SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Modeer T) ;srt2:(1995-1999)"

Sökning: WFRF:(Modeer T) > (1995-1999)

  • Resultat 1-37 av 37
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  • Yucel-Lindberg, T, et al. (författare)
  • Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts
  • 1999
  • Ingår i: Journal of dental research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 78:1, s. 61-68
  • Tidskriftsartikel (refereegranskat)abstract
    • Accumulating evidence indicates that prostaglandins play an important role in the pathogenesis of periodontal disease. In this study, the effects and interactions between IL-1β and TNFa on prostaglandin production and its regulation were investigated. The cytokines IL-1β and TNFa stimulated prostaglandin E2 (PGE2) and prostacyclin (PGI2) production in gingival fibroblasts. Simultaneous treatment of the cells with IL-1β and TNFa resulted in a synergistic stimulation of PGE2 and PGI2 formation. IL-1β and, to a lesser extent, TNFa stimulated the release of 3H-arachidonic acid (3H-AA), and simultaneous addition of IL-1β and TNFa further increased the release of 3H-AA from pre-labeled gingival fibroblasts. Furthermore, IL-1β and, to a lesser extent, TNFa induced the expression of cyclooxygenase-2 (COX-2) mRNA. Simultaneous addition of IL-1β and TNFa synergistically enhanced COX-2 mRNA levels, accompanied by a corresponding stimulation of PGE2 synthesis. Neither IL-1β, TNFa, nor the combination of these two cytokines affected COX-1 mRNA levels. PMA, known to activate protein kinase C (PKC), enhanced the stimulatory effect of IL-1β, TNFa, and the combination on COX-2 mRNA levels accompanied by a corresponding increase in PGE2 production. The phospholipase A2 (PLA2) inhibitor, BPB, and the PKC inhibitor, BIS, reduced PGE2 production, whereas dexamethasone, indomethacin, and NS-398 completely abolished PGE2 production induced by IL-1β, TNFa, and the combination. The study indicates that the synergistic stimulation of prostaglandin production by IL-1β, and TNFa is mediated partly at the level of COX-2 and partly at the level of PLA2 and that PKC is involved in the signal transduction of the synergy between the two cytokines. The synergy between IL-1β and TNFa may play an important role in the inflammatory processes in gingival tissue in vivo.
  •  
11.
  •  
12.
  •  
13.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  •  
18.
  •  
19.
  •  
20.
  •  
21.
  •  
22.
  •  
23.
  •  
24.
  •  
25.
  •  
26.
  •  
27.
  •  
28.
  •  
29.
  •  
30.
  •  
31.
  •  
32.
  •  
33.
  •  
34.
  •  
35.
  •  
36.
  •  
37.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-37 av 37

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy