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- Ramsey, L. B., et al.
(författare)
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy : 2014 Update
- 2014
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Ingår i: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 96:4, s. 423-428
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Tidskriftsartikel (refereegranskat)abstract
- Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin-induced myopathy.
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| 2. |
- Wilke, R. A., et al.
(författare)
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The Clinical Pharmacogenomics Implementation Consortium : CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy
- 2012
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Ingår i: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 92:1, s. 112-117
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Tidskriftsartikel (refereegranskat)abstract
- Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly.
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| 5. |
- Brown, Solomon, et al.
(författare)
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CO(2)QUEST : Techno-economic assessment of CO2 quality effect on its storage and transport
- 2014
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Ingår i: 12TH INTERNATIONAL CONFERENCE ON GREENHOUSE GAS CONTROL TECHNOLOGIES, GHGT-12. - : Elsevier BV. ; , s. 2622-2629
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Konferensbidrag (refereegranskat)abstract
- Presented is an overview of the CO(2)QUEST project that addresses fundamentally important issues regarding the impact of typical impurities in the gas or dense phase CO2 stream captured from fossil fuel power plants on its safe and economic transportation and storage. Previous studies have mainly investigated the impact of CO2 stream impurities on each part of the carbon capture and storage (CCS) chain in isolation. This is a significant drawback given the different sensitivities of pipeline, wellbore materials and storage sites to the various impurities. The project brings together leading researchers and stakeholders, to address the impact of the typical impurities upon safe and economic CO2 transportation and storage. State-of-the-art mathematical models, backed by laboratory and industrial-scale experimentation, are implemented to perform a comprehensive techno-economic assessment of the impact of impurities upon the thermo-physical phenomena governing pipeline and storage-site integrities.
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| 13. |
- Chernodub, M.N., et al.
(författare)
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Elastic Energy and Phase Structure in a Continuous Spin Ising Chain with Applications to the Protein Folding Problem
- 2011
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Ingår i: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics. - 1539-3755 .- 1550-2376. ; 83:1
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Tidskriftsartikel (refereegranskat)abstract
- We present a numerical Monte Carlo analysis of a continuos spin Ising chain that can describe the statistical proterties of folded proteins. We find that depending on the value of the Metropolis temperature, the model displays the three known nontrivial phases of polymers: At low temperatures the model is in a collapsed phase, at medium temperatures it is in a random walk phase, and at high temperatures it enters the self-avoiding random walk phase. By investigating the temperature dependence of the specific energy we confirm that the transition between the collapsed phase and the random walk phase is a phase transition, while the random walk phase and self-avoiding random walk phase are separated from each other by a cross-over transition. We also compare the predictions of the model to a phenomenological elastic energy formula, proposed by Huang and Lei to describe folded proteins.
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| 21. |
- Metaferia, Wondwosen, et al.
(författare)
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Selective area heteroepitaxy of InP nanopyramidal frusta on Si for nanophotonics
- 2013
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Ingår i: Indium Phosphide and Related Materials (IPRM), 2012 International Conference on. - : IEEE. - 9781467317252 ; , s. 81-84
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Konferensbidrag (refereegranskat)abstract
- InP nanopyramidal frusta on InP and InP precoated Si substrates were grown selectively from nano-imprinted circular openings in silicon dioxide mask using a low pressure hydride vapor phase epitaxy reactor. The grown InP nanopyramidal frusta, octagonal in shape, were characterized by Atomic Force Microscopy, Scanning Electron Microscopy and Photoluminescence. The growth is extremely selective and uniform over the entire patterned area on both substrates. The measured diagonal of the top surface is 30 nm and 90 nm for the nanopyramidal frusta grown from 120 nm and 300 nm diameter openings, respectively. The size and morphology as well as the optical quality of these pyramidal frusta make them suitable templates for quantum dot structures for nano photonics and silicon photonics.
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| 22. |
- Metaferia, Wondwosen, et al.
