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1.	Bouyoucef, S E, et al. (författare) Poster Session 2 : Monday 4 May 2015, 08 2015 Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Tidskriftsartikel (refereegranskat)
2.	Ferreira, Mjv, et al. (författare) Poster Session 3 : Tuesday 5 May 2015, 08 2015 Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Tidskriftsartikel (refereegranskat)
3.	Hudson, Lawrence N, et al. (författare) The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project 2017 Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188 Tidskriftsartikel (refereegranskat)abstract The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
4.	Broggio, D., et al. (författare) Child and adult thyroid monitoring after a reactor accident (CAThyMARA): Technical recommendations and remaining gaps 2019 Ingår i: Radiation Measurements. - : Elsevier BV. - 1350-4487. ; 128:Septemberg Tidskriftsartikel (refereegranskat)abstract © 2019 Elsevier Ltd Following a severe nuclear reactor accident large amounts of radioactive iodine are released in the atmosphere. Health consequences estimation for the affected population is based on the dose assessment which can be derived from in vivo measurements. Since the uptake of radioactive iodine increases the thyroid cancer risk of children it is of particular interest to dispose of technical recommendations on thyroid monitoring, particularly for children. This paper summarizes recommendations that have been issued by a group of European radiation protection specialists during the CAThyMARA project. It covers technical aspects such as the choice of instruments, the calibration process, the measurement preparedness, the dose assessment and communication issues. This paper also discusses remaining gaps and serves as an introduction to other papers of this special issue.
5.	Ilinskaya, O. A., et al. (författare) Mechanically induced thermal breakdown in magnetic shuttle structures 2018 Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 20 Tidskriftsartikel (refereegranskat)abstract A theory of a thermally induced single-electron 'shuttling' instability in a magnetic nano-mechanical device subject to an external magnetic field is presented in the Coulomb blockade regime of electron transport. The model magnetic shuttle device considered comprises a movable metallic grain suspended between two magnetic leads, which are kept at different temperatures and assumed to be fully spin-polarized with anti-parallel magnetizations. For a given temperature difference shuttling is found to occur for a region of external magnetic fields between a lower and an upper critical field strength, which separate the shuttling regime from normal small-amplitude 'vibronic' regimes. We find that (i) the upper critical magnetic field saturates to a constant value in the high temperature limit and that the shuttle instability domain expands with a decrease of the temperature; (ii) the lower critical magnetic field depends not only on the temperature-independent phenomenological friction coefficient used in the model but also on intrinsic friction (which vanishes in the high temperature limit) caused by magnetic exchange forces and electron tunneling between the quantum dot and the leads. The feasibility of using thermally driven magnetic shuttle systems to harvest thermal breakdown phenomena is discussed.
6.	Phelan, CM, et al. (författare) Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer 2017 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:5, s. 680-691 Tidskriftsartikel (refereegranskat)
7.	André, Mats, et al. (författare) Lower hybrid waves at comet 67P/Churyumov-Gerasimenko 2017 Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S29-S38 Tidskriftsartikel (refereegranskat)abstract We investigate the generation of waves in the lower hybrid frequency range by density gradients in the near plasma environment of comet 67P/Churyumov-Gerasimenko. When the plasma is dominated by water ions from the comet, a situation with magnetized electrons and unmagnetized ions is favourable for the generation of lower hybrid waves. These waves can transfer energy between ions and electrons and reshape the plasma environment of the comet. We consider cometocentric distances out to a few hundred km. We find that when the electron motion is not significantly interrupted by collisions with neutrals, large average gradients within tens of km of the comet, as well as often observed local large density gradients at larger distances, are often likely to be favourable for the generation of lower hybrid waves. Overall, we find that waves in the lower hybrid frequency range are likely to be common in the near plasma environment.
8.	Cherry, Zack, 1959- (författare) Aramaic Loanwords in Neo-Assyrian 900–600 B.C. 2017 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract This study aimed at identifying and analyzing Aramaic loanwords in Neo-Assyrian for the period 900–600 B.C. As two Semitic languages, Neo-Assyrian and Aramaic are sibling-descendants of a postulated common ancestor, Proto-Semitic. The study provides information about the contact between the two languages and about the people who spoke them.To achieve the purpose of the study, a total of 9057 unique Neo-Assyrian texts of different genre are utilized. A total of 166 proposed Aramaic loanwords in Neo-Assyrian are included and discussed in the study. The evaluation of the proposed loanwords is conducted using phonological, morphological and semantic criteria.The findings of the study demonstrate that only 69 words are considered to be confirmed loanwords, and 50 are considered to be possible loanwords. Additionally, 47 words are rejected for different reasons and are not considered Aramaic loanwords in Neo-Assyrian. The majority of the confirmed loanwords are attested in letters and legal and administrative documents from the 7th century B.C., stemming from the major Assyrian cities of Nineveh, Assur and Calah. Most of the confirmed loanwords are nouns.The relatively small number of certain and possible Aramaic loanwords is undoubtedly an evidence for the use of Aramaic in Assyria proper. The same evidence, however, fails to support the impression that Aramaic was widely spread in Assyria proper as a vernacular language, especially towards the end of the period studied. The evidence also corroborates the conclusion based on the extant prosopographical data that the predominantly Assyrian character was maintained in Assyria proper until the very end of the Assyrian empire.
9.	Edberg, Niklas J. T., et al. (författare) CME impact on comet 67P/Churyumov-Gerasimenko 2016 Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S45-S56 Tidskriftsartikel (refereegranskat)abstract We present Rosetta observations from comet 67P/Churyumov-Gerasimenko during the impact of a coronal mass ejection (CME). The CME impacted on 2015 Oct 5-6, when Rosetta was about 800 km from the comet nucleus, and 1.4 au from the Sun. Upon impact, the plasma environment is compressed to the level that solar wind ions, not seen a few days earlier when at 1500 km, now reach Rosetta. In response to the compression, the flux of suprathermal electrons increases by a factor of 5-10 and the background magnetic field strength increases by a factor of similar to 2.5. The plasma density increases by a factor of 10 and reaches 600 cm(-3), due to increased particle impact ionization, charge exchange and the adiabatic compression of the plasma environment. We also observe unprecedentedly large magnetic field spikes at 800 km, reaching above 200 nT, which are interpreted as magnetic flux ropes. We suggest that these could possibly be formed by magnetic reconnection processes in the coma as the magnetic field across the CME changes polarity, or as a consequence of strong shears causing Kelvin-Helmholtz instabilities in the plasma flow. Due to the limited orbit of Rosetta, we are not able to observe if a tail disconnection occurs during the CME impact, which could be expected based on previous remote observations of other CME-comet interactions.
