| 1. |
- Schael, S, et al.
(författare)
-
Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
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| 3. |
- Aamodt, K., et al.
(författare)
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The ALICE experiment at the CERN LHC
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08002
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Forskningsöversikt (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries, Its overall dimensions are 16 x 16 x 26 m(3) with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.
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| 4. |
- Armesto, N., et al.
(författare)
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Heavy-ion collisions at the LHC-Last call for predictions
- 2008
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 35:5, s. 054001-
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Forskningsöversikt (refereegranskat)abstract
- This writeup is a compilation of the predictions for the forthcoming Heavy Ion Program at the Large Hadron Collider, as presented at the CERN Theory Institute 'Heavy Ion Collisions at the LHC - Last Call for Predictions', held from 14th May to 10th June 2007.
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| 5. |
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| 6. |
- Andgren, Karin, et al.
(författare)
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Low-spin collective behavior in the transitional nuclei Mo-86,Mo-88
- 2007
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 76:1, s. 014307-
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Tidskriftsartikel (refereegranskat)abstract
- Low-spin structures in Mo-86,Mo-88 were populated using the Ni-58(Ar-36, x alpha yp) heavy-ion fusion-evaporation reaction at a beam energy of 111 MeV. Charged particles and gamma rays were emitted in the reactions and detected by the DIAMANT CsI ball and the EXOGAM Ge array, respectively. In addition to the previously reported low-to-medium spin states in these nuclei, new low-spin structures were observed. Angular correlation and linear polarization measurements were performed in order to unambiguously determine the spins and parities of intensely populated states in Mo-88. Quasiparticle Random Phase Approximation (QRPA) calculations were performed for the first and second excited 2(+) states in Mo-86 and Mo-88. The results are in qualitative agreement with the experimental results, supporting a collective interpretation of the low-spin states for these transitional nuclei.
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| 7. |
- Mason, P, et al.
(författare)
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Octupole signatures in Ba-124,Ba-125
- 2005
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Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 31:10, s. S1729-S1733
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Tidskriftsartikel (refereegranskat)abstract
- The gamma decay of the nuclei Ba-121,Ba-125 has been investigated with the EUROBALL array, using the reaction Ni-64+Ni-64 at E-beam = 255 and 261 MeV. Six new E1 transitions have been found in the nucleus Ba-125, suggesting a significant role of octupole correlations in the origin of its parity doublets. The J(pi) = 3(-) level of the nucleus Ba-124 has been identified for the first time. Its excitation energy is in very good agreement with a prediction based on a microscopic model including octupole interactions.
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| 8. |
- Tinker, N. A., et al.
(författare)
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New DArT markers for oat provide enhanced map coverage and global germplasm characterization
- 2009
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 10:39
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Tidskriftsartikel (refereegranskat)abstract
- Background: Genomic discovery in oat and its application to oat improvement have been hindered by a lack of genetic markers common to different genetic maps, and by the difficulty of conducting whole-genome analysis using high-throughput markers. This study was intended to develop, characterize, and apply a large set of oat genetic markers based on Diversity Array Technology (DArT). Results: Approximately 19,000 genomic clones were isolated from complexity-reduced genomic representations of pooled DNA samples from 60 oat varieties of global origin. These were screened on three discovery arrays, with more than 2000 polymorphic markers being identified for use in this study, and approximately 2700 potentially polymorphic markers being identified for use in future studies. DNA sequence was obtained for 2573 clones and assembled into a non-redundant set of 1770 contigs and singletons. Of these, 705 showed highly significant (Expectation < 10E-10) BLAST similarity to gene sequences in public databases. Based on marker scores in 80 recombinant inbred lines, 1010 new DArT markers were used to saturate and improve the 'Kanota' x 'Ogle' genetic map. DArT markers provided map coverage approximately equivalent to existing markers. After binning markers from similar clones, as well as those with 99% scoring similarity, a set of 1295 non-redundant markers was used to analyze genetic diversity in 182 accessions of cultivated oat of worldwide origin. Results of this analysis confirmed that major clusters of oat diversity are related to spring vs. winter type, and to the presence of major breeding programs within geographical regions. Secondary clusters revealed groups that were often related to known pedigree structure. Conclusion: These markers will provide a solid basis for future efforts in genomic discovery, comparative mapping, and the generation of an oat consensus map. They will also provide new opportunities for directed breeding of superior oat varieties, and guidance in the maintenance of oat genetic diversity.
