Sökning: WFRF:(Morales Ollallo)
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Preoperative tumor ...
Preoperative tumor localization by means of venous sampling for fibroblast growth factor-23 in a patient with tumor-induced osteomalacia
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- Westerberg, Per-Anton (författare)
- Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Olauson, Hannes (författare)
- Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Toss, Göran (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Wikström, Björn (författare)
- Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Morales, Ollallo (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Linde, Torbjörn, 1957- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Jonsson, Kenneth (författare)
- Departments of Surgical Science, Uppsala University Hospital, Uppsala, Sweden
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- Ljunggren, Östen (författare)
- Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Larsson, Tobias E. (författare)
- Departments of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Endocrine Practice. - 1530-891X .- 1934-2403. ; 14:3, s. 362-7
- Relaterad länk:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To report on a novel strategy for tumor localization in a 62-year-old man with hypophosphatemic tumor-induced osteomalacia (TIO). METHODS: Repeated computed tomographic and magnetic resonance imaging scans failed to localize any tumor in a patient with adult-onset hypophosphatemic osteomalacia. Therefore, venous sampling for fibroblast growth factor-23 (FGF23)--a circulating hormone that has been identified as a causative factor for TIO--in major veins was conducted. Serum FGF23 was measured from collected samples by an intact FGF23 enzyme-linked immunosorbent assay. RESULTS: Venous sampling suggested a local increase in serum FGF23 in the left femoral vein; this finding prompted performance of octreotide scintigraphy restricted to the left leg. A tumor was located at the lateral condyle of the left femur, which was also confirmed by magnetic resonance imaging. Surgical resection of the tumor normalized the serum phosphorus and 1,25-dihydroxyvitamin D3 levels within 5 to 10 days, and FGF23 declined to normal levels within 24 hours. Histologic analysis supported the diagnosis of a soft-tissue giant cell tumor. CONCLUSION: Our study case demonstrates the diagnostic complexity and difficulties in localizing a small tumor in a patient with TIO. Venous sampling for FGF23 may be helpful in tumor localization in sporadic cases of hypophosphatemic osteomalacia, especially when noninvasive diagnostic techniques prove insufficient.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Westerberg, Per- ...
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Olauson, Hannes
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Toss, Göran
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Wikström, Björn
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Morales, Ollallo
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Linde, Torbjörn, ...
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Jonsson, Kenneth
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Ljunggren, Östen
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Larsson, Tobias ...
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Endocrine Practi ...
- Av lärosätet
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Uppsala universitet
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Linköpings universitet