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Sökning: WFRF:(Markides K) > (2002)

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  • Bergström, Sara K., et al. (författare)
  • On-line coupling of microdialysis to packed capillary column liquid chromatography-tandem mass spectrometry demonstrated by measurement of free concentrations of ropivacaine and metabolite from spiked plasma samples
  • 2002
  • Ingår i: Journal of chromatography. B. - 1570-0232 .- 1873-376X. ; 775:1, s. 79-87
  • Tidskriftsartikel (refereegranskat)abstract
    • An on-line coupling of microdialysis to a packed capillary column switching liquid chromatographic system (0.2 mm I.D.) and mass spectrometric detection was developed. The microdialysates were collected in the loop of the first of three valves, coupled in direct series. A deuterated internal standard was added on-line by the middle valve and the third valve operated both a pre-column, for desalting of the physiological buffer used in the sampling procedure, and a separation column. The on-line system was used to study free concentrations of ropivacaine and its metabolite (PPX) in human plasma samples. The analytes were detected by electrospray ionization in a tandem mass spectrometer operating in multiple reaction monitoring mode. The free fractions of ropivacaine (200 nM total concentration) and PPX (20 nM total concentration) in spiked plasma samples were 12±3 and 47±5% (±standard deviation for day-to-day variations, n=3), respectively.
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  • Koivisto, P., et al. (författare)
  • Separation of L-DOPA and four metabolites in plasma using a porous graphitic carbon column in capillary liquid chromatography
  • 2002
  • Ingår i: Chromatographia. - 0009-5893 .- 1612-1112. ; 55:1-2, s. 39-42
  • Tidskriftsartikel (refereegranskat)abstract
    • Porous graphitic carbon has been successfully used for the separation of L-DOPA and four metabolites (dopamine, 3,4-dihydroxy-phenyl-acetic acid, homovanillic acid and 3-O-methyl-L-DOPA) and with a volatile mobile phase of relatively high percentage organic modifier (methanol-ammonium formate pH 2.9, 60∶40, v/v). The substances were analysed in plasma. Ultrafiltration was used to remove the proteins from the sample and a coupled column system to enrich and perform on-line sample clean up. Both precolumn and separation column of i. d. 0.2 mm were packed with porous graphitic carbon.
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  • Resultat 1-13 av 13

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