| 1. |
- Bhoo-Pathy, Nirmala, et al.
(författare)
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Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
- 2015
-
Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 17
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P-trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P-trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.
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| 2. |
- Nilsson, C. L., et al.
(författare)
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Use of ENCODE Resources to Characterize Novel Proteoforms and Missing Proteins in the Human Proteome
- 2015
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 14:2, s. 603-608
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Tidskriftsartikel (refereegranskat)abstract
- We describe the utility of integrated strategies that employ both translation of ENCODE data and major proteomic technology pillars to improve the identification of the "missing proteins", novel proteoforms, and PTMs. On one hand, databases in combination with bioinformatic tools are efficiently utilized to establish microarray-based transcript analysis and supply rapid protein identifications in clinical samples. On the other hand, sequence libraries are the foundation of targeted protein identification and quantification using mass spectrometric and immunoaffinity techniques. The results from combining proteoENCODEdb searches with experimental mass spectral data indicate that some alternative splicing forms detected at the transcript level are in fact translated to proteins. Our results provide a step toward the directives of the C-HPP initiative and related biomedical research.
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| 3. |
- Nilsson Ekdahl, Kristina, et al.
(författare)
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Dangerous liaisons : complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation
- 2016
-
Ingår i: Immunological Reviews. - : Wiley. - 0105-2896 .- 1600-065X. ; 274:1, s. 245-269
-
Forskningsöversikt (refereegranskat)abstract
- Innate immunity is fundamental to our defense against microorganisms. Physiologically, the intravascular innate immune system acts as a purging system that identifies and removes foreign substances leading to thromboinflammatory responses, tissue remodeling, and repair. It is also a key contributor to the adverse effects observed in many diseases and therapies involving biomaterials and therapeutic cells/organs. The intravascular innate immune system consists of the cascade systems of the blood (the complement, contact, coagulation, and fibrinolytic systems), the blood cells (polymorphonuclear cells, monocytes, platelets), and the endothelial cell lining of the vessels. Activation of the intravascular innate immune system in vivo leads to thromboinflammation that can be activated by several of the system's pathways and that initiates repair after tissue damage and leads to adverse reactions in several disorders and treatment modalities. In this review, we summarize the current knowledge in the field and discuss the obstacles that exist in order to study the cross-talk between the components of the intravascular innate immune system. These include the use of purified in vitro systems, animal models and various types of anticoagulants. In order to avoid some of these obstacles we have developed specialized human whole blood models that allow investigation of the cross-talk between the various cascade systems and the blood cells. We in particular stress that platelets are involved in these interactions and that the lectin pathway of the complement system is an emerging part of innate immunity that interacts with the contact/coagulation system. Understanding the resulting thromboinflammation will allow development of new therapeutic modalities.
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| 4. |
- Teramura, Yuji, et al.
(författare)
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Cell Adhesion Induced Using Surface Modification with Cell-Penetrating Peptide-Conjugated Poly(ethylene glycol)-Lipid : A New Cell Glue for 3D Cell-Based Structures
- 2017
-
Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 9:1, s. 244-254
-
Tidskriftsartikel (refereegranskat)abstract
- We synthesized a novel material, cell-penetrating peptide conjugated poly(ethylene glycol)-lipid (CPP-PEG-lipid), that can induce the adhesion of floating cells. Firm cell adhesion with spreading could be induced by cell surface modification with the CPP-PEG-lipids. Cell adhesion was induced by CPPs but not by any other cationic short peptides we tested. Here, we demonstrated adherence using the floating cell line CCRF-CEM as well as primary human T cells, B cells, erythrocytes, and hepatocytes. As compared to cells grown in suspension, adherent cells were more rapidly induced to attach to substrates with the cell-surface modification. The critical factor for attachment was localization of CPPs at the cell membrane by PEG-lipids with PEG > 20 kDa. These cationic CPPs on PEG chains were able to interact with substrate surfaces such as polystyrene (PS) surfaces, glass surfaces, and PS microfibers that are negatively charged, inducing firm cell adhesion and cell spreading. Also, as opposed to normal cationic peptides that interact strongly with cell membranes, CPPs were less interactive with the cell surfaces because of their cell-penetrating property, making them more available for adhering cells to the substrate surface. No effects on cell viability or cell proliferation were observed after the induction of cell adhesion. With this technique, cells could be easily immobilized onto PS microfibers, an important step in fabricating 3D cell-based structures. Cells immobilized onto 3D PS microfibers were alive, and human hepatocytes showed normal production of urea and albumin on the microfibers. This method is novel in inducing firm cell adhesion-via a one-step treatment.
