| 1. |
- Uronen, Riikka-Liisa, et al.
(författare)
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Niemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels
- 2010
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Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - 1524-4636 .- 1079-5642. ; 30:8, s. 230-1614
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Tidskriftsartikel (refereegranskat)abstract
- Objective-To study how Niemann-Pick disease type C1 (NPC1) influences hepatic triacylglycerol (TG) metabolism and to determine whether this is reflected in circulating lipid levels. Methods and Results-In Npc1(-/-) mice, the hepatic cholesterol content is increased but the TG content is decreased. We investigated lipid metabolism in Npc1(-/-) mouse hepatocytes and the association of NPC1 single-nucleotide polymorphisms with circulating TGs in humans. TGs were reduced in Npc1(-/-) mouse serum and hepatocytes. In Npc1(-/-) hepatocytes, the incorporation of [H-3] oleic acid and [H-3] acetate into TG was decreased, but shunting of oleic acid- or acetate-derived [H-3] carbons into cholesterol was increased. Inhibition of cholesterol synthesis normalized TG synthesis, content, and secretion in Npc1(-/-) hepatocytes, suggesting increased hepatic cholesterol neogenesis as a cause for the reduced TG content and secretion. We found a significant association between serum TG levels and 5 common NPC1 single-nucleotide polymorphisms in a cohort of 1053 men, with the lowest P=8.7 x 10(-4) for the single-nucleotide polymorphism rs1429934. The association between the rs1429934 A allele and higher TG levels was replicated in 2 additional cohorts, which included 8041 individuals. Conclusion-This study provides evidence of the following: (1) in mice, loss of NPC1 function reduces hepatocyte TG content and secretion by increasing the metabolic flux of carbons into cholesterol synthesis; and (2) common variation in NPC1 contributes to serum TG levels in humans. (Arterioscler Thromb Vasc Biol. 2010;30:1614-1620.)
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| 2. |
- Alvarez-Madrazo, S., et al.
(författare)
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Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension
- 2013
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Ingår i: Hypertension. - : Ovid Technologies (Wolters Kluwer Health). - 0194-911X .- 1524-4563. ; 61:1, s. 232-239
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Tidskriftsartikel (refereegranskat)abstract
- The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. We analyzed the association of polymorphisms at this locus with risk of essential hypertension, using 2 white case-control collections for discovery (n = 3340) and confirmation (n = 2929). Single-marker and haplotype analyses were performed, with the CYP11B2 Intron 2 Conversion polymorphism showing strongest association with hypertension in both cohorts and in combined analysis (odds ratio = 1.16, P = 8.54x10(-5)). The CYP11B1 ACA haplotype associated with increased risk of hypertension relative to the alternative, GTC (odds ratio = 1.11; P = 7.4x10(-3)), whereas the CYP11B2 TWtC haplotype seemed protective relative to the contrasting CConvT (odds ratio = 0.88, P = 2.2x10(-3)). Analysis spanning the whole CYP11B1/CYP11B2 locus showed that haplotypes associated with raised risk of hypertension tend to coexist. Functional analysis of heterozygous human adrenal tissue demonstrated decreased CYP11B2 expression and increased CYP11B1 expression for those alleles associating with reduced risk of hypertension. These results confirm the hypertensive influence of this locus, with data suggesting a complex digenic mechanism whereby altered relative CYP11B1 and CYP11B2 gene expression could have a chronic effect on enzyme activity and corticosteroid synthesis.
