| 1. |
- Berndt, Sonja I., et al.
(författare)
-
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
-
Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
|
|
| 2. |
- Ergawy, Amr, et al.
(författare)
-
Device discovery for the PalCom pervasive middleware with eliminated cross-networks periodic heart-beat messages
- 2014
-
Ingår i: Procedia Computer Science. - : Elsevier BV. - 1877-0509. ; 37, s. 64-71
-
Konferensbidrag (refereegranskat)abstract
- Service discovery is central in pervasive middleware systems, built on top of the communication substrate using the more fundamental mechanisms for device discovery. In mobile pervasive systems devices come and go, and switch network frequently, demanding support for device discovery across heterogeneous networks. We present the design of a device discovery mechanism for the PalCom middleware that eliminates the need for cross-network periodic keep-alive messages while still supporting timely detection of missing devices, i.e. undiscovery. The design has been implemented and is evaluated against the simplistic approach of flooding the inter-connected networks with keep-alive messages. (C) 2014 The Authors. Published by Elsevier B.V.
|
|
| 3. |
- Ergawy, Amr, et al.
(författare)
-
Media Abstraction Framework for the Pervasive Middleware PalCom
- 2014
-
Ingår i: [Host publication title missing]. ; , s. 68-75
-
Konferensbidrag (refereegranskat)abstract
- Pervasive middleware systems are important for enabling the configuration and coordination of the services provided by devices in pervasive environments. PalCom is an example of such a system that aims to enable interaction among pervasive services over heterogeneous networks. In this paper we discuss the need for providing networking-media independent messaging among pervasive devices, and identify the problem of designing a media abstraction framework for a pervasive middleware. We identify a number of design principles and features that need to be satisfied by such a framework. The most important of these principles is the separation of networking protocol aspects into abstraction representations, which are exposed in a unified format to upper layers of PalCom, and communication mechanisms which are hidden by media-specific implementations of our proposed media-abstraction framework for PalCom. Also, we explain our implementation and evaluation of that framework.
|
|
| 4. |
- Magnusson, Boris, et al.
(författare)
-
Some Like It Hot - Automating an Electric Kettle Using Palcom
- 2013
-
Ingår i: [Host publication title missing]. - New York, NY, USA : ACM. - 9781450322157 ; , s. 63-66
-
Konferensbidrag (refereegranskat)abstract
- In this demo we will show how devices from different vendors, using different protocols, can be combined and made to work together without detailed low-level programming by the user. The small example we have chosen uses a radio-controlled power socket from one vendor and a temperature sensor from another vendor. We use these to create a remotely controlled electric kettle, which keeps the water at the point of boiling, ready to make tea at any time. We also show how we very easy can use a mobile phone for remote control and monitoring of the kettle. It is all built with a simple-to-use graphical user interface offered by the PalCom middleware, and will be modified as part of the demo.
|
|
| 5. |
- Magnusson, Boris
(författare)
-
Support for User Control in Palcom
- 2011
-
Konferensbidrag (refereegranskat)abstract
- In this position paper we give an outline of the Palcom platform for pervasive computing and some of the design issues. With this as a background we initiate a discussion of the balance between the user being in control, and the system behaving in a helpful way.
|
|
| 6. |
- Magnusson, Boris
(författare)
-
Supporting Intelligibility in a Healthcare scenario using Palcom
- 2012
-
Konferensbidrag (refereegranskat)abstract
- In this paper we describe a scenario for supporting healthcare at home and identify some demands for intelligibility in this situation. In such a system we have identified a need for flexible adding and removing medical devices, and to support changing functionality depending on if a nurse is present or not. We suggest that this kind of variability can be addressed by introducing guards in our rule based formulation. and sketch a way it can be solved. The scenario we describe comes from an ongoing project in developing support
|
|
| 7. |
- Sandholm, Thomas, et al.
(författare)
-
An On-Demand WebRTC and IoT Device Tunneling Service for Hospitals
- 2014
-
Ingår i: [Host publication title missing]. - 9781479943579 ; , s. 53-60
-
Konferensbidrag (refereegranskat)abstract
- In this paper we present the implementation of a WebRTC gateway service that can forward ad-hoc RTP data plane traffic from a browser inside a local hospital network to a browser on a local home network. The gateway leverages the same infrastructure used by the hospital to tunnel sensor and control data for medical devices in home-care deployments. In our use case, doctors at hospitals can only access port 80 through the hospital firewall on external machines, and they need to communicate with patients who are typically behind a NAT in a local WiFi network. VPN solutions only work for staff but not between patients and staff. Our solution solves this problem by redirecting all WebRTC traffic through a gateway service on the local network that has a secure tunnel established with a public gateway. The public gateway redirects traffic from multiple concurrent streams securely between local gateway services that connect to it. The local gateways also communicate with browsers on their local network to mimic a direct browser-to-browser connection without having to change the browser runtime. We have demonstrated that this technique works well within the hospital network and arbitrary patient networks, without the need for any individual host configuration. In our evaluation we show that the latency overhead is 18-20 ms for each concurrent stream added to the same gateway service, which is not discernible with a naked eye until you have more than 10 concurrent streams.
|
|
| 8. |
|
|
| 9. |
- Åkesson, Linus, et al.
(författare)
-
Instance-aware assemblies of services in pervasive computing
- 2012
-
Ingår i: [Host publication title missing]. ; , s. 1554-1556
-
Konferensbidrag (refereegranskat)abstract
- With computers embedded almost everywhere, in domestic, industrial, and medical appliances and devices, computing is becoming increasingly pervasive. Services in pervasive systems can be combined and coordinated through user-defined scripts called assemblies, a light-weight and understandable way for end users to adapt services to fit their specific needs. Previous languages for assembly scripts focus on programming by example, using very simple scripting languages. We propose the addition of abstraction mechanisms to support multiple instances of conversations, connections and assembly configurations. The proposed extensions are motivated by example scenarios requiring the added power of expression. A language, compiler and run-time environment have been implemented and experimentally verified in a service robotics application.
|
|