10.	Edberg, Niklas J. T., et al. (författare) Spatial distribution of low-energy plasma around comet 67P/CG from Rosetta measurements 2015 Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 42:11, s. 4263-4269 Tidskriftsartikel (refereegranskat)abstract We use measurements from the Rosetta plasma consortium Langmuir probe and mutual impedance probe to study the spatial distribution of low-energy plasma in the near-nucleus coma of comet 67P/Churyumov-Gerasimenko. The spatial distribution is highly structured with the highest density in the summer hemisphere and above the region connecting the two main lobes of the comet, i.e., the neck region. There is a clear correlation with the neutral density and the plasma to neutral density ratio is found to be approximate to 1-210(-6), at a cometocentric distance of 10km and at 3.1AU from the Sun. A clear 6.2h modulation of the plasma is seen as the neck is exposed twice per rotation. The electron density of the collisionless plasma within 260km from the nucleus falls off with radial distance as approximate to 1/r. The spatial structure indicates that local ionization of neutral gas is the dominant source of low-energy plasma around the comet.
11.	Eriksson, Mikael, 1977- (författare) The complex internationalization process unfolded : The case of Atlas Copco’s entry into the Chinese mid-market 2016 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Despite its contemporary relevance, we still have limited empirical knowledge about the forces underlying complex internationalization processes as when multinational corporations (MNCs) seek to enter new growing markets. Based on a real-time process study comprising ninety interviews and two hundred hours of observation made between 2009 and 2012, Atlas Copco’s entry into the Chinese mid-market was investigated. The intra-organizational analysis showed that three inter-related processes were underlying Atlas’ market entry and the results suggest that multiple interrelated motors may drive many contemporary internationalization processes. The processes identified are a sequential strategy process, an evolutionary process which shows that routines changed, and a political process. A somewhat surprising finding is that the main driver of internationalization according to received theory, the firm’s accumulated experiences, not only can drive internationalization, but may also hamper MNC managers’ possibilities to enter many of today’s new and growing markets. The findings add to our knowledge of the internationalization process in an increasingly complex international business setting, and especially highlight the need to distinguish between the sequential strategy process – more in line with received theory – and the other processes, in order to get a more full-fledged picture of what internationalization in large MNCs is all about.
12.	Henderson, Audrey J., et al. (författare) Skin colour changes during experimentally-induced sickness 2017 Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 60, s. 312-318 Tidskriftsartikel (refereegranskat)abstract Skin colour may be an important cue to detect sickness in humans but how skin colour changes with acute sickness is currently unknown. To determine possible colour changes, 22 healthy Caucasian participants were injected twice, once with lipopolysaccharide (LPS, at a dose of 2ng/kg body weight) and once with placebo (saline), in a randomised cross-over design study. Skin colour across 3 arm and 3 face locations was recorded spectrophotometrically over a period of 8h in terms of lightness (L(∗)), redness (a(∗)) and yellowness (b(∗)) in a manner that is consistent with human colour perception. In addition, carotenoid status was assessed as we predicted that a decrease it skin yellowness would reflect a drop in skin carotenoids. We found an early change in skin colouration 1-3h post LPS injection with facial skin becoming lighter and less red whilst arm skin become darker but also less red and less yellow. The LPS injection also caused a drop in plasma carotenoids from 3h onwards. However, the timing of the carotenoid changes was not consistent with the skin colour changes suggesting that other mechanisms, such as a reduction of blood perfusion, oxygenation or composition. This is the first experimental study characterising skin colour associated with acute illness, and shows that changes occur early in the development of the sickness response. Colour changes may serve as a cue to health, prompting actions from others in terms of care-giving or disease avoidance. Specific mechanisms underlying these colour changes require further investigation.
13.	Ilinskaya, O. A., et al. (författare) Shuttling of spin polarized electrons in molecular transistors 2016 Ingår i: Synthetic Metals. - : Elsevier BV. - 0379-6779. ; 216, s. 83-87 Tidskriftsartikel (refereegranskat)abstract Shuttling of electrons in single-molecule transistors with magnetic leads in the presence of an external magnetic field is considered theoretically. For a current of partially spin-polarized electrons a shuttle instability is predicted to occur for a finite interval of external magnetic field strengths. The lower critical magnetic field is determined by the degree of spin polarization and it vanishes as the spin polarization approaches 100%. The feasibility of detecting magnetic shuttling in a C-60-based molecular transistor with magnetic (Ni) electrodes is discussed (Pasupathy et al. (2004) [7]). (C) 2015 Elsevier B.V. All rights reserved.
14.	Johansson, Oskar N., 1984, et al. (författare) Phenomics reveals a novel putative chloroplast fatty acid transporter in the marine diatom Skeletonema marinoi involved in temperature acclimation 2019 Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9 Tidskriftsartikel (refereegranskat)abstract Diatoms are the dominant phytoplankton in temperate oceans and coastal regions and yet little is known about the genetic basis underpinning their global success. Here, we address this challenge by developing the first phenomic approach for a diatom, screening a collection of randomly mutagenized but identifiably tagged transformants. Based upon their tolerance to temperature extremes, several compromised mutants were identified revealing genes either stress related or encoding hypothetical proteins of unknown function. We reveal one of these hypothetical proteins is a novel putative chloroplast fatty acid transporter whose loss affects several fatty acids including the two omega-3, long-chain polyunsaturated fatty acids - eicosapentaenoic and docosahexaenoic acid, both of which have medical importance as dietary supplements and industrial significance in aquaculture and biofuels. This mutant phenotype not only provides new insights into the fatty acid biosynthetic pathways in diatoms but also highlights the future value of phenomics for revealing specific gene functions in these ecologically important phytoplankton.
15.	Karlsson, Tomas, et al. (författare) Rosetta measurements of lower hybrid frequency range electric field oscillations in the plasma environment of comet 67P 2017 Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 44:4, s. 1641-1651 Tidskriftsartikel (refereegranskat)abstract Electric field measurements from cometary environments are very rare but can provide important information on how plasma waves help fashion the plasma environment. The long dwelling time of the Rosetta spacecraft close to comet 67P/Churyumov-Gerasimenko promises to improve this state. We here present the first electric field measurements from 67P, performed by the Rosetta dual Langmuir probe instrument LAP. Measurements of the electric field from cometocentric distances of 149 and 348 km are presented together with estimates of plasma density changes. Persistent wave activity around the local H2O+ lower hybrid frequency is observed, with the largest amplitudes observed at sharp plasma gradients. We demonstrate that the necessary requirements for the lower hybrid drift instability to be operating are fulfilled. We suggest that lower hybrid waves are responsible for the creation of a warm electron population, the origins of which have been unknown so far, by heating ambient electrons in the magnetic field-parallel direction.