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| 3. |
- Bendegard, Saga, 1982-
(författare)
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Begriplig EU-svenska? : Klarspråksarbetets förutsättningar inom den interinstitutionella översättningsprocessen
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is a study of the inter-institutional translation process through which the Swedish versions of EU legislative acts are created, focusing on the conditions for plain language work within this process. These Swedish translations have long been considered incomprehensible. Complicated originals and strong demands for close correspondence to the source text have been considered the main reason. This study aims to examine the translation process, to see how institutional factors shape the scope for plain language work. The theoretical and methodological bases of the study are the sociology of translation, focusing on translation as a social activity, and ethnography, focusing on the participants’ perspective. The data analysed consist of field notes, interviews, video recordings of participants translating, and revised translations.A key factor for plain language is shown to be the demands for close correspondence to previous texts – not only the source text but also previous Swedish translations. Close correspondence is necessary due to special demands on legal translation but is also supported by other institutional factors, such as translators’ insecurity regarding legal language, short deadlines and the needs of internal readers. The use of CAT tools such as TWB further reinforces this dependence on previous texts.Other institutional factors that stand out are the relative isolation of the translation units, with limited feedback from outside the unit, and the position of the translated documents within the EU legal system. The results indicate that the difficulties for a Swedish reader are often not due to linguistic or textual formulation of the documents, but to the gap this EU position creates, between the reader’s (Swedish) and the text’s (EU) frame of reference respectively.Support for plain language is strong at the units, but the concept appears to have been partially given a local meaning, showing that the traditional understanding of plain language may not be fully applicable in this setting. This shows the necessity to identify the aspects most central to comprehensibility, for different types of texts and in different settings – a necessity not only for plain language work within the EU, but in national settings as well.
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| 4. |
- Fedorowski, Artur, et al.
(författare)
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Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project
- 2014
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Ingår i: Journal of Hypertension. - 0263-6352 .- 1473-5598. ; 32:1, s. 75-81
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Tidskriftsartikel (refereegranskat)abstract
- Objective:Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.Methods:We assessed prospective association of orthostatic hypotension with mortality and major cardiovascular events [myocardial infarction (MI) and stroke] among 8788 treated hypertensive patients (52.2% men; mean age 52 years, mean BP 161/99mmHg) without history of MI or stroke at baseline. Orthostatic hypotension was defined according to combined international consensus criteria, and as either systolic (decrease 20mmHg) or diastolic orthostatic hypotension (decrease 10mmHg). Final Cox regression model was adjusted for age, sex, supine SBP and DBP, diabetes, smoking, and total cholesterol.Results:A total of 1060 (12.1%) study participants fulfilled combined orthostatic hypotension criteria, of these 886 (10.1%) met systolic and 290 (3.3%) diastolic criterion. In the crude analysis, combined orthostatic hypotension criteria were predictive of the composite endpoint, major cardiovascular event, total mortality, and stroke but not MI. After full adjustment, combined orthostatic hypotension criteria and systolic orthostatic hypotension were independently associated with stroke only (hazard ratio: 1.48, 1.07-2.05, P=0.019, and 1.53, 1.08-2.15, P=0.015, respectively), whereas the composite endpoint tended in the same direction (hazard ratio: 1.21, 0.98-1.51, P=0.075, and 1.24, 0.99-1.55, P=0.066, respectively). In contrast, diastolic orthostatic hypotension was associated with increased risk of MI (hazard ratio: 2.04, 1.20-3.46, P=0.008).Conclusion:Orthostatic hypotension has a dual role in cardiovascular events among hypertensive patients: SBP fall indicates higher risk of stroke, whereas DBP fall confers higher risk of MI.
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| 5. |
- Fernandez, Celine, et al.
