| 1. |
- Garte, S, et al.
(författare)
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Metabolic gene polymorphism frequencies in control populations
- 2001
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Ingår i: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1055-9965. ; 10:12, s. 1239-1248
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Olsson, J., et al.
(författare)
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Neural Networks for rainfall forecasting by atmospheric downscaling
- 2004
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Ingår i: Journal of Hydrologic Engineering. - 1084-0699. ; 9:1, s. 1-12
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have used artificial neural networks (NNs) to estimate local or regional recipitation/rainfall on the basis of relationships with coarse-resolution atmospheric variables. None of these experiments satisfactorily reproduced temporal intermittency and variability in rainfall. We attempt to improve performance by using two approaches: (1) couple two NNs in series, the first to determine rainfall occurrence, and the second to determine rainfall intensity during rainy periods; and (2) categorize rainfall into intensity categories and train the NN to reproduce these rather than the actual intensities. The experiments focused on estimating 12-h mean rainfall in the Chikugo River basin, Kyushu Island, southern Japan, from large-scale values of wind speeds at 850 hPa and precipitable water. The results indicated that (1) two NNs in series may greatly improve the reproduction of intermittency; (2) longer data series are required to reproduce variability; (3) intensity categorization may be useful for probabilistic forecasting; and (4) overall performance in this region is better during winter and spring than during summer and autumn.
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| 3. |
- Smits, KM, et al.
(författare)
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Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
- 2004
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 110:2, s. 266-270
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Tidskriftsartikel (refereegranskat)abstract
- Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
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