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- Kathiresan, Sekar, et al.
(författare)
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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
- 2008
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:2, s. 189-97
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Tidskriftsartikel (refereegranskat)abstract
- Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care.
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| 3. |
- Allardt Ljunggren, Barbro, 1957-
(författare)
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Åland som språksamhälle : Språk och språkliga attityder på Åland ur ett ungdomsperspektiv
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis deals with Åland, i.e. the Åland Islands, as a language environment. Its main focus is on the language attitudes of adolescents. The status, role and use of Swedish, Finnish and English are topical. Its main part consists of an empirical study, which is based on an extensive questionnaire answered by students in grade 9 of primary school and in the second grade of the (theoretical) secondary school in Åland.The thesis includes a description of Åland as a language environment. The legal framework making Åland an autonomous region in Finland with Swedish as the only official language is presented. Language policies in Åland are compared with those of Sweden and Finland (outside of Åland). Special treatment is given to the school as a linguistic environment and recent language related debate in Åland.The central questions in the questionnaire relate to language choice, media habits, subjective estimations of the respondents’ own language competence and language attitudes in a broad sense.Six hypotheses based on a model of secure and insecure majorities and minorities as well as the Interactive Acculturation Model are postulated and treated.The results of the empirical study reveal very strong feelings of affinity towards Åland. Attitudes towards English and English-speakers are in general positive. The results reveal somewhat ambivalent attitudes towards Finnish and Finland. Many variables show a tendency among the respondents to favour Sweden ahead of Finland and negative attitudes towards Finnish but there are also other conflicting results. The respondents who have parents who speak Finnish to them display more positive attitudes towards Finnish and Finland. These differences between the groups are statistically significant. However, the group with a Finnish language background also displays its strongest feelings of affinity towards Åland.
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| 5. |
- Lindgren, Leif, 1973-, et al.
(författare)
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A multiresolution 100-GOPS 4-Gpixels/s programmable smart vision sensor for multisense imaging
- 2005
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Ingår i: IEEE Journal of Solid-State Circuits. - 0018-9200 .- 1558-173X. ; 40:6, s. 1350-1359
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a multiresolution general-purpose high-speed machine vision sensor with on-chip image processing capabilities. The sensor comprises an innovative multiresolution sensing area, 1536 A/D converters, and a SIMD array of 1536 bit-serial processors with corresponding memory. The sensing area consists of an area part with 1536 × 512 pixels, and a line-scan part with a set of rows with 3072 pixels each. The SIMD processor array can deliver more than 100 GOPS sustained and the on-chip pixel-analysing rate can be as high as 4Gpixels/s. The sensor is ideal for high-speed multisense imaging where, e.g., color, greyscale, internal material light scatter, and 3-D profiles are captured simultaneously. When running only 3-D laser triangulation, a data rate of more than 20 000 profiles/s can be achieved when delivering 1536 range values per profile with 8 bits of range resolution. Experimental results showing very good image characteristics and a good digital to analog noise isolation are presented.
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| 10. |
- Melander, Björn, et al.
(författare)
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Försiktighet ändå bäst
- 2006
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Ingår i: Språkvård. - 0038-8440. ; :4, s. 41-43
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 11. |
- Melander, Björn
(författare)
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Kluster i Läsebok för folkskolan
- 2005
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Ingår i: Språk i tid.. - : Institutionen för nordiska språk, Uppsala. - 9150618105 ; , s. 315-324
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 12. |
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| 13. |
- Melander, Björn, 1958-
(författare)
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Språkpolitik och språkvård
- 2007
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Ingår i: Sociolingvistik. - Stockholm : Liber. - 9789147053254 ; , s. 310-335
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 14. |
- Melander, Björn, 1958-, et al.
(författare)
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Så tar man livet av ett språk
- 2006
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Ingår i: Språkvård: Tidskrift utgiven av svenska språknämnden. - Stockholm : Nämnden för svensk språkvård. - 0038-8440. ; :2, s. 39-42
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 15. |
- Olofsson, Louise, 1977, et al.
(författare)
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CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides.
- 2008
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 93:12, s. 4880-6
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcription factor involved in adipogenesis and hepatic glucose and lipid metabolism. OBJECTIVE: The aim of the study was to test the hypothesis that adipose tissue C/EBPalpha regulates genes in lipid and glucose metabolism and to test for an association between a polymorphism in C/EBPalpha and metabolic parameters. DESIGN AND METHODS: Adipose tissue C/EBPalpha mRNA expression was analyzed at four time points in obese subjects with (n = 12) and without (n = 12) the metabolic syndrome during caloric restriction (450 kcal/d for 16 wk) using DNA microarray and real-time PCR. Adenoviral overexpression of C/EBPalpha was used to identify genes regulated by C/EBPalpha in 3T3-L1 cells. Association between a genetic variation in C/EBPalpha (rs12691) and metabolic parameters was tested in the Swedish Obese Subjects (SOS) study (n = 528) and replicated in Finnish individuals from the Botnia type 2 diabetes study (n = 4,866). RESULTS: During caloric restriction, adipose tissue C/EBPalpha mRNA levels were reduced in subjects with the metabolic syndrome (P = 0.024) and correlated to metabolic parameters. In 3T3-L1 cells, C/EBPalpha regulated the expression of adiponectin; hexokinase 2; lipoprotein lipase; diacylglycerol O-acyltransferase 1 and 2; ATP-binding cassette, sub-family D, member 2; acyl-coenzyme A synthetase long-chain family member 1; CD36; and hydroxysteroid 11-beta dehydrogenase 1. Furthermore, the expression of the human homologs, except adiponectin, correlated to C/EBPalpha mRNA levels in human adipose tissue. The AA genotype of rs12691 was associated with higher serum triglyceride levels in the SOS study (P = 0.022), and this association was replicated in the Botnia study (P = 0.041). CONCLUSIONS: Adipose tissue C/EBPalpha regulates several genes in glucose and lipid metabolism, and a genetic variation in C/EBPalpha is associated with triglycerides in two independent populations.
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| 23. |
- Söderlundh, Hedda, 1981-, et al.
(författare)
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Language beyond English - A Reply to Ulla Paatola
- 2008
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Ingår i: Multiethnica. - Uppsala : Centrum för multietnisk forskning, Uppsala universitet. - 0284-396X. ; 31, s. 29-30
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Tidskriftsartikel (populärvet., debatt m.m.)
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