(författare)
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Plasma Lipid Composition and Risk of Developing Cardiovascular Disease
- 2013
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species. Methods and Results: Screening of the fasted plasma lipidome was performed by top-down shotgun analysis and lipidome compositions compared between incident CVD cases (n = 211) and controls (n = 216) from the prospective population-based MDC study using logistic regression adjusting for Framingham risk factors. Associations with incident CVD were seen for eight lipid species (0.21 <= q <= 0.23). Each standard deviation unit higher baseline levels of two lysophosphatidylcholine species (LPC), LPC16:0 and LPC20:4, was associated with a decreased risk for CVD (P=0.024-0.028). Sphingomyelin (SM) 38: 2 was associated with increased odds of CVD (P=0.057). Five triglyceride (TAG) species were associated with protection (P=0.031-0.049). LPC16:0 was negatively correlated with the carotid intima-media thickness (P=0.010) and with HbA1c (P=0.012) whereas SM38:2 was positively correlated with LDL-cholesterol (P=0.0*10(-6)) and the q-values were good (q <= 0.03). The risk allele of 8 CAD-associated gene variants showed significant association with the plasma level of several lipid species. However, the q-values were high for many of the associations (0.015 <= q <= 0.75). Risk allele carriers of 3 CAD-loci had reduced level of LPC16:0 and/or LPC 20:4 (P <= 0.056). Conclusion: Our study suggests that CVD development is preceded by reduced levels of LPC16: 0, LPC20: 4 and some specific TAG species and by increased levels of SM38:2. It also indicates that certain lipid species are intermediate phenotypes between genetic susceptibility and overt CVD. But it is a preliminary study that awaits replication in a larger population because statistical significance was lost for the associations between lipid species and future cardiovascular events when correcting for multiple testing.
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| 6. |
- Halldén, Sara, et al.
(författare)
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Smoking and obesity associated BDNF gene variance predicts total and cardiovascular mortality in smokers
- 2013
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Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 99:13, s. 949-953
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Tidskriftsartikel (refereegranskat)abstract
- Objective The brain derived neurotrophic factor (BDNF) locus has been implicated in psychiatric and substance related disorders. Recent genome-wide association studies (GWAS) have shown strong associations between single nucleotide polymorphisms in BDNF, smoking behaviour and high body mass index (BMI). Our aim was to test whether genetic BDNF variation alters the risk of smoking related morbidity and mortality. Design Cox proportional hazards models were used to relate the BDNF rs4923461(A/G) polymorphisms to all-cause, cancer and cardiovascular mortality and cardiovascular disease (CVD) incidence adjusted for age, sex, BMI, and smoking quantity. Setting The Malmo Diet and Cancer Study (MDCS), a population based prospective cohort study (n=30 447). Patients We obtained complete data on 25 071 subjects, of whom 6507 were current smokers and 18 564 were non-smokers who underwent a baseline examination from 1991-1996. Main outcome measures During a mean follow-up time of 12 years, 1049 deaths (346 cardiovascular deaths and 492 cancer deaths) and 802 incident CVD events occurred among current smokers. Results The major allele (A) of rs4923461 was significantly associated with ever having smoked (p=0.03) and high BMI (p=0.001). The A-allele was associated with risk of all-cause (HR=1.12, 95% CI 1.00 to 1.25; p<0.05) and CVD (HR=1.23, 95% CI 1.01 to 1.49; p=0.04) mortality. There was no significant association between the rs4923461 and cancer mortality or CVD incidence. Conclusions Our data suggest that smoking-and obesity-associated variation of the BDNF gene affects the risk of death, especially due to cardiovascular causes, in smokers. Determination of the BDNF genotype in smokers may guide the need for smoking cessation interventions.
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| 7. |
- Hamrefors, Viktor, et al.
(författare)
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Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.