16.	Lebacq, A L, et al. (författare) European intercomparison on the measurement of l-131 in thyroid of adults and children. 2019 Ingår i: Radiation Measurements. - : Elsevier BV. - 1350-4487. ; 129 Tidskriftsartikel (refereegranskat)abstract In case of a nuclear reactor accident affecting a large population the internal contamination of the workers and the public can be assessed through in vivo measurements. Since iodine-131 is one of the most important releases and since it is of health concern, thyroid monitoring of this radionuclide is of special interest. Intercomparisons of thyroid in vivo measurements usually focus on the adult case. Here we report about a European intercomparison exercise for spectroscopic devices. Three sets of thyroid phantoms of unknown activity were circulated, representing the following ages: 5 years-old, 10 years-old and the adult. Nineteen institutions from twelve countries in Europe took part in an intercomparison exercise. Twenty-nine measurement devices have been tested. In the adult case, 5 results were outside the acceptance criteria and 10 in the 10-years old case. In the 5 years-old case, the result was not reported for one measurement device and 11 results were outside the acceptance criteria. Devices that have been tested during this intercomparison now dispose of calibration coefficients for the three age groups.
17.	Lestinsky, M., et al. (författare) Physics book: CRYRING@ESR 2016 Ingår i: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6401 .- 1951-6355. ; 225:5, s. 797-882 Forskningsöversikt (refereegranskat)abstract The exploration of the unique properties of stored and cooled beams of highly-charged ions as provided by heavy-ion storage rings has opened novel and fascinating research opportunities in the realm of atomic and nuclear physics research. Since the late 1980s, pioneering work has been performed at the CRYRING at Stockholm (Abrahamsson et al. 1993) and at the Test Storage Ring (TSR) at Heidelberg (Baumann et al. 1988). For the heaviest ions in the highest charge-states, a real quantum jump was achieved in the early 1990s by the commissioning of the Experimental Storage Ring (ESR) at GSI Helmholtzzentrum für Schwerionenforschung (GSI) in Darmstadt (Franzke 1987) where challenging experiments on the electron dynamics in the strong field regime as well as nuclear physics studies on exotic nuclei and at the borderline to atomic physics were performed. Meanwhile also at Lanzhou a heavy-ion storage ring has been taken in operation, exploiting the unique research opportunities in particular for medium-heavy ions and exotic nuclei (Xia et al. 2002).
18.	Niederberger, C., et al. (författare) Forty years of IVF 2018 Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282. ; 110:2 Tidskriftsartikel (refereegranskat)abstract This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
19.	Parafilo, A. V., et al. (författare) Spin-mediated Photomechanical Coupling of a Nanoelectromechanical Shuttle 2016 Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:5 Tidskriftsartikel (refereegranskat)abstract We show that nanomechanical vibrations in a magnetic shuttle device can be strongly affected by external microwave irradiation through photo-assisted electronic spin-flip transitions. Mechanical consequences of these spin flips are due to a spin-dependent magnetic force, which may lead to a nanomechanical instability in the device. We derive a criterion for the instability to occur and analyze different regimes of nanomechanical oscillations. Possible experimental realizations of the spin-mediated photomechanical instability and detection of the device backaction are discussed.
20.	Spjuth, Ola, 1977-, et al. (författare) Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research 2016 Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 24:4, s. 521-528 Tidskriftsartikel (refereegranskat)abstract A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging. We describe three case studies where we have linked samples and sample descriptions in order to facilitate global searching of available samples for research. The use cases include the ENGAGE (European Network for Genetic and Genomic Epidemiology) consortium comprising at least 39 cohorts, the SUMMIT (surrogate markers for micro- and macro-vascular hard endpoints for innovative diabetes tools) consortium and a pilot for data integration between a Swedish clinical health registry and a biobank. We used the Sample avAILability (SAIL) method for data linking: first, created harmonised variables and then annotated and made searchable information on the number of specimens available in individual biobanks for various phenotypic categories. By operating on this categorised availability data we sidestep many obstacles related to privacy that arise when handling real values and show that harmonised and annotated records about data availability across disparate biomedical archives provide a key methodological advance in pre-analysis exchange of information between biobanks, that is, during the project planning phase.
21.	Tijani, Muyideen K., et al. (författare) Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion 2017 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:8 Tidskriftsartikel (refereegranskat)abstract Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression and utilization by P. falciparum to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates. Antibody levels against EBA140, EBA175, EBA181, PfRh2, PfRh4, and MSP2, were measured by ELISA. We also used parasites with disrupted EBA140, EBA175 and EBA181 genes to show that all these were targets of invasion inhibitory antibodies. However, antigenic targets of inhibitory antibodies were not stable and changed substantially over time in most individuals, independent of age. Antibodies levels measured by ELISA also varied within and between individuals over time and the antibodies against EBA181, PfRh2 and MSP2 declined more rapidly in younger individuals (15 years) compared with older (>15). The breadth of high antibody responses over time was more influenced by age than by the frequency of infection. High antibody levels were associated with a more stable invasion inhibitory response, which could indicate that during the long process of formation of immunity, many changes not only in levels but also in functional responses are needed. This is an important finding in understanding natural immunity against malaria, which is essential for making an efficacious vaccine.
22.	Abarenkov, Kessy, et al. (författare) Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard – a report from a May 23-24, 2016 workshop (Gothenburg, Sweden) 2016 Ingår i: MycoKeys. - : Pensoft Publishers. - 1314-4057 .- 1314-4049. ; 16, s. 1-15 Tidskriftsartikel (refereegranskat)abstract Recent molecular studies have identified substantial fungal diversity in indoor environments. Fungi and fungal particles have been linked to a range of potentially unwanted effects in the built environment, including asthma, decay of building materials, and food spoilage. The study of the built mycobiome is hampered by a number of constraints, one of which is the poor state of the metadata annotation of fungal DNA sequences from the built environment in public databases. In order to enable precise interrogation of such data – for example, “retrieve all fungal sequences recovered from bathrooms” – a workshop was organized at the University of Gothenburg (May 23-24, 2016) to annotate public fungal barcode (ITS) sequences according to the MIxS-Built Environment annotation standard (http://gensc.org/mixs/). The 36 participants assembled a total of 45,488 data points from the published literature, including the addition of 8,430 instances of countries of collection from a total of 83 countries, 5,801 instances of building types, and 3,876 instances of surface-air contaminants. The results were implemented in the UNITE database for molecular identification of fungi (http://unite.ut.ee) and were shared with other online resources. Data obtained from human/animal pathogenic fungi will furthermore be verified on culture based metadata for subsequent inclusion in the ISHAM-ITS database (http://its.mycologylab.org).
