analysis highlights the emotional attachments and political efforts that influence Kim’s experience. Kim's narrative reveals both challenges and positive interventions, illustrating the dynamics of belonging and exclusion within the school context. The principal's proactive measures to foster inclusivity are significant, demonstrating how leadership can mitigate negative heteronormative impacts and enhance a sense of belonging for LGBT staff. This study underscores the importance of inclusive practices in schools to support both teachers and students, aligning with Swedish educational policies that emphasize equality and non-discrimination. The findings suggest that promoting a supportive social environment is crucial for the credibility and effectiveness of education on sexuality, consent, and relationships.
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| 7. |
- Lundin, Mattias, 1970-, et al.
(författare)
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Swedish Boys’ Narratives on Sexual Harassment and their Ways of Doing Masculinity
- 2024
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Ingår i: Sexuality & Culture. - : Springer. - 1095-5143 .- 1936-4822.
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Tidskriftsartikel (refereegranskat)abstract
- When #MeToo was the most intensive, many girls, women and non-binary people’s voices were heard about being exposed. Knowledge on boys’ perspectives is important as they need to be involved to provide change. In research, boys’ and men’s voices are missing unless accounted for in settings associated with violence or harassment. This project contributes knowledge about schoolboys’ positionings with respect to masculine hegemony and sexual harassment. The analysis of pair interviews with 22 participating boys, aged 14–16, suggests three ways in which they relate to the topic. With respect to the discursive patterns labelled equal boy and let-go boy, gender issues are competently expressed and these two patterns convey knowledge about the power that the gender culture exercises. These two discursive patterns also suggest a proficient way of taking the gender order into account to fit in with the peer group. Nevertheless, the third pattern, labelled the dominant boy, suggests settings when a traditional masculinity culture exercises power. We conclude that discussions on situations where different discursive patterns are overt would facilitate a shift towards gender equal discourses with less risk of sexual harassment.
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