| 1. |
- Ades, M., et al.
(författare)
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Global Climate : in State of the climate in 2019
- 2020
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 101:8, s. S17-S127
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Ades, M., et al.
(författare)
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GLOBAL CLIMATE
- 2020
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Ingår i: BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY. - 0003-0007 .- 1520-0477. ; 101:8
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Iram, T., et al.
(författare)
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Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
- 2022
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 605, s. 509-515
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Tidskriftsartikel (refereegranskat)abstract
- Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing(1-3). Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds(4,5). We discovered that infusing young CSF directly into aged brains improves memory function. Unbiased transcriptome analysis of the hippocampus identified oligodendrocytes to be most responsive to this rejuvenated CSF environment. We further showed that young CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and differentiation in the aged hippocampus and in primary OPC cultures. Using SLAMseq to metabolically label nascent mRNA, we identified serum response factor (SRF), a transcription factor that drives actin cytoskeleton rearrangement, as a mediator of OPC proliferation following exposure to young CSF. With age, SRF expression decreases in hippocampal OPCs, and the pathway is induced by acute injection with young CSF. We screened for potential SRF activators in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is sufficient to induce OPC proliferation and long-term memory consolidation in aged mice while Fgf17 blockade impairs cognition in young mice. These findings demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the ageing brain.
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| 4. |
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| 5. |
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| 6. |
- Amizhtan, S. K., et al.
(författare)
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Experimental Study and ANN Analysis of Rheological Behavior of Mineral Oil-Based SiO2 Nanofluids
- 2022
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Ingår i: IEEE transactions on dielectrics and electrical insulation. - : Institute of Electrical and Electronics Engineers (IEEE). - 1070-9878 .- 1558-4135. ; 29:3, s. 956-964
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Tidskriftsartikel (refereegranskat)abstract
- This work reports an experimental and theoretical analysis of the rheological properties of mineral oil-based SiO2 nanofluid for their potential applications in transformer insulation. The flow electrification mechanism on the nanofluids with different surfactants such as cetyl trimethyl ammonium bromide (CTAB), oleic acid, and Span 80 is studied using a spinning disk technique. The results show a higher streaming current for the nanofluids with CTAB as a surfactant compared to oleic acid and Span 80. The rheological behavior of nanofluids is explored with the double gap concentric cylinder geometry. The variation of shear stress with shear rate follows a power law relationship along with a yield stress observed for all the nanofluids. A transition is seen from storage modulus to dominant loss modulus for the nanofluids during the frequency sweep analysis, whereas no transition is observed in the case of mineral oil. In addition, regression analysis using artificial neural network (ANN) algorithms are performed on the experimentally measured viscosity of the nanofluids in order to estimate theoretical parameters and provide insights into the streaming current formation. The desirable rheological characteristics of nanofluids are identified for achieving enhanced insulation performance in transformers.
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