| 1. |
- Avent, Neil D., et al.
(författare)
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The Bloodgen Project of the European Union, 2003-2009
- 2009
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Ingår i: Transfusion Medicine and Hemotherapy. - : S. Karger AG. - 1660-3818 .- 1660-3796. ; 36:3, s. 162-167
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Forskningsöversikt (refereegranskat)abstract
- The Bloodgen project was funded by the European Commission between 2003 and 2006, and involved academic blood centres, universities, and Progenika Biopharma S. A., a commercial supplier of genotyping platforms that incorporate glass arrays. The project has led to the development of a commercially available product, BLOODchip, that can be used to comprehensively genotype an individual for all clinically significant blood groups. The intention of making this system available is that blood services and perhaps even hospital blood banks would be able to obtain extended information concerning the blood group of routine blood donors and vulnerable patient groups. This may be of significant use in the current management of multi-transfused patients who become alloimmunised due to incomplete matching of blood groups. In the future it can be envisaged that better matching of donor-patient blood could be achieved by comprehensive genotyping of every blood donor, especially regular ones. This situation could even be extended to genotyping every individual at birth, which may prove to have significant long-term health economic benefits as it may be coupled with detection of inborn errors of metabolism.
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| 3. |
- Castillo, Luisa Eugenia, et al.
(författare)
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Water quality and macroinvertebrate community response following pesticide applications in a banana plantation, Limon, Costa Rica
- 2006
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 367:1, s. 418-432
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Tidskriftsartikel (refereegranskat)abstract
- Pesticides used in banana production may enter watercourses and pose ecological risks for aquatic ecosystems. The occurrence and effects of pesticides in a stream draining a banana plantation was evaluated using chemical characterization, toxicity testing and macrobenthic community composition. All nematicides studied were detected in the surface waters of the banana plantation during application periods, with peak concentrations following applications. Toxicity tests were limited to the carbofuran application and no toxicity was observed with the acute tests used. However, since pesticide concentrations were generally below the lowest LC50 value for crustaceans but above calculated aquatic quality criteria, there remains a risk of chronic toxicity. Accurate ecological assessments of pesticide use in banana plantations are currently limited by the lack of local short-term chronic toxicity tests and tests using sensitive native species. Relatively constant levels of four pesticides (imazalil, thiabendazole, chlorpyrifos and propiconazole), which had toxic effects according to the 96h hydra and 21d daphnia chronic test, were recorded in the effluent of the packing plant throughout the study, indicating that the solid waste trap used in this facility was not effective in eliminating toxic chemicals. Certain taxa, such as Heterelmis sp. (Elmidae), Heteragrion sp. (Megapodagrionidae, Odonata), Caenis sp. (Caenidae, Ephemerotera), and Smicridea sp. (Hidropsychidae, Trichoptera), were more abundant at reference sites than in the banana farm waters, and may be good candidates for toxicity testing. Multivariate analyses of the macroinvertebrate communities clearly showed that the banana plantation sites were significantly different from the reference sites. Moreover, following the pesticide applications, all the banana plantation sites showed significant changes in community composition, with the same genera being affected at all sites and for all pesticides (terbufas, cadusafos and carbofuran). Consequently, the results presented here show that multivariate analysis of community composition was more sensitive in distinguishing pesticide effects than the toxicity tests and richness and composition measures used. We conclude that monitoring macroinvertebrate communities can be a powerful tool in the assessment of ecological effects of banana production.
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| 4. |
- Larson, Keith W., et al.
(författare)
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Wintering Black Terns Foraging Among Manta Rays in Coastal Guerrero, Mexico
- 2007
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Ingår i: Waterbirds (De Leon Springs, Fla.). - 1524-4695 .- 1938-5390. ; 30:3, s. 448-449
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Tidskriftsartikel (refereegranskat)abstract
- Winter observations of Black Terns (Chlidonias niger) in Mexico are rare. On 19 January 2007, we observed over 3,000 Black Terns foraging among hundreds of breaching manta rays one kilometer offshore on the coast of Guerrero, Mexico.
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| 8. |
- Martínez, Eduardo, et al.
(författare)
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Noncollinear magnetism caused by intermixing at ferromagnetic/antiferromagnetic interfaces
- 2006
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 74:18, s. 184435-
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Tidskriftsartikel (refereegranskat)abstract
- Fe-Cr alloy layers on Fe(001) substrates with different atomic environments are theoretically investigated through a self-consistent real-space tight-binding method parametrized to density functional theory and without collinear restriction for the spin directions. We show that the intermixing at the Cr/Fe interface, experimentally observed at the first stages of the Cr growth on Fe, originates noncollinear magnetic arrangements within the system and even induces magnetic walls in the Fe layer with a magnetic domain close to the interface. A different behavior is shown if steps are present at the interface; i.e., noncollinear magnetism becomes more localized and the induced magnetic wall in Fe vanishes.
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| 11. |
- Martínez-Galván, Eduardo, et al.
(författare)
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Heat transfer and film thickness measurements in a closed loop spray cooling system with R134a
- 2009
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Ingår i: 15th International Workshop on Thermal Investigations of ICs and Systems, THERMINIC 2009. - : Academic Conferences Publishing. - 9782355000102 ; , s. 180-185
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Konferensbidrag (refereegranskat)abstract
- Experimental measurements in a spray cooling test rig have been carried out for different heat fluxes in the heater and different volumetric spray fluxes of the refrigerant. Results of the thermal parameters and the sprayed refrigerant liquid film thickness over the heater are presented. The film thickness measurements have been made with a high speed camera equipped with a long distance microscope. It has been found that there is a relation between the variation of the heat transfer coefficient and the film thickness along the spray boiling curve.
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| 12. |
- Mastroiacovo, Pierpaolo, et al.
(författare)
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Gastroschisis and associated defects : an international study
- 2007
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Ingår i: American Journal of Medical Genetics, Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 143A:7, s. 660-671
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Tidskriftsartikel (refereegranskat)abstract
- Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.
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