23.	Abrantes, João A., et al. (författare) Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII 2019 Ingår i: CPT. - : Wiley. - 2163-8306. ; 8:12, s. 894-903 Tidskriftsartikel (refereegranskat)abstract Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast the ability to predict the future occurrence of bleeds based on individual (i) pharmacokinetic, (ii) bleeding, and (iii) pharmacokinetic, bleeding and covariate information using observed data from the Long‐Term Efficacy Open‐Label Program in Severe Hemophilia A Disease (LEOPOLD) clinical trials (172 severe hemophilia A patients taking prophylactic treatment). The predictive performance assessed by the area under receiver operating characteristic (ROC) curves was 0.67 (95% confidence interval (CI), 0.65–0.69), 0.78 (95% CI, 0.76–0.80), and 0.79 (95% CI, 0.77–0.81) for patients ≥ 12 years when using pharmacokinetics, bleeds, and all data, respectively, suggesting that individual bleed information adds value to the optimization of prophylactic dosing regimens in severe hemophilia A. Further steps to optimize the proposed tool for factor VIII dose adaptation in the clinic are required.
24.	Abrantes, João A., et al. (författare) Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data 2019 Ingår i: British Journal of Clinical Pharmacology. - : John Wiley & Sons. - 0306-5251 .- 1365-2125. ; 85:6, s. 1326-1336 Tidskriftsartikel (refereegranskat)abstract AIMS: This study aims to assess approaches to handle interoccasion variability (IOV) in a model-based therapeutic drug monitoring (TDM) context, using a population pharmacokinetic model of coagulation factor VIII as example.METHODS: We assessed five model-based TDM approaches: empirical Bayes estimates (EBEs) from a model including IOV, with individualized doses calculated based on individual parameters either (i) including or (ii) excluding variability related to IOV; and EBEs from a model excluding IOV by (iii) setting IOV to zero, (iv) summing variances of interindividual variability (IIV) and IOV into a single IIV term, or (v) re-estimating the model without IOV. The impact of varying IOV magnitudes (0-50%) and number of occasions/observations was explored. The approaches were compared with conventional weight-based dosing. Predictive performance was assessed with the prediction error (PE) percentiles.RESULTS: When IOV was lower than IIV, the accuracy was good for all approaches (50th percentile of the PE [P50] <7.4%), but the precision varied substantially between IOV magnitudes (P97.5 61-528%). Approach (ii) was the most precise forecasting method across a wide range of scenarios, particularly in case of sparse sampling or high magnitudes of IOV. Weight-based dosing led to less precise predictions than the model-based TDM approaches in most scenarios.CONCLUSIONS: Based on the studied scenarios and theoretical expectations, the best approach to handle IOV in model-based dose individualisation is to include IOV in the generation of the EBEs, but exclude the portion of unexplained variability related to IOV in the individual parameters used to calculate the future dose.
25.	Abrantes, João A. (författare) Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A 2019 Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches.A population pharmacokinetic (PK) model of FVIII activity following the administration of moroctocog alfa was developed based on data from a large heterogeneous cohort of moderate to severe hemophilia A patients. Body weight, age, neutralizing anti-FVIII inhibitors, race, and analytical assay were found to be significant predictors of FVIII activity PK. In addition, large inter-individual variability (IIV) and inter-occasion variability (IOV) was identified highlighting the need for dose individualization.High magnitudes of IOV are known to impair model-based therapeutic drug monitoring. Using a population PK model of FVIII activity, several approaches to handle IOV in Bayesian forecasting of individual PK parameters were assessed across a wide range of features. Considering IOV in Bayesian forecasting, but ignoring IOV in dose calculation, led to the most precise individualized doses, in particular, when sparse data was used.The dose-exposure-response relationship of FVIII replacement therapy remains unclear. A parametric repeated time-to-categorical event (RTTCE) model was developed to characterize the relationship between the dose of octocog alfa, plasma FVIII activity, bleeding frequency and severity, and covariates, using data from clinical trials. The bleeding hazard was found to decrease throughout time and to be affected by plasma FVIII activity and number of previous bleeds. Unexplained IIV in the bleeding hazard was found to be large.Bayesian forecasting based on the RTTCE model was used to predict the future occurrence of bleeds, and to contrast the predicted outcome using individual i) PK, ii) bleeding, and iii) PK, bleeding and covariate information, from data collected in clinical trials. The results support that individual bleed information can inform the optimization of prophylactic dosing regimens in severe hemophilia A patients.In summary, the pharmacometric approaches presented provide a valuable quantitative framework to improve dose individualization in hemophilia A. Furthermore, enhanced dosing has the potential to reduce bleeding frequency and to lower the high costs associated to treatment.
26.	Aharony, A., et al. (författare) Effects of Different Lead Magnetizations on the Datta-Das Spin Field-Effect Transistor 2019 Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 123:17, s. 11094-11100 Tidskriftsartikel (refereegranskat)abstract A Datta-Das spin field-effect transistor is built of a one-dimensional weak link, with Rashba spin-orbit interactions (SOIs), which connects two magnetized reservoirs. The particle and spin currents between the two reservoirs are calculated to lowest order in the tunneling through the weak link and in the wide-band approximation, with emphasis on their dependence on the origins of the "bare" magnetizations in the reservoirs. The SOI is found to generate magnetization components in each reservoir, which rotate in the plane of the electric field (generating the SOI) and the weak link, only if the "bare" magnetization of the other reservoir has a nonzero component in that plane. The SOI affects the charge current only if both reservoirs are polarized. The charge current is conserved, but the transverse rotating magnetization current is not conserved because the SOI in the weak link generates extra spin polarizations which are injected into the reservoirs.
27.	Aharony, A., et al. (författare) Electric and magnetic gating of Rashba-active weak links 2018 Ingår i: Physical Review B. - 2469-9950. ; 97:22 Tidskriftsartikel (refereegranskat)abstract In a one-dimensional weak-link wire the spin-orbit interaction (SOI) alone cannot generate a nonzero spin current. We show that a Zeeman field acting in the wire in conjunction with the Rashba SOI there does yield such a current, whose magnitude and direction depend on the direction of the field. When this field is not parallel to the effective field due to the SOI, both the charge and the spin currents oscillate with the length of the wire. Measuring the oscillating anisotropic magnetoresistance can thus yield information on the SOI strength. These features are tuned by applying a magnetic and/or an electric field, with possible applications to spintronics.
28.	Ahnlide, Ingela, et al. (författare) Preoperative prediction of histopathologic outcome in basal cell carcinoma - flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types. 2016 Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 175:4, s. 751-761 Tidskriftsartikel (refereegranskat)abstract Prediction of histopathologic subtype of basal cell carcinoma (BCC) is important for tailoring optimal treatment, especially in patients with suspected superficial BCC.
29.	Alekseychik, Pavel, et al. (författare) Surface energy exchange in pristine and managed boreal peatlands 2018 Ingår i: Mires and Peat. - 1819-754X. ; 21 Tidskriftsartikel (refereegranskat)abstract Surface–atmosphere energy exchange is strongly ecosystem-specific. At the same time, as the energy balance constitutes responses of an ecosystem to environmental stressors including precipitation, humidity and solar radiation, it results in feedbacks of potential importance for the regional climate. Northern peatlands represent a diverse class of ecosystems that cover nearly 6 × 106 km2 in the Boreal region, which makes the inter-comparison of their energy balances an important objective. With this in mind we studied energy exchange across a broad spectrum of peatlands from pristine fens and bogs to forested and agriculturally managed peatlands, which represent a large fraction of the landscape in Finland and Sweden. The effects of management activities on the energy balance were extensively examined from the micrometeorological point of view, using eddy covariance data from eight sites in these two countries (56º 12'–62º 11' N, 13º 03'–30º 05' E). It appears that the surface energy balance varies widely amongst the different peatland types. Generally, energy exchange features including the Bowen ratio, surface conductance, coupling to the atmosphere, responses to water table fluctuations and vapour pressure deficit could be associated directly with the peatland type. The relative constancy of the Bowen ratio in natural open mires contrasted with its variation in tree-covered and agricultural peatlands. We conclude that the impacts of management and the consequences of land-use change in peatlands for the local and regional climate might be substantial.
30.	Alskär, Oskar, et al. (författare) Semi-mechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes 2016 Ingår i: Journal of clinical pharmacology. - : Wiley. - 0091-2700 .- 1552-4604. ; 56:3, s. 340-348 Tidskriftsartikel (refereegranskat)abstract The integrated glucose-insulin (IGI) model is a previously published semi-mechanistic model, which describes plasma glucose and insulin concentrations after glucose challenges. The aim of this work was to use knowledge of physiology to improve the IGI model's description of glucose absorption and gastric emptying after tests with varying glucose doses. The developed model's performance was compared to empirical models. To develop our model, data from oral and intravenous glucose challenges in patients with type 2 diabetes and healthy control subjects were used together with present knowledge of small intestinal transit time, glucose inhibition of gastric emptying and saturable absorption of glucose over the epithelium to improve the description of gastric emptying and glucose absorption in the IGI model. Duodenal glucose was found to inhibit gastric emptying. The performance of the saturable glucose absorption was superior to linear absorption regardless of the gastric emptying model applied. The semi-physiological model developed performed better than previously published empirical models and allows for better understanding of the mechanisms underlying glucose absorption. In conclusion, our new model provides a better description and improves the understanding of dynamic glucose tests involving oral glucose.
31.	Amato, Alberto, et al. (författare) Grazer-induced transcriptomic and metabolomic response of the chain-forming diatom Skeletonema marinoi 2018 Ingår i: ISME Journal. - : Springer Science and Business Media LLC. - 1751-7362 .- 1751-7370. ; 12, s. 1594-1604 Tidskriftsartikel (refereegranskat)abstract Diatoms and copepods are main actors in marine food webs. The prey-predator interactions between them affect bloom dynamics, shape marine ecosystems and impact the energy transfer to higher trophic levels. Recently it has been demonstrated that the presence of grazers may affect the diatom prey beyond the direct effect of grazing. Here, we investigated the response of the chain-forming centric diatom Skeletonema marinoi to grazer cues, including changes in morphology, gene expression and metabolic profile. S. marinoi cells were incubated with Calanus finmarchicus or with Centropages typicus and in both cases responded by reducing the chain length, whereas changes in gene expression indicated an activation of stress response, changes in the lipid and nitrogen metabolism, in cell cycle regulation and in frustule formation. Transcripts linked to G protein-coupled receptors and to nitric oxide synthesis were differentially expressed suggesting involvement of these signalling transduction pathways in the response. Downregulation of a lipoxygenase in the transcriptomic data and of its products in the metabolomic data also indicate an involvement of oxylipins. Our data contribute to a better understanding of the gene function in diatoms, providing information on the nature of genes implicated in the interaction with grazers, a crucial process in marine ecosystems.
32.	André, Mats, et al. (författare) Outflow of low-energy ions and the solar cycle 2015 Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 120:2, s. 1072-1085 Tidskriftsartikel (refereegranskat)abstract Magnetospheric ions with energies less than tens of eV originate from the ionosphere. Positive low-energy ions are complicated to detect onboard sunlit spacecraft at higher altitudes, which often become positively charged to several tens of volts. We use two Cluster spacecraft and study low-energy ions with a technique based on the detection of the wake behind a charged spacecraft in a supersonic ion flow. We find that low-energy ions usually dominate the density and the outward flux in the geomagnetic tail lobes during all parts of the solar cycle. The global outflow is of the order of 10(26) ions/s and often dominates over the outflow at higher energies. The outflow increases by a factor of 2 with increasing solar EUV flux during a solar cycle. This increase is mainly due to the increased density of the outflowing population, while the outflow velocity does not vary much. Thus, the outflow is limited by the available density in the ionospheric source rather than by the energy available in the magnetosphere to increase the velocity.
33.	Arvidsson, Per I., et al. (författare) Öppenheten förstör chansen till patent 2015 Ingår i: Svenska dagbladet. - Stockholm : Svenska Dagbladet AB & Co.. - 2001-3868. Tidskriftsartikel (populärvet., debatt m.m.)
34.	Banaschewski, T., et al. (författare) Growth and Puberty in a 2-Year Open-Label Study of Lisdexamfetamine Dimesylate in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder 2018 Ingår i: Cns Drugs. - : Springer Science and Business Media LLC. - 1172-7047 .- 1179-1934. ; 32:5, s. 455-467 Tidskriftsartikel (refereegranskat)
35.	Beier, Sebastian, et al. (författare) Construction of a map-based reference genome sequence for barley, Hordeum vulgare L. 2017 Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 4 Tidskriftsartikel (refereegranskat)abstract Barley (Hordeum vulgare L.) is a cereal grass mainly used as animal fodder and raw material for the malting industry. The map-based reference genome sequence of barley cv. â € Morex' was constructed by the International Barley Genome Sequencing Consortium (IBSC) using hierarchical shotgun sequencing. Here, we report the experimental and computational procedures to (i) sequence and assemble more than 80,000 bacterial artificial chromosome (BAC) clones along the minimum tiling path of a genome-wide physical map, (ii) find and validate overlaps between adjacent BACs, (iii) construct 4,265 non-redundant sequence scaffolds representing clusters of overlapping BACs, and (iv) order and orient these BAC clusters along the seven barley chromosomes using positional information provided by dense genetic maps, an optical map and chromosome conformation capture sequencing (Hi-C). Integrative access to these sequence and mapping resources is provided by the barley genome explorer (BARLEX).