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| 5. |
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| 6. |
- Boza-Serrano, Antonio, et al.
(författare)
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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
- 2019
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 138:2, s. 251-273
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer’s disease) mice and found specifically expressed in microglia associated with Aβ plaques. Single-nucleotide polymorphisms in the LGALS3 gene, which encodes gal3, were associated with an increased risk of AD. Gal3 deletion in 5xFAD mice attenuated microglia-associated immune responses, particularly those associated with TLR and TREM2/DAP12 signaling. In vitro data revealed that gal3 was required to fully activate microglia in response to fibrillar Aβ. Gal3 deletion decreased the Aβ burden in 5xFAD mice and improved cognitive behavior. Interestingly, a single intrahippocampal injection of gal3 along with Aβ monomers in WT mice was sufficient to induce the formation of long-lasting (2 months) insoluble Aβ aggregates, which were absent when gal3 was lacking. High-resolution microscopy (stochastic optical reconstruction microscopy) demonstrated close colocalization of gal3 and TREM2 in microglial processes, and a direct interaction was shown by a fluorescence anisotropy assay involving the gal3 carbohydrate recognition domain. Furthermore, gal3 was shown to stimulate TREM2–DAP12 signaling in a reporter cell line. Overall, our data support the view that gal3 inhibition may be a potential pharmacological approach to counteract AD.
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| 7. |
- Durmo, Faris, et al.
(författare)
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Brain Tumor Characterization Using Multibiometric Evaluation of MRI
- 2018
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Ingår i: Tomography : a journal for imaging research. - : MDPI AG. - 2379-1381. ; 4:1, s. 14-25
-
Tidskriftsartikel (refereegranskat)abstract
- The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest. A binary logistic regression model was applied for multiparametric analysis and receiver operating characteristic (ROC) analysis. Statistically significant differences were found for normalized-ADC-tumor (nADC-T), normalized-CBF-tumor (nCBF-T), normalized-CBV-tumor (nCBV-T), and normalized-CBF-edema (nCBF-E) between LGG and HGG, and when these metrics were combined, HGG could be distinguished from LGG with a sensitivity and specificity of 100%. The only metric to distinguish HGG from MET was the normalized-ADC-E with a sensitivity of 68.8% and a specificity of 80%. LGG can be distinguished from MET by combining edema volume (Vol-E), Vol-E/tumor volume (Vol-T), nADC-T, nCBF-T, nCBV-T, and nADC-E with a sensitivity of 93.3% and a specificity of 100%. The present study confirms the usability of a multibiometric approach including volume, perfusion, and diffusion metrics in differentially diagnosing brain tumors in preoperative patients and adds to the growing body of evidence in the clinical field in need of validation and standardization.
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| 8. |
- Ericson, Ulrika, et al.
(författare)
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Food patterns in relation to weight change and incidence of type 2 diabetes, coronary events and stroke in the Malmö Diet and Cancer cohort
- 2019
-
Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6207 .- 1436-6215. ; 58:5, s. 1801-1814
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: We examined if data-driven food-patterns associate with weight change, incidence of type 2 diabetes (T2D), coronary events (CE) and stroke. Methods: The study included 20,487 individuals (61% women) from the Malmö Diet and Cancer cohort, 45–74 years, without diabetes and CVD at baseline (1991–1996) and who did not report dietary changes. Diet was measured with a modified diet history method. During 15 years follow-up, 2206 T2D, 1571 CE and 1332 stroke cases were identified. Data on weight change after 16.7 years were available in 2627 individuals. Results: From principal component analysis, we identified six food-patterns which were similar in women and men. The first pattern, explaining 7% of the variance, was characterized by high intake of fibre-rich bread, breakfast cereals, fruits, vegetables, fish and low-fat yoghurt, and by low intake of low-fibre bread. This health conscious pattern was associated with lower T2D risk (HR comparing highest quintile with lowest: 0.75; 95% CI 0.61–0.92, 0.82; 95% CI 0.68–1.00 in women and men, respectively, P trends = 0.003, 0.01) and CE (HR 0.77; 95% CI 0.58–1.02, HR 0.83; 95% CI 0.68–1.01, P trends = 0.05, 0.07), and in men also with lower risk of ischemic stroke (HR 0.69; 95% CI 0.54–0.88; P trend = 0.001) and less pronounced weight gain (0.93 kg/10 years, P trend = 0.03). A low-fat product pattern was associated with increased T2D risk in gender combined analyses (P trend = 0.03) and a pattern characterized by dressing and vegetables with lower CE risk in men (P trend = 0.02). Conclusions: Our main finding was that a dietary pattern indicating health conscious food choices was associated with lower risk of cardiometabolic diseases in both genders.
