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Träfflista för sökning "WFRF:(Macintyre E) srt2:(2010-2014)"

Sökning: WFRF:(Macintyre E) > (2010-2014)

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  • Langerak, A. W., et al. (författare)
  • EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
  • 2012
  • Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 26:10, s. 2159-2171
  • Forskningsöversikt (refereegranskat)abstract
    • PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations.
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  • MacIntyre, Sally, et al. (författare)
  • Buoyancy flux, turbulence, and the gas transfer coefficient in a stratified lake
  • 2010
  • Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 37:L24604
  • Tidskriftsartikel (refereegranskat)abstract
    • Gas fluxes from lakes and other stratified water bodies, computed using conservative values of the gas transfer coefficient k600, have been shown to be a significant component of the carbon cycle. We present a mechanistic analysis of the dominant physical processes modifying k600 in a stratified lake and resulting new models of k600 whose use will enable improved computation of carbon fluxes. Using eddy covariance results, we demonstrate that i) higher values of k600 occur during low to moderate winds with surface cooling than with surface heating; ii) under overnight low wind conditions k600 depends on buoyancy flux β rather than wind speed; iii) the meteorological conditions at the time of measurement and the inertia within the lake determine k600; and iv) eddy covariance estimates of k600 compare well with predictions of k600 using a surface renewal model based on wind speed and β.
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  • Resultat 1-14 av 14

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