| 1. |
- Acciari, V. A., et al.
(författare)
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Radio Imaging of the Very-High-Energy gamma-Ray Emission Region in the Central Engine of a Radio Galaxy
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 325:5939, s. 444-448
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Tidskriftsartikel (refereegranskat)abstract
- The accretion of matter onto a massive black hole is believed to feed the relativistic plasma jets found in many active galactic nuclei (AGN). Although some AGN accelerate particles to energies exceeding 10(12) electron volts and are bright sources of very-high-energy (VHE) gamma-ray emission, it is not yet known where the VHE emission originates. Here we report on radio and VHE observations of the radio galaxy Messier 87, revealing a period of extremely strong VHE gamma-ray flares accompanied by a strong increase of the radio flux from its nucleus. These results imply that charged particles are accelerated to very high energies in the immediate vicinity of the black hole.
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| 2. |
- Adolph, C, et al.
(författare)
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Measurement of the eta -> 3 pi(0) Dalitz plot distribution with the WASA detector at COSY
- 2009
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 677:1-2, s. 24-29
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Tidskriftsartikel (refereegranskat)abstract
- In the first production run of the WASA experiment at COSY, the eta decay into three neutral pions was measured in proton-proton interactions at a proton beam kinetic energy of 1.4 GeV. The Dalitz plot of the three pious was Studied using 1.2 x 10(5) fully reconstructed events. and the quadratic slope parameter alpha was determined to be -0.027 +/- 0.008(stat) +/- 0.005(syst). The result is consistent with previous measurements and further corroborates the importance of pion-pion final state interactions. (C) 2009 Elsevier B.V. All rights reserved.
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| 3. |
- Oellers, D., et al.
(författare)
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Polarizing a stored proton beam by spin flip?
- 2009
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 674:4-5, s. 269-275
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Tidskriftsartikel (refereegranskat)abstract
- We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin-flip cross section in low-energy electron–proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam.
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| 4. |
- Ng, M Y M, et al.
(författare)
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Meta-analysis of 32 genome-wide linkage studies of schizophrenia
- 2009
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 14:8, s. 774-785
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Tidskriftsartikel (refereegranskat)abstract
- A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P(SR)) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for 'aggregate' genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.
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| 5. |
- Maierbeck, P., et al.
(författare)
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Structure of 55Ti from relativistic one-neutron knockout
- 2009
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693. ; 675:1, s. 22-27
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Tidskriftsartikel (refereegranskat)abstract
- Results are presented from a one-neutron knockout reaction at relativistic energies on 56Ti using the GSI FRS as a two-stage magnetic spectrometer and the Miniball array for gamma-ray detection. Inclusive and exclusive longitudinal momentum distributions and cross-sections were measured enabling the determination of the orbital angular momentum of the populated states. First-time observation of the 955(6) keV -hole state in 55Ti is reported. The measured data for the first time proves that the ground state of 55Ti is a 1/2- state, in agreement with shell-model calculations using the GXPF1A interaction that predict a sizable N=34 gap in 54Ca.
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| 6. |
- Al-Dahan, N., et al.
(författare)
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Nuclear Structure "Southeast" of 208Pb: Isomeric states in 208Hg and 209Tl
- 2009
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:6
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Tidskriftsartikel (refereegranskat)abstract
- The nuclear structure of neutron-rich N>126 nuclei has been investigated following their production via relativistic projectile fragmentation of a E/A=1 GeV U-238 beam. Metastable states in the N=128 isotones Hg-208 and Tl-209 have been identified. Delayed gamma-ray transitions are interpreted as arising from the decay of I-pi=(8(+)) and (17/2(+)) isomers, respectively. The data allow for the so far most comprehensive verification of the shell-model approach in the region determined by magic numbers Z < 82 and N>126.
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| 7. |
- Maierbeck, P., et al.
(författare)
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Probing the single particle structure around Ca-54 with one-neutron knock-out
- 2008
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Ingår i: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 89-93
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Konferensbidrag (refereegranskat)abstract
- The nuclei Ca-47 and Ti-55 were populated in one-neutron knock-out reactions at relativistic energies. Momentum distributions of the residual nuclei as well as gamma-ray spectra were measured at the GSI fragment separator (FRS). Preliminary results of the ongoing analysis including cross sections and spin/parity assignments are presented.
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| 8. |
- Podolyak, Zs., et al.