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| 9. |
- Göransson, Elisabet, et al.
(författare)
-
Vad är en disciplin? Om det gränslösa latinet och ämnets position vid Lunds universitet
- 2017
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Ingår i: Humanitas. Festskrift till Arne Jönsson. - 9789170612442 ; , s. 790-803
-
Bokkapitel (refereegranskat)abstract
- In this contribution, Göransson explores the historical background of classical philology,in particular Latin, in Sweden. Research in Latin encompasses studies on Latin of alltimes: both classical, medieval and Neo-Latin. Göransson discusses the growth of the subjectboth in the upper secondary school and in the universities in the late 1990s. Today,however, the economic system is hard on all minor disciplines. Collaboration, especiallywithin graduate education, would be the best way to make sure that the Latin disciplineremains strong in all four main universities in Sweden.
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| 10. |
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| 11. |
- Janelidze, Shorena, et al.
(författare)
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Increased CSF biomarkers of angiogenesis in Parkinson disease
- 2015
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Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 85:21, s. 1834-1842
-
Tidskriftsartikel (refereegranskat)abstract
- To study biomarkers of angiogenesis in Parkinson disease (PD), and how these are associated with clinical characteristics, blood-brain barrier (BBB) permeability, and cerebrovascular disease.
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| 12. |
- Jørgensen Hasse, Stina, et al.
(författare)
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Identification as Process in Participatory Design
- 2018
-
Ingår i: PDC '18 Proceedings of the 15th Participatory Design Conference: Short Papers, Situated Actions, Workshops and Tutorial - Volume 2. - New York, NY, USA : ACM Digital Library. ; , s. 1-4
-
Konferensbidrag (refereegranskat)abstract
- In this workshop we invite participants to discuss and map techniques, approaches and principles to address processes of identification in Participatory Design endeavors. The key objective of the workshop is to present identification as process as a concept to think with, and to explore how different lenses can engage workshop participants in thinking about participatory design endeavors in connection to this concept. As the outcome the workshop participants produce set of principles for identification as process for PD work.
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| 13. |
- Kokosar, Milana, et al.
(författare)
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Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
- 2016
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA methylation in adipose tissue from 64 women with PCOS and 30 controls. In total, 1720 unique genes were differentially expressed (Q < 0.05). Six out of twenty selected genes with largest expression difference (CYP1B1, GPT), genes linked to PCOS (RAB5B) or type 2 diabetes (PPARG, SVEP1), and methylation (DMAP1) were replicated in a separate case-control study. In total, 63,213 sites (P < 0.05) and 440 sites (Q < 0.15) were differently methylated. Thirty differentially expressed genes had corresponding changes in 33 different DNA methylation sites. Moreover, a total number of 1913 pairs of differentially expressed "gene-CpG" probes were significantly correlated after correction for multiple testing and corresponded with 349 unique genes. In conclusion, we identified a large number of genes and pathways that are affected in adipose tissue from women with PCOS. We also identified specific DNA methylation pathways that may affect mRNA expression. Together, these novel findings show that women with PCOS have multiple transcriptional and epigenetic changes in adipose tissue that are relevant for development of the disease.
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| 14. |
- Nilsson, Elisabet M., et al.