36.	Bengtsson, Erik, 1984, et al. (författare) Unequal poverty and equal industrialisation: Finnish wealth, 1750-1900 2019 Ingår i: Scandinavian Economic History Review. - : Informa UK Limited. - 0358-5522 .- 1750-2837. ; 67:3, s. 229-248 Tidskriftsartikel (refereegranskat)abstract We present the first comprehensive, long-run estimates of Finnish wealth and its distribution from 1750 to 1900. Using wealth data from 17,279 probate inventories, we show that Finland was very unequal between 1750 and 1850; the top decile owned about 90% of total wealth. This means that Finland was more unequal than the much wealthier economies Britain, France and the US, which goes against the common assumption of richer economies being more unequal. Moreover, when industrialisation took off in Finland, inequality started a downward trajectory. High inequality 1750-1850 was bottom-driven, by a large share of the population owning nothing or close to nothing of value, while economic development after 1850 was pro-equal since the ownership of forests, since long in the hands of the peasantry, became more valuable with the development of forest-based industries. Our findings thus contradict commonplace assumptions that economic growth and industrialisation are associated with more inequality, as well as recent arguments that very few factors beyond catastrophes can decrease inequality. We instead argue for a more inductive and open approach to the determinants of long-run inequality.
37.	Bhatti, M. K., et al. (författare) Scheduling of Parallel Tasks with Proportionate Priorities 2016 Ingår i: Arabian Journal for Science and Engineering. - : Springer Verlag. - 2193-567X .- 1319-8025 .- 2191-4281. ; 41:8, s. 3279-3295 Tidskriftsartikel (refereegranskat)abstract Parallel computing systems promise higher performance for computationally intensive applications. Since programmes for parallel systems consist of tasks that can be executed simultaneously, task scheduling becomes crucial for the performance of these applications. Given dependence constraints between tasks, their arbitrary sizes, and bounded resources available for execution, optimal task scheduling is considered as an NP-hard problem. Therefore, proposed scheduling algorithms are based on heuristics. This paper presents a novel list scheduling heuristic, called the Noodle heuristic. Noodle is a simple yet effective scheduling heuristic that differs from the existing list scheduling techniques in the way it assigns task priorities. The priority mechanism of Noodle maintains a proportionate fairness among all ready tasks belonging to all paths within a task graph. We conduct an extensive experimental evaluation of Noodle heuristic with task graphs taken from Standard Task Graph. Our experimental study includes results for task graphs comprising of 50, 100, and 300 tasks per graph and execution scenarios with 2-, 4-, 8-, and 16-core systems. We report results for average Schedule Length Ratio (SLR) obtained by producing variations in Communication to Computation cost Ratio. We also analyse results for different degree of parallelism and number of edges in the task graphs. Our results demonstrate that Noodle produces schedules that are within a maximum of 12 % (in worst-case) of the optimal schedule for 2-, 4-, and 8-core systems. We also compare Noodle with existing scheduling heuristics and perform comparative analysis of its performance. Noodle outperforms existing heuristics for average SLR values.
38.	Bianchi, M., et al. (författare) One-dimensional spin texture of Bi(441): Quantum spin Hall properties without a topological insulator 2015 Ingår i: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 91:16 Tidskriftsartikel (refereegranskat)abstract The high index (441) surface of bismuth has been studied using scanning tunneling microscopy (STM), angle resolved photoemission spectroscopy (APRES), and spin-resolved ARPES. The surface is strongly corrugated, exposing a regular array of (110)-like terraces. Two surface localized states are observed, both of which are linearly dispersing in one in-plane direction (k(x)), and dispersionless in the orthogonal in-plane direction (k(y)), and both of which have a Dirac-like crossing at k(x) = 0. Spin ARPES reveals a strong in-plane polarization, consistent with Rashba-like spin-orbit coupling. One state has a strong out-of-plane spin component, which matches with the miscut angle, suggesting its possible origin as an edge state. The electronic structure of Bi(441) has significant similarities with topological insulator surface states and is expected to support one-dimensional quantum spin Hall-like coupled spin-charge transport properties with inhibited backscattering, without requiring a topological insulator bulk.
39.	Björk, Yvonne, et al. (författare) Androgens in women after allogeneic hematopoietic cell transplantation : Impact of chronic GvHD and glucocorticoid therapy 2017 Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 52:3, s. 431-437 Tidskriftsartikel (refereegranskat)abstract Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P<0.0001 and P<0.05, respectively. Androgens in the autoHCT group were similar or higher than controls. In the subgroup of alloHCT patients without cGvHD, free T was similar to controls (7.2 vs 8.6 pmol/L; P=0.42), whereas DHEAS levels was lower than controls (1.7 vs 2.5 μmol/L; P=0.008). Compared with controls, cGvHD without GC (n=10) was associated with lower free T and DHEAS; P=0.004 and P=0.0004, respectively). The lowest androgen levels were seen in women with both cGvHD and GC therapy. In conclusion, low serum androgens were associated with cGvHD and GC therapy, prompting for studies assessing a possible association between low androgens and sexual dysfunction and quality of life in allografted women.
40.	Bogers, M., et al. (författare) The open innovation research landscape : established perspectives and emerging themes across different levels of analysis 2017 Ingår i: Industry and Innovation. - : Routledge. - 1366-2716 .- 1469-8390. ; 24:1, s. 8-40 Tidskriftsartikel (refereegranskat)abstract This paper provides an overview of the main perspectives and themes emerging in research on open innovation (OI). The paper is the result of a collaborative process among several OI scholars–having a common basis in the recurrent Professional Development Workshop on ‘Researching Open Innovation’ at the Annual Meeting of the Academy of Management. In this paper, we present opportunities for future research on OI, organised at different levels of analysis. We discuss some of the contingencies at these different levels, and argue that future research needs to study OI–originally an organisational-level phenomenon–across multiple levels of analysis. While our integrative framework allows comparing, contrasting and integrating various perspectives at different levels of analysis, further theorising will be needed to advance OI research. On this basis, we propose some new research categories as well as questions for future research–particularly those that span across research domains that have so far developed in isolation.