(författare)
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Structure of Neutron-rich Nuclei Around the N=126 Closed Shell; the Yrast Structure of 205Au up to Spin-parity I = (19/2+)
- 2009
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 42:3, s. 489-493
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Konferensbidrag (refereegranskat)abstract
- Heavy neutron-rich nuclei have been populated through the relativistic fragmentation of a Pb-208(82) beam at E/A = 1 GeV on a 2.5 g/cm(2) thick Be target. The synthesised nuclei were selected and identified in-flight using the fragment separator at GSI. Approximately 300 ns after production, the selected nuclei were implanted in an similar to 8 mm thick perspex stopper, positioned at the centre of the RISING gamma-ray detector spectrometer array. A previously unreported isomer with a half-life T-1/2 = 163(5) ns has been observed in the N = 126 closed-shell nucleus Au-205(79). Through gamma-ray singles and gamma-gamma coincidence analysis a level scheme was established. The comparison with a shell model calculation tentatively identifies the spin-parity of the excited states, including the isomer itself, which is found to be I-pi = (19/2(+)).
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| 9. |
- Steer, S. J., et al.
(författare)
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Isomeric Decay Studies In Neutron-Rich N Approximate To 126 Nuclei
- 2009
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Ingår i: International Journal Of Modern Physics E-Nuclear Physics. - 0218-3013. ; 18:4, s. 1002-1007
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Konferensbidrag (refereegranskat)abstract
- Heavy neutron-rich nuclei were populated via relativistic energy fragmentation of a E/A= 1 GeV Pb-208 beam. The nuclei of interest were selected and identified by a fragment separator and then implanted in a passive plastic stopper. Delayed. rays following internal isomeric decays were detected by the RISING array. Experimental information was obtained on a number of nuclei with Z=73-80 (Ta-Hg), providing new information both on the prolate-oblate transitional region as well as on the N=126 closed shell nuclei.
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| 10. |
- Steer, S. J., et al.
(författare)
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Single-particle Behavior at N=126: Isomeric Decays in Neutron-rich 204Pt
- 2008
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 78:6
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Tidskriftsartikel (refereegranskat)abstract
- The four proton-hole nucleus Pt-204 was populated in the fragmentation of an E/A = 1 GeV Pb-208 beam. The yrast structure of Pt-204 has been observed up to angular momentum I = 10h by detecting delayed gamma-ray transitions originating from metastable states. These long-lived excited states have been identified to have spin-parities of I-pi = (10(+)), (7(-)), and (5(-)) and half-lives of T-1/2 = 146(14) ns, 55(3) mu s, and 5.5(7) mu s, respectively. The structure of the magic N = 126 Pt-204 nucleus is discussed and understood in terms of the spherical shell model. The data suggest a revision of the two-body interaction for N = 126, Z < 82, which determines the evolution of nuclear structure toward the r-process waiting point nuclei.
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| 11. |
- Podolyak, Zs., et al.
(författare)
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Proton-hole excitation in the closed shell nucleus Au-205
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 672:2, s. 116-119
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Tidskriftsartikel (refereegranskat)abstract
- The neutron-rich N = 126 nucleus Au-205 has been populated following the relativistic energy projectile fragmentation of E/A = 1 GeV Pb-208, and studied via charged-particle decay spectroscopy. An internal decay with a transition energy of 907(5) keV and a half-life of T-1/2 = 6(2) s has been identified through the observation of the corresponding K and L internal conversion electron lines. The 907 keV energy level corresponds to the pi h(11/2)(-1) proton-hole state and decays both internally into the pi d(3/2)(-1) ground-state and via beta decay into Hg-205. The obtained data provides information on the evolution of single-proton hole energies which are vital inputs of shell model descriptions for nuclei around the Pb-208(82)126 doubly magic core. (C) 2009 Elsevier B.V. All rights reserved.
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| 12. |
- Gorska, M., et al.
(författare)
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Nuclear Structure Addressed At GSI/RISING
- 2009
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Ingår i: International Journal Of Modern Physics E - Nuclear Physics. - 0218-3013. ; 18:4, s. 759-766
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Konferensbidrag (refereegranskat)abstract
- Nuclear structure spectroscopy studies at GSI recently gained increased momentum within a broad international community with the installation of the Rare Isotopes Spectroscopic INvestigation at GSI (RISING) project. A wide range of physical phenomena has been addressed by high-resolution in-beam gamma-ray spectroscopy experiments with radioactive beams. Relativistic radioactive beams are implanted and their subsequent. and beta decay is investigated. Within this "stopped beam campaign" germanium detectors were arranged in a close geometry around the passive stopper or an array of DSSSD detectors. The exceptionally high gamma-ray efficiency of that configuration made it possible to identify decays of excited or ground states of nuclei which have not been observed before. The results discussed here include the astrophysically relevant shell structure of N=82 isotones, N=Z nuclei around Ni-54, and proton drip-line nuclei below Sn-100. The experimental data are compared to the results of large scale shell-model calculations using various sets of realistic residual two-body interaction.