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| 9. |
- Hegyesi, G., et al.
(författare)
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Ethernet based distributed data acquisition system for a small animal PET
- 2006
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Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 53:4, s. 2112-2117
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Tidskriftsartikel (refereegranskat)abstract
- We report on the design of a small animal PET scanner being developed at our institutes. The existing setup is the first version of the miniPET machine consisting of four detector modules. Each detector module consists of an 8 x 8 LSO scintillator crystal block, a position sensitive photomultiplier, a digitizer including a digital signal processing board and an Ethernet interface board. There is no hardware coincidence detection implemented in the system and coincidence is determined based on a time stamp attached to every event by a digital CFD algorithm. The algorithm is implemented in the digital signal processing board and generates a time stamp with a coincidence resolution of less than 2 us. The data acquisition system is based on Ethernet network and is highly scalable in size and performance.
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| 10. |
- Kis, S. A., et al.
(författare)
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Performance Characteristics of a miniPET Scanner Dedicated to Small Animal Imaging
- 2005
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Ingår i: 2005 IEEE Nuclear Science Symposium Conference Record. - 0780392213 - 9780780392212 ; , s. 1645-1648
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Konferensbidrag (refereegranskat)abstract
- An easy to scale up modular PET scanner was developed for imaging small animals. Energy resolution, spatial resolution and count rate performance were determined as system parameters. The configuration provided an average energy resolution of 19.6 % and the image resolution ranges was 1.5 to 2.3 mm in radial direction. The sensitivity of the miniPET was 1.08 cps/kBq as determined using a point source. In addition, results of rat brain scan performed with FDG are given to characterize imaging capability of the system. The displayed data document that the miniPET scanner supports good quality brain imaging of small animals.
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| 11. |
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| 12. |
- Imrek, J., et al.
(författare)
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Development of an improved detector module for miniPET-II
- 2007
-
Ingår i: 2006 IEEE Nuclear Science Symposium Conference Record. - : IEEE. - 1424405610 - 9781424405619 ; , s. 3037-3040
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Konferensbidrag (refereegranskat)abstract
- We present a new detector module developed for miniPET-II, the second generation of the miniPET small animal PET scanners. The improved module features new hardware components for better performance: LySO crystal material, increased number of crystal segments, Hamamatsu H9500 PSPMT, Xilinx Virtex-4 FPGA and Gigabit Ethernet. However, the principle of operation is the same: no hardware coincidence detection is implemented, data is acquired in list mode and transfered over an Ethernet network. The resulting new module is more suitable for full ring configurations.
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| 13. |
- Kis, S. A., et al.
(författare)
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Comparison of Monte Carlo simulated and measured performance parameters of miniPET scanner
- 2007
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 571:02-jan, s. 449-452
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Tidskriftsartikel (refereegranskat)abstract
- In vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose, miniPET, an easy to scale modular small animal PET camera has been developed at our institutes. The system has four modules, which makes it possible to rotate the whole detector system around the axis of the field of view. Data collection and image reconstruction are performed using a data acquisition (DAQ) module with Ethernet communication facility and a computer cluster of commercial PCs. Performance tests were carried out to deter-mine system parameters, such as energy resolution, sensitivity and noise equivalent count rate. A modified GEANT4-based GATE Monte Carlo software package was used to simulate PET data analogous to those of the performance measurements. GATE was run on a Linux cluster of 10 processors (64 bit, Xeon with 3.0 GHz) and controlled by a SUN grid engine. The application of this special computer cluster reduced the time necessary for the simulations by an order of magnitude. The simulated energy spectra, maximum rate of true coincidences and sensitivity of the camera were in good agreement with the measured parameters.
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| 14. |
- Nyako, B. M., et al.
