| 1. |
|
|
| 2. |
- Hoffknecht, A, et al.
(författare)
-
Recombination of F6+ with free electrons at very low energies
- 1999
-
Ingår i: Physica Scripta. Topical Issues. ; T80B, s. 298-300
-
Tidskriftsartikel (refereegranskat)abstract
- Radiative and dielectronic recombination of F6+ have been studied at the heavy ion storage ring TSR in Heidelberg. For a detailed investigation of rate enhancement effects at very low electron-ion center-of-mass energies experimental parameters such as the magnetic guiding field, the electron density and the adiabatic expansion factor of the electron beam have been varied systematically. Whereas measurements at different electron densities show no influence on the enhancement and while a variation of the expansion factor evokes the predicted behaviour, we see an increase of the enhancement with increasing axial magnetic field between 20 mT and 70 mT.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Muller-Lissner, S A, et al.
(författare)
-
Interobserver agreement in defecography--an international study
- 1998
-
Ingår i: Zeitschrift für Gastroenterologie. - 0044-2771. ; 36:4, s. 273-279
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Defecography is considered to be an essential investigation in the evaluation of functional anorectal disorders, but the agreement between observers from different clinical centers has never been evaluated. METHODS: 14 defecographic studies were selected aimed to cover the most relevant defecographic findings responsible for disordered defecation. Eight studies were considered unequivocal, but six were thought to be controversial. All were sent to the ten participants in Europe and the US (five proctosurgeons, three radiologists, two gastroenterologists). They evaluated the studies using a previously agreed upon questionnaire. Interobserver agreement was quantified by kappa statistics and by the proportions of positive and negative agreement as compared to chance agreement, respectively. RESULTS: Overall, only the completeness of rectal emptying and the presence of a rectocele achieved acceptable kappa values above 0.4. When restricting the evaluation to the studies considered to be unequivocal, agreement improved considerably and was moderate to good for all items describing the images (kappa 0.43-0.63). However, whether proctosurgery should be performed and whether defecography contributed to the management of the particular patient remained controversial with very low kappa. CONCLUSIONS: It is doubtful whether defecography contributes substantially to the management of patients with disordered defecation.
|
|
| 6. |
|
|
| 7. |
- Gärdlund, B, et al.
(författare)
-
Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases. The Heparin Prophylaxis Study Group.
- 1996
-
Ingår i: The Lancet. - : Elsevier BV. - 0140-6736 .- 1474-547X. ; 347:9012, s. 1357-61
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Fatal pulmonary embolism and other thromboembolic complications are common in hospital inpatients. However, there is little evidence on the routine use of pharmacological thromboprophylaxis in non-surgical patients. We assessed the efficacy and safety of low-dose heparin in the prevention of hospital-acquired, clinically relevant, fatal pulmonary embolism in patients with infectious diseases.METHODS: Our study used the postrandomisation consent design. 19,751 consecutive patients, aged 55 years or older, admitted to departments of infectious diseases in six Swedish hospitals, were screened for inclusion in the randomised, controlled, unblinded, multicentre trial. Of the eligible patients, 5776 were assigned subcutaneous standard heparin (5000 IU every 12 h) until hospital discharge or for a maximum of 3 weeks; 5917 were assigned no prophylactic treatment (control group). We sought consent only from the heparin group. Follow-up was for 3 weeks after discharge from hospital or for a maximum of 60 days from randomisation. The primary endpoint was necropsy-verified pulmonary embolism of predefined clinical relevance.FINDINGS: By intention-to-treat analysis mortality was similar in the heparin and control groups (5.3 vs 5.6%, p = 0.39) and the median time from admission to death was 16 days in both groups (IQR 8-31 vs 6-28 days). Necropsy-verified pulmonary embolism occurred in 15 heparin-treated and 16 control-group patients. There was a significant difference between heparin and control groups in median time from randomisation to fatal pulmonary embolism (28 [24-36] vs 12.5 [10-20] days, p = 0.007). This difference corresponds to the duration of heparin prophylaxis. Non-fatal thromboembolic complications occurred in more of the control than of the heparin group (116 vs 70, p = 0.0012).INTERPRETATION: Our findings do not support the routine use of heparin prophylaxis for 3 weeks or less in large groups of non-surgical patients. Further studies are needed to investigate whether heparin prophylaxis of longer duration may prevent fatal pulmonary embolism.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- de Zegher, F, et al.