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| 13. |
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| 14. |
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| 15. |
- Hauser, J, et al.
(författare)
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Effects of prenatal dexamethasone treatment on physical growth, pituitary-adrenal hormones, and performance of motor, motivational, and cognitive tasks in juvenile and adolescent common marmoset monkeys
- 2008
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Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 149:12, s. 6343-6355
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Tidskriftsartikel (refereegranskat)abstract
- Synthetic glucocorticoids such as dexamethasone (DEX) are commonly used to prevent respiratory distress syndrome in preterm infants, but there is emerging evidence of subsequent neurobehavioral abnormalities (e.g. problems with inattention/hyperactivity). In the present study, we exposed pregnant common marmosets (Callithrix jacchus, primates) to daily repeated DEX (5 mg/kg by mouth) during either early (d 42–48) or late (d 90–96) pregnancy (gestation period of 144 days). Relative to control, and with a longitudinal design, we investigated DEX effects in offspring in terms of physical growth, plasma ACTH and cortisol titers, social and maintenance behaviors, skilled motor reaching, motivation for palatable reward, and learning between infancy and adolescence. Early DEX resulted in reduced sociability in infants and increased motivation for palatable reward in adolescents. Late DEX resulted in a mild transient increase in knee-heel length in infants and enhanced reversal learning of stimulus-reward association in adolescents. There was no effect of either early or late DEX on basal plasma ACTH or cortisol titers. Both treatments resulted in impaired skilled motor reaching in juveniles, which attenuated in early DEX but persisted in late DEX across test sessions. The increased palatable-reward motivation and decreased social motivation observed in early DEX subjects provide experimental support for the clinical reports that prenatal glucocorticoid treatment impairs social development and predisposes to metabolic syndrome. These novel primate findings indicate that fetal glucocorticoid overexposure can lead to abnormal development of motor, affective, and cognitive behaviors. Importantly, the outcome is highly dependent upon the timing of glucocorticoid overexposure.
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| 16. |
- Matthews, G. F., et al.
(författare)
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Overview of the ITER-like wall project
- 2007
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; T128, s. 137-143
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Tidskriftsartikel (refereegranskat)abstract
- Work is in progress to completely replace, in 2008/9, the existing JET CFC tiles with a configuration of plasma facing materials consistent with the ITER design. The ITER-like wall (ILW) will be created with a combination of beryllium ( Be), tungsten ( W), W-coated CFC and Be-coated inconel tiles, with the material depending on the local anticipated heat flux and geometry. It is part of an integrated package of JET enhancements whose aim is to develop an understanding of the ITER materials issues and develop the techniques required to operate with inductive and advanced scenarios as close as possible to ITER parameters. Over 4000 tiles will be replaced and the ILW will accommodate additional heating up to at least 50 MW for 10 s. This paper describes the scientific background to the project, the technical objectives, the material configuration selected, the R&D behind the practical realization of the objectives and the generic problems associated with the Be tiles ( power handling capacity and disruption induced eddy currents). One of the objectives is to maintain or improve the existing CFC tile power handling performance which has been achieved in most cases by hiding bolt holes, optimizing tile size and profile and introducing castellations on plasma facing surfaces.
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| 17. |
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| 18. |
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| 19. |
- Lacroix, Brigitte, 1978-, et al.
(författare)
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A Pharmacodynamic Markov Mixed-Effects Model for Determining the Effect of Exposure to Certolizumab Pegol on the ACR20 Score in Patients With Rheumatoid Arthritis
- 2009
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Ingår i: Clinical Pharmacology and Therapeutics. - : Nature Publishing Group. - 0009-9236 .- 1532-6535. ; 86:4, s. 387-395
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Tidskriftsartikel (refereegranskat)abstract
- The American College of Rheumatology 20% preliminary definition of improvement of rheumatoid arthritis (ACR20) is widely used in clinical trials to assess response to treatment. The objective of this analysis was to develop an exposure-response model of ACR20 in subjects treated with certolizumab pegol, and to predict clinical outcome following various treatment schedules. At each visit, subjects were classified as being ACR20 responders, ACR20 non-responders, or having dropped out. A Markov mixed-effect model was developed to investigate the drug effect on the transitions between the 3 defined states. Increasing certolizumab pegol exposure predicted an increasing probability of becoming a responder and remaining a responder, as well as a reduced probability of dropping out of treatment. Simulations of the ACR20 response rate support dosing regimens of 400 mg at weeks 0, 2 and 4 followed by 200 mg every 2 weeks, or alternative maintenance regimen of 400 mg every 4 weeks.
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| 20. |
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