41.	Brailo, V., et al. (författare) World Workshop on Oral Medicine VI: Utilization of Oral Medicine-specific software for support of clinical care, research, and education: current status and strategy for broader implementation 2015 Ingår i: Oral Surgery Oral Medicine Oral Pathology Oral Radiology. - : Elsevier BV. - 2212-4403. ; 120:2, s. 172-184 Tidskriftsartikel (refereegranskat)abstract Objectives. To assess the current scope and status of Oral Medicine-specific software (OMSS) utilized to support clinical care, research, and education in Oral Medicine and to propose a strategy for broader implementation of OMSS within the global Oral Medicine community. Study Design. An invitation letter explaining the objectives was sent to the global Oral Medicine community. Respondents were interviewed to obtain information about different aspects of OMSS functionality. Results. Ten OMSS tools were identified. Four were being used for clinical care, one was being used for research, two were being used for education, and three were multipurpose. Clinical software was being utilized as databases developed to integrate of different type of clinical information. Research software was designed to facilitate multicenter research. Educational software represented interactive, case-orientated technology designed for clinical training in Oral Medicine. Easy access to patient data was the most commonly reported advantage. Difficulty of use and poor integration with other software was the most commonly reported disadvantage. Conclusions. The OMSS presented in this paper demonstrate how information technology (IT) can have an impact on the quality of patient care, research, and education in the field of Oral Medicine. A strategy for broader implementation of OMSS is proposed.
42.	Brinson, Robert G., et al. (författare) Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics 2019 Ingår i: mAbs. - : Informa UK Limited. - 1942-0862 .- 1942-0870. ; 11:1, s. 94-105 Tidskriftsartikel (refereegranskat)abstract The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new analytical techniques that can precisely assess physicochemical properties of these large and very complex drugs for the purpose of correctly identifying quality attributes (QA). One QA, higher order structure (HOS), is unique to biopharmaceuticals and essential for establishing consistency in biopharmaceutical manufacturing, detecting process-related variations from manufacturing changes and establishing comparability between biologic products. To address this measurement challenge, two-dimensional nuclear magnetic resonance spectroscopy (2D-NMR) methods were introduced that allow for the precise atomic-level comparison of the HOS between two proteins, including mAbs. Here, an inter-laboratory comparison involving 26 industrial, government and academic laboratories worldwide was performed as a benchmark using the NISTmAb, from the National Institute of Standards and Technology (NIST), to facilitate the translation of the 2D-NMR method into routine use for biopharmaceutical product development. Two-dimensional H-1,N-15 and H-1,C-13 NMR spectra were acquired with harmonized experimental protocols on the unlabeled Fab domain and a uniformly enriched-N-15, 20%-C-13-enriched system suitability sample derived from the NISTmAb. Chemometric analyses from over 400 spectral maps acquired on 39 different NMR spectrometers ranging from 500 MHz to 900 MHz demonstrate spectral fingerprints that are fit-for-purpose for the assessment of HOS. The 2D-NMR method is shown to provide the measurement reliability needed to move the technique from an emerging technology to a harmonized, routine measurement that can be generally applied with great confidence to high precision assessments of the HOS of mAb-based biotherapeutics.
43.	Brännström, Mats, 1958, et al. (författare) One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation 2016 Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 106:2, s. 261-266 Tidskriftsartikel (refereegranskat)abstract Objective: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Patient(s): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. Result(s): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. Conclusion(s): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. (C) 2016 by American Society for Reproductive Medicine.
44.	Bundgaard, E., et al. (författare) Matrix Organization and Merit Factor Evaluation as a Method to Address the Challenge of Finding a Polymer Material for Roll Coated Polymer Solar Cells 2015 Ingår i: Advanced Energy Materials. - : Wiley. - 1614-6840 .- 1614-6832. ; 5:10, s. Art. no. 1402186- Tidskriftsartikel (refereegranskat)abstract The results presented demonstrate how the screening of 104 light-absorbing low band gap polymers for suitability in roll coated polymer solar cells can be accomplished through rational synthesis according to a matrix where 8 donor and 13 acceptor units are organized in rows and columns. Synthesis of all the polymers corresponding to all combinations of donor and acceptor units is followed by characterization of all the materials with respect to molecular weight, electrochemical energy levels, band gaps, photochemical stability, carrier mobility, and photovoltaic parameters. The photovoltaic evaluation is carried out with specific reference to scalable manufacture, which includes large area (1 cm(2)), stable inverted device architecture, an indium-tin-oxide-free fully printed flexible front electrode with ZnO/PEDOT:PSS (poly(3,4-ethylenedioxythiophene):polystyrene sulfonate), and a printed silver comb back electrode structure. The matrix organization enables fast identification of active layer materials according to a weighted merit factor that includes more than simply the power conversion efficiency and is used as a method to identify the lead candidates. Based on several characteristics included in the merit factor, it is found that 13 out of the 104 synthesized polymers outperformed poly(3-hexylthiophene) under the chosen processing conditions and thus can be suitable for further development.
45.	Carinelli, S., et al. (författare) Yoctomole electrochemical genosensing of Ebola virus cDNA by rolling circle and circle to circle amplification 2017 Ingår i: Biosensors & bioelectronics. - : Elsevier BV. - 0956-5663 .- 1873-4235. ; 93, s. 65-71 Tidskriftsartikel (refereegranskat)abstract This work addresses the design of an Ebola diagnostic test involving a simple, rapid, specific and highly sensitive procedure based on isothermal amplification on magnetic particles with electrochemical readout. Ebola padlock probes were designed to detect a specific L-gene sequence present in the five most common Ebola species. Ebola cDNA was amplified by rolling circle amplification (RCA) on magnetic particles. Further re-amplification was performed by circle-to-circle amplification (C2CA) and the products were detected in a double-tagging approach using a biotinylated capture probe for immobilization on magnetic particles and a readout probe for electrochemical detection by square-wave voltammetry on commercial screen-printed electrodes. The electrochemical genosensor was able to detect as low as 200 ymol, corresponding to 120 cDNA molecules of L-gene Ebola virus with a limit of detection of 33 cDNA molecules. The isothermal double-amplification procedure by C2CA combined with the electrochemical readout and the magnetic actuation enables the high sensitivity, resulting in a rapid, inexpensive, robust and user-friendly sensing strategy that offers a promising approach for the primary care in low resource settings, especially in less developed countries.
46.	Castellón, L. A. R., et al. (författare) The history behind successful uterine transplantation in humans 2017 Ingår i: Jornal Brasileiro de Reproducao Assistida. - : GN1 Genesis Network. - 1517-5693. ; 21:2, s. 126-134 Tidskriftsartikel (refereegranskat)abstract This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003. Twenty-five UTx procedures have been performed in humans. The first two cases were unsuccessful, but established the need for rigorous research to improve success rates. As a result of a controlled clinical study under a strictly designed research protocol, nine subsequent UTx procedures have resulted in six healthy live births, the first of them in 2014. Further failed UTx procedures have been performed in China, Czech Republic, Brazil, Germany, and the United States, most of which using living donors. Albeit still an experimental procedure in, UTx is the first potential alternative for the treatment of absolute uterine factor infertility (AUFI). © 2017, Sociedade Brasileira de Reproducao Assistida. All rights reserved.