(författare)
-
Androgens and fetal growth
- 1998
-
Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 50:4, s. 243-244
-
Tidskriftsartikel (refereegranskat)abstract
- Boys are heavier than girls at term birth. Children with a 46,XY karyotype and androgen insensitivity syndrome (clinically complete form and/or proven mutations in the androgen receptor gene) were found to have a birth weight comparable to that of girls. These findings support the hypothesis that the difference in birth weight between boys and girls is generated by androgen action.
|
|
| 14. |
- Delarue, M., et al.
(författare)
-
Increased auxin efflux in the IAA-overproducing sur1 mutant of Arabidopsis thaliana: A mechanism for reducing auxin levels?
- 1999
-
Ingår i: Physiologia Plantarum. - : Wiley. - 0031-9317 .- 1399-3054. ; 107:1, s. 120-127
-
Tidskriftsartikel (refereegranskat)abstract
- With the aim of investigating the mechanisms that maintain auxin homeostasis in plants, we have monitored the net uptake and metabolism of exogenously supplied indole-3-acetic acid (IAA) and naphthalene-1-acetic acid (NAA) in seedlings of wild type and the IAA-overproducing mutant sur1 of Arabidopsis thaliana. Tritiated IAA and NAA entered the seedling tissues within minutes and were mostly accumulated as metabolites, probably amino acid and sugar conjugates, The mutant seedlings were marked by a strong increase of [H-3]IAA metabolism and a reduction of the accumulation levels of both free [H-3]IAA and [H-3]NAA. The same characteristics were observed in wild-type seedlings grown on 5 mu M picloram. We measured [H-3]NAA uptake in the presence of high concentrations of unlabeled NAA or the auxin efflux carrier inhibitor naphthylphthalamic acid (NPA). This abolished the difference in free [H-3]NAA accumulation between the mutant or picloram-treated seedlings and wild-type seedlings. These data indicated that active auxin efflux carriers were present in Arabidopsis seedling tissues. Picloram-treated seedlings and seedlings of the IAA-overproducing mutant sur1 displayed increased auxin efflux carrier activity as well as elevated conjugation of IAA. There is previous evidence to suggest that conjugation is a means to remove excess IAA in plant cells. Here, we discuss the possibility of efflux constituting an additional mechanism for regulating free IAA levels in the face of an excess auxin supply.
|
|
| 15. |
- Engelmann, U, et al.
(författare)
-
Experiences with the German teleradiology system MEDICUS
- 1997
-
Ingår i: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. - 0169-2607. ; 54:1-2, s. 131-139
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper introduces the teleradiology system, MEDICUS, which has been developed at the Deutsches Krebsforschungszentrum (German Cancer Research Center) in Heidelberg, Germany. The system is designed to work on ISDN lines as well as in a local area netwo
|
|
| 16. |
- Engelmann U. Schröter A, Baur U, Werner O, Göransson B, Borälv E, Schwab M, Müller H, Bahner M, Meinzer HP.
(författare)
-
Experiences with the German teleradiology system MEDICUS
- 1998
-
Ingår i: Yearbook of Medical Informatics '98 - Health Informatics and the Internet. - : Stuttgart: Schattauer. ; , s. 199-207
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- JUUL, A, et al.
(författare)
-
Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation
- 1995
-
Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 80:8, s. 2534-2542
-
Tidskriftsartikel (refereegranskat)
|
|
| 22. |
- Lagerros, JSV, et al.