(författare)
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Search for hyperdeformation in light Xe nuclei
- 2005
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Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 36:4, s. 1033-1038
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Tidskriftsartikel (refereegranskat)abstract
- The ultimate search for hyperdeformation (HD) at high spins with the EUROBALL spectrometer was performed for Ba-126 as a hyper long (HLHD) experiment. The DIAMANT ancillary detector was used to tag gamma-rays in coincidence with the emitted light charged particles. Using gamma-energy correlation methods, the particle-xn-gamma data have been analysed to search for hyperdeformed structures in the corresponding residual nuclei. Data in coincidence with one alpha particle indicate the presence of normal deformed collective bands up to very high spins and the possible occurrence of HD-like ridge structures in Xe-122.
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| 15. |
- Brunner, M, et al.
(författare)
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Towards Ambient Networks Management
- 2005
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Ingår i: MOBILITY AWARE TECHNOLOGIES AND APPLICATIONS, PROCEEDINGS. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 3540294104 ; , s. 215-229
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Konferensbidrag (refereegranskat)abstract
- Ambient Networks (AN) are under development and they are based on novel networking concepts and systems that will enable a wide range of user and business communication scenarios beyond today's fixed, 3(rd) generation mobile and IP standards. Central to this project is the concept of Ambient Control Space (ACS) and the Domain Manager control function, which manages the underlying data transfer capabilities and presents a set of interfaces towards the supported services and applications. Network Management Systems of Ambient Networks must work in an environment where heterogeneous networks compose and cooperate, on demand and transparently, without the need for manual (pre or re)-configuration or offline negotiations between network operators. To achieve these goals, ambient network management systems must become dynamic, distributed, self-managing and responsive to the network and its ambience. This paper describes the different management research challenges and four complementary solution approaches (i.e. Pattern-based Management, Peer-to-Peer Management, (Un)PnP Management, Traffic Engineering Management Application Approaches) that enable efficient management of ambient networks, and the relationships between them, and presents the main results achieved so far.
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| 16. |
- Divaris, K, et al.
(författare)
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The academic environment: the students' perspective
- 2008
-
Ingår i: European journal of dental education : official journal of the Association for Dental Education in Europe. - : Wiley. - 1396-5883. ; 1212 Suppl 1, s. 120-130
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Tidskriftsartikel (refereegranskat)
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| 17. |
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| 18. |
- Simon, A., et al.
(författare)
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High spatial resolution measurement of depth-of-interaction of a PET LSO crystal
- 2005
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 546:1-2, s. 33-36
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Tidskriftsartikel (refereegranskat)abstract
- A new type of experimental technique to investigate the depth- of-interaction (DOI) dependence in small scintillator elements designed for high-resolution animal PET is tested. An Oxford-type nuclear microprobe was used to irradiate a lutetium oxyorthosilicate (LSO) crystal (2 x 2 x 10 mm) with a highly focused, (few micrometers diam.), 2 MeV He+ beam. Pulse height spectra from a PMT attached to one end of the LSO crystal were collected in list mode. By scanning the beam over the crystal high-resolution 2D-images are generated and thus the DOI effect in the scintillator could be investigated. The obtained results of the overall DOI dependence confirm previous findings using gamma-rays. Since the present experimental setup allows obtaining data with several orders of magnitude better spatial resolution than with collimated gamma-beam, the method can be applied for variety of problems where high spatial resolution is required.
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| 19. |
- Valastyán, Iván, et al.
(författare)
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A SPECT demonstrator - revival of a gamma camera
- 2006
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 563:1, s. 274-277
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Tidskriftsartikel (refereegranskat)abstract
- A gamma camera has been updated and converted to serve as a demonstrator for educational purposes. The gantry and the camera head were the only part of the system that remained untouched. The main reason for this modernization was to increase the transparency of the gamma camera by partitioning the different logical building blocks of the system and thus providing access for inspection and improvements throughout the chain. New data acquisition and reconstruction software has been installed. By taking these measures, the camera is now used in education and also serves as a platform for tests of new hardware and software solutions. The camera is also used to demonstrate 3D (SPECT) imaging by collecting 2D projections from a rotatable cylindrical phantom. Since the camera head is not attached mechanically to the phantom, the effect of misalignment between the head and the rotation axis of the phantom can be studied. (c) 2006 Elsevier B.V. All rights reserved.
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| 20. |
- Valastyán, Iván, et al.