(författare)
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Becoming a co-archivist. ReDoing archival practices for democratising the access to and participation in archives
- 2017
-
Ingår i: REDO Cumulus Conference Proceedings 2017. - : Cumulus International Association of Universities and Colleges of Art, Design and Media. ; , s. 365-371
-
Konferensbidrag (refereegranskat)abstract
- This paper presents the second phase of the project Co-archiving Flight Documentation, aimed at exploring and prototyping co-archiving practices for involving underrepresented voices in sharing stories of our times from their point of view. The prototypes developed can be iterated and put in use, but may also potentially contribute to challenging the role of the archivist. What parallels can be drawn between the practices of a co-designer and an archivist interested in becoming a co-archivist? Building on outcomes from previous design interventions within the co-archiving research theme, we will run a co-design process involving practitioners and newcomers. Since the design process is not yet completed, we cannot present any concrete prototypes. This paper suggests imaginative ways of ReDoing by applying co-design approaches in other disciplines, and contributes to the discussion of how co-designers can step into other domains and be part of developing practices and approaches in other fields.
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| 15. |
- Nilsson, Elisabet M., et al.
(författare)
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Co-designing newcomers archives : discussing ethical challenges when establishing collaboration with vulnerable user groups
- 2016
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Ingår i: Cumulus Hong Kong 2016. - : Hong Kong Design Institute. ; , s. 211-214
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Konferensbidrag (refereegranskat)abstract
- Living Archives is a research project exploring the roles of archives in a digitized society. Together, with the Malmö City Archives, we initiated a project aiming at prototyping co-archiving practices for young newcomers, to contribute to a newcomers archive. The project emerged as a reaction to the situation in 2015, where 162,877 people sought asylum in Sweden. In response to this situation the Malmö City Archives is organising activities to welcome and help integrate newcomers. This paper however, doesn't focus on the design proposals prototyped as part of the project, but on ethical challenges when collaborating with vulnerable user groups. Before starting the research process we attended a seminar to discuss our ethical stand. We also revisited the ethical standards in research, as well as papers on ethical considerations in design research. Nevertheless, in encountering the youngsters we realised that we were not adequately prepared. To think about ethical standpoints in theory is one thing, but what happens in situ is something else. In this paper we highlight our personal experiences in our first meetings with the user group. We discuss the complexities of establishing collaborations with vulnerable groups, to avoid a naïve view of what such projects, and collaborations require in terms of time and resources. Given the current refugee situation and the potentials of design actions to tackle major societal problems, it is likely that many design researchers will be engaging with these issues, thus these discussions are required.
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| 16. |
- Nilsson, Elisabet M., et al.
(författare)
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Eat a Memory : A Tool for Urban Archival Practices to Support Citizens’ Participation in Urban Development
- 2015
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The work presented in this paper explores the potential of urban gardening communities to be ‘read’ as urban archives and become platforms for collecting, storing, transmitting new and diverse stories about neighbourhoods, and/or communities. The first step of this exploratory study is to create a series of interventions in form of design activities and artistic actions/gestures dedicated to prototype and test how an urban garden can be collected and stored in an urban archive. The series of interventions results in a methodological toolbox containing a set of tools and methods. In this paper the tool Eat a Memory is presented and discussed. The basic idea of this intervention is to explore food and meals as performed memories, and cooking as archival practice. Through the act of cooking and eating, memories are performed, shared and stored in various formats. A joint meal in form of a potluck is applied as a platform to access and record histories of people and places. We suggest that Eat a Memory can be applied as a tool for capturing intangible data of neighbourhoods, and communities, and create a new kind of urban archive which may support and encourage citizen participation, and become a resource in urban development.
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| 17. |
- Nilsson, Elisabet M., et al.
(författare)
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Gardening communities as urban archives and social resource in urban planning
- 2015
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Ingår i: Nordes;6. - : Konstfack. ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- This exploratory paper presents initial thoughts on a research theme described as Urban Archiving. The aim is to explore potentials of urban gardening communities both to be read as urban archives and to become platforms for transmitting knowledge and connecting different communities of practices that engage in urban development and societal change (e.g., design communities and urban gardening communities). Issues to be explored concern how practices of urban archiving can contribute to a more holistic view of our cities, including urban gardening communities that engage in urban sustainable development but are seldom invited to influence matters of urban development.
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| 18. |
- Nilsson, Elisabet M.
