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Folliculitis decalv...
Folliculitis decalvans has a heterogeneous microbiological signature and impaired immunological response
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Moreno-Arrones, O. M. (författare)
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Garcia-Hoz, C. (författare)
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del Campo, R. (författare)
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visa fler...
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Roy, G. (författare)
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Saceda-Corralo, D. (författare)
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Jimenez-Cauhe, J. (författare)
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Ponce-Alonso, M. (författare)
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Serrano-Villar, S. (författare)
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Jaen, P. (författare)
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- Paoli, John, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology
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Vano-Galvan, S. (författare)
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(creator_code:org_t)
- 2023-01-30
- 2023
- Engelska.
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Ingår i: Dermatology. - : S. Karger AG. - 1018-8665 .- 1421-9832. ; 239:3, s. 454-461
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Folliculitis decalvans (FD) is a rare primary neutrophilic scarring alopecia whose etiology has not been completely elucidated yet.Objective: To determine if the follicular microbiota residing in FD-affected hair follicles had a distinct microbiological signature and if an aberrant immune response was present in the pathogenesis of FD.Methods: We conducted a cross-sectional study of ten patients affected by FD. Trichoscopy-guided follicular biopsies were taken from affected and healthy scalp to identify the follicular microbiome using next-generation sequencing. We searched for microbiological biomarkers of FD-affected follicles using the linear discriminant analysis (LDA) effect size (LEfSe) tool. Additionally, peripheral blood mononuclear cells were obtained, and their cytokine production was quantified after incubation with pathogen-associated molecular patterns isolated from patients' biopsies and compared with healthy controls.Results: beta-diversity analysis showed statistically significant differences regarding bacteria comparing follicular microbiota of healthy and FD-affected hairs. Ruminococcaceae, Agathobacter sp., Tyzzerella sp. and Bacteriodales vadin HA21 family were good predictors of disease status. IL-10, TNF-alpha and IL-6 levels were significantly decreased in patients after incubation with various strains of bacteria compared with controls.Conclusion: FD hair follicles have a specific heterogenous follicular bacterial microbiota signature. Additionally, these patients seem to have an impaired immunological response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- bacteria
- Dermatology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Moreno-Arrones, ...
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Garcia-Hoz, C.
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del Campo, R.
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Roy, G.
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Saceda-Corralo, ...
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Jimenez-Cauhe, J ...
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visa fler...
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Ponce-Alonso, M.
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Serrano-Villar, ...
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Jaen, P.
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Paoli, John, 197 ...
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Vano-Galvan, S.
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visa färre...
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Dermatology
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Göteborgs universitet