(författare)
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Data acquisition and image reconstruction systems from the MiniPET scanners to the CARDIOTOM camera
- 2007
-
Ingår i: Nuclear Physics Methods And Accelerators In Biology And Medicine. - : American Institute of Physics (AIP). - 9780735404724 ; , s. 282-283
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Bokkapitel (refereegranskat)abstract
- Nuclear imaging devices play an important role in medical diagnosis as well as drug research. The first and second generation data acquisition systems and the image reconstruction library developed provide a unified hardware and software platform for the miniPET-I, miniPET-II small animal PET scanners and for the CARDIOTOM(TM).
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| 21. |
- Valastyán, Iván, et al.
(författare)
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Experimental scanner setup from miniPET II detector module
- 2009
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Ingår i: 2008 IEEE Nuclear Science SYmposium Conference Record. - 9781424427147 ; , s. 3121-3124
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The PET technique is widely used in human clinical studies and recent developments of image resolution has made it suitable for small animal research. The second generation of our PET scanner consists of 12 detector modules and has a field of view large enough to image mice and rats. Parameters of the incoming data are extracted by Digital Signal Processing in the detector modules and a System-on-Module is used to transmit the data through an Ethernet network for storage and reconstruction. The experimental scanner setup described in this paper was constructed in order to investigate the applicability of the developed detector modules in a full ring small animal PET camera. The preliminary results of the system are also presented.
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| 22. |
- Valastyán, Iván, et al.
(författare)
-
Full 3-D cluster-based iterative image reconstruction tool for a small animal PET camera
- 2007
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 571:1-2, s. 219-222
-
Tidskriftsartikel (refereegranskat)abstract
- Iterative reconstruction methods are commonly used to obtain images with high resolution and good signal-to-noise ratio in nuclear imaging. The aim of this work was to develop a scalable, fast, cluster based, fully 3-D iterative image reconstruction package for our small animal PET camera, the miniPET. The reconstruction package is developed to determine the 3-D radioactivity distribution from list mode type of data sets and it can also simulate noise-free projections of digital phantoms. We separated the system matrix generation and the fully 3-D iterative reconstruction process. As the detector geometry is fixed for a given camera, the system matrix describing this geometry is calculated only once and used for every image reconstruction, making the process much faster. The Poisson and the random noise sensitivity of the ML-EM iterative algorithm were studied for our small animal PET system with the help of the simulation and reconstruction tool. The reconstruction tool has also been tested with data collected by the miniPET from a line and a cylinder shaped phantom and also a rat.
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| 23. |
- Valastyán, Iván, et al.
(författare)
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Validation of an iterative reconstruction for a mobile tomographic gamma camera system - The Cardiotom
- 2007
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 580:2, s. 1097-1100
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Tidskriftsartikel (refereegranskat)abstract
- The Cardiotom is a mobile gamma camera that uses ectomography, an alternative method of acquisition to SPECT. It is designed for early diagnosis of myocardial and cerebral infarctions in the emergency room. Ectomography is a limited view angle method, using a rotating slant hole collimator and a stationary camera head, to acquire projection images. The aim of this work was to validate a fully 3D ML-EM iterative reconstruction algorithm for the Cardiotom. Validation measurements were performed with Tc-99m point sources. Resolution in the reconstructed volume was determined in X, Y. and Z directions from the point spread functions. The results were compared with the values for the formerly used filtered back projection (FBP). The new reconstruction algorithm provides greatly improved depth resolution with respect to the FBP method previously implemented on the Cardiotom. Furthermore, for clinical examinations, images can be available for interpretation within 15 min of the injection, therefore, valuable information can be obtained without delaying treatment of the patient. (c) 2007 Elsevier B.V. All rights reserved.
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| 24. |
- Angyal, G., et al.
(författare)
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PET examination in intracranial tumor diagnosis of a cat
- 2008
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Ingår i: AIP Conference Proceedings. - : AIP. ; , s. 199-203
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Konferensbidrag (refereegranskat)abstract
- This paper shows the significance of the Positron Emission Tomography (PET) in the veterinary medication through a case study of a cat brain tumor. A castrated male cat with bilateral mydriasis and blindness arrived at the veterinary clinic. After physical, laboratory and neurological investigations other sickness was ruled out and the inkling of the intracranial lesion had come to light. Brain tumor seemed the most likely to cause the illness because other symptoms appeared (for example: anorexia, depression) and they progrediated fast. PET examination, using 18F-FDG isotope, was performed to confirm the possible causes of the cat's symptoms
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| 25. |
- DeHenauw, Stefaan, et al.