(författare)
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Prototyping collaborative (co)-archiving practices : From archival appraisal to co-archival facilitation
- 2016
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Ingår i: 2016 22nd International Conference on Virtual System & Multimedia (VSMM). - : IEEE. ; , s. 313-316
-
Konferensbidrag (refereegranskat)abstract
- This paper presents a series of prototyped collaborative (co-)archiving practices developed within the interdisciplinary research project Living Archives. The aim is to explore co-archiving practices for involving underrepresented voices in contributing to our archives, and to create conditions for accessing intangible heritage resources beyond traditional methods. The methodological approach is design research, and participatory design. Six co-archiving practices are presented, designed to invite the user groups to collect, store and share their memories and cultural heritages. We argue that the co-archiving practices prototyped assume an inclusive and a democratic approach. They allow for the involvement of many senses when accessing and generating archive material in an open, but still highly structured way. Applying such co-archiving approach could potentially result in more representative archives, and support archivists interested in going from a focus on archival appraisal to co-archival facilitation.
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| 19. |
- Nilsson, Elisabet M., et al.
(författare)
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Re-thinking archiving for increased diversity : Insights from a co-design project with museum professionals and refugees
- 2018
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Ingår i: Cumulus Conference Proceedings Series;5. - : Cumulus International Association of Universities and Colleges of Art, Design and Media. ; , s. 548-561
-
Konferensbidrag (refereegranskat)abstract
- The design research project Co-archiving Refugee Documentation is based on a collaboration with museum professionals and refugees. The overall aim of the project is to explore and develop collaborative (co-)archiving practices involving underrepresented voices in generating materials for the public archives and museum collections. The underlying assumption is that inviting more people to contribute to the public archives would result in a more diverse and representative record of human existence. A co-design process involving museum professionals and refugees resulted in a design concept for increasing the participation in archives referred to as the Co-archiving Toolbox. The toolbox is designed for archivists and museum professionals to use when collecting material in the field. It is meant to be administered by a public institution (a museum or an archive), left in the field for a period of two weeks, and used by the people who are being documented, that is, the ‘subjects’ of the archive. By applying the archiving practices included in the toolbox, they are invited to document their life situations with limited interference from the institution. The focus of this paper is on the outcome of the first field test of the co-archiving toolbox. The insights gained serve as input to the next iteration of the concept. The test was conducted at a leisure centre hosted by a non-governmental organisation that organizes on a voluntary basis activities for unaccompanied refugees under 18 years. Seven teenage boys participated in the field test. It turned out that only a few of them contributed with material to the co-archiving toolbox. According to the museum professional who worked with the toolbox, some of the boys even seemed to avoid the box. Her impression was that the barrier to engage was too high. The boys expressed a sense of dejection and wondered who would be interested in hearing their stories anyway. Some archival material was however generated during field test, mainly written material. Seeing the toolbox in the specific context of the leisure centre brought forward a clearer picture of the use of toolbox as very much a situated practice, where the physical placement and the specifics of the field influence the kind of tools applied and the way they are used. Whatever the boys’ reasons were for not feeling motivated to contribute to the archive, an important lesson to learn is that the toolbox ought to be carefully adopted and adjusted according to the specific context and user group. The final iteration of the Co-archiving Toolbox will be designed as a completely open source co-archiving toolbox, where both the physical box in form of files for replicating the build, all materials and the handbook are made available for download, re-production and replication. The open source kit will be distributed via online maker communities. The results of this research project will thus reach beyond the academic community and be made accessible to professionals who are interested in continuing to innovate and create better conditions for increased participation in and access to our common archives.
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| 20. |
- Nilsson, Elisabet M., et al.
(författare)
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The Co-archiving Toolbox : Designing conditions for diversity in public archives
- 2018
-
Ingår i: Proceedings of DRS 2018 International Conference: Catalys. - : Design Research Society. - 9781912294275 ; , s. 717-728
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Konferensbidrag (refereegranskat)abstract
- This paper reports the development of a method for increasing the diversity in public archives, referred to as the Co-archiving Toolbox and developed in collaboration with three museums. Museum professionals and refugees were invited to co-design workshops to explore and prototype alternative ways to document and archive refugee stories – told in their own voices and through their own perspectives. Besides elaborating on alternative, and more inclusive archiving practices, the project also explored how co-design approaches and prototyping can become a resource in rethinking the role of archivists and museum professionals who are interested in coarchival facilitation. The co-archiving toolbox currently includes seven co-archiving practices designed to be applied at temporary refugee housing but could potentially also be used in other contexts. The project may serve as an example of how design interventions can contribute to developing existing archival practices by encouraging archivists and museum professionals to assume a collaborative approach.
