| 1. |
- Malmqvist, K. G., et al.
(författare)
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PIXE and proton microprobe advances at the Lund Institute of Technology
- 1989
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Ingår i: Nuclear Inst. and Methods in Physics Research, B. - 0168-583X. ; 40-41:PART 1, s. 685-689
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Tidskriftsartikel (refereegranskat)abstract
- A review of recent advances in high-energy ion beam analysis at the Lund Institute of Technology is presented. A nonvacuum specimen chamber allows chemical speciation using a combination of ion beam analysis and controlled heating. The development of a new versatile scanning proton microbeam based on a new dedicated accelerator, an achromatic triplet lens and an advanced specimen chamber is outlined together with the performance of a microVAX-II/VMEbus-based data acquisition system.
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| 2. |
- Larsson, N. P.O., et al.
(författare)
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Characterization of the response function of a Si(Li) detector using an absorber technique
- 1989
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Ingår i: Nuclear Inst. and Methods in Physics Research, B. - 0168-583X. ; 43:4, s. 574-580
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Tidskriftsartikel (refereegranskat)abstract
- The non-Gaussian response function of a Si(Li) detector has been measured for characteristic Kα X-rays in the energy interval 1.5-8.6 keV using an absorber technique. The method is based on the different response to an attenuating absorber placed in front of the detector for the detector tail as compared to fully absorbed photons in the same position in the spectrum. The shape of the tail of a Kα X-ray peak could be derived from three X-ray spectra acquired with different attenuating absorbers using the PIXE or XRF method for excitation of single element standards. The line shape function could be described by a full energy Gaussian, a shelf, an exponential and a Si-escape component. The results presented are in good agreement with previously reported response functions obtained in measurements of monochromatic X-rays. The results will be implemented in a computer program for evaluating micro-PIXE spectra.
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| 3. |
- Martinsson, T, et al.
(författare)
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Tumorigenicity of SEWA murine tumor cells correlates with degree of c-myc amplification
- 1988
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Ingår i: Oncogene. - : Nature Publishing Group. - 0950-9232 .- 1476-5594. ; 3:4, s. 437-441
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Tidskriftsartikel (refereegranskat)abstract
- Previous studies have shown that cells of the SEWA mouse tumor contain amplified copies of the proto-oncogene c-myc in the aberrant chromosomal structures of double minutes (DMs), homogeneously staining regions (HSRs) and C-bandless chromosomes (CMs). DMs, and to a lesser degree CMs, tend to disappear from the cells grown in vitro and again reappear after transfer back in vivo, as if DNA amplification confers a growth advantage upon the tumor cells. We have now isolated five in vitro clones that exhibit different degrees of c-myc amplification. When we inoculated cells of the different clones into compatible hosts, we found that there was a positive correlation between degree of c-myc amplification, level of c-myc RNA, and tumorigenicity. Our results lend further support to the idea that gene amplification contributes to the higher malignant phenotype, and to progression of tumors.
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| 4. |
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