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- Rhind, Nicholas, et al.
(författare)
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Comparative Functional Genomics of the Fission Yeasts
- 2011
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 332:6032, s. 930-936
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Tidskriftsartikel (refereegranskat)abstract
- The fission yeast clade-comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus-occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
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- Watson, Richard T., et al.
(författare)
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Frugal information systems (IS)
- 2013
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Ingår i: Information Technology for Development. - : Informa UK Limited. - 0268-1102 .- 1554-0170. ; 19:2, s. 176-187
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Tidskriftsartikel (refereegranskat)abstract
- A discussion of the factors contributing to a likely increase in austerity establishes the case for a greater emphasis on frugal information systems (IS), which is defined as an information system that is developed and deployed with minimal resources to meet the pre-eminent goal of the client. The U-constructs are adopted as a foundation for a frugal IS, and two simple messaging system-based case studies illustrate their application. Design guidelines and practices for frugal IS are considered. The challenges and potential gains of frugal IS are reviewed.
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