(författare)
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Nutritional status and lifestyle of adolescents from a public health perspective. The HELENA Project - Healthy Lifestyle in Europe by Nutrition in Adolescence.
- 2007
-
Ingår i: Journal of Public Health. ; 15:3, s. 187-197
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Tidskriftsartikel (refereegranskat)abstract
- The HELENA Project—Healthy Lifestyle in Europe by Nutrition in Adolescence—is a European, collaborative research project financed by the EU Sixth Framework Programme in the area of nutrition-related adolescent health. The basic objective of the HELENA project is to obtain reliable and comparable data from a random sample of European adolescents (boys and girls aged 13–16 years) on a broad battery of relevant nutrition and health-related parameters: dietary intake, food choices and preferences, anthropometry, serum indicators of lipid metabolism and glucose metabolism, vitamin and mineral status, immunological markers, physical activity, fitness and genetic markers. The HELENA project is conceived as a scientific construction with four complementary sub-studies that are elaborated through 14 well-defined work packages. Sub-studies are focused, respectively, on “a cross-sectional description of lifestyles and indicators of nutritional status (HELENA-CSS)”, “a lifestyle education intervention programme (HELENA-LSEI), “a metabolic study with cross-over design (HELENA-COMS)” and a “study on behaviour, food preferences and food development” (HELENA-BEFO). The project unites 20 research centres from 10 European countries. In addition, the consortium comprises five SMEs (small and medium-sized enterprises) that are actively involved in the research activities. The core of the HELENA project study material is an overall European cohort of 3,000 adolescents, equally recruited in ten cities from nine countries. Standardization of methods among partners is a key issue in the project and is obtained through the development of standard protocols, training sessions, validation sub-studies and pilot projects. Health-related problems have a tendency to evolve in cycles, with ever new problems emerging in ever new contexts that call for appropriate and tailored actions. The HELENA project is expected to offer essential elements for use in the overall machinery of required public health nutrition cycles. It is of the greatest importance for its results to prove useful that it can communicate with other initiatives on the level of science and society.
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| 26. |
- Dénes, E., et al.
(författare)
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Radiation tolerance qualification tests of the final source interface unit for the ALICE experiment for the ALICE collaboration
- 2007
-
Ingår i: Proceedings - 12th Workshop on Electronics for LHC and Future Experiments, LECC 2006. - : CERN. ; , s. 438-441
-
Konferensbidrag (refereegranskat)abstract
- The ALICE Detector Data Link (DDL) is a high-speed optical link designed to interface the readout electronics of ALICE sub-detectors to the DAQ computers. The Source Interface Unit (SIU) of the DDL will operate in radiation environment. Previous tests showed that a configuration loss of SRAM-based FPGA devices may happen and the frequency of undetected data errors in the FPGA user memory area is also not acceptable. Therefore, we redesigned the SIU card using another FPGA based on flash technology. In order to detect bit errors in the user memory we added parity check logic to the design. The new SIU has been extensively tested using neutron and proton irradiation to verify its radiation tolerance. In this paper we summarize the design changes, introduce the final design, and the results of the radiation tolerance measurements on the final card.
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| 27. |
- Dénes, E., et al.
(författare)
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Radiation tolerant source interface unit for the ALICE experiment
- 2005
-
Ingår i: Proceedings - 11th Workshop on Electronics for LHC and Future Experiments, LECC 2005. - : CERN. ; , s. 291-293
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Konferensbidrag (refereegranskat)abstract
- The ALICE Detector Data Link (DDL) is a high-speed optical link designed to interface the readout electronics of ALICE sub-detectors to the DAQ computers. The Source Interface Unit (SIU) of the DDL will operate in radiation environment. Tests showed that configuration loss of the Altera APEX II FPGA device used earlier on the DDL SIU card is only marginally acceptable. We developed a new version of the SIU card using Actel ProASIC+ device based on flash memory technology. The new SIU card has been extensively tested using neutron and proton irradiation. In this paper we present the SIU card and describe the results of irradiation measurements.
