Sökning: WFRF:(Mandal Tanushree)
> (2023) >
Continuous ex vivo ...
Continuous ex vivo glucose sensing in human physiological fluids using an enzymatic sensor in a vein replica
-
- Psotta, Carolin (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Aptusens AB, S-29394 Kyrkhult, Sweden.
-
- Cirovic, Stefan (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
-
- Gudmundsson, Petri (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
-
visa fler...
-
- Falk, Magnus (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
-
- Mandal, Tanushree (författare)
- Univ Galway, Sch Chem & Ryan Inst, Univ Rd, Galway, Ireland.
-
- Reichhart, Thomas (författare)
- Univ Nat Resources & Life Sci, Dept Food Sci & Technol, BOKU, A-1190 Vienna, Austria.;DirectSens Biosensors GmbH, A-3400 Klosterneuburg, Austria.
-
- Leech, Donal (författare)
- Univ Galway, Sch Chem & Ryan Inst, Univ Rd, Galway, Ireland.
-
- Ludwig, Roland (författare)
- Univ Nat Resources & Life Sci, Dept Food Sci & Technol, BOKU, A-1190 Vienna, Austria.;DirectSens Biosensors GmbH, A-3400 Klosterneuburg, Austria.
-
- Kittel, Roman (författare)
- Univ Nat Resources & Life Sci, Dept Food Sci & Technol, BOKU, A-1190 Vienna, Austria.
-
- Schuhmann, Wolfgang (författare)
- Ruhr Univ Bochum, Fac Chem & Biochem, Analyt Chem Ctr Electrochem Sci, D-44780 Bochum, Germany.
-
- Shleev, Sergey (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Aptusens AB, S-29394 Kyrkhult, Sweden.
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
-
Ingår i: Bioelectrochemistry. - : Elsevier. - 1567-5394 .- 1878-562X. ; 152
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://mau.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Managing blood glucose can affect important clinical outcomes during the intraoperative phase of surgery. However, currently available instruments for glucose monitoring during surgery are few and not optimized for the specific application. Here we report an attempt to exploit an enzymatic sensor in a vein replica that could continuously monitor glucose level in an authentic human bloodstream. First, detailed investigations of the superficial venous systems of volunteers were carried out using ocular and palpating examinations, as well as advanced ultrasound measurements. Second, a tubular glucose-sensitive biosensor mimicking a venous system was designed and tested. Almost ideal linear dependence of current output on glucose concentration in phosphate buffer saline was obtained in the range 2.2-22.0 mM, whereas the dependence in human plasma was less linear. Finally, the developed biosensor was investigated in whole blood under homeostatic conditions. A specific correlation was found between the current output and glucose concentration at the initial stage of the biodevice operation. However, with time, blood coagulation during measurements negatively affected the performance of the biodevice. When the experimental results were remodeled to predict the response without the influence of blood coagulation, the sensor output closely followed the blood glucose level.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Continuous glucose sensing
- Enzymatic sensor
- Vein replica
- Human physiological fluids
- Surgery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Psotta, Carolin
-
Cirovic, Stefan
-
Gudmundsson, Pet ...
-
Falk, Magnus
-
Mandal, Tanushre ...
-
Reichhart, Thoma ...
-
visa fler...
-
Leech, Donal
-
Ludwig, Roland
-
Kittel, Roman
-
Schuhmann, Wolfg ...
-
Shleev, Sergey
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Bioelectrochemis ...
- Av lärosätet
-
Malmö universitet