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| 21. |
- Nilsson, Elisabet M., Senior lecturer in interaction design, 1972-
(författare)
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The Smell of Urban Data : Urban Archiving Practices Beyond Open Data
- 2015
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Ingår i: The Politics, Practices and Poetics of Openness. - Malmö : Malmö University. ; :151209
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The chapter presents the research theme Urban Archiving aming at to explore and prototype urban archiving practices generating intangible urban data, that is, urban data that potentially can give us insights and deeper understanding of urban matters and human behaviour. A series of research interventions are presented, conducted in the form of design activities and artistic actions or gestures. The process results in a collection of prototyped urban archiving practices. The tools and methods are developed together with the communities and artists we are collaborating with, and new tools and methods are continuously added.
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| 22. |
- Nilsson, Elisabet M., et al.
(författare)
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Urban Archiving for Smarter Cities : Archival practices beyond Open data
- 2015
-
Ingår i: Proceedings 2015 International Conference on Culture and Computing Culture and Computing. - : IEEE. ; , s. 189-190
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Konferensbidrag (refereegranskat)abstract
- Urban Archiving is a research theme within the project Living Archives exploring the roles of archives and archival practices in a digitized society. One of the aims is to create design interventions dedicated to exploring, prototyping and testing relevant possibilities for digital archives and archiving practices in various contexts, such as urban development. The research intervention presented in this paper explores and prototypes tools and archiving practices for capturing, representing, and disseminating the intangible culture heritage of a particular neighbourhood, or an area in a city. The data generated is of a qualitative kind, and can be used as a complement, or maybe even a provocation to the image of a neighbourhood outlined by open data sources. If urban open data can be useful in answering the “What?” of a city, the methods and tools we develop can help answering the “Why?” and thus deepen our understanding of urban areas, and how we can plan for sustainable cities.
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| 23. |
- Svärd, Veronica, et al.
(författare)
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Experiences of specialist social workers for asylum seeking patients at a large Swedish hospital
- 2019
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Ingår i: European Journal of Public Health. 29, Suppl 4, ckz186.060. - : Oxford University Press (OUP). - 1101-1262 .- 1464-360X.
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Konferensbidrag (refereegranskat)abstract
- Background In 2016, the Karolinska University Hospital introduced a one-year-project with a mobile team of five asylum social workers (ASW), specializing in migration. This study evaluates the ordinary hospital social workers (HSW) experiences of introducing ASWs for asylum seeking patients. Methods Descriptive analysis was made of answers from a questionnaire sent to all 144 HSW at the hospital (57% response rate). Qualitative content analysis was made of written comments. Results Of the HSWs, 51% always and 29% sometimes contacted an ASW in relation to asylum seeking patients. Of those who contacted an ASW, 74% stated that the ASWs increased the efficiency of care of asylum seeking patients. 65% agreed that ASWs had an improving effect on the quality of encounters between staff and asylum seekers. Also, 67% agreed that the ASWs off-loading function improved the HSWs working conditions. Even though the ASWs were working at two hospitals located in different parts of the region, 78% of HSWs found them to be available. The main reason to not always contact an ASW was that it was not necessary in the specific case (55%). A majority (66%) reported increased knowledge about asylum processes as an outcome of introducing the ASWs at the hospital. This was also highlighted in the written comments, where ASWs detailed and updated knowledge as well as established contacts with e.g. the Swedish Migration Board was emphasized. ASWs specialist competence enabled patients to quickly receive legally correct and accurate information, which decreased worries among patients as well as staff members. Conclusions The HSWs described the ASWs as being important to patients as well as to staff. The ASWs improved the quality of encounters between staff and asylum seekers and strengthened the patient’s right to health and social care. The HSWs also reported an off-loading function, improving the working conditions and the over-all efficiency of care.
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| 24. |
- Wang, X. D., et al.
(författare)
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Association of chromosome 19 to lung cancer genotypes and phenotypes
- 2015
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Ingår i: Cancer and Metastasis Reviews. - : Springer Science and Business Media LLC. - 0167-7659 .- 1573-7233. ; 34:2, s. 217-226
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Forskningsöversikt (refereegranskat)abstract
- The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, ), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGF beta 1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.
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