- 2012
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Ingår i: Journal of Hypertension. - 1473-5598. ; 30:6, s. 1151-1160
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE:: We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS:: In 3863 Swedish hypertensive patients, we related number of unfavorable alleles of each SNP (i.e. alleles associated with higher baseline BP) to the magnitude of BP reduction during 6 months of monotherapy with either a beta-blocker, a thiazide diuretic or diltiazem. RESULTS:: For six SNPs (rs16998073, rs1378942, rs3184504, rs1530440, rs16948048, rs17367504) no pharmacogenetic interactions were suggested, whereas two SNPs showed nominal evidence of association with treatment response: PLCD3-rs12946454 associated with more SBP (beta = 1.53 mmHg per unfavorable allele; P = 0.010) and DBP (beta = 0.73 mmHg per unfavorable allele; P = 0.014) reduction in patients treated with diltiazem, in contrast to those treated with beta-blockers or diuretics wherein no treatment response association was found. CYP17A1-rs11191548 associated with less DBP reduction (beta = -1.26 mmHg per unfavorable allele; P = 0.018) in patients treated with beta-blockers or diuretics, whereas there was no treatment response association in diltiazem-treated patients. However, if accounting for multiple testing, the significant associations for rs12946454 and rs11191548 were attenuated. CONCLUSION:: For a majority of these, eight recently identified BP-associated SNPs, there are probably no important pharmacogenetic interactions for BP reduction with use of beta-blockers, diuretics or diltiazem. Whether the nominally significant associations for rs12946454 and rs11191548 are true signals and could be of possible clinical relevance for deciding treatment of polygenic essential hypertension should be further tested.
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| 8. |
- Johnson, Toby, et al.
(författare)
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Blood Pressure Loci Identified with a Gene-Centric Array.
- 2011
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 89:6, s. 688-700
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Tidskriftsartikel (refereegranskat)abstract
- Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56× 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56× 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.
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| 9. |
- Larsson, Erik, 1975, et al.
(författare)
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Hypertension and Genetic Variation in Endothelial-Specific Genes
- 2013
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association (GWA) studies usually detect common genetic variants with low-to-medium effect sizes. Many contributing variants are not revealed, since they fail to reach significance after strong correction for multiple comparisons. The WTCCC study for hypertension, for example, failed to identify genome-wide significant associations. We hypothesized that genetic variation in genes expressed specifically in the endothelium may be important for hypertension development. Results from the WTCCC study were combined with previously published gene expression data from mice to specifically investigate SNPs located within endothelial-specific genes, bypassing the requirement for genome-wide significance. Six SNPs from the WTCCC study were selected for independent replication in 5205 hypertensive patients and 5320 population-based controls, and successively in a cohort of 16537 individuals. A common variant (rs10860812) in the DRAM (damage-regulated autophagy modulator) locus showed association with hypertension (P = 0.008) in the replication study. The minor allele (A) had a protective effect (OR = 0.93; 95% CI 0.88-0.98 per A-allele), which replicates the association in the WTCCC GWA study. However, a second follow-up, in the larger cohort, failed to reveal an association with blood pressure. We further tested the endothelial-specific genes for co-localization with a panel of newly discovered SNPs from large meta-GWAS on hypertension or blood pressure. There was no significant overlap between those genes and hypertension or blood pressure loci. The result does not support the hypothesis that genetic variation in genes expressed in endothelium plays an important role for hypertension development. Moreover, the discordant association of rs10860812 with blood pressure in the case control study versus the larger Malmo "Preventive Project-study highlights the importance of rigorous replication in multiple large independent studies.
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| 10. |
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| 11. |
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| 12. |
- Melander, Björn, 1958-
(författare)
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Makten över språket i svensk språkpolitik
- 2011
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Ingår i: Språket, makten och härligheten.. - Uppsala : Hugo Valentin-Centrum, Uppsala universitet. - 9789186531072 ; , s. 23-45
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 13. |
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| 14. |
- Melander, Björn, 1958-
(författare)
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Språkpolitik och språkvård
- 2013. - 2
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Ingår i: Sociolingvistik. - Stockholm : Liber. ; , s. 325-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 15. |
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| 16. |
- Melander, Björn, 1958-, et al.
