| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Farahnak, P, et al.
(författare)
-
Parathyroid Hormone's Acute Effect on Vasodilatory Function
- 2010
-
Ingår i: Clinical medicine insights. Endocrinology and diabetes. - : SAGE Publications. - 1179-5514. ; 3, s. 37-42
-
Tidskriftsartikel (refereegranskat)abstract
- Parathyroid hormone (PTH) seems to affect the risk of cardiovascular disease. The aim of the present study was to investigate PTH's acute effect on endothelial vasodilatory function in forearm resistance vessels. Ten healthy subjects underwent forearm venous occlusion plethysmography. We measured forearm blood flow at baseline and at a stable, locally increased PTH level after intra-arterial infusion of metacholine and nitroprusside. The contralateral arm served as a control. Ionized calcium (Ca++) and PTH values were normal in all subjects at baseline (1.26 ± 0.02 mM/L, 3.6 ± 1.2 pM/L). After 30 minutes of PTH infusion, the PTH level increased in the active arm (13.8 ± 4.0 pM/L P < 0.01), while the Ca++ level was unchanged (1.25 ± 0.04; mM/L). Both the PTH and the Ca++ level in the contralateral arm remained unchanged, which indicates no systemic influence. The endothelial-dependent vasodilation was inversely correlated to the Ca++ level at baseline (r = −0.75, P < 0.05) and after PTH infusion (r = −0.68, P < 0.05). The vasodilatory function was not affected during PTH-infusion.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Nilsson, Klas, et al.
(författare)
-
Enabling reuse of robot tasks and capabilities by business-related skills grounded in natural language
- 2013
-
Konferensbidrag (refereegranskat)abstract
- Definition and reuse of robot instructions is still an art that requires extensive engineering, not only of the infrastructure but also of the adaptation of robot capabilities to the context and domain at hand. Technical approaches are numerous, but the lack of practical success is an indication of hidden difficulties, which we have experienced as complications over the last two decades. Based on recent insights we got the idea that it is insufficient to consider technical, economical, and human aspects separately; a new and more coherent type of integration is necessary. A key example is the notion of (robot) skills, which according to this idea should be defined such that the technical capabilities are encapsulated according to business values, and at the same time grounded in terms of knowledge such that human operation is facilitated.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Ring, M., et al.
(författare)
-
Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D
- 2012
-
Ingår i: PLoS ONE. - 1932-6203. ; 7:7
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Elevated levels of calcium and parathyroid hormone (PTH), characteristics of primary hyperparathyroidism (PHPT), may be associated with cardiovascular morbidity and mortality in the general population. We evaluated the possible vascular effects of these risk factors in patients with mild PHPT by using standard methods and new imaging techniques. Design: A prospective case-control study. Subjects and Methods: Forty-eight patients with mild PHPT without any known cardiovascular risk factors were studied at baseline and at one year after parathyroidectomy (PTX) in comparison with 48 healthy age-and gender-matched controls. We measured biochemical variables, augmentation index (AIx), aortic pulse wave velocity (PWVao), radial (IMTrad) and common carotid artery (IMTcca) intima media thicknesses, and the grayscale median (IM-GSM) of the latter. Results: No significant differences were observed between PHPT patients and controls at baseline for AIx (28.6+/-12.2 vs. 27.7+/-12.8%), IMTrad (0.271+/-0.060 vs. 0.255+/-0.053 mm), IMTcca (0.688+/-0.113 vs. 0.680+/-0.135 mm), or IM-GSM (82.3+/-17.2 vs. 86.5+/-15.3), while PWVao was slightly higher in patients (8.68+/-1.50 vs. 8.13+/-1.55, p<0.05). Systolic blood pressure (SBP), calcium, and PTH were higher in patients compared with controls, and decreased after PTX, while vitamin D was lower in patients and increased after PTX. While AIx, PWVao, IMTrad, and IMTcca were related to SBP, neither correlated to vitamin D levels. Only PWVao correlated weakly to plasma PTH (r=0.29, p<0.01) and ionized calcium (r=0.22, p<0.05) but showed no relation when age and SBP were adjusted for. Conclusion: We found normal arterial function despite high calcium, PTH, and low vitamin D levels, in patients with mild PHPT without cardiovascular risk factors. The cardiovascular risk associated with low vitamin D and/or high PTH and calcium levels may be explained by their coupling to blood pressure and other risk factors rather than direct effects on arterial structure.
|
|
| 17. |
- Ring, M., et al.
(författare)
-
Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D
- 2012
-
Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 7:7, s. Art. no. e39519-
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Elevated levels of calcium and parathyroid hormone (PTH), characteristics of primary hyperparathyroidism (PHPT), may be associated with cardiovascular morbidity and mortality in the general population. We evaluated the possible vascular effects of these risk factors in patients with mild PHPT by using standard methods and new imaging techniques.Design: A prospective case-control study.Subjects and Methods: Forty-eight patients with mild PHPT without any known cardiovascular risk factors were studied at baseline and at one year after parathyroidectomy (PTX) in comparison with 48 healthy age-and gender-matched controls. We measured biochemical variables, augmentation index (AIx), aortic pulse wave velocity (PWVao), radial (IMTrad) and common carotid artery (IMTcca) intima media thicknesses, and the grayscale median (IM-GSM) of the latter.Results: No significant differences were observed between PHPT patients and controls at baseline for AIx (28.6+/-12.2 vs. 27.7+/-12.8%), IMTrad (0.271+/-0.060 vs. 0.255+/-0.053 mm), IMTcca (0.688+/-0.113 vs. 0.680+/-0.135 mm), or IM-GSM (82.3+/-17.2 vs. 86.5+/-15.3), while PWVao was slightly higher in patients (8.68+/-1.50 vs. 8.13+/-1.55, p
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Aad, G., et al.
(författare)
-
- 2012
-
swepub:Mat__t
|
|
