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1.	Bhangu, A, et al. (author) Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study 2018 In: The Lancet. Infectious diseases. - : Elsevier. - 1474-4457 .- 1473-3099. ; 18:5, s. 516-525 Journal article (peer-reviewed)
2.	Antovic, A, et al. (author) Venous Thromboembolic Events in Idiopathic Inflammatory Myopathy: Occurrence and Relation to Disease Onset 2018 In: Arthritis care & research. - : Wiley. - 2151-4658 .- 2151-464X. ; 70:12, s. 1849-1855 Journal article (peer-reviewed)
3.	Barsotti, S, et al. (author) Performance of the New EULAR/Acr Classification Criteria for Idiopathic Inflammatory Myopathies (IIM) in a Large Monocentric IIM Cohort 2018 In: ARTHRITIS & RHEUMATOLOGY. - 2326-5191. ; 70 Conference paper (other academic/artistic)
4.	Cerqueira, CF, et al. (author) Anti-Jo1-positive myositis patients display a specific immunoglobulin G Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies 2018 In: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. - 0300-9742. ; 47, s. 10-10 Conference paper (other academic/artistic)
5.	Cerqueira, CF, et al. (author) Myositis-specific anti-histidyl tRNA synthetase (HisRS) autoantibodies display high reactivity against HisRS conformational epitopes and are associated with lung and joint involvement 2018 In: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. - 0300-9742. ; 47, s. 14-15 Conference paper (other academic/artistic)
6.	Fernandes-Cerqueira, C, et al. (author) Anti-Jo1 Positive Myositis Patients Display a Characteristic IgG Fc-Glycan Profile Which Is Further Enhanced in Anti-Jo1 Autoantibodies 2018 In: ARTHRITIS & RHEUMATOLOGY. - 2326-5191. ; 70 Conference paper (other academic/artistic)
7.	Fernandes-Cerqueira, C, et al. (author) Myositis Specific Anti-Histidyl tRNA Synthetase (HisRS) Autoantibodies Display High Reactivity Against Hisrs Conformational Epitopes and Associate with Lung and Joint Involvement 2018 In: ARTHRITIS & RHEUMATOLOGY. - : BMJ Publishing Group Ltd and European League Against Rheumatism. - 2326-5191. ; 77, s. 736-736 Conference paper (other academic/artistic)
8.	Fernandes-Cerqueira, C, et al. (author) Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies 2018 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 17958- Journal article (peer-reviewed)abstract IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in patients with idiopathic inflammatory myopathies (IIM) and anti-synthetase syndrome (ASS) with associated interstitial lung disease (ILD). Thus, we hypothesized that the total-IgG Fc-glycans from Jo1+ versus Jo1− patients and anti-Jo1-IgG would show characteristic differences, and that particular Fc-glycan features would be associated with specific clinical manifestations. By proteomics based mass spectrometry we observed a high abundance of agalactosylated IgG1 Fc-glycans in ASS/IIM patients (n = 44) compared to healthy age matched controls (n = 24). Using intra-individual normalization of the main agalactosylated glycan (FA2) of IgG1 vs FA2-IgG2, ASS/IIM and controls were distinguished with an area under the curve (AUC) of 79 ± 6%. For Jo1+ patients (n = 19) the AUCs went up to 88 ± 6%. Bisected and afucosylated Fc-glycans were significantly lower in Jo1+ compared to Jo1− patients. Anti-Jo1-IgG enriched from eleven patients contained even significantly lower abundances of bisected, afucosylated and galactosylated forms compared to matched total-IgG. ASS and ILD diagnosis, as well as lysozyme and thrombospondin correlated with Jo1+ characteristic Fc-glycan features. These results suggest that the anti-Jo1+ patient Fc-glycan profile contains phenotype specific features which may underlie the pathogenic role of Jo1 autoantibodies.

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Result 1-8 of 8

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Type of publication: conference paper (5); journal article (3)

Type of content: other academic/artistic (5); peer-reviewed (3)

Author/Editor: Cole, S. (1); Haddad, N. (1); Mahmoud, S. (1); Palma, A. (1); White, R. (1); Ye, J. (1); show more...; Ahmed, H. (1); Gupta, A. (1); Lim, H. (1); Aziz, NA (1); Espin-Basany, E (1); Kumar, S (1); Mikalauskas, S (1); Park, J (1); Wilson, M (1); Moore, R. (1); Zielinski, M. (1); Evans, D. (1); Roy, C. (1); Davies, R (1); Mohamed, A. (1); Mostafa, M. (1); Lopez, M. (1); Mohan, M. (1); Patel, P. (1); Hall, E (1); Ali, S (1); Mohammed, H (1); Mohammed, S (1); Negoi, I (1); Rickard, J (1); Abbas, A. (1); Kumar, B (1); Carpio, J. (1); Sharma, A (1); Mohamed, M. (1); Muller, J. (1); Sanchez, D. (1); Mustafa, M (1); Abdelhady, S (1); Abdelkader, M. (1); Yang, J. (1); Cox, M (1); Sander, A. (1); Roy, S (1); O'Neill, S (1); King, S. (1); Ali, A. (1); Sacco, M (1); Svensson, J (1); show less...

University: Karolinska Institutet (8); Umeå University (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2018 (8)Undo refine

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