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- Fallani, M, et al.
(författare)
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Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres
- 2011
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Ingår i: Microbiology (Reading, England). - : Microbiology Society. - 1465-2080 .- 1350-0872. ; 157:Pt 5, s. 1385-1392
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Tidskriftsartikel (refereegranskat)abstract
- Although it is well established that early infant feeding has a major influence on the establishment of the gut microbiota, very little is understood about how the introduction of first solid food influences the colonization process. This study aimed to determine the impact of weaning on the faecal microbiota composition of infants from five European countries (Sweden, Scotland, Germany, Italy and Spain) which have different lifestyle characteristics and infant feeding practices. Faecal samples were collected from 605 infants approximately 4 weeks after the introduction of first solid foods and the results were compared with the same infants before weaning (6 weeks of age) to investigate the association with determining factors such as geographical origin, mode of delivery, previous feeding method and age of weaning. Samples were analysed by fluorescence in situ hybridization and flow cytometry using a panel of 10 rRNA targeted group- and species-specific oligonucleotide probes. The genus Bifidobacterium (36.5 % average proportion of total detectable bacteria), Clostridium coccoides group (14 %) and Bacteroides (13.6 %) were predominant after weaning. Similar to pre-weaning, northern European countries were associated with a higher proportion of bifidobacteria in the infant gut microbiota while higher levels of Bacteroides and lactobacilli characterized southern European countries. As before weaning, the initial feeding method influenced the Clostridium leptum group and Clostridium difficile+Clostridium perfringens species, and bifidobacteria still dominated the faeces of initially breast-fed infants. Formula-fed babies presented significantly higher proportions of Bacteroides and the C. coccoides group. The mode of birth influenced changes in the proportions of bacteroides and atopobium. Although there were significant differences in the mean weaning age between countries, this was not related to the populations of bifidobacteria or bacteroides. Thus, although the faecal microbiota of infants after first complementary foods was different to that before weaning commenced, many of the initial influences on microbiota composition were still evident.
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- Wågström, Linus, 1977, et al.
(författare)
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A methodology for improving structural robustness in frontal car-to-car crash scenarios
- 2013
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Ingår i: International Journal of Crashworthiness. - : Informa UK Limited. - 1358-8265 .- 1754-2111. ; 18:4, s. 385-396
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Tidskriftsartikel (refereegranskat)abstract
- There has been significant development in passenger car crashworthiness over the last few decades. However, real-world crashes often occur in scenarios dissimilar to laboratory barrier crash set-ups. Further knowledge is required on how different impact scenarios affect vehicle structural response and occupant injury risk in real-world scenarios. This study introduces a methodology for assessing crash configuration parameters that influence the structural response in car-to-car frontal collisions by using finite element models of two identical vehicles. The crash configuration parameters included in this study were initial velocities, oblique angle and lateral offset distance. An evaluation was made in terms of passenger compartment intrusion and crash pulse severity. Special focus was directed towards investigating whether these input parameters can be used to define incompatible scenarios, i.e. where the structural response in one vehicle is significantly different compared to the other vehicle. Results indicate that collision scenarios with large overlap as extreme in terms of crash pulse severity, and incompatible car-to-car crash scenarios were found at small overlap and an oblique angle of 15 degrees. An outlook for future model and method validation work is described.
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