(författare)
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Underbart är kort? Om taltidsrespekt i svenska och franska EU-debatter
- 2014
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Ingår i: Le Nord en français: traduction, interprétation, interculturalité. - Mons : Éditions du C.I.P.A.. - 9782930200439 - 9782930200446 ; , s. 143-157
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Bokkapitel (refereegranskat)abstract
- Le débat parlementaire est, à la différence de la conversation ordinaire, un genre institutionnalisé où l’ordre de passage ainsi que le temps de parole sont strictement réglementés et non négociables. Le temps de parole alloué aux députés du parlement européen est distribué en fonction d’un ordre du jour établi, où chacun d’entre eux se voit attribuer de 1 à 5 minutes. Une des tâches principales du président de séance est d’assurer que ce temps est respecté. Celui-ci dispose de trois moyens pour intervenir : il peut frapper la table avec son marteau, faire une remarque et finalement couper le micro du ou de la députée.Dans le corpus, nous avons identifié des séquences où l’orateur dépasse le temps imparti, ce qui constitue l’écart à la norme le plus fréquent. Dans un premier temps, nous avons recensé, dans différentes allocutions, les dépassements de temps de parole, ensuite mesurés en pourcent du temps de parole imparti. Nous avons également relevé les occurrences où le président de séance intervient et dans ce cas quand et de quelle manière.Les résultats montrent que les Français dépassent leur temps de parole en moyenne de 17%, alors que la moyenne des Suédois est de 13%. Sur la totalité de l’étude, on ne peut observer de différences marquantes entre les sexes. Or, lorsque la nationalité est prise en considération, il se montre que les parlementaires françaises ont plus tendance à dépasser leur temps de parole (18% contre 16% pour les hommes), tandis que la tendance est inverse pour les parlementaires suédois : 14% pour les hommes, 11% pour les femmes. D’après nos observations, l’appartenance aux partis politiques ne semble pas avoir d’impact sur les données.L’étude est basée sur C-ParlEur – Corpus de discours du Parlement européen, qui est composé de la totalité des interventions de députés français et suédois en séance plénière du Parlement européen pour la période avril 2006 – mars 2008, ce qui représente 360 contributions suédoises et 919 françaises. Le corpus est constitué de séquences vidéo enregistrées, ce qui permet une analyse des interactionnelle.
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| 17. |
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| 18. |
- Nyroos, Lina, 1979-
(författare)
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The Social Organization of Institutional Norms : Interactional Management of Knowledge, Entitlement and Stance
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present thesis explores talk in institutional settings, with a particular focus on how institutionality and institutional norms are constructed and reproduced in interaction. A central aim is to enhance our understanding of how institutional agendas are talked into being. In line with the ethnomethodological approach, norms are viewed as accomplished in everyday interaction, whereas institutionality represents dimensions of talk where participants demonstrably orient to particular contextual constraints. Five studies were conducted using Conversation Analysis (CA), focusing on how institutional constraints impact sequential trajectories and shape different opportunities for participants. The data consists of two corpora of video recordings: group tutorials at a Swedish university (UTs), and performance appraisal interviews in an organization (PAIs). The thesis pays particular attention to the interactional management of knowledge, entitlement and stance, and analytic foci include how speakers manage epistemic claims and rights at a certain point in interaction, and how they accomplish social positioning. The UT studies examine the negotiation of rights to speak for others in a group (Study I), and how diverging understandings of the institutional activity-at-hand can be negotiated on the basis of students’ advice-seeking questions (Study II). In Study III, orientations to institutional and sociocultural norms are investigated in the PAIs, where managers and employees treat negative stances on stress as problematic. The relationship between theory and institutional practice in the use of question templates in PAIs is also examined, through an analysis of the delivery and receipt of a particular question in different interviews (Study IV). Focusing on different adaptations of a preset item, this analysis shows how the same question sets up for a variety of subsequent actions. Finally, deployment of the verb känna (‘feel’) in managing epistemic access and primacy is examined (Study V). It is argued that ‘feel’ allows for a reduction of accountability when making epistemic claims. The studies highlight the relationship between linguistic formats and social actions and illustrate how institutional agendas have consequences for participant conduct. Attention to the details of actions in institutional interaction can thus shed light on social and linguistic underpinnings of the enactment of institutional norms.
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| 19. |
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| 25. |
- Svensson, Patrik, et al.
