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- Hauffman, Anna, et al.
(författare)
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Cocreated internet-based stepped care for individuals with cancer and concurrent symptoms of anxiety and depression : Results from the U-CARE AdultCan randomized controlled trial
- 2020
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Ingår i: Psycho-Oncology. - : John Wiley & Sons. - 1057-9249 .- 1099-1611. ; 29:12, s. 2012-2018
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Tidskriftsartikel (refereegranskat)abstract
- Objective The aim was to evaluate the effects of cocreated internet-based stepped care (iCAN-DO) on anxiety, depression, posttraumatic stress, and health-related quality of life (HRQoL) in individuals with cancer and self-reported anxiety and/or depression symptoms, compared with standard care.Methods Clinically recruited individuals with breast, colorectal, or prostate cancer underwent online screening with the Hospital Anxiety and Depression Scale (HADS). Those with anxiety and/or depression symptoms (>7 on any of the HADS subscales) were randomized to iCAN-DO or standard care. iCAN-DO comprised psychoeducation and self-care strategies (step 1) and internet-based cognitive behavioral therapy (iCBT, step 2). Data were collected before randomization and at 1, 4, 7, and 10 months and analyzed with intention-to-treat regression analysis and randomization tests.Results Online screening identified 245 (27%) of 909 individuals who reported anxiety and/or depression symptoms. They were randomized to iCAN-DO (n = 124) or standard care (n = 121). Of them 49% completed the 10-month assessment, and in the iCAN-DO group 85% accessed step 1 and 13% underwent iCBT. iCAN-DO decreased the levels of symptoms of depression (−0.54, 95% confidence interval: −1.08 to −0.01, P < .05) and the proportion of individuals with symptoms of depression (P < .01) at 10 months, compared with standard care, according to HADS. There were no significant effects on anxiety, posttraumatic stress, or HRQoL.Conclusion Internet-based stepped care improves symptoms of depression in individuals with cancer. Further studies are needed to gain knowledge on how to optimize and implement internet-based support in oncology care.
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| 3. |
- Saguti, Fredy, et al.
(författare)
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Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19.
- 2021
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Ingår i: Water research. - : Elsevier BV. - 1879-2448 .- 0043-1354. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- SARS-CoV-2 was discovered among humans in Wuhan, China in late 2019, and then spread rapidly, causing a global pandemic. The virus was found to be transmitted mainly by respiratory droplets from infected persons or by direct contact. It was also shown to be excreted in feces, why we investigated whether the virus could be detected in wastewater and if so, to which extent its levels reflects its spread in society. Samples of wastewater from the city of Gothenburg, and surrounding municipalities in Sweden were collected daily from mid-February until June 2020 at the Rya wastewater treatment plant. Flow proportional samples of wastewater were collected to ensure that comparable amounts were obtained for analysis. Daily samples were pooled into weekly samples. Virus was concentrated on a filter and analyzed by RT-qPCR. The amount of SARS-CoV-2 varied with peaks approximately every four week, preceding variations in number of newly hospitalized patients by 19-21 days. At that time virus testing for COVID-19 was limited to patients with severe symptoms. Local differences in viral spread was shown by analyzing weekly composite samples of wastewater from five sampling sites for four weeks. The highest amount of virus was found from the central, eastern, and northern parts of the city. SARS-CoV-2 was also found in the treated effluent wastewater from the WWTP discharged into the recipient, the Göta River, although with a reduction of 4-log10. The viral peaks with regular temporal intervals indicated that SARS-CoV-2 may have a cluster spread, probably reflecting that the majority of infected persons only spread the disease during a few days. Our results are important for both the planning of hospital care and to rapidly identify and intervene against local spread of the virus.
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| 4. |
- Saguti, Fredy, et al.
(författare)
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Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19
- 2021
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Ingår i: Water Research. - : Elsevier BV. - 0043-1354 .- 1879-2448. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- SARS-CoV-2 was discovered among humans in Wuhan, China in late 2019, and then spread rapidly, causing a global pandemic. The virus was found to be transmitted mainly by respiratory droplets from infected persons or by direct contact. It was also shown to be excreted in feces, why we investigated whether the virus could be detected in wastewater and if so, to which extent its levels reflects its spread in society. Samples of wastewater from the city of Gothenburg, and surrounding municipalities in Sweden were collected daily from mid-February until June 2020 at the Rya wastewater treatment plant. Flow proportional samples of wastewater were collected to ensure that comparable amounts were obtained for analysis. Daily samples were pooled into weekly samples. Virus was concentrated on a filter and analyzed by RT-qPCR. The amount of SARS-CoV-2 varied with peaks approximately every four week, preceding variations in number of newly hospitalized patients by 19-21 days. At that time virus testing for COVID-19 was limited to patients with severe symptoms. Local differences in viral spread was shown by analyzing weekly composite samples of wastewater from five sampling sites for four weeks. The highest amount of virus was found from the central, eastern, and northern parts of the city. SARS-CoV-2 was also found in the treated effluent wastewater from the WWTP discharged into the recipient, the Göta River, although with a reduction of 4-log10. The viral peaks with regular temporal intervals indicated that SARS-CoV-2 may have a cluster spread, probably reflecting that the majority of infected persons only spread the disease during a few days. Our results are important for both the planning of hospital care and to rapidly identify and intervene against local spread of the virus.
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| 5. |
- Yang, H., et al.
(författare)
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Numerical investigations of Re-independence and influence of wall heating on flow characteristics and ventilation in full-scale 2D street canyons
- 2021
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Ingår i: Building and Environment. - : IEEE. - 0360-1323 .- 1873-684X. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- Validated by wind tunnel data, this study numerically investigates the integrated impacts of wind and thermal buoyancy on urban turbulence, ventilation and pollutant dispersion in full-scale 2D deep street canyons (aspect ratio AR = H/W = 3 and 5, W = 24 m). Isothermal urban airflows for such deep street canyons can be Reynolds-number-independent when reference Reynolds number (Re) exceeds the critical Re (Rec~106,107 when AR = 3, 5), i.e. AR = 5 experiences two main vortices and one-order smaller NEV* (~10−3, the normalized net escape velocity) than AR = 3 with a single main vortex (NEV*~10−2). With sufficiently large Re (Re > Rec) and the same air-wall temperature difference (Ri = 2.62, 4.36 when AR = 3, 5), four uniform wall heating patterns were considered, including leeward-wall heating (L-H), windward-wall heating (W–H), ground heating (G-H), and all-wall heating (A-H). Various indicators were adopted to evaluate street ventilation and pollutant dilution capacity (e.g. age of air (τ,s), NEV*, pollutant transport rates (PTR)). Full-scale wall heating produces a strong upward near-wall buoyancy force, which significantly influences flow patterns and improves street ventilation for most cases. When AR = 3, L-H strengthens the single-vortex airflow. When AR = 5, L-H converts the isothermal double vortices into a single-clockwise vortex. For both ARs, W–H reverses the main clockwise vortex to an enhanced counterclockwise one, moreover G-H and A-H cause a more complicated multi-vortex pattern than isothermal cases. Overall, when AR = 3, L-H and W–H increase NEV* by 68% and 40% than the isothermal case. When AR = 5, four wall heating patterns all raise NEV* considerably (by 150%–556%). For both ARs, the L-H, W–H and A-H amplify the contribution of mean flows on removing pollutants but reduce that by turbulent diffusion compared with isothermal cases.
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