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| 28. |
- Jeans, Alexander F., et al.
(författare)
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A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse
- 2007
-
Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 104:7, s. 2431-2436
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Tidskriftsartikel (refereegranskat)abstract
- The neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for synaptic vesicle exocytosis, but its study has been limited by the neonatal lethality of murine SNARE knockouts. Here, we describe a viable mouse line carrying a mutation in the b-isoform of neuronal SNARE synaptosomal-associated protein of 25 kDa (SNAP-25) The causative I67T missense mutation results in increased binding affinities within the SNARE complex, impaired exocytotic vesicle recycling and granule exocytosis in pancreatic beta-cells, and a reduction in the amplitude of evoked cortical excitatory postsynaptic potentials. The mice also display ataxia and impaired sensorimotor gating, a phenotype which has been associated with psychiatric disorders in humans. These studies therefore provide insights into the role of the SNARE complex in both diabetes and psychiatric disease.
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| 29. |
- Novák, D., et al.
(författare)
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Component tests for the PRISMA spacecraft
- 2007
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Ingår i: RADECS 2007. - : IEEE. - 9781424417049 ; , s. 595-598
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Konferensbidrag (refereegranskat)abstract
- TID and proton tests are reported on some COTS components for the PRISMA satellite project. TID test level was more than 20 krad and 170 MeV protons were used for the single event tests.
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| 30. |
- Novák, D., et al.
(författare)
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In flight SEU tests on the European SMART-1 spacecraft
- 2005
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Ingår i: Proceedings of the European Conference on Radiation and its Effects on Components and Systems, RADECS. - 0780395018 - 9780780395015 ; , s. PH11-PH13
-
Konferensbidrag (refereegranskat)abstract
- The SMART-I satellite launched by the European Space Agency has traveled to an orbit around the Moon driven by its own ion engine. Because of the characteristics of the ion engine mission required many revolutions to reach the Moon and the time to pass through the radiation belts around the Earth was significant. The spacecraft is exposed to solar protons throughout its mission. In advance the flight in-beam test data was collected to asses the radiation hardness properties of an SRAM, one of the components of the system unit of the satellite. Single Event Upset data is available for this component and Solar Proton Flux was measured by the GOES satellite in Geosynchronous orbit. The aim of this work is to compare the predictions of the in-beam tests and the effects of the in space irradiation of SRAM circuits on board.
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| 31. |
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| 32. |
- Valastyán, Iván, et al.
(författare)
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Gated tomographic imaging in ectomography using a dynamic heart phantom
- 2007
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Ingår i: Nuclear Science Symposium Conference Record, 2007. NSS '07. IEEE. - : IEEE. - 9781424409228 ; , s. 3414-3417
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Konferensbidrag (refereegranskat)abstract
- A new computer controlled dynamic heart phantom and the connection of an ECG unit to a tomographic gamma camera system, developed for ectomographic imaging, is presented. The phantom is used for validation of the camera. Measurements were performed to test the phantom as well as to study the feasibility of gated imaging in ectomography. The camera is intended for early diagnosis of myocardial and cerebral infarctions.
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| 33. |
- Wesolowska, O., et al.
(författare)
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Benzo [a] phenoxazines: A new group of potent P-glycoprotein inhibitors
- 2006
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Ingår i: In Vivo. - 0258-851X. ; 20:1, s. 109-113
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Tidskriftsartikel (refereegranskat)abstract
- The ability of fifteen novel phenoxazine derivatives (four phenoxazines and eleven benzo[a]phenoxazines) to modulate multidrug resistance (MDR) in a P-gp-overexpressing mouse T lymphoma cell line (L5178 MDR) was studied. A flow cytometric functional test, based on the differential accumulation of rhodamine 123 by sensitive and multidrug-resistant cells, was employed. Seven benzo[a]phenoxazines were observed to increase the amount of rhodamine 123 accumulated by resistant cells, i.e. to be new effective MDR modulators. The results allowed us to draw preliminary conclusions about the structural features of benzo[a]phenoxazines which are important for MDR modulation.
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