(författare)
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A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients.
- 2011
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Ingår i: Journal of Hypertension. - 1473-5598. ; 29:2, s. 388-395
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The capability of the protein NEDD4L to reduce renal tubular expression of epithelial Na+ channel (ENaC) is influenced by a functional rs4149601 G→A NEDD4L polymorphism. As diuretics and β-blockers inhibit renal sodium reabsorption and renin release, respectively, we hypothesized that the β-blocker or diuretic-induced blood pressure reduction and prevention of cardiovascular disease would be greater in patients with the highest ENaC expression (rs4149601 G-allele), whereas there would be no such genetically mediated differences in treatment efficacy among patients treated with the vasodilator diltiazem. METHODS: We related rs4149601 status to 6-month blood pressure reduction and risk of cardiovascular events in 5152 hypertensive patients (DBP ≥ 100 mmHg) from the Nordic Diltiazem Study (NORDIL) randomized to either β-blocker and/or diuretic-based treatment or diltiazem-based treatment. RESULTS: In patients on β-blocker or diuretic monotherapy, carriers of the G-allele had greater SBP reduction (19.5 ± 16.8 vs. 15.0 ± 19.3 mmHg, P < 0.001) and DBP reduction (15.4 ± 8.3vs. 14.1 ± 8.4 mmHg, P = 0.02) and during 4.5 years of follow-up among patients randomized to β-blockers and/or diuretics, carriers of the G-allele had greater protection from cardiovascular events [relative risk (RR) = 0.52, 95% confidence interval (CI) = 0.36-0.74, P < 0.001] as compared to AA homozygotes. Within the diltiazem group, there was no difference in blood pressure reduction or risk of cardiovascular events according to genotype. CONCLUSION: The functional NEDD4L rs4149601 polymorphism influences the efficacy of β-blocker and/or diuretic-based antihypertensive treatment both in terms of blood pressure reduction and cardiovascular disease protection, whereas diltiazem-based antihypertensive treatment efficacy is not influenced by this NEDD4L polymorphism.
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| 26. |
- Söderlundh, Hedda, 1981-
(författare)
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Internationella universitet – lokala språkval : Om bruket av talad svenska i engelskspråkiga kursmiljöer
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis deals with the use of spoken Swedish on six English-medium university courses in Sweden. The courses are taken by both Swedish and foreign students, with English as the common language of instruction. The aim of the study is to describe and understand the oral use of Swedish, by students in particular, in the type of linguistic environment that arises when English is the medium of instruction. Language use is studied from three angles: the use of spoken Swedish, the functions of Swedish in interaction, and participants’ attitudes to Swedish and English and to the choice of one language or the other. The analysis is based on observations and recordings of naturally occurring talk on courses in the subject areas business studies, engineering and computer science, and on interviews with students and teaching staff. Close analysis of the Swedish spoken is combined with ethnographic knowledge of the broader social context of the courses, and in both theory and method the thesis combines the research fields of sociolinguistics and ethnography. The study shows that Swedish is spoken on all the courses observed. It is used primarily outside whole-group teaching, in interactions not involving foreign students. The language occurs both in talk relating to the course subject and in private conversations. Thus, English-medium education does not by definition mean that English is the only language employed; Swedish, too, has a more or less prominent place. In the thesis, attitudes and patterns of language choice are attributed to the national, rather than international, character of the courses, and to the fact that most of the students and lecturers have experience of and routines from Swedish-medium education. The old routines are carried over into the nominally English-medium courses, giving Swedish a special position and local prestige in these environments.
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| 27. |
- Thelander, Mats, 1945-, et al.
(författare)
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Som det heter på nysvenska ...
- 2014
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Ingår i: Fint språk/Good language. - Göteborg : Styrelsen för Mejerbergs institut vid Göteborgs universitet. - 9789187850004 ; , s. 183-194
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Bokkapitel (refereegranskat)
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| 28. |
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