(författare)
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Selective area heteroepitaxy through nanoimprint lithography for large area InP on Si
- 2012
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Ingår i: Physica Status Solidi. C, Current topics in solid state physics. - : Wiley. - 1610-1634 .- 1610-1642. ; 9:7, s. 1610-1613
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Tidskriftsartikel (refereegranskat)abstract
- The use of nanoimprint lithography, a low cost and time saving alternative to E-beam lithography, for growing heteroepitaxial indium phosphide layer on silicon is demonstrated. Two types of patterns on 500 nm and 200 nm thick silicon dioxide mask either on InP substrate or InP seed layer on silicon were generated by UV nanoimprint lithography: (i) circular openings of diameter 150 nm and 200 nm and (ii) line openings of width ranging from 200 nm to 500 nm. Selective area growth and epitaxial lateral overgrowth of InP were conducted on these patterns in a low pressure hydride vapour phase epitaxy reactor. The epitaxial layers obtained were characterized by atomic force microscopy, scanning electron microscopy and micro photoluminescence. The growth from the circular openings on InP substrate and InP (seed) on Si substrate is extremely selective with similar growth morphology. The final shape has an octahedral flat top pyramid type geometry. These can be used as templates for growing InP nanostructures on silicon. The grown InP layers from the line openings on InP substrates are ∌ 2.5 Όm thick with root mean square surface roughness as low as 2 nm. Completely coalesced layer of InP over an area of 1.5 mm x 1.5 mm was obtained.The room temperature photoluminescence intensity from InP layers on InP substrate is 55% of that of homoepitaxial InP layer. The decrease in PL intensity with respect to that of the homoepitaxial layer is probably due to defects associated with stacking faults caused by surface roughness of the mask surface. Thus in this study, we have demonstrated that growth of heteroepitaxial InP both homogeneously and selectively on the large area of silicon can be achieved. This opens up the feasibility of growing InP on large area silicon for several photonic applications.
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| 24. |
- Niemi, Johanna, et al.
(författare)
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Oikeuden tekstit empiirisen tutkimuksen kohteena
- 2010
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Ingår i: Empiirisen oikeustutkimuksen kokemukset, haasteet ja tulevaisuus Itä-Suomen yliopiston julkaisuja. ; , s. 97-118
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 26. |
- Rowe, K. G., et al.
(författare)
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Lessons from the lollipop : Biotribology, tribocorrosion, and irregular surfaces
- 2014
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Ingår i: Tribology letters. - : Springer New York LLC. - 1023-8883 .- 1573-2711. ; 56:2, s. 273-280
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Tidskriftsartikel (refereegranskat)abstract
- Biotribology and tribocorrosion are often not included in numerical or computational modeling efforts to predict wear because of the apparent complexity in the geometry, the variability in removal rates, and the challenge associated with mixing time-dependent removal processes such as corrosion with cyclic material removal from wear. The lollipop is an accessible bio-tribocorrosion problem that is well known but underexplored scientifically as a tribocorrosion process. Stress-assisted dissolution was found to be the dominant tribocorrosion process driving material removal in this system. A model of material removal was described and approached by lumping the intrinsically time-dependent process with a mechanically driven process into a single cyclic volumetric material removal rate. This required the collection of self-reported wear data from 58 participants that were used in conjunction with statistical analysis of actual lollipop cross-sectional information. Thousands of repeated numerical simulations of material removal and shape evolution were conducted using a simple Monte Carlo process that varied the input parameters and geometries to match the measured variability. The resulting computations were analyzed to calculate both the average number of licks required to reach the Tootsie Roll® center of a Tootsie Roll® pop, as well as the expected variation thereof.
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| 27. |
- Saarela, Juha M., et al.
(författare)
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Detection of laser induced dielectric breakdown in water using a laser doppler vibrometer
- 2010
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Ingår i: Central European Journal of Physics. - : Walter de Gruyter GmbH. - 1895-1082 .- 1644-3608. ; 8:2, s. 235-241
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Tidskriftsartikel (refereegranskat)abstract
- This study is focused on exploring the feasibility of an all-optic surface scanning method in determining the size and position of a submerged, laser generated, optoacoustic source. The optoacoustic effect was here generated when the absorption of a short electromagnetic pulse in matter caused a dielectric breakdown, a plasma emission flash and a subsequent acoustic wave. In the experiment, a laser pulse with l = 1064 nm and 12 ns pulse length was aimed at a volume of deionized water. When the laser beam was focused by a f = 16 mm lens, a single dielectric breakdown spot occurred. When a f = 40 mm was used several breakdowns in a row were induced. The breakdowns were photographed using a double shutter camera. The acoustic wave generated by the dielectric breakdowns were detected at a point on the water surface using a laser Doppler vibrometer (LDV). First, the LDV signal was used to calculate the speed of sound with an accuracy of 10 m/s. Secondly, the location and length of the dielectric breakdown was calculated with an accuracy of 1 mm. The calculated position matched the breakdown location recorded by a camera. The results show that it is possible to use LDV surface measurements from a single spot to determine both the position and length of the OA source as well as the speed of sound in the medium. Furthermore, the LDV measurements also show a secondary peak that originates from the OA source. To unravel the origin and properties of this interesting feature, further investigations are necessary.
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