(författare)
-
ISOPHOT polarization measurements of the asteroids (6) Hebe and (9) Metis at 25 mu m
- 1999
-
Ingår i: ICARUS. - : ACADEMIC PRESS INC. - 0019-1035. ; 142:2, s. 454-463
-
Tidskriftsartikel (refereegranskat)abstract
- The subsurface thermal IR emission of asteroids becomes linearly polarized when scattered across the surface, The disk integrated mid-IR Stokes parameters are computed by extending the new thermophysical model by Lagerros (1996, Astron. Astrophys. 315, 62
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
|
|
| 26. |
|
|
| 27. |
- Olofsson, A M, et al.
(författare)
-
Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis
- 1999
-
Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 104:7, s. 885-894
-
Tidskriftsartikel (refereegranskat)abstract
- Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Affinity isolation and enzymatic degradation demonstrated that HBP released from human neutrophils binds to endothelial cell-surface proteoglycans, such as syndecans and glypican. Flow cytometry indicated that a significant fraction of proteoglycan-bound HBP is taken up by the endothelial cells, and we used radiolabeled HBP to determine the internalization rate of surface-bound HBP. Confocal and electron microscopy revealed that internalized HBP is targeted to perinuclear compartments of endothelial cells, where it colocalizes with mitochondria. Western blotting of isolated mitochondria from HBP-treated endothelial cells showed that HBP is present in 2 forms - 28 and 22 kDa. Internalized HBP markedly reduced growth factor deprivation-induced caspase-3 activation and protected endothelial cells from apoptosis, suggesting that uptake and intracellular routing of exogenous HBP to mitochondria contributes to the sustained viability of endothelial cells in the context of locally activated neutrophils.
|
|
| 28. |
- Ristow, M, et al.
(författare)
-
Deficiency of phosphofructo-1-kinase/muscle subtype in humans is associated with impairment of insulin secretory oscillations
- 1999
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 48:8, s. 1557-1561
-
Tidskriftsartikel (refereegranskat)abstract
- In healthy humans, insulin is secreted in an oscillatory manner. While the underlying mechanisms generating these oscillations are not fully established, increasing evidence suggests a central role for phosphofructo-1-kinase/muscle subtype (PFK1-M), which also serves as the predominantly active PFK1 subtype in the pancreatic beta-cell. The fact that normal oscillatory secretion is impaired in subjects with impaired glucose tolerance and healthy relatives of patients with type 2 diabetes suggests that this defect may be involved in the secretory dysfunction. To evaluate a possible link between inherited PFK1-M deficiency in humans (Tarui's disease or glycogenosis type VII) and altered insulin oscillations, in vivo studies were performed. We determined basal insulin oscillations during 2 h of frequent plasma sampling in two related teen-aged individuals with homozygous and heterozygous PFK1-M deficiency compared with nondeficient, unrelated control subjects. As predicted by the underlying hypothesis, normal oscillations in insulin secretion were completely abolished in the individual with homozygous deficiency of PFK1-M and significantly impaired in the heterozygous individual, as shown by spectral density and autocorrelation analyses. Thus, deficiency of PFK1-M subtype in humans appears to be associated with an impaired oscillatory insulin secretion pattern and may contribute to the commonly observed secretion defects occurring in type 2 diabetes.
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
|
|
| 34. |
- THOMSEN, JW, et al.
(författare)
-
ORBITAL ALIGNMENT DEPENDENCE OF ELECTRON-TRANSFER CROSS-SECTIONS .2. 1-15-KEV HE+ NA(3P) COLLISIONS
- 1995
-
Ingår i: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - : IOP PUBLISHING LTD. ; 28:4
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This letter reports experimental results for the influence of target excitation and orbital alignment on the electron transfer process for the He+-Na(3s,3p) collision. The impact energy range is 1-15 keV in which the electron transfer cross sections have
|
|
| 35. |
|
|
| 36. |
|
|
| 37. |
|
|
