| 1. |
- Bryois, J., et al.
(författare)
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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
- 2020
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
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| 2. |
- Landström, Daniel, et al.
(författare)
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Time and frequency offset estimation in OFDM systems employing pulse shaping
- 1997
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Ingår i: Bridging the way to the 21st century. - Piscataway, NJ : IEEE Communications Society. - 0780337778 ; , s. 279-283, s. 279-283
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Konferensbidrag (refereegranskat)abstract
- Time and frequency offset estimation is addressed in an OFDM system that uses a cyclic prefix and pulse shaping. Earlier work has presented a method that avoids the use of pilots by exploiting the inherent correlation in the cyclically extended OFDM symbol. In this paper this technique is extended to include systems with pulse shaping. The joint Maximum Likelihood estimator of time and frequency offsets for such systems is presented and evaluated. An implementable structure of the extended estimator is given. Simulations show that it is possible to maintain the performance when introducing pulse shaping into an OFDM system.
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| 3. |
- Lønnebotn, Marianne, et al.
(författare)
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Body silhouettes as a tool to reflect obesity in the past
- 2018
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- Life course data on obesity may enrich the quality of epidemiologic studies analysing health consequences of obesity. However, achieving such data may require substantial resources. We investigated the use of body silhouettes in adults as a tool to reflect obesity in the past. We used large population-based samples to analyse to what extent self-reported body silhouettes correlated with the previously measured (9-23 years) body mass index (BMI) from both measured (European Community Respiratory Health Survey, N = 3 041) and selfreported (Respiratory Health In Northern Europe study, N = 3 410) height and weight. We calculated Spearman correlation between BMI and body silhouettes and ROC-curve analyses for identifying obesity (BMI >= 30) at ages 30 and 45 years. Spearman correlations between measured BMI age 30 (+/- 2y) or 45 (+/- 2y) and body silhouettes in women and men were between 0.62-0.66 and correlations for self-reported BMI were between 0.58-0.70. The area under the curve for identification of obesity at age 30 using body silhouettes vs previously measured BMI at age 30 (+/- 2y) was 0.92 (95% CI 0.87, 0.97) and 0.85 (95% CI 0.75, 0.95) in women and men, respectively; for previously self-reported BMI, 0.92 (95% CI 0.88, 0.95) and 0.90 (95% CI 0.85, 0.96). Our study suggests that body silhouettes are a useful epidemiological tool, enabling retrospective differentiation of obesity and non-obesity in adult women and men.
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| 4. |
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| 5. |
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| 6. |
- van de Beek, Jan-Jaap, et al.
(författare)
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Three non-pilot-based time and frequency estimators for OFDM
- 1998
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Time-domain Maximum-Likelihood (ML) estimators of time and frequency o¤sets are derived for three Orthogonal Frequency Division Multiplexing (OFDM) signal models: a pulse-shaped one-shot OFDM signal, a stream of multiple OFDM signals and an OFDM signal in a dispersive channel environment. We then develop structures to simplify their implementation. Simulation results show the relative performance and strengths of each of these three estimators.
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| 7. |
- van de Beek, Jan-Jaap, et al.
(författare)
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Three non-pilot based time- and frequency estimators for OFDM
- 2000
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Ingår i: Signal Processing. - 0165-1684 .- 1872-7557. ; 80:7, s. 1321-1334
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Tidskriftsartikel (refereegranskat)abstract
- Time-domain maximum-likelihood (ML) estimators of time and frequency offsets are derived for three orthogonal frequency division multiplexing (OFDM) signal models: a pulse-shaped one-shot OFDM signal, a stream of multiple OFDM signals and an OFDM signal in a dispersive channel environment. We then develop structures to simplify their implementation. Simulation results show the relative performance and strengths of each of these three estimators.
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| 8. |
- van de Beek, Jaap, et al.
(författare)
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On synchronization in an OFDM based UMTS proposal
- 1997
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Ingår i: Emerging techniques for communication terminals. - Toulouse : INP-ENSEEIHT. ; , s. 315-320
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this paper we discuss three signal models and respective Maximum Likelihood estimators of time and frequency osets. We consider implementation structures for these estimators. Furthermore, we discuss the applicability of these estimators and some variants in a proposal for the future UMTS.
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| 9. |
- van de Beek, Jaap, et al.
(författare)
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Synchronization of a TDMA-OFDM frequency hopping system
- 1998
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Ingår i: Pathway to a global wireless revolution. - Piscataway, NJ : IEEE Communications Society. - 0780343204 ; , s. 1290-1294
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a Time Division Multiple Access-Orthogonal Frequency Division Multiplexing (TDMA-OFDM)-based radio interface proposal for the Universal Mobile Telecommunication System (UMTS). We focus on synchronization and present an implementable algorithm for the tracking of the mobiles' time and frequency offsets at the base station in the uplink. This algorithm is based on recently developed estimation methods that use redundancy introduced by the cyclic prefix. A modified Maximum Likelihood (ML) estimator for the Additive White Gaussian Noise (AWGN) channel is used to meet both implementational requirements and performance requirements for frequency-selective fading multiuser environments. Simulation results for a typical UMTS mobile channel environment show that the uncoded symbol error rate of a coherently modulated system using our synchronization scheme is virtually indistinguishable from that of a system with no time and frequency offset.
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| 10. |
- Wahlqvist, Mattias, et al.
(författare)
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Description of Telias OFDM based proposal
- 1997
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This document gives an overview of Telias OFDM based proposal for UTRA and should be cinsidered as an input to the OFDM concept group within SMG 2. The document describes the fundamental frame structure, principles of the detection, modulation, coding and synchronization. Further, the channel structure, the resource management and handover principles are outlined
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