The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.

• While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study.

Nyckelord

Adult

Aged

Aged

80 and over

Aging

genetics

metabolism

Alzheimer Disease

cerebrospinal fluid

diagnosis

genetics

Amyloid beta-Protein

analysis

cerebrospinal fluid

Apolipoprotein E4

genetics

Apolipoproteins E

genetics

Biological Markers

analysis

cerebrospinal fluid

DNA Mutational Analysis

Dinoprost

analogs & derivatives

analysis

cerebrospinal fluid

Female

Gene Frequency

genetics

Genetic Predisposition to Disease

genetics

Genotype

Humans

Male

Middle Aged

Oxidative Stress

genetics

Peptide Fragments

analysis

cerebrospinal fluid

Phosphorylation

Polymorphism

Genetic

genetics

tau Proteins

analysis

cerebrospinal fluid

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)