47.	Denby, B. R., et al. (författare) Road salt emissions : A comparison of measurements and modelling using the NORTRIP road dust emission model 2016 Ingår i: Atmospheric Environment. - : Elsevier Ltd. - 1352-2310 .- 1873-2844. ; 141, s. 508-522 Tidskriftsartikel (refereegranskat)abstract De-icing of road surfaces is necessary in many countries during winter to improve vehicle traction. Large amounts of salt, most often sodium chloride, are applied every year. Most of this salt is removed through drainage or traffic spray processes but a certain amount may be suspended, after drying of the road surface, into the air and will contribute to the concentration of particulate matter. Though some measurements of salt concentrations are available near roads, the link between road maintenance salting activities and observed concentrations of salt in ambient air is yet to be quantified. In this study the NORTRIP road dust emission model, which estimates the emissions of both dust and salt from the road surface, is applied at five sites in four Nordic countries for ten separate winter periods where daily mean ambient air measurements of salt concentrations are available. The model is capable of reproducing many of the salt emission episodes, both in time and intensity, but also fails on other occasions. The observed mean concentration of salt in PM10, over all ten datasets, is 4.2 μg/m3 and the modelled mean is 2.8 μg/m3, giving a fractional bias of −0.38. The RMSE of the mean concentrations, over all 10 datasets, is 2.9 μg/m3 with an average R2 of 0.28. The mean concentration of salt is similar to the mean exhaust contribution during the winter periods of 2.6 μg/m3. The contribution of salt to the kerbside winter mean PM10 concentration is estimated to increase by 4.1 ± 3.4 μg/m3 for every kg/m2 of salt applied on the road surface during the winter season. Additional sensitivity studies showed that the accurate logging of salt applications is a prerequisite for predicting salt emissions, as well as good quality data on precipitation. It also highlights the need for more simultaneous measurements of salt loading together with ambient air concentrations to help improve model parameterisations of salt and moisture removal processes. © 2016 The Authors
48.	Deyanova, Diana, et al. (författare) Contribution of seagrass plants to CO2 capture in a tropical seagrass meadow under experimental disturbance 2017 Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:7 Tidskriftsartikel (refereegranskat)abstract Coastal vegetative habitats are known to be highly productive environments with a high ability to capture and store carbon. During disturbance this important function could be compromised as plant photosynthetic capacity, biomass, and/or growth are reduced. To evaluate effects of disturbance on CO2 capture in plants we performed a five-month manipulative experiment in a tropical seagrass (Thalassia hemprichii) meadow exposed to two intensity levels of shading and simulated grazing. We assessed CO2 capture potential (as net CO2 fixation) using areal productivity calculated from continuous measurements of diel photosynthetic rates, and estimates of plant morphology, biomass and productivity/respiration (P/R) ratios (from the literature). To better understand the plant capacity to coping with level of disturbance we also measured plant growth and resource allocation. We observed substantial reductions in seagrass areal productivity, biomass, and leaf area that together resulted in a negative daily carbon balance in the two shading treatments as well as in the high-intensity simulated grazing treatment. Additionally, based on the concentrations of soluble carbohydrates and starch in the rhizomes, we found that the main reserve sources for plant growth were reduced in all treatments except for the low-intensity simulated grazing treatment. If permanent, these combined adverse effects will reduce the plants' resilience and capacity to recover after disturbance. This might in turn have long-lasting and devastating effects on important ecosystem functions, including the carbon sequestration capacity of the seagrass system.
49.	Dimmock, Andrew P., et al. (författare) The GIC and Geomagnetic Response Over Fennoscandia to the 7-8 September 2017 Geomagnetic Storm 2019 Ingår i: Space Weather. - 1542-7390. ; 17:7, s. 989-1010 Tidskriftsartikel (refereegranskat)abstract Between 7 and 8 September 2017, Earth experienced extreme space weather events. We have combined measurements made by the IMAGE magnetometer array, ionospheric equivalent currents, geomagnetically induced current (GIC) recordings in the Finnish natural gas pipeline, and multiple ground conductivity models to study the Fennoscandia ground effects. This unique analysis has revealed multiple interesting physical and technical insights. We show that although the 7-8 September event was significant by global indices (Dst similar to 150 nT), it produced an unexpectedly large peak GIC. It is intriguing that our peak GIC did not occur during the intervals of largest geomagnetic depressions, nor was there any clear upstream trigger. Another important insight into this event is that unusually large and rare GIC amplitudes (>10 A) occurred in multiple Magnetic Local Time (MLT) sectors and could be associated with westward and eastward electrojets. We were also successfully able to model the geoelectric field and GIC using multiple models, thus providing a further important validation of these models for an extreme event. A key result from our multiple conductivity model comparison was the good agreement between the temporal features of 1-D and 3-D model results. This provides an important justification for past and future uses of 1-D models at Mantsala which is highly relevant to additional uses of this data set. Although the temporal agreement (after scaling) was good, we found a large (factor of 4) difference in the amplitudes between local and global ground models due to the difference in model conductivities. Thus, going forward, obtaining accurate ground conductivity values are key for GIC modeling.
50.	Divakar, Pradeep K., et al. (författare) Evolution of complex symbiotic relationships in a morphologically derived family of lichen-forming fungi 2015 Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 208:4, s. 1217-1226 Tidskriftsartikel (refereegranskat)abstract We studied the evolutionary history of the Parmeliaceae (Lecanoromycetes, Ascomycota), one of the largest families of lichen-forming fungi with complex and variable morphologies, also including several lichenicolous fungi. We assembled a six-locus data set including nuclear, mitochondrial and low-copy protein-coding genes from 293 operational taxonomic units (OTUs). The lichenicolous lifestyle originated independently three times in lichenized ancestors within Parmeliaceae, and a new generic name is introduced for one of these fungi. In all cases, the independent origins occurred c. 24 million yr ago. Further, we show that the Paleocene, Eocene and Oligocene were key periods when diversification of major lineages within Parmeliaceae occurred, with subsequent radiations occurring primarily during the Oligocene and Miocene. Our phylogenetic hypothesis supports the independent origin of lichenicolous fungi associated with climatic shifts at the Oligocene-Miocene boundary. Moreover, diversification bursts at different times may be crucial factors driving the diversification of Parmeliaceae. Additionally, our study provides novel insight into evolutionary relationships in this large and diverse family of lichen-forming ascomycetes.

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